Sickle cell vaso-occlusion causes activation of iNKT cells that is decreased by the adenosine A2A receptor agonist regadenoson

Targeting iNKT cells for the treatment of sickle cell disease

(2011) Joshua J. Field et al.   CLINICAL IMMUNOLOGY

Invariant natural killer T cells recognize lipid self antigen induced by microbial danger signals

(2011) Patrick J Brennan et al.   NATURE IMMUNOLOGY

P-Selectin–Mediated Platelet-Neutrophil Aggregate Formation Activates Neutrophils in Mouse and Human Sickle Cell Disease

(2010) Renata Polanowska-Grabowska et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Adenosine A2A receptors induced on iNKT and NK cells reduce pulmonary inflammation and injury in mice with sickle cell disease

(2010) K. L. Wallace et al.   BLOOD

Invariant natural killer T cells: bridging innate and adaptive immunity

(2010) Luc Van Kaer et al.   CELL AND TISSUE RESEARCH

Elevated IL-8 levels during sickle cell crisis

(2010) A. J. Duits et al.   EUROPEAN JOURNAL OF HAEMATOLOGY

Detrimental effects of adenosine signaling in sickle cell disease

(2010) Yujin Zhang et al.   NATURE MEDICINE

NKT cells mediate pulmonary inflammation and dysfunction in murine sickle cell disease through production of IFN-  and CXCR3 chemokines

(2009) K. L. Wallace et al.   BLOOD

Increased adenosine contributes to penile fibrosis, a dangerous feature of priapism, via A2B adenosine receptor signaling

(2009) Jiaming Wen et al.   FASEB JOURNAL

Adenosine Deaminase Enzyme Therapy Prevents and Reverses the Heightened Cavernosal Relaxation in Priapism

(2009) Jiaming Wen et al.   Journal of Sexual Medicine