Role of γδT cells in liver diseases and its relationship with intestinal microbiota

New Aspect of Liver IL-17+ γδ T Cells

(2019) Chen Xi et al.   MOLECULAR IMMUNOLOGY

Activated γδ T cells exhibit cytotoxicity and the capacity for viral clearance in patients with acute hepatitis B

(2019) Zheng-Hu Jia et al.   CLINICAL IMMUNOLOGY

Hepatocellular Carcinoma

(2019) Augusto Villanueva   NEW ENGLAND JOURNAL OF MEDICINE

An imbalance between stellate cells and γδT cells contributes to hepatocellular carcinoma aggressiveness and recurrence

(2019) Bao-Yong Zhou et al.   Hepatology International

γδ T cells Promote Steatohepatitis by Orchestrating Innate and Adaptive Immune Programming

(2019) Alejandro Torres‐Hernandez et al.   HEPATOLOGY

Clinical Management of Primary Biliary Cholangitis—Strategies and Evolving Trends

(2019) Lixia Gao et al.   CLINICAL REVIEWS IN ALLERGY & IMMUNOLOGY

Hepatitis C

(2019) C Wendy Spearman et al.   LANCET

Immune Responses in the Liver

(2018) Paul Kubes et al.   Annual Review of Immunology

Alterations in Intestinal Microbiota Lead to Production of Interleukin 17 by Intrahepatic γδ T-Cell Receptor–Positive Cells and Pathogenesis of Cholestatic Liver Disease

(2018) Dana Tedesco et al.   GASTROENTEROLOGY

Chronic Hepatitis B Infection

(2018) Lydia S. Y. Tang et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Traditional Herbal Medicine-Derived Sulforaphene LFS-01 Reverses Colitis in Mice by Selectively Altering the Gut Microbiota and Promoting Intestinal Gamma-Delta T Cells

(2018) Ming Li et al.   Frontiers in Pharmacology

The role of gamma delta T lymphocytes in breast cancer: a review

(2018) Elizabeth S. Morrow et al.   Translational Research

Tissue Adaptations of Memory and Tissue-Resident Gamma Delta T Cells

(2018) Camille Khairallah et al.   Frontiers in Immunology

γδT cells are indispensable for interleukin-23-mediated protection against Concanavalin A-induced hepatitis in hepatitis B virus transgenic mice

(2017) Ziyu Meng et al.   IMMUNOLOGY

The microbiota maintain homeostasis of liver-resident γδT-17 cells in a lipid antigen/CD1d-dependent manner

(2017) Fenglei Li et al.   Nature Communications

Upregulation of Intestinal Barrier Function in Mice with DSS-Induced Colitis by a Defined Bacterial Consortium Is Associated with Expansion of IL-17A Producing Gamma Delta T Cells

(2017) Ming Li et al.   Frontiers in Immunology

Total fecal microbiota transplantation alleviates high-fat diet-induced steatohepatitis in mice via beneficial regulation of gut microbiota

(2017) Da Zhou et al.   Scientific Reports

Characteristics of IL-9 induced by Schistosoma japonicum infection in C57BL/6 mouse liver

(2017) Lu Li et al.   Scientific Reports

Human γδT-cell subsets and their involvement in tumor immunity

(2016) Dang Wu et al.   Cellular & Molecular Immunology

MicroRNA-26a-interleukin (IL)-6-IL-17 axis regulates the development of non-alcoholic fatty liver disease in a murine model

(2016) Q. He et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Interleukin 17, Produced by γδ T Cells, Contributes to Hepatic Inflammation in a Mouse Model of Biliary Atresia and Is Increased in Livers of Patients

(2016) Christian Klemann et al.   GASTROENTEROLOGY

Comment on “Exosome-mediated activation of toll-like receptor 3 in stellate cells stimulates interleukin-17 production by γδ T cells in liver fibrosis”

(2016) Ming Ni et al.   HEPATOLOGY

Exosome-mediated activation of toll-like receptor 3 in stellate cells stimulates interleukin-17 production by γδ T cells in liver fibrosis

(2016) Wonhyo Seo et al.   HEPATOLOGY

Immunity, tolerance and autoimmunity in the liver: A comprehensive review

(2016) Derek G. Doherty   JOURNAL OF AUTOIMMUNITY

γδ T Cells Protect the Liver and Lungs of Mice from Autoimmunity Induced by Scurfy Lymphocytes

(2016) Hideyuki Ujiie et al.   JOURNAL OF IMMUNOLOGY

Primary Sclerosing Cholangitis

(2016) Konstantinos N. Lazaridis et al.   NEW ENGLAND JOURNAL OF MEDICINE

Dual Effects of Cellular Immunotherapy in Inhibition of Virus Replication and Prolongation of Survival in HCV-Positive Hepatocellular Carcinoma Patients

(2016) Lei Qian et al.   Journal of Immunology Research

Innate Immune Recognition of Cancer

(2015) Seng-Ryong Woo et al.   Annual Review of Immunology

Interleukin-23-Independent IL-17 Production Regulates Intestinal Epithelial Permeability

(2015) Jacob S. Lee et al.   IMMUNITY

The Jekyll and Hyde story of IL17-Producing γδT Cells

(2015) Rushikesh S. Patil et al.   Frontiers in Immunology

Enhanced Functions of Peripheral γδ T Cells in Chronic Hepatitis B Infection during Interferon α Treatment In Vivo and In Vitro

(2015) Min Chen et al.   PLoS One

Microbiota Modulate Tumoral Immune Surveillance in Lung through a   T17 Immune Cell-Dependent Mechanism

(2014) M. Cheng et al.   CANCER RESEARCH

Regeneration of stalled immune responses to transformed and infected cells using γδ T cells

(2014) Kenth Gustafsson et al.   DRUG DISCOVERY TODAY

γδ T Cells and Their Potential for Immunotherapy

(2014) Yan-Ling Wu et al.   International Journal of Biological Sciences

SCART Scavenger Receptors Identify a Novel Subset of Adult    T Cells

(2014) J. Kisielow et al.   JOURNAL OF IMMUNOLOGY

T-bet and Eomesodermin Play Critical Roles in Directing T Cell Differentiation to Th1 versus Th17

(2014) Y. Yang et al.   JOURNAL OF IMMUNOLOGY

γδT Cells Drive Myeloid-Derived Suppressor Cell–Mediated CD8+T Cell Exhaustion in Hepatitis B Virus–Induced Immunotolerance

(2014) Xiaohui Kong et al.   JOURNAL OF IMMUNOLOGY

Liver cirrhosis

(2014) Emmanuel A Tsochatzis et al.   LANCET

TCRγδ+CD4−CD8− T Cells Suppress the CD8+ T-Cell Response to Hepatitis B Virus Peptides, and Are Associated with Viral Control in Chronic Hepatitis B

(2014) Qintao Lai et al.   PLoS One

Anti-metastatic potential of human Vδ1+ γδ T cells in an orthotopic mouse xenograft model of colon carcinoma

(2013) Christel Devaud et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

Chemokine receptor CCR6-dependent accumulation of γδ T cells in injured liver restricts hepatic inflammation and fibrosis

(2013) Linda Hammerich et al.   HEPATOLOGY

Characteristics of IL-17 induction bySchistosoma japonicuminfection in C57BL/6 mouse liver

(2013) Dianhui Chen et al.   IMMUNOLOGY

Regulatory functions of γδ T cells

(2013) Dieter Kabelitz et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Combination of radiofrequency ablation and sequential cellular immunotherapy improves progression-free survival for patients with hepatocellular carcinoma

(2013) Jiuwei Cui et al.   INTERNATIONAL JOURNAL OF CANCER

Gammadelta T Cells: Innately Adaptive Immune Cells?

(2013) Leonardo M. R. Ferreira   INTERNATIONAL REVIEWS OF IMMUNOLOGY

Protective Role of the Inflammatory CCR2/CCL2 Chemokine Pathway through Recruitment of Type 1 Cytotoxic    T Lymphocytes to Tumor Beds

(2013) T. Lanca et al.   JOURNAL OF IMMUNOLOGY

IL-17A Plays a Critical Role in the Pathogenesis of Liver Fibrosis through Hepatic Stellate Cell Activation

(2013) Z. Tan et al.   JOURNAL OF IMMUNOLOGY

Decreased Vδ2 γδ T Cells Associated With Liver Damage by Regulation of Th17 Response in Patients With Chronic Hepatitis B

(2013) Xiaoli Wu et al.   JOURNAL OF INFECTIOUS DISEASES

Interleukin-17 Signaling in Inflammatory, Kupffer Cells, and Hepatic Stellate Cells Exacerbates Liver Fibrosis in Mice

(2012) Fanli Meng et al.   GASTROENTEROLOGY

High-mobility group box 1 (HMGB1)-toll-like receptor (TLR)4-interleukin (IL)-23-IL-17A axis in drug-induced damage-associated lethal hepatitis: Interaction of γδ T cells with macrophages

(2012) Xuefu Wang et al.   HEPATOLOGY

Enhanced Peripheral γδT Cells Cytotoxicity Potential in Patients with HBV-Associated Acute-On-Chronic Liver Failure Might Contribute to the Disease Progression

(2012) Min Chen et al.   JOURNAL OF CLINICAL IMMUNOLOGY

The activity of γδ T cells against paediatric liver tumour cells and spheroids in cell culture

(2012) Alexander Hoh et al.   LIVER INTERNATIONAL

Liver TCRγδ+ CD3+ CD4− CD8− T cells contribute to murine hepatitis virus strain 3-induced hepatic injury through a TNF-α-dependent pathway

(2012) Yulei Lu et al.   MOLECULAR IMMUNOLOGY

Vγ4 γδ T Cell-Derived IL-17A Negatively Regulates NKT Cell Function in Con A-Induced Fulminant Hepatitis

(2011) Na Zhao et al.   JOURNAL OF IMMUNOLOGY

Autoimmune hepatitis

(2011) Giorgina Mieli-Vergani et al.   Nature Reviews Gastroenterology & Hepatology

Naturally Activated V 4    T Cells Play a Protective Role in Tumor Immunity through Expression of Eomesodermin

(2010) W. He et al.   JOURNAL OF IMMUNOLOGY

Ligand recognition during thymic development and γδ T cell function specification

(2010) Christina Meyer et al.   SEMINARS IN IMMUNOLOGY

Toll-Like Receptor 3 in Liver Diseases

(2010) Shi Yin et al.   Gastroenterology Research and Practice

CCR6 and NK1.1 distinguish between IL-17A and IFN-γ-producing γδ effector T cells

(2009) Jan D. Haas et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

CD27 is a thymic determinant of the balance between interferon-γ- and interleukin 17–producing γδ T cell subsets

(2009) Julie C Ribot et al.   NATURE IMMUNOLOGY

Isopentenyl Pyrophosphate-Activated CD56+    T Lymphocytes Display Potent Antitumor Activity toward Human Squamous Cell Carcinoma

(2008) A. A.Z. Alexander et al.   CLINICAL CANCER RESEARCH

A subset of IL-10-producing γδ T cells protect the liver fromListeria-elicited, CD8+T cell-mediated injury

(2008) Katherine A. Rhodes et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

In vivo equilibrium of proinflammatory IL-17+and regulatory IL-10+Foxp3+RORγt+T cells

(2008) Matthias Lochner et al.   JOURNAL OF EXPERIMENTAL MEDICINE

  T Cells Initiate Acute Inflammation and Injury in Adenovirus-Infected Liver via Cytokine-Chemokine Cross Talk

(2008) M. N. Ajuebor et al.   JOURNAL OF VIROLOGY

Interactions among the transcription factors Runx1, RORγt and Foxp3 regulate the differentiation of interleukin 17–producing T cells

(2008) Fuping Zhang et al.   NATURE IMMUNOLOGY