Emerging point-of-care technologies for sickle cell disease screening and monitoring

Quantitative, Point-of-Care Immunoassay Platform to Guide and Monitor Sickle Cell Disease Therapy

(2016) Xiaoxi Yang et al.   ANALYTICAL CHEMISTRY

Neutrophils, platelets, and inflammatory pathways at the nexus of sickle cell disease pathophysiology

(2016) D. Zhang et al.   BLOOD

A rapid, inexpensive and disposable point-of-care blood test for sickle cell disease using novel, highly specific monoclonal antibodies

(2016) Charles T. Quinn et al.   BRITISH JOURNAL OF HAEMATOLOGY

The European Hematology Association Roadmap for European Hematology Research: a consensus document

(2016) A. Engert et al.   HAEMATOLOGICA

Validation of a Low-Cost Paper-Based Screening Test for Sickle Cell Anemia

(2016) Nathaniel Z. Piety et al.   PLoS One

Sickle cell disease biochip: a functional red blood cell adhesion assay for monitoring sickle cell disease

(2016) Yunus Alapan et al.   Translational Research

The European Hematology Association Roadmap for European Hematology Research: a consensus document

(2016) A. Engert et al.   HAEMATOLOGICA

Single-dose intravenous gammaglobulin can stabilize neutrophil Mac-1 activation in sickle cell pain crisis

(2015) Deepa Manwani et al.   AMERICAN JOURNAL OF HEMATOLOGY

Characteristics of a rapid, point-of-care lateral flow immunoassay for the diagnosis of sickle cell disease

(2015) Patrick T. McGann et al.   AMERICAN JOURNAL OF HEMATOLOGY

A rapid paper-based test for quantifying sickle hemoglobin in blood samples from patients with sickle cell disease

(2015) Nathaniel Z. Piety et al.   AMERICAN JOURNAL OF HEMATOLOGY

Micro- and nanodevices integrated with biomolecular probes

(2015) Yunus Alapan et al.   BIOTECHNOLOGY ADVANCES

Randomized phase 2 study of GMI-1070 in SCD: reduction in time to resolution of vaso-occlusive events and decreased opioid use

(2015) M. J. Telen et al.   BLOOD

Validation of a novel point of care testing device for sickle cell disease

(2015) Julie Kanter et al.   BMC Medicine

Advances in detection of hemoglobinopathies

(2015) Dina N. Greene et al.   CLINICA CHIMICA ACTA

Modulation of Sickle Red Blood Cell Adhesion and its Associated Changes in Biomarkers by Sulfated Nonanticoagulant Heparin Derivative

(2015) Abdulelah Alshaiban et al.   CLINICAL AND APPLIED THROMBOSIS-HEMOSTASIS

Monocytosis is associated with hemolysis in sickle cell disease

(2015) Naritsara Wongtong et al.   Hematology

Sickle cell in sickle cell disease in Latin America and the United States

(2015) Alexandra Huttle et al.   PEDIATRIC BLOOD & CANCER

Amelioration of inflammation and tissue damage in sickle cell model mice by Nrf2 activation

(2015) Nadine Keleku-Lukwete et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Kinetics of sickle cell biorheology and implications for painful vasoocclusive crisis

(2015) E Du et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Factors associated with survival in a contemporary adult sickle cell disease cohort

(2014) Hany Elmariah et al.   AMERICAN JOURNAL OF HEMATOLOGY

Heme-induced neutrophil extracellular traps contribute to the pathogenesis of sickle cell disease

(2014) G. Chen et al.   BLOOD

Effects of oxidative stress on red blood cell rheology in sickle cell patients

(2014) Régine Hierso et al.   BRITISH JOURNAL OF HAEMATOLOGY

Investigational selectin-targeted therapy of sickle cell disease

(2014) Iheanyi Okpala   EXPERT OPINION ON INVESTIGATIONAL DRUGS

Cellular Adhesion and the Endothelium

(2014) Abdullah Kutlar et al.   HEMATOLOGY-ONCOLOGY CLINICS OF NORTH AMERICA

Cellular Adhesion and the Endothelium

(2014) Marilyn J. Telen   HEMATOLOGY-ONCOLOGY CLINICS OF NORTH AMERICA

Hydroxycarbamide Decreases Sickle Reticulocyte Adhesion to Resting Endothelium by Inhibiting Endothelial Lutheran/Basal Cell Adhesion Molecule (Lu/BCAM) through Phosphodiesterase 4A Activation

(2014) Vicky Chaar et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Perspective: We need a global solution

(2014) Isaac Odame   NATURE

Haemoglobinopathies in Europe: health & migration policy perspectives

(2014) Patricia Aguilar Martinez et al.   Orphanet Journal of Rare Diseases

Endothelial Activation by Platelets from Sickle Cell Anemia Patients

(2014) Renata Proença-Ferreira et al.   PLoS One

Density-based separation in multiphase systems provides a simple method to identify sickle cell disease

(2014) A. A. Kumar et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Heterogeneous Red Blood Cell Adhesion and Deformability in Sickle Cell Disease

(2014) Yunus Alapan et al.   Scientific Reports

Flow cytometry analyses reveal association between Lu/BCAM adhesion molecule and osteonecrosis in sickle cell disease

(2013) Julien Picot et al.   AMERICAN JOURNAL OF HEMATOLOGY

Systematic Review: Hydroxyurea for the Treatment of Adults with Sickle Cell Disease

(2013) Sophie Lanzkron et al.   ANNALS OF INTERNAL MEDICINE

Viscoelasticity of blood and viscoelastic blood analogues for use in polydymethylsiloxane in vitro models of the circulatory system

(2013) Laura Campo-Deaño et al.   Biomicrofluidics

Sickle cell vaso-occlusion causes activation of iNKT cells that is decreased by the adenosine A2A receptor agonist regadenoson

(2013) J. J. Field et al.   BLOOD

Heme triggers TLR4 signaling leading to endothelial cell activation and vaso-occlusion in murine sickle cell disease

(2013) J. D. Belcher et al.   BLOOD

Genetic determinants of haemolysis in sickle cell anaemia

(2013) Jacqueline N. Milton et al.   BRITISH JOURNAL OF HAEMATOLOGY

Simple Paper-Based Test for Measuring Blood Hemoglobin Concentration in Resource-Limited Settings

(2013) X. Yang et al.   CLINICAL CHEMISTRY

Hemostatic abnormalities in sickle cell disease

(2013) Ming Y. Lim et al.   CURRENT OPINION IN HEMATOLOGY

Chronic inflammatory state in sickle cell anemia patients is associated with HBB*S haplotype

(2013) Izabel C.J. Bandeira et al.   CYTOKINE

The contribution of red blood cells to thrombin generation in sickle cell disease: meizothrombin generation on sickled red blood cells

(2013) M. F. Whelihan et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

A simple, rapid, low-cost diagnostic test for sickle cell disease

(2013) Xiaoxi Yang et al.   LAB ON A CHIP

Hydrodynamics of Hemostasis in Sickle-Cell Disease

(2013) S. I. A. Cohen et al.   PHYSICAL REVIEW LETTERS

Blood Viscosity and the Expression of Inflammatory and Adhesion Markers in Homozygous Sickle Cell Disease Subjects with Chronic Leg Ulcers

(2013) Andre S. Bowers et al.   PLoS One

Probing vasoocclusion phenomena in sickle cell anemia via mesoscopic simulations

(2013) H. Lei et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Flow induces epithelial-mesenchymal transition, cellular heterogeneity and biomarker modulation in 3D ovarian cancer nodules

(2013) I. Rizvi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Exhaustion of Racing Sperm in Nature-Mimicking Microfluidic Channels During Sorting

(2013) Savas Tasoglu et al.   Small

Sickle Cell Disease: New Opportunities and Challenges in Africa

(2013) J. Makani et al.   TheScientificWorldJOURNAL

Current Management of Sickle Cell Anemia

(2013) P. T. McGann et al.   Cold Spring Harbor Perspectives in Medicine

Vaso-occlusion in sickle cell disease: pathophysiology and novel targeted therapies

(2013) D. Manwani et al.   Hematology-American Society of Hematology Education Program

Sickle Cell Disease: Management options and challenges in developing countries

(2013) Daniel Ansong et al.   Mediterranean Journal of Hematology and Infectious Diseases

Optical measurement of biomechanical properties of individual erythrocytes from a sickle cell patient

(2012) HeeSu Byun et al.   Acta Biomaterialia

A potent oral P-selectin blocking agent improves microcirculatory blood flow and a marker of endothelial cell injury in patients with sickle cell disease

(2012) Abdullah Kutlar et al.   AMERICAN JOURNAL OF HEMATOLOGY

Epinephrine Modulates BCAM/Lu and ICAM-4 Expression on the Sickle Cell Trait Red Blood Cell Membrane

(2012) Jamie L. Maciaszek et al.   BIOPHYSICAL JOURNAL

Erythrocyte density in sickle cell syndromes is associated with specific clinical manifestations and hemolysis

(2012) P. Bartolucci et al.   BLOOD

Meta-analysis of 2040 sickle cell anemia patients: BCL11A and HBS1L-MYB are the major modifiers of HbF in African Americans

(2012) H. T. Bae et al.   BLOOD

Tissue factor-positive monocytes in children with sickle cell disease: correlation with biomarkers of haemolysis

(2012) B. N. Yamaja Setty et al.   BRITISH JOURNAL OF HAEMATOLOGY

High lactate dehydrogenase levels at admission for painful vaso-occlusive crisis is associated with severe outcome in adult SCD patients

(2012) Katia Stankovic Stojanovic et al.   CLINICAL BIOCHEMISTRY

Autonomic nervous system dysfunction: Implication in sickle cell disease

(2012) Philippe Connes et al.   COMPTES RENDUS BIOLOGIES

Effect of Propranolol as Antiadhesive Therapy in Sickle Cell Disease

(2012) Laura M. De Castro et al.   CTS-Clinical and Translational Science

The relationship between the severity of hemolysis, clinical manifestations and risk of death in 415 patients with sickle cell anemia in the US and Europe

(2012) M. Nouraie et al.   HAEMATOLOGICA

Global epidemiology of sickle haemoglobin in neonates: a contemporary geostatistical model-based map and population estimates

(2012) Frédéric B Piel et al.   LANCET

Hydroxyurea for the treatment of sickle cell disease: Efficacy, barriers, toxicity, and management in children

(2012) John J. Strouse et al.   PEDIATRIC BLOOD & CANCER

A Genome-Wide Association Study of Total Bilirubin and Cholelithiasis Risk in Sickle Cell Anemia

(2012) Jacqueline N. Milton et al.   PLoS One

A Biophysical Indicator of Vaso-occlusive Risk in Sickle Cell Disease

(2012) D. K. Wood et al.   Science Translational Medicine

Smart Interface Materials Integrated with Microfluidics for On-Demand Local Capture and Release of Cells

(2012) Umut Atakan Gurkan et al.   Advanced Healthcare Materials

An Elevated Estimated Pulmonary Arterial Systolic Pressure, Whenever Measured, Is Associated with Excess Mortality in Adults with Sickle Cell Disease

(2011) Daniel Lorch et al.   ACTA HAEMATOLOGICA

Sickle Cell Disease in Africa

(2011) Scott D. Grosse et al.   AMERICAN JOURNAL OF PREVENTIVE MEDICINE

Peripheral Vasoconstriction and Abnormal Parasympathetic Response to Sighs and Transient Hypoxia in Sickle Cell Disease

(2011) Suvimol Sangkatumvong et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Epidemiology of sickle cell disease in Saudi Arabia

(2011) Wasil Jastaniah   ANNALS OF SAUDI MEDICINE

The obstetric management of sickle cell disease

(2011) Jo Howard et al.   BEST PRACTICE & RESEARCH CLINICAL OBSTETRICS & GYNAECOLOGY

Miniaturized lensless imaging systems for cell and microorganism visualization in point-of-care testing

(2011) Umut Atakan Gurkan et al.   Biotechnology Journal

Pharmacokinetics, pharmacodynamics, and pharmacogenetics of hydroxyurea treatment for children with sickle cell anemia

(2011) R. E. Ware et al.   BLOOD

Relationship between oxidative stress, glutathione S-transferase polymorphisms and hydroxyurea treatment in sickle cell anemia

(2011) Danilo Grünig Humberto Silva et al.   BLOOD CELLS MOLECULES AND DISEASES

Improvements in haemolysis and indicators of erythrocyte survival do not correlate with acute vaso-occlusive crises in patients with sickle cell disease: a phase III randomized, placebo-controlled, double-blind study of the gardos channel blocker senicapo

(2011) Kenneth I. Ataga et al.   BRITISH JOURNAL OF HAEMATOLOGY

Targeting iNKT cells for the treatment of sickle cell disease

(2011) Joshua J. Field et al.   CLINICAL IMMUNOLOGY

Hydroxyurea for sickle cell anemia: what have we learned and what questions still remain?

(2011) Patrick T McGann et al.   CURRENT OPINION IN HEMATOLOGY

Can new optical techniques for in vivo imaging and flow cytometry of the microcirculation benefit sickle cell disease research?

(2011) Stephen P. Morgan   CYTOMETRY PART A

In vivo photoacoustic and photothermal cytometry for monitoring multiple blood rheology parameters

(2011) Ekaterina I. Galanzha et al.   CYTOMETRY PART A

In vivo flow cytometry: A horizon of opportunities

(2011) Valery V. Tuchin et al.   CYTOMETRY PART A

CXCL1 and its receptor, CXCR2, mediate murine sickle cell vaso-occlusion during hemolytic transfusion reactions

(2011) Jung-Eun Jang et al.   JOURNAL OF CLINICAL INVESTIGATION

In vitro modeling of the microvascular occlusion and thrombosis that occur in hematologic diseases using microfluidic technology

(2011) Michelle Tsai et al.   JOURNAL OF CLINICAL INVESTIGATION

Neutrophil extracellular traps promote deep vein thrombosis in mice

(2011) A. BRILL et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Lensless imaging for simultaneous microfluidic sperm monitoring and sorting

(2011) Xiaohui Zhang et al.   LAB ON A CHIP

Controlled viable release of selectively captured label-free cells in microchannels

(2011) Umut Atakan Gurkan et al.   LAB ON A CHIP

Mortality in Sickle Cell Anemia in Africa: A Prospective Cohort Study in Tanzania

(2011) Julie Makani et al.   PLoS One

Enumeration of CD4+ T-Cells Using a Portable Microchip Count Platform in Tanzanian HIV-Infected Patients

(2011) SangJun Moon et al.   PLoS One

Excess Risk of Maternal Death from Sickle Cell Disease in Jamaica: 1998–2007

(2011) Monika R. Asnani et al.   PLoS One

Sickle Cell Biomechanics

(2010) Gilda A. Barabino et al.   Annual Review of Biomedical Engineering

A circular cross-section PDMS microfluidics system for replication of cardiovascular flow conditions

(2010) Lindsey K. Fiddes et al.   BIOMATERIALS

GMI-1070, a novel pan-selectin antagonist, reverses acute vascular occlusions in sickle cell mice

(2010) J. Chang et al.   BLOOD

How I use hydroxyurea to treat young patients with sickle cell anemia

(2010) R. E. Ware   BLOOD

Peripheral blood neutrophil count and candidacidal activity correlate with the clinical severity of sickle cell anaemia (SCA)

(2010) C.C. Anyaegbu et al.   EUROPEAN JOURNAL OF HAEMATOLOGY

Hydroxyurea for Children with Sickle Cell Disease

(2010) Matthew M. Heeney et al.   HEMATOLOGY-ONCOLOGY CLINICS OF NORTH AMERICA

Specific Binding of Red Blood Cells to Endothelial Cells Is Regulated by Nonadsorbing Macromolecules

(2010) Yang Yang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Extracellular DNA traps promote thrombosis

(2010) T. A. Fuchs et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The cost of health care for patients with sickle cell disease

(2009) Samir K. Ballas   AMERICAN JOURNAL OF HEMATOLOGY

The cost of health care for children and adults with sickle cell disease

(2009) Teresa L. Kauf et al.   AMERICAN JOURNAL OF HEMATOLOGY

NKT cells mediate pulmonary inflammation and dysfunction in murine sickle cell disease through production of IFN-  and CXCR3 chemokines

(2009) K. L. Wallace et al.   BLOOD

Circulating endothelial cells: A potential parameter of organ damage in sickle cell anemia?

(2009) Michiel H. Strijbos et al.   BLOOD CELLS MOLECULES AND DISEASES

Elevated endothelial progenitor cells during painful sickle cell crisis

(2009) Rachel T. van Beem et al.   EXPERIMENTAL HEMATOLOGY

Heterotypic interactions enabled by polarized neutrophil microdomains mediate thromboinflammatory injury

(2009) Andrés Hidalgo et al.   NATURE MEDICINE

Sickle red cells induce adhesion of lymphocytes and monocytes to endothelium

(2008) R. Zennadi et al.   BLOOD

Red cell membrane: past, present, and future

(2008) N. Mohandas et al.   BLOOD

Global epidemiology of haemoglobin disorders and derived service indicators

(2008) Bernadette Modell   BULLETIN OF THE WORLD HEALTH ORGANIZATION

Adhesion molecules and hydroxyurea in the pathophysiology of sickle cell disease

(2008) C. Johnson et al.   HAEMATOLOGICA

Neonatal haemoglobinopathy screening in Belgium

(2008) B Gulbis et al.   JOURNAL OF CLINICAL PATHOLOGY

Altered levels of cytokines and inflammatory mediators in plasma and leukocytes of sickle cell anemia patients and effects of hydroxyurea therapy

(2008) C. Lanaro et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Sickle Red Cell–Endothelium Interactions

(2008) Dhananjay K. Kaul et al.   MICROCIRCULATION

Chronic Hyper-Hemolysis in Sickle Cell Anemia: Association of Vascular Complications and Mortality with Less Frequent Vasoocclusive Pain

(2008) James G. Taylor et al.   PLoS One

DNA polymorphisms at the BCL11A, HBS1L-MYB, and  -globin loci associate with fetal hemoglobin levels and pain crises in sickle cell disease

(2008) G. Lettre et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Sickle Cell Anemia, the First Molecular Disease: Overview of Molecular Etiology, Pathophysiology, and Therapeutic Approaches

(2008) Martin H. Steinberg   TheScientificWorldJOURNAL

Intravenous immunoglobulins reverse acute vaso-occlusive crises in sickle cell mice through rapid inhibition of neutrophil adhesion

(2007) J. Chang et al.   BLOOD