Multilayered regulation of proteome stoichiometry

Expression attenuation as a mechanism of robustness against gene duplication

(2021) Diana Ascencio et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

WNK1 is an assembly factor for the human ER membrane protein complex

(2021) Tino Pleiner et al.   MOLECULAR CELL

Co-translational, Post-translational, and Non-catalytic Roles of N-Terminal Acetyltransferases

(2019) Henriette Aksnes et al.   MOLECULAR CELL

Mechanisms and functions of ribosome-associated protein quality control

(2019) Claudio A. P. Joazeiro   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Protein aggregation mediates stoichiometry of protein complexes in aneuploid cells

(2019) Christopher M. Brennan et al.   GENES & DEVELOPMENT

Mapping Degradation Signals and Pathways in a Eukaryotic N-terminome

(2018) Ilia Kats et al.   MOLECULAR CELL

Quality Control of Orphaned Proteins

(2018) Szymon Juszkiewicz et al.   MOLECULAR CELL

Cotranslational assembly of protein complexes in eukaryotes revealed by ribosome profiling

(2018) Ayala Shiber et al.   NATURE

Ribosome Profiling: Global Views of Translation

(2018) Nicholas T. Ingolia et al.   Cold Spring Harbor Perspectives in Biology

Precise Post-translational Tuning Occurs for Most Protein Complex Components during Meiosis

(2018) Amy Rose Eisenberg et al.   Cell Reports

Production of Protein-Complex Components Is Stoichiometric and Lacks General Feedback Regulation in Eukaryotes

(2018) James C. Taggart et al.   Cell Systems

Gene duplication can impart fragility, not robustness, in the yeast protein interaction network

(2017) Guillaume Diss et al.   SCIENCE

UBE2O is a quality control factor for orphans of multiprotein complexes

(2017) Kota Yanagitani et al.   SCIENCE

Cyanobacteria Maintain Constant Protein Concentration despite Genome Copy-Number Variation

(2017) Xiao-yu Zheng et al.   Cell Reports

Post-Translational Dosage Compensation Buffers Genetic Perturbations to Stoichiometry of Protein Complexes

(2017) Koji Ishikawa et al.   PLoS Genetics

Proteome complexity and the forces that drive proteome imbalance

(2016) J. Wade Harper et al.   NATURE

Ribosome-associated protein quality control

(2016) Onn Brandman et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Expression homeostasis during DNA replication

(2016) Y. Voichek et al.   SCIENCE

First Things First: Vital Protein Marks by N-Terminal Acetyltransferases

(2016) Henriette Aksnes et al.   TRENDS IN BIOCHEMICAL SCIENCES

Dealing with Gene-Dosage Imbalance during S Phase

(2016) Raz Bar-Ziv et al.   TRENDS IN GENETICS

Ribosome-associated protein quality control

(2016) Onn Brandman et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

The Cost of Protein Production

(2016) Moshe Kafri et al.   Cell Reports

A conserved quality-control pathway that mediates degradation of unassembled ribosomal proteins

(2016) Min-Kyung Sung et al.   eLife

Not4-dependent translational repression is important for cellular protein homeostasis in yeast

(2015) S. Preissler et al.   EMBO JOURNAL

Aneuploid proliferation defects in yeast are not driven by copy number changes of a few dosage-sensitive genes

(2015) Megan E. Bonney et al.   GENES & DEVELOPMENT

Quantitative nature of overexpression experiments

(2015) Hisao Moriya   MOLECULAR BIOLOGY OF THE CELL

Protein degradation corrects for imbalanced subunit stoichiometry in OST complex assembly

(2015) Susanne Mueller et al.   MOLECULAR BIOLOGY OF THE CELL

Gene dosage imbalances: action, reaction, and models

(2015) Reiner A. Veitia et al.   TRENDS IN BIOCHEMICAL SCIENCES

Quantifying Absolute Protein Synthesis Rates Reveals Principles Underlying Allocation of Cellular Resources

(2014) Gene-Wei Li et al.   CELL

Aneuploidy: implications for protein homeostasis and disease

(2014) A. B. Oromendia et al.   Disease Models & Mechanisms

Largen: A Molecular Regulator of Mammalian Cell Size Control

(2014) Kazuo Yamamoto et al.   MOLECULAR CELL

The Not4 E3 Ligase and CCR4 Deadenylase Play Distinct Roles in Protein Quality Control

(2014) David Halter et al.   PLoS One

Quantitative proteomic analysis reveals posttranslational responses to aneuploidy in yeast

(2014) Noah Dephoure et al.   eLife

Aneuploid yeast strains exhibit defects in cell growth and passage through START

(2013) Rebecca R. Thorburn et al.   MOLECULAR BIOLOGY OF THE CELL

A Cotranslational Ubiquitination Pathway for Quality Control of Misfolded Proteins

(2013) Feng Wang et al.   MOLECULAR CELL

Control of Protein Quality and Stoichiometries by N-Terminal Acetylation and the N-End Rule Pathway

(2013) Anna Shemorry et al.   MOLECULAR CELL

Principles of Cotranslational Ubiquitination and Quality Control at the Ribosome

(2013) Stefanie Duttler et al.   MOLECULAR CELL

A Systematic Approach for the Genetic Dissection of Protein Complexes in Living Cells

(2013) Guillaume Diss et al.   Cell Reports

Activation of autophagy in cells with abnormal karyotype

(2012) Silvia Stingele et al.   Autophagy

Aneuploidy causes proteotoxic stress in yeast

(2012) A. B. Oromendia et al.   GENES & DEVELOPMENT

Identification of dosage-sensitive genes in Saccharomyces cerevisiae using the genetic tug-of-war method

(2012) K. Makanae et al.   GENOME RESEARCH

Global analysis of genome, transcriptome and proteome reveals the response to aneuploidy in human cells

(2012) Silvia Stingele et al.   Molecular Systems Biology

Cellular crowding imposes global constraints on the chemistry and evolution of proteomes

(2012) E. D. Levy et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Protein N-terminal acetyltransferases: when the start matters

(2012) Kristian K. Starheim et al.   TRENDS IN BIOCHEMICAL SCIENCES

Identification of Aneuploidy-Selective Antiproliferation Compounds

(2011) Yun-Chi Tang et al.   CELL

The N-end rule pathway and regulation by proteolysis

(2011) Alexander Varshavsky   PROTEIN SCIENCE

NatF Contributes to an Evolutionary Shift in Protein N-Terminal Acetylation and Is Important for Normal Chromosome Segregation

(2011) Petra Van Damme et al.   PLoS Genetics

Variability in gene expression underlies incomplete penetrance

(2010) Arjun Raj et al.   NATURE

Cellular strategies for controlling protein aggregation

(2010) Jens Tyedmers et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

N-Terminal Acetylation of Cellular Proteins Creates Specific Degradation Signals

(2010) C.-S. Hwang et al.   SCIENCE

Nascent Peptide-dependent Translation Arrest Leads to Not4p-mediated Protein Degradation by the Proteasome

(2009) Lyudmila N. Dimitrova et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Histone levels are regulated by phosphorylation and ubiquitylation-dependent proteolysis

(2009) Rakesh Kumar Singh et al.   NATURE CELL BIOLOGY

Genome-Wide Analysis in Vivo of Translation with Nucleotide Resolution Using Ribosome Profiling

(2009) N. T. Ingolia et al.   SCIENCE

Robustness: mechanisms and consequences

(2009) Joanna Masel et al.   TRENDS IN GENETICS

Nature, Nurture, or Chance: Stochastic Gene Expression and Its Consequences

(2008) Arjun Raj et al.   CELL

Cellular reactions to gene dosage imbalance: genomic, transcriptomic and proteomic effects

(2008) Reiner A. Veitia et al.   TRENDS IN GENETICS