Mediator MED23 regulates inflammatory responses and liver fibrosis

From NASH to HCC: current concepts and future challenges

(2019) Quentin M. Anstee et al.   Nature Reviews Gastroenterology & Hepatology

The balancing act of the liver: tissue regeneration versus fibrosis

(2018) Lucía Cordero-Espinoza et al.   JOURNAL OF CLINICAL INVESTIGATION

RORα controls inflammatory state of human macrophages

(2018) Neda Nejati Moharrami et al.   PLoS One

Retinoic acid receptor-related orphan receptor α stimulates adipose tissue inflammation by modulating endoplasmic reticulum stress

(2017) Yin Liu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Transcription regulation by the Mediator complex

(2017) Julie Soutourina   NATURE REVIEWS MOLECULAR CELL BIOLOGY

RORα controls hepatic lipid homeostasis via negative regulation of PPARγ transcriptional network

(2017) Kyeongkyu Kim et al.   Nature Communications

Mediator MED23 cooperates with RUNX2 to drive osteoblast differentiation and bone development

(2016) Zhen Liu et al.   Nature Communications

CXCL10-Mediates Macrophage, but not Other Innate Immune Cells-Associated Inflammation in Murine Nonalcoholic Steatohepatitis

(2016) Kyoko Tomita et al.   Scientific Reports

The Mediator subunit MED23 couples H2B mono‐ubiquitination to transcriptional control and cell fate determination

(2015) Xiao Yao et al.   EMBO JOURNAL

Hepatic inflammation and fibrosis: Functional links and key pathways

(2015) Ekihiro Seki et al.   HEPATOLOGY

Liver Med23 ablation improves glucose and lipid metabolism through modulating FOXO1 activity

(2014) Yajing Chu et al.   CELL RESEARCH

The Mediator complex: a master coordinator of transcription and cell lineage development

(2014) J.-w. Yin et al.   DEVELOPMENT

Roles for Chemokines in Liver Disease

(2014) Fabio Marra et al.   GASTROENTEROLOGY

Evolving therapies for liver fibrosis

(2013) Detlef Schuppan et al.   JOURNAL OF CLINICAL INVESTIGATION

Lack of CC chemokine ligand 2 differentially affects inflammation and fibrosis according to the genetic background in a murine model of steatohepatitis

(2012) Sara Galastri et al.   CLINICAL SCIENCE

Mediator MED23 plays opposing roles in directing smooth muscle cell and adipocyte differentiation

(2012) J.-w. Yin et al.   GENES & DEVELOPMENT

Hepatic activation of IKK/NFκB signaling induces liver fibrosis via macrophage-mediated chronic inflammation

(2012) Yoshiaki Sunami et al.   HEPATOLOGY

Mediator Complex Regulates Alternative mRNA Processing via the MED23 Subunit

(2012) Yan Huang et al.   MOLECULAR CELL

Selective requirement for Mediator MED23 in Ras-active lung cancer

(2012) X. Yang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Transcriptional profiling reveals a role for RORα in regulating gene expression in obesity-associated inflammation and hepatic steatosis

(2011) Hong Soon Kang et al.   PHYSIOLOGICAL GENOMICS

CXCL10 promotes liver fibrosis by prevention of NK cell mediated hepatic stellate cell inactivation

(2010) Edith Hintermann et al.   JOURNAL OF AUTOIMMUNITY

Antagonism of the chemokine Ccl5 ameliorates experimental liver fibrosis in mice

(2010) Marie-Luise Berres et al.   JOURNAL OF CLINICAL INVESTIGATION

The metazoan Mediator co-activator complex as an integrative hub for transcriptional regulation

(2010) Sohail Malik et al.   NATURE REVIEWS GENETICS

Cortactin is involved in transforming growth factor- 1-induced epithelial-mesenchymal transition in AML-12 cells

(2009) K. Zhang et al.   ACTA BIOCHIMICA ET BIOPHYSICA SINICA

Dual Role of CCR2 in the Constitution and the Resolution of Liver Fibrosis in Mice

(2009) Claudia Mitchell et al.   AMERICAN JOURNAL OF PATHOLOGY

Mediator MED23 Links Insulin Signaling to the Adipogenesis Transcription Cascade

(2009) Wei Wang et al.   DEVELOPMENTAL CELL

CCR2 promotes hepatic fibrosis in mice

(2009) Ekihiro Seki et al.   HEPATOLOGY

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(2009) Valeria Mas et al.   MOLECULAR MEDICINE

The Orphan Nuclear Receptor, RORα, Regulates Gene Expression That Controls Lipid Metabolism

(2008) Patrick Lau et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

MED19 and MED26 Are Synergistic Functional Targets of the RE1 Silencing Transcription Factor in Epigenetic Silencing of Neuronal Gene Expression

(2008) Ning Ding et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mediator Links Epigenetic Silencing of Neuronal Gene Expression with X-Linked Mental Retardation

(2008) Ning Ding et al.   MOLECULAR CELL