Inflammasome activation and IL ‐1β signalling in group A Streptococcus disease

Activation mechanisms of inflammasomes by bacterial toxins

(2021) Weidong Jing et al.   CELLULAR MICROBIOLOGY

Streptococcus pyogenes M1T1 Variants Induce an Inflammatory Neutrophil Phenotype Including Activation of Inflammatory Caspases

(2021) Jonathan G. Williams et al.   Frontiers in Cellular and Infection Microbiology

The Relevance of IL-1-Signaling in the Protection against Gram-Positive Bacteria

(2021) Angelina Midiri et al.   Pathogens

Gasdermin D pore structure reveals preferential release of mature interleukin-1

(2021) Shiyu Xia et al.   NATURE

Toll-like Receptors and the Control of Immunity

(2020) Katherine A. Fitzgerald et al.   CELL

All major cholesterol-dependent cytolysins use glycans as cellular receptors

(2020) Lucy K. Shewell et al.   Science Advances

Group A Streptococcus Infection of the Nasopharynx Requires Proinflammatory Signaling Through the Interleukin-1 Receptor

(2020) Doris L. LaRock et al.   INFECTION AND IMMUNITY

Extracellular bacterial lymphatic metastasis drives Streptococcus pyogenes systemic infection

(2020) Matthew K. Siggins et al.   Nature Communications

IL‐1α cleavage by inflammatory caspases of the noncanonical inflammasome controls the senescence‐associated secretory phenotype

(2019) Kimberley A. Wiggins et al.   AGING CELL

MCC950 directly targets the NLRP3 ATP-hydrolysis motif for inflammasome inhibition

(2019) Rebecca C. Coll et al.   Nature Chemical Biology

The Secreted Virulence Factor NADase of Group A Streptococcus Inhibits P2X7 Receptor-Mediated Release of IL-1β

(2019) Elsa Westerlund et al.   Frontiers in Immunology

Inflammasomes: Threat-Assessment Organelles of the Innate Immune System

(2019) Charles L. Evavold et al.   IMMUNITY

The Gasdermin-D pore acts as a conduit for IL-1β secretion in mice

(2018) Rosalie Heilig et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

The Pore-Forming Protein Gasdermin D Regulates Interleukin-1 Secretion from Living Macrophages

(2018) Charles L. Evavold et al.   IMMUNITY

DPP8/DPP9 inhibitor-induced pyroptosis for treatment of acute myeloid leukemia

(2018) Darren C. Johnson et al.   NATURE MEDICINE

Salient type 1 interleukin 1 receptor expression in peripheral non-immune cells

(2018) Anping Song et al.   Scientific Reports

Group A Streptococcus M1T1 Intracellular Infection of Primary Tonsil Epithelial Cells Dampens Levels of Secreted IL-8 Through the Action of SpyCEP

(2018) Amelia T. Soderholm et al.   Frontiers in Cellular and Infection Microbiology

Neutralization of Streptolysin S-Dependent and Independent Inflammatory Cytokine IL-1β Activity Reduces Pathology During Early Group A Streptococcal Skin Infection

(2018) Rebecca A. Flaherty et al.   Frontiers in Cellular and Infection Microbiology

Neutrophil: A Cell with Many Roles in Inflammation or Several Cell Types?

(2018) Carlos Rosales   Frontiers in Physiology

The inflammasomes, immune guardians at defence barriers

(2018) Pablo Palazon-Riquelme et al.   IMMUNOLOGY

Interleukin-1β Maturation Triggers Its Relocation to the Plasma Membrane for Gasdermin-D-Dependent and -Independent Secretion

(2018) Mercedes Monteleone et al.   Cell Reports

Dysregulated IL-1β-GM-CSF Axis in Acute Rheumatic Fever That Is Limited by Hydroxychloroquine

(2018) Man Lyang Kim et al.   CIRCULATION

Anakinra Therapy for Non-cancer Inflammatory Diseases

(2018) Giulio Cavalli et al.   Frontiers in Pharmacology

Pattern Recognition Receptors and the Host Cell Death Molecular Machinery

(2018) Gustavo P. Amarante-Mendes et al.   Frontiers in Immunology

IL-1 and IL-1 regulatory pathways in cancer progression and therapy

(2017) Alberto Mantovani et al.   IMMUNOLOGICAL REVIEWS

Cellular interactions of covR/S mutant group A Streptococci

(2017) Emma L. Langshaw et al.   MICROBES AND INFECTION

Binding of NAD + -Glycohydrolase to Streptolysin O Stabilizes Both Toxins and Promotes Virulence of Group A Streptococcus

(2017) Jorge J. Velarde et al.   mBio

Inhibition of Inflammasome-Dependent Interleukin 1β Production by Streptococcal NAD + -Glycohydrolase: Evidence for Extracellular Activity

(2017) Dóra Hancz et al.   mBio

Group A streptococcal M protein activates the NLRP3 inflammasome

(2017) J. Andrés Valderrama et al.   Nature Microbiology

Association between cytokine response, the LRINEC score and outcome in patients with necrotising soft tissue infection: a multicentre, prospective study

(2017) Marco Bo Hansen et al.   Scientific Reports

Type I Interferon Signaling Prevents IL-1β-Driven Lethal Systemic Hyperinflammation during Invasive Bacterial Infection of Soft Tissue

(2016) Virginia Castiglia et al.   Cell Host & Microbe

Genetic Architecture of Group A Streptococcal Necrotizing Soft Tissue Infections in the Mouse

(2016) Karthickeyan Chella Krishnan et al.   PLoS Pathogens

Group A Streptococcus exploits human plasminogen for bacterial translocation across epithelial barrier via tricellular tight junctions

(2016) Tomoko Sumitomo et al.   Scientific Reports

Gasdermin D is an executor of pyroptosis and required for interleukin-1β secretion

(2015) Wan-ting He et al.   CELL RESEARCH

Mechanisms of unconventional secretion of IL-1 family cytokines

(2015) Mercedes Monteleone et al.   CYTOKINE

Sensing of Interleukin-1 Cytokines during Streptococcus pneumoniae Colonization Contributes to Macrophage Recruitment and Bacterial Clearance

(2015) Jamie K. Lemon et al.   INFECTION AND IMMUNITY

Streptolysin S Promotes Programmed Cell Death and Enhances Inflammatory Signaling in Epithelial Keratinocytes during Group A Streptococcus Infection

(2015) Rebecca A. Flaherty et al.   INFECTION AND IMMUNITY

TLR8 Senses Bacterial RNA in Human Monocytes and Plays a Nonredundant Role for Recognition ofStreptococcus pyogenes

(2015) Tatjana Eigenbrod et al.   JOURNAL OF IMMUNOLOGY

Caspase-11 cleaves gasdermin D for non-canonical inflammasome signalling

(2015) Nobuhiko Kayagaki et al.   NATURE

Cleavage of GSDMD by inflammatory caspases determines pyroptotic cell death

(2015) Jianjin Shi et al.   NATURE

A small-molecule inhibitor of the NLRP3 inflammasome for the treatment of inflammatory diseases

(2015) Rebecca C Coll et al.   NATURE MEDICINE

Interleukin-1 function and role in rheumatic disease

(2015) Georg Schett et al.   Nature Reviews Rheumatology

A Group A Streptococcus ADP-Ribosyltransferase Toxin Stimulates a Protective Interleukin 1β-Dependent Macrophage Immune Response

(2015) Ann E. Lin et al.   mBio

Rapid Lymphatic Dissemination of Encapsulated Group A Streptococci via Lymphatic Vessel Endothelial Receptor-1 Interaction

(2015) Nicola N. Lynskey et al.   PLoS Pathogens

An Extracellular Bacterial Pathogen Modulates Host Metabolism to Regulate Its Own Sensing and Proliferation

(2014) Moshe Baruch et al.   CELL

Noncanonical Inflammasome Activation of Caspase-4/Caspase-11 Mediates Epithelial Defenses against Enteric Bacterial Pathogens

(2014) Leigh A. Knodler et al.   Cell Host & Microbe

Disease Manifestations and Pathogenic Mechanisms of Group A Streptococcus

(2014) M. J. Walker et al.   CLINICAL MICROBIOLOGY REVIEWS

Inflammatory caspases are innate immune receptors for intracellular LPS

(2014) Jianjin Shi et al.   NATURE

Kallistatin Modulates Immune Cells and Confers Anti-Inflammatory Response To Protect Mice from Group A Streptococcal Infection

(2013) Shiou-Ling Lu et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

The Globally Disseminated M1T1 Clone of Group A Streptococcus Evades Autophagy for Intracellular Replication

(2013) Timothy C. Barnett et al.   Cell Host & Microbe

Group A Streptococcal Cysteine Protease Cleaves Epithelial Junctions and Contributes to Bacterial Translocation

(2013) Tomoko Sumitomo et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cytoplasmic LPS Activates Caspase-11: Implications in TLR4-Independent Endotoxic Shock

(2013) J. A. Hagar et al.   SCIENCE

Noncanonical Inflammasome Activation by Intracellular LPS Independent of TLR4

(2013) N. Kayagaki et al.   SCIENCE

Reduction of Streptolysin O (SLO) Pore-Forming Activity Enhances Inflammasome Activation

(2013) Peter Keyel et al.   Toxins

Updated model of group A Streptococcus M proteins based on a comprehensive worldwide study

(2012) D.J. McMillan et al.   CLINICAL MICROBIOLOGY AND INFECTION

Serine/Threonine Phosphatase (SP-STP), Secreted fromStreptococcus pyogenes, Is a Pro-apoptotic Protein

(2012) Shivani Agarwal et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Importance of Toll-Like Receptor 9 in Host Defense against M1T1 Group A Streptococcus Infections

(2011) Annelies S. Zinkernagel et al.   Journal of Innate Immunity

Streptolysin S-like virulence factors: the continuing sagA

(2011) Evelyn M. Molloy et al.   NATURE REVIEWS MICROBIOLOGY

IL-1β-driven neutrophilia preserves antibacterial defense in the absence of the kinase IKKβ

(2010) Li-Chung Hsu et al.   NATURE IMMUNOLOGY

Activation of the Nlrp3 Inflammasome by Streptococcus pyogenes Requires Streptolysin O and NF- B Activation but Proceeds Independently of TLR Signaling and P2X7 Receptor

(2009) J. Harder et al.   JOURNAL OF IMMUNOLOGY

Innate immune-induced depletion of bone marrow neutrophils aggravates systemic bacterial infections

(2009) A. A. Navarini et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Incompetence of Neutrophils to Invasive Group A streptococcus Is Attributed to Induction of Plural Virulence Factors by Dysfunction of a Regulator

(2008) Manabu Ato et al.   PLoS One