Microvessels support engraftment and functionality of human islets and hESC-derived pancreatic progenitors in diabetes models

Patch-Seq Links Single-Cell Transcriptomes to Human Islet Dysfunction in Diabetes

(2020) Joan Camunas-Soler et al.   Cell Metabolism

Macrophages of diverse phenotypes drive vascularization of engineered tissues

(2020) P. L. Graney et al.   Science Advances

Transplanted microvessels improve pluripotent stem cell–derived cardiomyocyte engraftment and cardiac function after infarction in rats

(2020) Xuetao Sun et al.   Science Translational Medicine

Single-Cell Transcriptome Profiling Reveals β Cell Maturation in Stem Cell-Derived Islets after Transplantation

(2020) Punn Augsornworawat et al.   Cell Reports

Single-Nucleus and In Situ RNA–Sequencing Reveal Cell Topographies in the Human Pancreas

(2020) Luca Tosti et al.   GASTROENTEROLOGY

Human blood vessel organoids as a model of diabetic vasculopathy

(2019) Reiner A. Wimmer et al.   NATURE

Mature vessel networks in engineered tissue promote graft–host anastomosis and prevent graft thrombosis

(2019) Shahar Ben-Shaul et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Navigating Two Roads to Glucose Normalization in Diabetes: Automated Insulin Delivery Devices and Cell Therapy

(2019) Esther Latres et al.   Cell Metabolism

Type I Diabetes Delays Perfusion and Engraftment of 3D Constructs by Impinging on Angiogenesis; Which can be Rescued by Hepatocyte Growth Factor Supplementation

(2019) Wafa Altalhi et al.   Cellular and Molecular Bioengineering

Charting cellular identity during human in vitro β-cell differentiation

(2019) Adrian Veres et al.   NATURE

Navigating the Depths and Avoiding the Shallows of Pancreatic Islet Cell Transcriptomes

(2019) Alex M. Mawla et al.   DIABETES

Sufu- and Spop-mediated downregulation of Hedgehog signaling promotes beta cell differentiation through organ-specific niche signals

(2019) Theodora Yung et al.   Nature Communications

Engineering transferrable microvascular meshes for subcutaneous islet transplantation

(2019) Wei Song et al.   Nature Communications

The Pericyte of the Pancreatic Islet Regulates Capillary Diameter and Local Blood Flow

(2018) Joana Almaça et al.   Cell Metabolism

Clinical islet transplantation

(2018) Andrew R. Pepper et al.   Current Opinion in Organ Transplantation

Self-Condensation Culture Enables Vascularization of Tissue Fragments for Efficient Therapeutic Transplantation

(2018) Yoshinobu Takahashi et al.   Cell Reports

Single‐cell transcriptomic analyses reveal distinct dorsal/ventral pancreatic programs

(2018) Lin‐Chen Li et al.   EMBO REPORTS

HLA-E-expressing pluripotent stem cells escape allogeneic responses and lysis by NK cells

(2017) Germán G Gornalusse et al.   NATURE BIOTECHNOLOGY

Regulation of heat shock transcription factors and their roles in physiology and disease

(2017) Rocio Gomez-Pastor et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Modular tissue engineering for the vascularization of subcutaneously transplanted pancreatic islets

(2017) Alexander E. Vlahos et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Glycoprotein 2 is a specific cell surface marker of human pancreatic progenitors

(2017) Kathryn F. Cogger et al.   Nature Communications

Transplantation of Human Pancreatic Endoderm Cells Reverses Diabetes Post Transplantation in a Prevascularized Subcutaneous Site

(2017) Andrew R. Pepper et al.   Stem Cell Reports

Host non-inflammatory neutrophils mediate the engraftment of bioengineered vascular networks

(2017) Ruei-Zeng Lin et al.   Nature Biomedical Engineering

Age-Dependent Pancreatic Gene Regulation Reveals Mechanisms Governing Human β Cell Function

(2016) H. Efsun Arda et al.   Cell Metabolism

Single-Cell Transcriptome Profiling of Human Pancreatic Islets in Health and Type 2 Diabetes

(2016) Åsa Segerstolpe et al.   Cell Metabolism

Research-Focused Isolation of Human Islets From Donors With and Without Diabetes at the Alberta Diabetes Institute IsletCore

(2016) James Lyon et al.   ENDOCRINOLOGY

Long-term glycemic control using polymer-encapsulated human stem cell–derived beta cells in immune-competent mice

(2016) Arturo J Vegas et al.   NATURE MEDICINE

Human pancreatic beta-like cells converted from fibroblasts

(2016) Saiyong Zhu et al.   Nature Communications

A Single-Cell Transcriptome Atlas of the Human Pancreas

(2016) Mauro J. Muraro et al.   Cell Systems

A Single-Cell Transcriptomic Map of the Human and Mouse Pancreas Reveals Inter- and Intra-cell Population Structure

(2016) Maayan Baron et al.   Cell Systems

A prevascularized subcutaneous device-less site for islet and cellular transplantation

(2015) Andrew R Pepper et al.   NATURE BIOTECHNOLOGY

Efficient Generation of NKX6-1+ Pancreatic Progenitors from Multiple Human Pluripotent Stem Cell Lines

(2015) M. Cristina Nostro et al.   Stem Cell Reports

The nuclear hormone receptor family member NR5A2 controls aspects of multipotent progenitor cell formation and acinar differentiation during pancreatic organogenesis

(2014) M. A. Hale et al.   DEVELOPMENT

The MafA Transcription Factor Becomes Essential to Islet β-Cells Soon After Birth

(2014) Yan Hang et al.   DIABETES

Reversal of diabetes with insulin-producing cells derived in vitro from human pluripotent stem cells

(2014) Alireza Rezania et al.   NATURE BIOTECHNOLOGY

Cotransplantation of Adipose-Derived Mesenchymal Stromal Cells and Endothelial Cells in a Modular Construct Drives Vascularization in SCID/bg Mice

(2012) Mark J. Butler et al.   TISSUE ENGINEERING PART A

Vessel Arterial-Venous Plasticity in Adult Neovascularization

(2011) Sara S. Nunes et al.   PLoS One

Human Islet Distribution Program for Basic Research at a Single Center

(2011) T. Kin et al.   TRANSPLANTATION PROCEEDINGS

Islet Transplantation: Alternative Sites

(2010) Amer Rajab   Current Diabetes Reports

Implanted microvessels progress through distinct neovascularization phenotypes

(2009) Sara S. Nunes et al.   MICROVASCULAR RESEARCH

Hepatocyte Growth Factor Enhances Engraftment and Function of Nonhuman Primate Islets

(2008) N. M. Fiaschi-Taesch et al.   DIABETES

A new immunodeficient hyperglycaemic mouse model based on the Ins2 Akita mutation for analyses of human islet and beta stem and progenitor cell function

(2008) T. Pearson et al.   DIABETOLOGIA

Pancreatic endoderm derived from human embryonic stem cells generates glucose-responsive insulin-secreting cells in vivo

(2008) Evert Kroon et al.   NATURE BIOTECHNOLOGY