Two Aldehyde Clearance Systems Are Essential to Prevent Lethal Formaldehyde Accumulation in Mice and Humans

Alcohol-derived DNA crosslinks are repaired by two distinct mechanisms

(2020) Michael R. Hodskinson et al.   NATURE

The repertoire of mutational signatures in human cancer

(2020) Ludmil B. Alexandrov et al.   NATURE

The mutational landscape of normal human endometrial epithelium

(2020) Luiza Moore et al.   NATURE

The mutational constraint spectrum quantified from variation in 141,456 humans

(2020) Konrad J. Karczewski et al.   NATURE

Genetic predisposition to MDS: clinical features and clonal evolution

(2019) Alyssa L. Kennedy et al.   BLOOD

ALDH2 deficiency promotes alcohol-associated liver cancer by activating oncogenic pathways via oxidized DNA enriched extracellular vesicles

(2019) Wonhyo Seo et al.   JOURNAL OF HEPATOLOGY

Hallmarks of ribosomopathies

(2019) Kim R Kampen et al.   NUCLEIC ACIDS RESEARCH

Machine learning predicts putative haematopoietic stem cells within large single-cell transcriptomics datasets

(2019) Fiona K. Hamey et al.   EXPERIMENTAL HEMATOLOGY

The landscape of somatic mutation in normal colorectal epithelial cells

(2019) Henry Lee-Six et al.   NATURE

A single-cell hematopoietic landscape resolves 8 lineage trajectories and defects in Kit mutant mice

(2018) Joakim S. Dahlin et al.   BLOOD

Alcohol and endogenous aldehydes damage chromosomes and mutate stem cells

(2018) Juan I. Garaycoechea et al.   NATURE

Population dynamics of normal human blood inferred from somatic mutations

(2018) Henry Lee-Six et al.   NATURE

Clinical utility of next-generation sequencing for inherited bone marrow failure syndromes

(2017) Hideki Muramatsu et al.   GENETICS IN MEDICINE

Mammals divert endogenous genotoxic formaldehyde into one-carbon metabolism

(2017) Guillermo Burgos-Barragan et al.   NATURE

Tissue-specific mutation accumulation in human adult stem cells during life

(2016) Francis Blokzijl et al.   NATURE

Per2 induction limits lymphoid-biased haematopoietic stem cells and lymphopoiesis in the context of DNA damage and ageing

(2016) Jianwei Wang et al.   NATURE CELL BIOLOGY

Somatic ERCC2 mutations are associated with a distinct genomic signature in urothelial tumors

(2016) Jaegil Kim et al.   NATURE GENETICS

The Fanconi anaemia pathway: new players and new functions

(2016) Raphael Ceccaldi et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Dissecting the multicellular ecosystem of metastatic melanoma by single-cell RNA-seq

(2016) I. Tirosh et al.   SCIENCE

A Personalized Medicine Approach for Asian Americans with the Aldehyde Dehydrogenase 2*2 Variant

(2015) Eric R. Gross et al.   Annual Review of Pharmacology and Toxicology

What is the DNA repair defect underlying Fanconi anemia?

(2015) Julien P Duxin et al.   CURRENT OPINION IN CELL BIOLOGY

Endogenous Formaldehyde Is a Hematopoietic Stem Cell Genotoxin and Metabolic Carcinogen

(2015) Lucas B. Pontel et al.   MOLECULAR CELL

Exit from dormancy provokes DNA-damage-induced attrition in haematopoietic stem cells

(2015) Dagmar Walter et al.   NATURE

Clock-like mutational processes in human somatic cells

(2015) Ludmil B Alexandrov et al.   NATURE GENETICS

Formation, Accumulation, and Hydrolysis of Endogenous and Exogenous Formaldehyde-Induced DNA Damage

(2015) Rui Yu et al.   TOXICOLOGICAL SCIENCES

Variant ALDH2 is associated with accelerated progression of bone marrow failure in Japanese Fanconi anemia patients

(2013) A. Hira et al.   BLOOD

Fanconi anaemia and the repair of Watson and Crick DNA crosslinks

(2013) Molly C. Kottemann et al.   NATURE

Biomarkers of Exposure and Effect in Human Lymphoblastoid TK6 Cells Following [13C2]-Acetaldehyde Exposure

(2013) Benjamin C. Moeller et al.   TOXICOLOGICAL SCIENCES

Genotoxic consequences of endogenous aldehydes on mouse haematopoietic stem cell function

(2012) Juan I. Garaycoechea et al.   NATURE

Determination ofN2-Hydroxymethyl-dG Adducts in the Nasal Epithelium and Bone Marrow of Nonhuman Primates Following13CD2-Formaldehyde Inhalation Exposure

(2011) Benjamin C. Moeller et al.   CHEMICAL RESEARCH IN TOXICOLOGY

[13C2]- Acetaldehyde Promotes Unequivocal Formation of 1,N2-Propano-2′-deoxyguanosine in Human Cells

(2011) Camila Carrião M. Garcia et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Fancd2 counteracts the toxic effects of naturally produced aldehydes in mice

(2011) Frédéric Langevin et al.   NATURE

Formaldehyde catabolism is essential in cells deficient for the Fanconi anemia DNA-repair pathway

(2011) Ivan V Rosado et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Ribosomopathies: human disorders of ribosome dysfunction

(2010) A. Narla et al.   BLOOD

Differential Requirement for H2AX and 53BP1 in Organismal Development and Genome Maintenance in the Absence of Poly(ADP)ribosyl Polymerase 1

(2010) B. Orsburn et al.   MOLECULAR AND CELLULAR BIOLOGY

Dyskeratosis Congenita

(2009) Sharon A. Savage et al.   HEMATOLOGY-ONCOLOGY CLINICS OF NORTH AMERICA

Mortality From Lymphohematopoietic Malignancies Among Workers in Formaldehyde Industries: The National Cancer Institute Cohort

(2009) Laura E. Beane Freeman et al.   JNCI-Journal of the National Cancer Institute

The Alcohol Flushing Response: An Unrecognized Risk Factor for Esophageal Cancer from Alcohol Consumption

(2009) Philip J Brooks et al.   PLOS MEDICINE