The requirement for pyruvate dehydrogenase in leukemogenesis depends on cell lineage

The distribution of cellular turnover in the human body

(2021) Ron Sender et al.   NATURE MEDICINE

Metabolomic profiling of rare cell populations isolated by flow cytometry from tissues

(2021) Andrew W DeVilbiss et al.   eLife

Restraining Lysosomal Activity Preserves Hematopoietic Stem Cell Quiescence and Potency

(2020) Raymond Liang et al.   Cell Stem Cell

Mitochondrial Pyruvate Carrier 1 Promotes Peripheral T Cell Homeostasis through Metabolic Regulation of Thymic Development

(2020) Andrew G. Ramstead et al.   Cell Reports

Dissecting cell-type-specific metabolism in pancreatic ductal adenocarcinoma

(2020) Allison N Lau et al.   eLife

Two Aldehyde Clearance Systems Are Essential to Prevent Lethal Formaldehyde Accumulation in Mice and Humans

(2020) Felix A. Dingler et al.   MOLECULAR CELL

Increased demand for NAD+ relative to ATP drives aerobic glycolysis

(2020) Alba Luengo et al.   MOLECULAR CELL

Brain metabolism modulates neuronal excitability in a mouse model of pyruvate dehydrogenase deficiency

(2019) Vikram Jakkamsetti et al.   Science Translational Medicine

Targeted Determination of Tissue Energy Status by LC-MS/MS

(2019) Xiaorong Fu et al.   ANALYTICAL CHEMISTRY

Metabolic Profiling Using Stable Isotope Tracing Reveals Distinct Patterns of Glucose Utilization by Physiologically Activated CD8+ T Cells

(2019) Eric H. Ma et al.   IMMUNITY

Regulation of Tumor Initiation by the Mitochondrial Pyruvate Carrier

(2019) Claire L. Bensard et al.   Cell Metabolism

Metabolic heterogeneity confers differences in melanoma metastatic potential

(2019) Alpaslan Tasdogan et al.   NATURE

Extraction and Quantitation of Nicotinamide Adenine Dinucleotide Redox Cofactors

(2018) Wenyun Lu et al.   ANTIOXIDANTS & REDOX SIGNALING

B-Cell-Specific Diversion of Glucose Carbon Utilization Reveals a Unique Vulnerability in B Cell Malignancies

(2018) Gang Xiao et al.   CELL

Inosine Monophosphate Dehydrogenase Dependence in a Subset of Small Cell Lung Cancers

(2018) Fang Huang et al.   Cell Metabolism

Compartmentalized activities of the pyruvate dehydrogenase complex sustain lipogenesis in prostate cancer

(2018) Jingjing Chen et al.   NATURE GENETICS

Antagonism of PPAR-γ signaling expands human hematopoietic stem and progenitor cells by enhancing glycolysis

(2018) Bin Guo et al.   NATURE MEDICINE

PPM1K Regulates Hematopoiesis and Leukemogenesis through CDC20-Mediated Ubiquitination of MEIS1 and p21

(2018) Xiaoye Liu et al.   Cell Reports

Fumarate hydratase is a critical metabolic regulator of hematopoietic stem cell functions

(2017) Amelie V. Guitart et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Age-related clinical and biological features of PTEN abnormalities in T-cell acute lymphoblastic leukaemia

(2017) M Tesio et al.   LEUKEMIA

Metabolic gatekeeper function of B-lymphoid transcription factors

(2017) Lai N. Chan et al.   NATURE

Ascorbate regulates haematopoietic stem cell function and leukaemogenesis

(2017) Michalis Agathocleous et al.   NATURE

Glucose feeds the TCA cycle via circulating lactate

(2017) Sheng Hui et al.   NATURE

Lactate dehydrogenase activity drives hair follicle stem cell activation

(2017) Aimee Flores et al.   NATURE CELL BIOLOGY

The mitochondrial respiratory chain is essential for haematopoietic stem cell function

(2017) Elena Ansó et al.   NATURE CELL BIOLOGY

Control of intestinal stem cell function and proliferation by mitochondrial pyruvate metabolism

(2017) John C. Schell et al.   NATURE CELL BIOLOGY

The genomic landscape of pediatric and young adult T-lineage acute lymphoblastic leukemia

(2017) Yu Liu et al.   NATURE GENETICS

Pyruvate dehydrogenase kinase 1 is essential for transplantable mouse bone marrow hematopoietic stem cell and progenitor function

(2017) Camilla Halvarsson et al.   PLoS One

Adult hematopoietic stem cells lacking Hif-1  self-renew normally

(2016) M. Vukovic et al.   BLOOD

Metabolic regulation of stem cell function in tissue homeostasis and organismal ageing

(2016) Navdeep S. Chandel et al.   NATURE CELL BIOLOGY

Tissue of origin dictates branched-chain amino acid metabolism in mutant Kras-driven cancers

(2016) J. R. Mayers et al.   SCIENCE

Sensitivity of hematopoietic stem cells to mitochondrial dysfunction by SdhD gene deletion

(2016) José Antonio Bejarano-García et al.   Cell Death & Disease

Specification of haematopoietic stem cell fate via modulation of mitochondrial activity

(2016) Nicola Vannini et al.   Nature Communications

Revised Estimates for the Number of Human and Bacteria Cells in the Body

(2016) Ron Sender et al.   PLOS BIOLOGY

Metabolic reprogramming during neuronal differentiation from aerobic glycolysis to neuronal oxidative phosphorylation

(2016) Xinde Zheng et al.   eLife

Multiple Mass Isotopomer Tracing of Acetyl-CoA Metabolism in Langendorff-perfused Rat Hearts

(2015) Qingling Li et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Metabolic reprogramming induces resistance to anti-NOTCH1 therapies in T cell acute lymphoblastic leukemia

(2015) Daniel Herranz et al.   NATURE MEDICINE

MetaboAnalyst 3.0—making metabolomics more meaningful

(2015) Jianguo Xia et al.   NUCLEIC ACIDS RESEARCH

An MTCH2 pathway repressing mitochondria metabolism regulates haematopoietic stem cell fate

(2015) Maria Maryanovich et al.   Nature Communications

A Nuclear Pyruvate Dehydrogenase Complex Is Important for the Generation of Acetyl-CoA and Histone Acetylation

(2014) Gopinath Sutendra et al.   CELL

Cell-State-Specific Metabolic Dependency in Hematopoiesis and Leukemogenesis

(2014) Ying-Hua Wang et al.   CELL

The Glucose Transporter Glut1 Is Selectively Essential for CD4 T Cell Activation and Effector Function

(2014) Andrew N. Macintyre et al.   Cell Metabolism

Glucose and Glutamine Metabolism Regulate Human Hematopoietic Stem Cell Lineage Specification

(2014) Leal Oburoglu et al.   Cell Stem Cell

Identification of Regulatory Networks in HSCs and Their Immediate Progeny via Integrated Proteome, Transcriptome, and DNA Methylome Analysis

(2014) Nina Cabezas-Wallscheid et al.   Cell Stem Cell

Glutamine Oxidation Maintains the TCA Cycle and Cell Survival during Impaired Mitochondrial Pyruvate Transport

(2014) Chendong Yang et al.   MOLECULAR CELL

Direct measurement of local oxygen concentration in the bone marrow of live animals

(2014) Joel A. Spencer et al.   NATURE

Hif-2  is not essential for cell-autonomous hematopoietic stem cell maintenance

(2013) A. V. Guitart et al.   BLOOD

Regulation of Glycolysis by Pdk Functions as a Metabolic Checkpoint for Cell Cycle Quiescence in Hematopoietic Stem Cells

(2013) Keiyo Takubo et al.   Cell Stem Cell

Widespread and Enzyme-independentNϵ-Acetylation andNϵ-Succinylation of Proteins in the Chemical Conditions of the Mitochondrial Matrix

(2013) Gregory R. Wagner et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Heterogeneity of tumor-induced gene expression changes in the human metabolic network

(2013) Jie Hu et al.   NATURE BIOTECHNOLOGY

Quantitative imaging of haematopoietic stem and progenitor cell localization and hypoxic status in the bone marrow microenvironment

(2013) César Nombela-Arrieta et al.   NATURE CELL BIOLOGY

The transcriptional landscape of αβ T cell differentiation

(2013) Michael Mingueneau et al.   NATURE IMMUNOLOGY

Meis1 regulates the metabolic phenotype and oxidant defense of hematopoietic stem cells

(2012) F. Kocabas et al.   BLOOD

The Metabolic Profile of Tumors Depends on Both the Responsible Genetic Lesion and Tissue Type

(2012) Mariia O. Yuneva et al.   Cell Metabolism

Analysis of Tumor Metabolism Reveals Mitochondrial Glucose Oxidation in Genetically Diverse Human Glioblastomas in the Mouse Brain In Vivo

(2012) Isaac Marin-Valencia et al.   Cell Metabolism

Metabolic differentiation in the embryonic retina

(2012) Michalis Agathocleous et al.   NATURE CELL BIOLOGY

A PML–PPAR-δ pathway for fatty acid oxidation regulates hematopoietic stem cell maintenance

(2012) Keisuke Ito et al.   NATURE MEDICINE

NIH Image to ImageJ: 25 years of image analysis

(2012) Caroline A Schneider et al.   NATURE METHODS

Interleukin-22 Drives Endogenous Thymic Regeneration in Mice

(2012) J. A. Dudakov et al.   SCIENCE

Evi1 represses PTEN expression and activates PI3K/AKT/mTOR via interactions with polycomb proteins

(2011) A. Yoshimi et al.   BLOOD

The role of the PTEN/AKT Pathway in NOTCH1-induced leukemia

(2011) Teresa Palomero et al.   CELL CYCLE

Cripto Regulates Hematopoietic Stem Cells as a Hypoxic-Niche-Related Factor through Cell Surface Receptor GRP78

(2011) Kenichi Miharada et al.   Cell Stem Cell

Acetyl-CoA Induces Cell Growth and Proliferation by Promoting the Acetylation of Histones at Growth Genes

(2011) Ling Cai et al.   MOLECULAR CELL

The Distinct Metabolic Profile of Hematopoietic Stem Cells Reflects Their Location in a Hypoxic Niche

(2010) Tugba Simsek et al.   Cell Stem Cell

Regulation of the HIF-1α Level Is Essential for Hematopoietic Stem Cells

(2010) Keiyo Takubo et al.   Cell Stem Cell

Pten Deletion in Adult Neural Stem/Progenitor Cells Enhances Constitutive Neurogenesis

(2009) C. Gregorian et al.   JOURNAL OF NEUROSCIENCE

Physiologic Thymic Uptake of 18F-FDG in Children and Young Adults: A PET/CT Evaluation of Incidence, Patterns, and Relationship to Treatment

(2009) J. Jerushalmi et al.   JOURNAL OF NUCLEAR MEDICINE

A robust and high-throughput Cre reporting and characterization system for the whole mouse brain

(2009) Linda Madisen et al.   NATURE NEUROSCIENCE

Tissue-specific pyruvate dehydrogenase complex deficiency causes cardiac hypertrophy and sudden death of weaned male mice

(2008) Sukhdeep Sidhu et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Multi-genetic events collaboratively contribute to Pten-null leukaemia stem-cell formation

(2008) Wei Guo et al.   NATURE