Galectin-1 inhibitors and their potential therapeutic applications: a patent review

Galectin expression in cancer diagnosis and prognosis: A systematic review

(2015) Victor L. Thijssen et al.   BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER

Redox state influence on human galectin-1 function

(2015) Xing Yu et al.   BIOCHIMIE

Liposome-based Formulation for Intracellular Delivery of Functional Proteins

(2015) Benoît Chatin et al.   Molecular Therapy-Nucleic Acids

Galectin-1-secreting neural stem cells elicit long-term neuroprotection against ischemic brain injury

(2015) Jiayin Wang et al.   Scientific Reports

Synthetic Galectin-3 Inhibitor Increases Metastatic Cancer Cell Sensitivity to Taxol-Induced Apoptosis In Vitro and In Vivo

(2015) Vladislav V. Glinsky et al.   NEOPLASIA

Inhibition of Prostate Cancer Bone Metastasis by Synthetic TF Antigen Mimic/Galectin-3 Inhibitor Lactulose-l-Leucine

(2015) Olga V. Glinskii et al.   NEOPLASIA

Inhibitors of Galectins and Implications for Structure-Based Design of Galectin-Specific Therapeutics

(2014) Helen Blanchard et al.   AUSTRALIAN JOURNAL OF CHEMISTRY

Synthesis and evaluation of iminocoumaryl and coumaryl derivatized glycosides as galectin antagonists

(2014) Vishal Kumar Rajput et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Glycosylation-Dependent Lectin-Receptor Interactions Preserve Angiogenesis in Anti-VEGF Refractory Tumors

(2014) Diego O. Croci et al.   CELL

Recent advances in characterization of nonviral vectors for delivery of nucleic acids: impact on their biological performance

(2014) Claudia Oliveira et al.   Expert Opinion on Drug Delivery

Galectin-3 inhibitors: a patent review (2008–present)

(2014) Helen Blanchard et al.   EXPERT OPINION ON THERAPEUTIC PATENTS

Galectin-1 and -9 in angiogenesis: A sweet couple

(2014) V. L. Thijssen et al.   GLYCOBIOLOGY

Regulatory role of glycans in the control of hypoxia-driven angiogenesis and sensitivity to anti-angiogenic treatment

(2014) D. O. Croci et al.   GLYCOBIOLOGY

Structural basis of redox-dependent modulation of galectin-1 dynamics and function

(2014) Carlos M Guardia et al.   GLYCOBIOLOGY

Differential Roles of Galectin-1 and Galectin-3 in Regulating Leukocyte Viability and Cytokine Secretion

(2014) S. R. Stowell et al.   JOURNAL OF IMMUNOLOGY

Mammalian galectins bind Galactoseβ1–4Fucose disaccharide, a unique structural component of protostomial N-type glycoproteins

(2013) Tomoharu Takeuchi et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Pharmacokinetics and antineoplastic activity of galectin-1-targeting OTX008 in combination with sunitinib

(2013) Massimo Zucchetti et al.   CANCER CHEMOTHERAPY AND PHARMACOLOGY

Unraveling galectin-1 as a novel therapeutic target for cancer

(2013) Lucile Astorgues-Xerri et al.   CANCER TREATMENT REVIEWS

Context-dependent multifunctionality of galectin-1: a challenge for defining the lectin as therapeutic target

(2013) Karel Smetana et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

Polycationic calixarene PTX013, a potent cytotoxic agent against tumors and drug resistant cancer

(2013) Ruud P. M. Dings et al.   INVESTIGATIONAL NEW DRUGS

Tuning the Preference of Thiodigalactoside- and Lactosamine-Based Ligands to Galectin-3 over Galectin-1

(2013) Hilde van Hattum et al.   JOURNAL OF MEDICINAL CHEMISTRY

Single-Site Mutational Engineering and Following MonoPEGylation of the Human Lectin Galectin-2: Effects on Ligand Binding, Functional Aspects, and Clearance from Serum

(2013) Jürgen Kopitz et al.   MOLECULAR PHARMACEUTICS

Hierarchical and selective roles of galectins in hepatocarcinogenesis, liver fibrosis and inflammation of hepatocellular carcinoma

(2013) María L Bacigalupo   WORLD JOURNAL OF GASTROENTEROLOGY

Galectin-1 as a potent target for cancer therapy: role in the tumor microenvironment

(2012) Koichi Ito et al.   CANCER AND METASTASIS REVIEWS

Targeting Galectin-1 Overcomes Breast Cancer-Associated Immunosuppression and Prevents Metastatic Disease

(2012) T. Dalotto-Moreno et al.   CANCER RESEARCH

Synthesis of lactosylated glycoclusters and inhibition studies with plant and human lectins

(2012) Samy Cecioni et al.   CARBOHYDRATE RESEARCH

Glycobiology in Malignant Gliomas: Expression and Functions of Galectins and Possible Therapeutic Options

(2012) Herwig M. Strik et al.   CURRENT PHARMACEUTICAL BIOTECHNOLOGY

Neural stem cells, adult neurogenesis, and galectin-1: From bench to bedside

(2012) Masanori Sakaguchi et al.   Developmental Neurobiology

High galectin-1 expression correlates with poor prognosis and is involved in epithelial ovarian cancer proliferation and invasion

(2012) Ha-Jeong Kim et al.   EUROPEAN JOURNAL OF CANCER

Galectin 1 expression is associated with tumor invasion and metastasis in stage IB to IIA cervical cancer

(2012) Ha-Jeong Kim et al.   HUMAN PATHOLOGY

Antitumor Agent Calixarene 0118 Targets Human Galectin-1 as an Allosteric Inhibitor of Carbohydrate Binding

(2012) Ruud P. M. Dings et al.   JOURNAL OF MEDICINAL CHEMISTRY

Bi- to tetravalent glycoclusters: synthesis, structure–activity profiles as lectin inhibitors and impact of combining both valency and headgroup tailoring on selectivity

(2012) Guan-Nan Wang et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Advances and prospects of anginex as a promising anti-angiogenesis and anti-tumor agent

(2012) Ju Bo Wang et al.   PEPTIDES

The sweet and bitter sides of galectins in melanoma progression

(2012) Russell R. Braeuer et al.   Pigment Cell & Melanoma Research

A decrease in galectin-1 (Gal-1) levels correlates with an increase in anti-Gal-1 antibodies at the synovial level in patients with rheumatoid arthritis

(2012) D Xibillé-Friedmann et al.   SCANDINAVIAN JOURNAL OF RHEUMATOLOGY

Galectin-1-Specific Inhibitors as a New Class of Compounds To Treat HIV-1 Infection

(2011) Christian St-Pierre et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Inhibitory potential of chemical substitutions at bioinspired sites of β-d-galactopyranose on neoglycoprotein/cell surface binding of two classes of medically relevant lectins

(2011) Denis Giguère et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Taloside Inhibitors of Galectin-1 and Galectin-3

(2011) Patrick M. Collins et al.   Chemical Biology & Drug Design

Arene-Anion Based Arginine-Binding Motif on a Galactose Scaffold: Structure-Activity Relationships of Interactions with Arginine-Rich Galectins

(2011) Christopher T. Öberg et al.   CHEMISTRY-A EUROPEAN JOURNAL

Galectin-1 research in T cell immunity: Past, present and future

(2011) Filiberto Cedeno-Laurent et al.   CLINICAL IMMUNOLOGY

Galectin-1 and immunotherapy for brain cancer

(2011) Tina Verschuere et al.   Expert Review of Neurotherapeutics

The role of galectins in colorectal cancer progression

(2011) Hannah Barrow et al.   INTERNATIONAL JOURNAL OF CANCER

The Anti-angiogenic Peptide Anginex Greatly Enhances Galectin-1 Binding Affinity for Glycoproteins

(2011) Emma Salomonsson et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Host-Soluble Galectin-1 Promotes HIV-1 Replication through a Direct Interaction with Glycans of Viral gp120 and Host CD4

(2011) C. St-Pierre et al.   JOURNAL OF VIROLOGY

Synthesis of 3-amido-3-deoxy-β-d-talopyranosides: all-cis-substituted pyranosides as lectin inhibitors

(2011) Christopher T. Öberg et al.   TETRAHEDRON

Monovalent Interactions of Galectin-1

(2010) Emma Salomonsson et al.   BIOCHEMISTRY

Galectin inhibitory disaccharides promote tumour immunity in a breast cancer model

(2010) Kimberley A. Stannard et al.   CANCER LETTERS

Multimeric Lactoside “Click Clusters” as Tools to Investigate the Effect of Linker Length in Specific Interactions with Peanut Lectin, Galectin-1, and -3

(2010) Sébastien G. Gouin et al.   CHEMBIOCHEM

Intra-articular lentivirus-mediated delivery of galectin-3 shRNA and galectin-1 gene ameliorates collagen-induced arthritis

(2010) C-R Wang et al.   GENE THERAPY

Galectin multimerization and lattice formation are regulated by linker region structure

(2010) L. A. Earl et al.   GLYCOBIOLOGY

Lung Cancer-Derived Galectin-1 Mediates Dendritic Cell Anergy through Inhibitor of DNA Binding 3/IL-10 Signaling Pathway

(2010) P.-L. Kuo et al.   JOURNAL OF IMMUNOLOGY

Development of a Nascent Galectin-1 Chimeric Molecule for Studying the Role of Leukocyte Galectin-1 Ligands and Immune Disease Modulation

(2010) F. Cedeno-Laurent et al.   JOURNAL OF IMMUNOLOGY

Synthesis and screening of a small glycomimetic library for inhibitory activity on medically relevant galactoside-specific lectins in assays of increasing biorelevance

(2010) Sabine André et al.   NEW JOURNAL OF CHEMISTRY

Targeted Delivery of Protein Drugs by Nanocarriers

(2010) Roberto Solaro et al.   Materials

Inhibiting Tumor Growth by Targeting Tumor Vasculature with Galectin-1 Antagonist Anginex Conjugated to the Cytotoxic Acylfulvene, 6-Hydroxylpropylacylfulvene

(2009) Ruud P. M. Dings et al.   BIOCONJUGATE CHEMISTRY

Synthesis and Evaluation of New Thiodigalactoside-Based Chemical Probes to Label Galectin-3

(2009) Monique van Scherpenzeel et al.   CHEMBIOCHEM

Fragment-based development of triazole-substituted O-galactosyl aldoximes with fragment-induced affinity and selectivity for galectin-3

(2009) Johan Tejler et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Synthesis of stable and selective inhibitors of human galectins-1 and -3

(2008) Denis Giguère et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Ovarian tumor growth regression using a combination of vascular targeting agents anginex or topomimetic 0118 and the chemotherapeutic irofulven

(2008) Ruud P.M. Dings et al.   CANCER LETTERS

Calix[n]arene‐Based Glycoclusters: Bioactivity of Thiourea‐Linked Galactose/Lactose Moieties as Inhibitors of Binding of Medically Relevant Lectins to a Glycoprotein and Cell‐Surface Glycoconjugates and Selectivity among Human Adhesion/Growth‐Regulatory Galectins

(2008) Sabine André et al.   CHEMBIOCHEM

Double Affinity Amplification of Galectin–Ligand Interactions through Arginine–Arene Interactions: Synthetic, Thermodynamic, and Computational Studies with Aromatic Diamido Thiodigalactosides

(2008) Ian Cumpstey et al.   CHEMISTRY-A EUROPEAN JOURNAL

Functional and structural bases of a cysteine-less mutant as a long-lasting substitute for galectin-1

(2008) Nozomu Nishi et al.   GLYCOBIOLOGY

Structural Features of Galectin-9 and Galectin-1 That Determine Distinct T Cell Death Pathways

(2008) Shuguang Bi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Novel insights into the inhibitory effects of Galectin-1 on neutrophil recruitment under flow

(2008) D. Cooper et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Arginine Binding Motifs: Design and Synthesis of Galactose-Derived Arginine Tweezers as Galectin-3 Inhibitors

(2008) Christopher T. Öberg et al.   JOURNAL OF MEDICINAL CHEMISTRY

Galectin-Inhibitory Thiodigalactoside Ester Derivatives Have Antimigratory Effects in Cultured Lung and Prostate Cancer Cells

(2008) Tamara Delaine et al.   JOURNAL OF MEDICINAL CHEMISTRY

Serum Galectin-1 and Galectin-3 Levels in Benign and Malignant Nodular Thyroid Disease

(2008) Sven Saussez et al.   THYROID

Roles of galectins in inflammatory bowel disease

(2008) Akira Hokama et al.   WORLD JOURNAL OF GASTROENTEROLOGY

Galectin-1 promotes HIV-1 infectivity in macrophages through stabilization of viral adsorption

(2007) Simon Mercier et al.   VIROLOGY