Inhibitors of Galectins and Implications for Structure-Based Design of Galectin-Specific Therapeutics

Synthetic Galectin-3 Inhibitor Increases Metastatic Cancer Cell Sensitivity to Taxol-Induced Apoptosis In Vitro and In Vivo

(2015) Vladislav V. Glinsky et al.   NEOPLASIA

Inhibition of Prostate Cancer Bone Metastasis by Synthetic TF Antigen Mimic/Galectin-3 Inhibitor Lactulose-l-Leucine

(2015) Olga V. Glinskii et al.   NEOPLASIA

Synergistic Effects of PectaSol-C Modified Citrus Pectin an Inhibitor of Galectin-3 and Paclitaxel on Apoptosis of Human SKOV-3 Ovarian Cancer Cells

(2014) Ghamartaj Hossein et al.   Asian Pacific Journal of Cancer Prevention

Synthesis and evaluation of iminocoumaryl and coumaryl derivatized glycosides as galectin antagonists

(2014) Vishal Kumar Rajput et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Galectin-3 in cancer

(2014) Lin Song et al.   CLINICA CHIMICA ACTA

A Short Treatment with Galactomannan GM-CT-01 Corrects the Functions of Freshly Isolated Human Tumor-Infiltrating Lymphocytes

(2014) N. Demotte et al.   CLINICAL CANCER RESEARCH

Differential Roles of Galectin-1 and Galectin-3 in Regulating Leukocyte Viability and Cytokine Secretion

(2014) S. R. Stowell et al.   JOURNAL OF IMMUNOLOGY

Design and Synthesis of Hydrolytically Stable Multivalent Ligands Bearing Thiodigalactoside Analogues for Peanut Lectin and Human Galectin-3 Binding

(2014) Alejandro J. Cagnoni et al.   JOURNAL OF ORGANIC CHEMISTRY

Nuclear transport of galectin-3 and its therapeutic implications

(2014) Tatsuyoshi Funasaka et al.   SEMINARS IN CANCER BIOLOGY

Mammalian galectins bind Galactoseβ1–4Fucose disaccharide, a unique structural component of protostomial N-type glycoproteins

(2013) Tomoharu Takeuchi et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Galectins: new agonists of platelet activation

(2013) Mirta Schattner et al.   BIOLOGICAL CHEMISTRY

Unraveling galectin-1 as a novel therapeutic target for cancer

(2013) Lucile Astorgues-Xerri et al.   CANCER TREATMENT REVIEWS

Investigation into the Feasibility of Thioditaloside as a Novel Scaffold for Galectin-3-Specific Inhibitors

(2013) Khuchtumur Bum-Erdene et al.   CHEMBIOCHEM

Human Galectin-3 Selective and High Affinity Inhibitors. Present State and Future Perspectives

(2013) R. Tellez-Sanz et al.   CURRENT MEDICINAL CHEMISTRY

Galectins in hematological malignancies

(2013) Mirta Giordano et al.   CURRENT OPINION IN HEMATOLOGY

Inhibition of galectin-3 reduces atherosclerosis in apolipoprotein E-deficient mice

(2013) A. C. MacKinnon et al.   GLYCOBIOLOGY

Polycationic calixarene PTX013, a potent cytotoxic agent against tumors and drug resistant cancer

(2013) Ruud P. M. Dings et al.   INVESTIGATIONAL NEW DRUGS

Tuning the Preference of Thiodigalactoside- and Lactosamine-Based Ligands to Galectin-3 over Galectin-1

(2013) Hilde van Hattum et al.   JOURNAL OF MEDICINAL CHEMISTRY

Galectin-3 Interactions with Glycosphingolipids

(2013) Patrick M. Collins et al.   JOURNAL OF MOLECULAR BIOLOGY

Galectin-3 in pre-B acute lymphoblastic leukemia

(2013) F Fei et al.   LEUKEMIA

The Third Dimension of Reading the Sugar Code by Lectins: Design of Glycoclusters with Cyclic Scaffolds as Tools with the Aim to Define Correlations between Spatial Presentation and Activity

(2013) Paul Murphy et al.   MOLECULES

Galectin-4 Reduces Migration and Metastasis Formation of Pancreatic Cancer Cells

(2013) Ana I. Belo et al.   PLoS One

Therapy of Experimental NASH and Fibrosis with Galectin Inhibitors

(2013) Peter G. Traber et al.   PLoS One

Regression of Fibrosis and Reversal of Cirrhosis in Rats by Galectin Inhibitors in Thioacetamide-Induced Liver Disease

(2013) Peter G. Traber et al.   PLoS One

Galectin-4, a Novel Predictor for Lymph Node Metastasis in Lung Adenocarcinoma

(2013) Takuo Hayashi et al.   PLoS One

A Correction to the Editors' Choice Summary Titled "Not So Different After All" by Annalisa M. VanHook

(2013)   Science Signaling

Abrogation of galectin-4 expression promotes tumorigenesis in colorectal cancer

(2013) Seung Won Kim et al.   CELLULAR ONCOLOGY

Comparative studies on the anti-tumor activities of high temperature- and pH-modified citrus pectins

(2013) Miao Hao et al.   Food & Function

The effect of galectins on leukocyte trafficking in inflammation: sweet or sour?

(2012) Dianne Cooper et al.   Annals of the New York Academy of Sciences

Galectins in acute and chronic inflammation

(2012) Fu-Tong Liu et al.   Annals of the New York Academy of Sciences

Glycans, galectins, and HIV-1 infection

(2012) Sachiko Sato et al.   Annals of the New York Academy of Sciences

Animal Lectins: Potential Antitumor Therapeutic Targets in Apoptosis

(2012) Zhe Liu et al.   APPLIED BIOCHEMISTRY AND BIOTECHNOLOGY

Galectin-3 Mediates Aldosterone-Induced Vascular Fibrosis

(2012) Laurent Calvier et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Peptide–Drug Conjugate Linked via a Disulfide Bond for Kidney Targeted Drug Delivery

(2012) Qian Geng et al.   BIOCONJUGATE CHEMISTRY

Synthesis of lactosylated glycoclusters and inhibition studies with plant and human lectins

(2012) Samy Cecioni et al.   CARBOHYDRATE RESEARCH

Inhibition of metastatic tumor formation in vivo by a bacteriophage display-derived galectin-3 targeting peptide

(2012) Jessica R. Newton-Northup et al.   CLINICAL & EXPERIMENTAL METASTASIS

Galectins and their ligands: negative regulators of anti-tumor immunity

(2012) Filiberto Cedeno-Laurent et al.   GLYCOCONJUGATE JOURNAL

Analysis of the neutral polysaccharide fraction of MCP and its inhibitory activity on galectin-3

(2012) Xiaoge Gao et al.   GLYCOCONJUGATE JOURNAL

Synergistic and Additive Effects of Modified Citrus Pectin With Two Polybotanical Compounds, in the Suppression of Invasive Behavior of Human Breast and Prostate Cancer Cells

(2012) Jiahua Jiang et al.   INTEGRATIVE CANCER THERAPIES

Antitumor Agent Calixarene 0118 Targets Human Galectin-1 as an Allosteric Inhibitor of Carbohydrate Binding

(2012) Ruud P. M. Dings et al.   JOURNAL OF MEDICINAL CHEMISTRY

Bi- to tetravalent glycoclusters: synthesis, structure–activity profiles as lectin inhibitors and impact of combining both valency and headgroup tailoring on selectivity

(2012) Guan-Nan Wang et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Advances and prospects of anginex as a promising anti-angiogenesis and anti-tumor agent

(2012) Ju Bo Wang et al.   PEPTIDES

Regulation of Transforming Growth Factor-β1–driven Lung Fibrosis by Galectin-3

(2011) Alison C. MacKinnon et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Galectin-1-Specific Inhibitors as a New Class of Compounds To Treat HIV-1 Infection

(2011) Christian St-Pierre et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

The Carbohydrate-Binding Site in Galectin-3 Is Preorganized To Recognize a Sugarlike Framework of Oxygens: Ultra-High-Resolution Structures and Water Dynamics

(2011) Kadhirvel Saraboji et al.   BIOCHEMISTRY

When Galectins Recognize Glycans: From Biochemistry to Physiology and Back Again

(2011) Santiago Di Lella et al.   BIOCHEMISTRY

Treatment of prostate carcinoma with (Galectin-3)-targeted HPMA copolymer-(G3-C12)-5-Fluorouracil conjugates

(2011) Yang Yang et al.   BIOMATERIALS

Inhibitory potential of chemical substitutions at bioinspired sites of β-d-galactopyranose on neoglycoprotein/cell surface binding of two classes of medically relevant lectins

(2011) Denis Giguère et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Activation of Human T-Helper/Inducer Cell, T-Cytotoxic Cell, B-Cell, and Natural Killer (NK)-Cells and induction of Natural Killer Cell Activity against K562 Chronic Myeloid Leukemia Cells with Modified Citrus Pectin

(2011) Cheppail Ramachandran et al.   BMC Complementary and Alternative Medicine

A galectin-3 sequence polymorphism confers TRAIL sensitivity to human breast cancer cells

(2011) Nachman Mazurek et al.   CANCER

Taloside Inhibitors of Galectin-1 and Galectin-3

(2011) Patrick M. Collins et al.   Chemical Biology & Drug Design

Combining carbohydrate substitutions at bioinspired positions with multivalent presentation towards optimising lectin inhibitors: case study with calixarenes

(2011) Sabine André et al.   CHEMICAL COMMUNICATIONS

Arene-Anion Based Arginine-Binding Motif on a Galactose Scaffold: Structure-Activity Relationships of Interactions with Arginine-Rich Galectins

(2011) Christopher T. Öberg et al.   CHEMISTRY-A EUROPEAN JOURNAL

Inhibition of Galectins with Small Molecules

(2011) Christopher T. Öberg et al.   CHIMIA

Inhibition mechanism of human galectin-7 by a novel galactose-benzylphosphate inhibitor

(2011) Geoffrey Masuyer et al.   FEBS Journal

Structural features for α-galactomannan binding to galectin-1

(2011) Michelle C Miller et al.   GLYCOBIOLOGY

Galectin-3 deficiency prevents concanavalin A-induced hepatitis in mice

(2011) Vladislav Volarevic et al.   HEPATOLOGY

Galectin-8-N-domain Recognition Mechanism for Sialylated and Sulfated Glycans

(2011) Hiroko Ideo et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Anti-angiogenic Peptide Anginex Greatly Enhances Galectin-1 Binding Affinity for Glycoproteins

(2011) Emma Salomonsson et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cyclic neoglycodecapeptides: how to increase their inhibitory activity and selectivity on lectin/toxin binding to a glycoprotein and cells

(2011) Sabine André et al.   JOURNAL OF PEPTIDE SCIENCE

Modified Citrus Pectin Reduces Galectin-3 Expression and Disease Severity in Experimental Acute Kidney Injury

(2011) Maria Kolatsi-Joannou et al.   PLoS One

Structural Basis for Distinct Binding Properties of the Human Galectins to Thomsen-Friedenreich Antigen

(2011) Cheng-Feng Bian et al.   PLoS One

Synthesis of 3-amido-3-deoxy-β-d-talopyranosides: all-cis-substituted pyranosides as lectin inhibitors

(2011) Christopher T. Öberg et al.   TETRAHEDRON

1H-1,2,3-Triazol-1-yl thiodigalactoside derivatives as high affinity galectin-3 inhibitors

(2010) Bader A. Salameh et al.   BIOORGANIC & MEDICINAL CHEMISTRY

GCS-100, a novel galectin-3 antagonist, modulates MCL-1, NOXA, and cell cycle to induce myeloma cell death

(2010) M. J. Streetly et al.   BLOOD

Galectin inhibitory disaccharides promote tumour immunity in a breast cancer model

(2010) Kimberley A. Stannard et al.   CANCER LETTERS

A Galectin-3 Ligand Corrects the Impaired Function of Human CD4 and CD8 Tumor-Infiltrating Lymphocytes and Favors Tumor Rejection in Mice

(2010) N. Demotte et al.   CANCER RESEARCH

PectaSol-C Modified Citrus Pectin Induces Apoptosis and Inhibition of Proliferation in Human and Mouse Androgen-Dependent and- Independent Prostate Cancer Cells

(2010) Jun Yan et al.   INTEGRATIVE CANCER THERAPIES

Galectin-4 functions as a tumor suppressor of human colorectal cancer

(2010) Arun Satelli et al.   INTERNATIONAL JOURNAL OF CANCER

Synthesis and screening of a small glycomimetic library for inhibitory activity on medically relevant galactoside-specific lectins in assays of increasing biorelevance

(2010) Sabine André et al.   NEW JOURNAL OF CHEMISTRY

Calpain activation through galectin-3 inhibition sensitizes prostate cancer cells to cisplatin treatment

(2010) Y Wang et al.   Cell Death & Disease

Carbamate-Linked Lactose: Design of Clusters and Evidence for Selectivity to Block Binding of Human Lectins to (Neo)Glycoproteins with Increasing Degree of Branching and to Tumor Cells

(2009) Sabine André et al.   BIOCONJUGATE CHEMISTRY

Inhibiting Tumor Growth by Targeting Tumor Vasculature with Galectin-1 Antagonist Anginex Conjugated to the Cytotoxic Acylfulvene, 6-Hydroxylpropylacylfulvene

(2009) Ruud P. M. Dings et al.   BIOCONJUGATE CHEMISTRY

Anti-angiogenesis and anti-tumor effects of AdNT4-anginex

(2009) Dan Feng Dong et al.   CANCER LETTERS

Using pulse field gradient NMR diffusion measurements to define molecular size distributions in glycan preparations

(2009) Michelle C. Miller et al.   CARBOHYDRATE RESEARCH

Potential directions for drug development against galectin-7 in cancer

(2009) Yves St-Pierre et al.   Expert Opinion on Drug Discovery

The  -galactomannan Davanat binds galectin-1 at a site different from the conventional galectin carbohydrate binding domain

(2009) M. C Miller et al.   GLYCOBIOLOGY

Synthesis of Bivalent Lactosides Based on Terephthalamide,N,N′-Diglucosylterephthalamide, and Glycophane Scaffolds and Assessment of Their Inhibitory Capacity on Medically Relevant Lectins

(2009) Rosaria Leyden et al.   JOURNAL OF ORGANIC CHEMISTRY

Galectin-3 Targeted Therapy with a Small Molecule Inhibitor Activates Apoptosis and Enhances Both Chemosensitivity and Radiosensitivity in Papillary Thyroid Cancer

(2009) C.-I. Lin et al.   MOLECULAR CANCER RESEARCH

Tumor targeting and SPECT imaging properties of an 111In-labeled galectin-3 binding peptide in prostate carcinoma

(2009) Susan L. Deutscher et al.   NUCLEAR MEDICINE AND BIOLOGY

Fragment-based development of triazole-substituted O-galactosyl aldoximes with fragment-induced affinity and selectivity for galectin-3

(2009) Johan Tejler et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

The Role of Galectins in Protein Trafficking

(2009) Delphine Delacour et al.   TRAFFIC

Synthesis of stable and selective inhibitors of human galectins-1 and -3

(2008) Denis Giguère et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Protein subtype-targeting through ligand epimerization: Talose-selectivity of galectin-4 and galectin-8

(2008) Christopher T. Öberg et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Modified citrus pectin anti-metastatic properties: one bullet, multiple targets

(2008) Vladislav V. Glinsky et al.   CARBOHYDRATE RESEARCH

Thermodynamic Analysis of Nylon Nucleic Acids

(2008) Yu Liu et al.   CHEMBIOCHEM

Double Affinity Amplification of Galectin–Ligand Interactions through Arginine–Arene Interactions: Synthetic, Thermodynamic, and Computational Studies with Aromatic Diamido Thiodigalactosides

(2008) Ian Cumpstey et al.   CHEMISTRY-A EUROPEAN JOURNAL

Galectins: structure, function and therapeutic potential

(2008) Ri-Yao Yang et al.   EXPERT REVIEWS IN MOLECULAR MEDICINE

Structural analysis of the recognition mechanism of poly-N-acetyllactosamine by the human galectin-9 N-terminal carbohydrate recognition domain

(2008) M. Nagae et al.   GLYCOBIOLOGY

Arginine Binding Motifs: Design and Synthesis of Galactose-Derived Arginine Tweezers as Galectin-3 Inhibitors

(2008) Christopher T. Öberg et al.   JOURNAL OF MEDICINAL CHEMISTRY

Galectin-Inhibitory Thiodigalactoside Ester Derivatives Have Antimigratory Effects in Cultured Lung and Prostate Cancer Cells

(2008) Tamara Delaine et al.   JOURNAL OF MEDICINAL CHEMISTRY

111In-Labeled Galectin-3-Targeting Peptide as a SPECT Agent for Imaging Breast Tumors

(2008) S. R. Kumar et al.   JOURNAL OF NUCLEAR MEDICINE

Galectin-4 Controls Intestinal Inflammation by Selective Regulation of Peripheral and Mucosal T Cell Apoptosis and Cell Cycle

(2008) Daniela Paclik et al.   PLoS One

Roles of galectins in inflammatory bowel disease

(2008) Akira Hokama et al.   WORLD JOURNAL OF GASTROENTEROLOGY

Inhibitory effect of modified citrus pectin on liver metastases in a mouse colon cancer model

(2008) Hai-Ying Liu et al.   WORLD JOURNAL OF GASTROENTEROLOGY