Context-dependent multifunctionality of galectin-1: a challenge for defining the lectin as therapeutic target

Beyond glycoproteins as galectin counterreceptors: tumor-effector T cell growth control via ganglioside GM1

(2012) Robert W. Ledeen et al.   Annals of the New York Academy of Sciences

Galectins in acute and chronic inflammation

(2012) Fu-Tong Liu et al.   Annals of the New York Academy of Sciences

Galectin-9 Acts as a Prognostic Factor with Antimetastatic Potential in Hepatocellular Carcinoma

(2012) Zhao-Yang Zhang et al.   Asian Pacific Journal of Cancer Prevention

Glycosylation of mouse and human immune cells: insights emerging from N-glycomics analyses

(2012) Aristotelis Antonopoulos et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Analysis of homodimeric avian and human galectins by two methods based on fluorescence spectroscopy: Different structural alterations upon oxidation and ligand binding

(2012) Antonia Göhler et al.   BIOCHIMIE

Moonlighting is mainstream: Paradigm adjustment required

(2012) Shelley D. Copley   BIOESSAYS

Effects of Single Genetic Damage in Carbohydrate-Recognizing Proteins in Mouse Serum N-Glycan Profile Revealed by Simple Glycotyping Analysis

(2012) Maho Amano et al.   CHEMBIOCHEM

Tumour suppressor p16INK4a- anoikis-favouring decrease in N/O-glycan/cell surface sialylation by down-regulation of enzymes in sialic acid biosynthesis in tandem in a pancreatic carcinoma model

(2012) Maho Amano et al.   FEBS Journal

Colonic carcinogenesis along different genetic routes: glycophenotyping of tumor cases separated by microsatellite instability/stability

(2012) Johannes Gebert et al.   HISTOCHEMISTRY AND CELL BIOLOGY

Smooth muscle actin-expressing stromal fibroblasts in head and neck squamous cell carcinoma: Increased expression of galectin-1 and induction of poor prognosis factors

(2012) Jaroslav Valach et al.   INTERNATIONAL JOURNAL OF CANCER

Lung Cancer-derived Galectin-1 Enhances Tumorigenic Potentiation of Tumor-associated Dendritic Cells by Expressing Heparin-binding EGF-like Growth Factor

(2012) Po-Lin Kuo et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Overexpression of galectin-1 is associated with poor prognosis in human hepatocellular carcinoma following resection

(2012) Han Wu et al.   JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY

Assumptions of Expected Benefits in Randomized Phase III Trials Evaluating Systemic Treatments for Cancer

(2012) H. K. Gan et al.   JNCI-Journal of the National Cancer Institute

Raise standards for preclinical cancer research

(2012) C. Glenn Begley et al.   NATURE

Identification of Galectin-1 as a Critical Factor in Function of Mouse Mesenchymal Stromal Cell-Mediated Tumor Promotion

(2012) Gábor János Szebeni et al.   PLoS One

Overexpressed Galectin-3 in Pancreatic Cancer Induces Cell Proliferation and Invasion by Binding Ras and Activating Ras Signaling

(2012) Shumei Song et al.   PLoS One

Revised mechanism of complement lectin-pathway activation revealing the role of serine protease MASP-1 as the exclusive activator of MASP-2

(2012) D. Heja et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Human deficiencies of fucosylation and sialylation affecting selectin ligands

(2012) Kerstin Lühn et al.   Seminars in Immunopathology

Two opposing roles of O-glycans in tumor metastasis

(2012) Shigeru Tsuboi et al.   TRENDS IN MOLECULAR MEDICINE

How does it act when soluble? Critical evaluation of mechanism of galectin-1 induced T-cell apoptosis

(2011) Andrea Blaskó et al.   ACTA BIOLOGICA HUNGARICA

Glycobiomarkers by glycoproteomics and glycan profiling (glycomics): emergence of functionality

(2011) Hans-Joachim Gabius   BIOCHEMICAL SOCIETY TRANSACTIONS

Tumor suppressor p16INK4a controls oncogenic K-Ras function in human pancreatic cancer cells

(2011) Anja Rabien et al.   CANCER SCIENCE

Human Galectins Induce Conversion of Dermal Fibroblasts into Myofibroblasts and Production of Extracellular Matrix: Potential Application in Tissue Engineering and Wound Repair

(2011) Barbora Dvořánková et al.   CELLS TISSUES ORGANS

Combining carbohydrate substitutions at bioinspired positions with multivalent presentation towards optimising lectin inhibitors: case study with calixarenes

(2011) Sabine André et al.   CHEMICAL COMMUNICATIONS

Mannan-binding lectin deficiency — Good news, bad news, doesn't matter?

(2011) Sabine Heitzeneder et al.   CLINICAL IMMUNOLOGY

Glycosylation, galectins and cellular signaling

(2011) Cecile Boscher et al.   CURRENT OPINION IN CELL BIOLOGY

Ganglioside GM1 Deficiency in Effector T Cells From NOD Mice Induces Resistance to Regulatory T-Cell Suppression

(2011) G. Wu et al.   DIABETES

Lectins for histochemical demonstration of glycans

(2011) Jürgen Roth   HISTOCHEMISTRY AND CELL BIOLOGY

Quantitative immunohistochemical fingerprinting of adhesion/growth-regulatory galectins in salivary gland tumours: divergent profiles with diagnostic potential

(2011) Myriam Remmelink et al.   HISTOPATHOLOGY

Toward Bioinspired Galectin Mimetics: Identification of Ligand-Contacting Peptides by Proteolytic-Excision Mass Spectrometry

(2011) Adrian Moise et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Galectin-1-induced down-regulation of T lymphocyte activation protects (NZB x NZW) F1 mice from lupus-like disease

(2011) SD Liu et al.   LUPUS

From lectin structure to functional glycomics: principles of the sugar code

(2011) Hans-Joachim Gabius et al.   TRENDS IN BIOCHEMICAL SCIENCES

Human galectin-3 (Mac-2 antigen): Defining molecular switches of affinity to natural glycoproteins, structural and dynamic aspects of glycan binding by flexible ligand docking and putative regulatory sequences in the proximal promoter region

(2010) Mickaël Krzeminski et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Galectin-1 is silenced by promoter hypermethylation and its re-expression induces apoptosis in human colorectal cancer cells

(2010) Arun Satelli et al.   CANCER LETTERS

Galectin-1 sensitizes carcinoma cells to anoikis via the fibronectin receptor α5β1-integrin

(2010) H Sanchez-Ruderisch et al.   CELL DEATH AND DIFFERENTIATION

Tumor suppressor p16INK4a: Downregulation of galectin-3, an endogenous competitor of the pro-anoikis effector galectin-1, in a pancreatic carcinoma model

(2010) Hugo Sanchez-Ruderisch et al.   FEBS Journal

SR proteins and galectins: what's in a name?

(2010) K. C. Haudek et al.   GLYCOBIOLOGY

How adhesion/growth-regulatory galectins-1 and -3 attain cell specificity: Case study defining their target on neuroblastoma cells (SK-N-MC) and marked affinity regulation by affecting microdomain organization of the membrane

(2010) Jürgen Kopitz et al.   IUBMB LIFE

Identification of Siglec-9 as the receptor for MUC16 on human NK cells, B cells, and monocytes

(2010) Jennifer A. Belisle et al.   Molecular Cancer

Synthesis and screening of a small glycomimetic library for inhibitory activity on medically relevant galactoside-specific lectins in assays of increasing biorelevance

(2010) Sabine André et al.   NEW JOURNAL OF CHEMISTRY

Unique Chicken Tandem-Repeat-Type Galectin: Implications of Alternative Splicing and a Distinct Expression Profile Compared to Those of the Three Proto-Type Proteins

(2009) Herbert Kaltner et al.   BIOCHEMISTRY

Compensation of loss of protein function in microsatellite-unstable colon cancer cells (HCT116): A gene-dependent effect on the cell surface glycan profile

(2009) G. Patsos et al.   GLYCOBIOLOGY

Suppression of Autoimmune Diabetes by Soluble Galectin-1

(2009) M. J. Perone et al.   JOURNAL OF IMMUNOLOGY

Cross-Linking of GM1 Ganglioside by Galectin-1 Mediates Regulatory T Cell Activity Involving TRPC5 Channel Activation: Possible Role in Suppressing Experimental Autoimmune Encephalomyelitis

(2009) J. Wang et al.   JOURNAL OF IMMUNOLOGY

Galectin-1 Is a Novel Functional Receptor for Tissue Plasminogen Activator in Pancreatic Cancer

(2008) Oriol Roda et al.   GASTROENTEROLOGY

Lgals6, a 2-Million-Year-Old Gene in Mice: A Case of Positive Darwinian Selection and Presence/Absence Polymorphism

(2008) D. Houzelstein et al.   GENETICS

Genetic assessment of the importance of galectin-3 in cancer initiation, progression, and dissemination in mice

(2008) Isabelle Eude-Le Parco et al.   GLYCOBIOLOGY

Expression of galectin-3 involved in prognosis of patients with hepatocellular carcinoma

(2008) Yasunori Matsuda et al.   HEPATOLOGY RESEARCH

Increased expression and altered intracellular distribution of adhesion/growth-regulatory lectins galectins-1 and -7 during tumour progression in hypopharyngeal and laryngeal squamous cell carcinomas

(2008) S Saussez et al.   HISTOPATHOLOGY

Homodimeric Chicken Galectin CG-1B (C-14): Crystal Structure and Detection of Unique Redox-Dependent Shape Changes Involving Inter- and Intrasubunit Disulfide Bridges by Gel Filtration, Ultracentrifugation, Site-Directed Mutagenesis, and Peptide Mass Fingerprinting

(2008) María F. López-Lucendo et al.   JOURNAL OF MOLECULAR BIOLOGY