Systemic cancer therapy with engineered adenovirus that evades innate immunity

Interactions of viruses and the humoral innate immune response

(2020) Bailey E. Maloney et al.   CLINICAL IMMUNOLOGY

Expanding the Spectrum of Adenoviral Vectors for Cancer Therapy

(2020) Jian Gao et al.   Cancers

Checkpoint inhibitors go viral

(2019) Melanie Senior   NATURE BIOTECHNOLOGY

A phase 1 dose escalation study of the oncolytic adenovirus enadenotucirev, administered intravenously to patients with epithelial solid tumors (EVOLVE)

(2019) Jean-Pascal Machiels et al.   Journal for ImmunoTherapy of Cancer

Complement C4 Prevents Viral Infection through Capsid Inactivation

(2019) Maria Bottermann et al.   Cell Host & Microbe

A review of 65 years of human adenovirus seroprevalence

(2019) Franck J. D. Mennechet et al.   Expert Review of Vaccines

Xenoantigen-dependent complement-mediated neutralization of LCMV glycoprotein pseudotyped VSV in human serum

(2019) Lisa Pipperger et al.   JOURNAL OF VIROLOGY

Human Adenovirus Serotype 5 Is Sensitive to IgM-Independent Neutralization In Vitro and In Vivo

(2019) Andor Doszpoly et al.   Viruses-Basel

MonoRes: Automatic and Accurate Estimation of Local Resolution for Electron Microscopy Maps

(2018) Jose Luis Vilas et al.   STRUCTURE

Lung macrophage scavenger receptor SR-A6 (MARCO) is an adenovirus type-specific virus entry receptor

(2018) Nicole Stichling et al.   PLoS Pathogens

cisTEM, user-friendly software for single-particle image processing

(2018) Timothy Grant et al.   eLife

Revised Crystal Structure of Human Adenovirus Reveals the Limits on Protein IX Quasi-Equivalence and on Analyzing Large Macromolecular Complexes

(2018) S. Kundhavai Natchiar et al.   JOURNAL OF MOLECULAR BIOLOGY

The IgM pentamer is an asymmetric pentagon with an open groove that binds the AIM protein

(2018) Emiri Hiramoto et al.   Science Advances

Atomic Structures of Minor Proteins VI and VII in Human Adenovirus

(2017) Xinghong Dai et al.   JOURNAL OF VIROLOGY

MotionCor2: anisotropic correction of beam-induced motion for improved cryo-electron microscopy

(2017) Shawn Q Zheng et al.   NATURE METHODS

UCSF ChimeraX: Meeting modern challenges in visualization and analysis

(2017) Thomas D. Goddard et al.   PROTEIN SCIENCE

Preclinical Safety Studies of Enadenotucirev, a Chimeric Group B Human-Specific Oncolytic Adenovirus

(2017) Sam Illingworth et al.   Molecular Therapy-Oncolytics

Patterns of Clinical Response with Talimogene Laherparepvec (T-VEC) in Patients with Melanoma Treated in the OPTiM Phase III Clinical Trial

(2016) Robert H. I. Andtbacka et al.   ANNALS OF SURGICAL ONCOLOGY

A phased strategy to differentiate human CD14+monocytes into classically and alternatively activated macrophages and dendritic cells

(2016) Jelani C. Zarif et al.   BIOTECHNIQUES

The relevance of coagulation factor X protection of adenoviruses in human sera

(2016) M R Duffy et al.   GENE THERAPY

CD55 is a key complement regulatory protein that counteracts complement-mediated inactivation of Newcastle Disease Virus

(2016) Udaya S. Rangaswamy et al.   JOURNAL OF GENERAL VIROLOGY

Gctf: Real-time CTF determination and correction

(2016) Kai Zhang   JOURNAL OF STRUCTURAL BIOLOGY

Talimogene Laherparepvec Improves Durable Response Rate in Patients With Advanced Melanoma

(2015) Robert H.I. Andtbacka et al.   JOURNAL OF CLINICAL ONCOLOGY

Ad 2.0: a novel recombineering platform for high-throughput generation of tailored adenoviruses

(2015) Martin Mück-Häusl et al.   NUCLEIC ACIDS RESEARCH

I-TASSER server: new development for protein structure and function predictions

(2015) Jianyi Yang et al.   NUCLEIC ACIDS RESEARCH

Re-engineering Vesicular Stomatitis Virus to Abrogate Neurotoxicity, Circumvent Humoral Immunity, and Enhance Oncolytic Potency

(2014) A. Muik et al.   CANCER RESEARCH

Vesiculovirus Neutralization by Natural IgM and Complement

(2014) M. Z. Tesfay et al.   JOURNAL OF VIROLOGY

Circulating Antibodies and Macrophages as Modulators of Adenovirus Pharmacology

(2013) R. Khare et al.   JOURNAL OF VIROLOGY

Coagulation factor X shields adenovirus type 5 from attack by natural antibodies and complement

(2013) Zhili Xu et al.   NATURE MEDICINE

An Intrinsically Disordered Region of the Adenovirus Capsid Is Implicated in Neutralization by Human Alpha Defensin 5

(2013) Justin W. Flatt et al.   PLoS One

The Transcription Factor IRF3 Triggers “Defensive Suicide” Necrosis in Response to Viral and Bacterial Pathogens

(2013) Nelson C. Di Paolo et al.   Cell Reports

Cryo-Electron Microscopy Modeling by the Molecular Dynamics Flexible Fitting Method

(2012) Kwok-Yan Chan et al.   BIOPOLYMERS

RELION: Implementation of a Bayesian approach to cryo-EM structure determination

(2012) Sjors H.W. Scheres   JOURNAL OF STRUCTURAL BIOLOGY

Coagulation Factor X Activates Innate Immunity to Human Species C Adenovirus

(2012) K. Doronin et al.   SCIENCE

Real-time PCR-based assay to quantify the relative amount of human and mouse tissue present in tumor xenografts

(2011) Sergio Y Alcoser et al.   BMC BIOTECHNOLOGY

Macrophage-Derived AIM Is Endocytosed into Adipocytes and Decreases Lipid Droplets via Inhibition of Fatty Acid Synthase Activity

(2010) Jun Kurokawa et al.   Cell Metabolism

Virus Binding to a Plasma Membrane Receptor Triggers Interleukin-1α-Mediated Proinflammatory Macrophage Response In Vivo

(2009) Nelson C. Di Paolo et al.   IMMUNITY

FREAD revisited: Accurate loop structure prediction using a database search algorithm

(2009) Yoonjoo Choi et al.   PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS

Adenovirus Serotype 5 Hexon Mediates Liver Gene Transfer

(2008) Simon N. Waddington et al.   CELL

Clearance of Adenovirus by Kupffer Cells Is Mediated by Scavenger Receptors, Natural Antibodies, and Complement

(2008) Z. Xu et al.   JOURNAL OF VIROLOGY

Directed Evolution Generates a Novel Oncolytic Virus for the Treatment of Colon Cancer

(2008) Irene Kuhn et al.   PLoS One

Adenovirus serotype 5 hexon is critical for virus infection of hepatocytes in vivo

(2008) O. Kalyuzhniy et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Flexible Fitting of Atomic Structures into Electron Microscopy Maps Using Molecular Dynamics

(2008) Leonardo G. Trabuco et al.   STRUCTURE

A quantitative assay for measuring clearance of adenovirus vectors by Kupffer cells

(2007) Jeffrey S. Smith et al.   JOURNAL OF VIROLOGICAL METHODS