FXR activation protects against NAFLD via bile-acid-dependent reductions in lipid absorption
出版年份 2021 全文链接
标题
FXR activation protects against NAFLD via bile-acid-dependent reductions in lipid absorption
作者
关键词
-
出版物
Cell Metabolism
Volume 33, Issue 8, Pages 1671-1684.e4
出版商
Elsevier BV
发表日期
2021-07-15
DOI
10.1016/j.cmet.2021.06.012
参考文献
相关参考文献
注意:仅列出部分参考文献,下载原文获取全部文献信息。- Vertical sleeve gastrectomy confers metabolic improvements by reducing intestinal bile acids and lipid absorption in mice
- (2021) Lili Ding et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Regulation of intestinal lipid metabolism: current concepts and relevance to disease
- (2020) Chih-Wei Ko et al. Nature Reviews Gastroenterology & Hepatology
- Obeticholic acid for the treatment of nonalcoholic steatohepatitis
- (2020) Raj A. Shah et al. Expert Review of Gastroenterology & Hepatology
- An integrative systems genetic analysis of mammalian lipid metabolism
- (2019) Benjamin L. Parker et al. NATURE
- Obeticholic acid may increase the risk of gallstone formation in susceptible patients
- (2019) Samer Al-Dury et al. JOURNAL OF HEPATOLOGY
- Bile acids in glucose metabolism and insulin signalling — mechanisms and research needs
- (2019) Tiara R. Ahmad et al. Nature Reviews Endocrinology
- Expert consensus document: Clinical and molecular diagnosis, screening and management of Beckwith–Wiedemann syndrome: an international consensus statement
- (2018) Frédéric Brioude et al. Nature Reviews Endocrinology
- Lipin 2/3 phosphatidic acid phosphatases maintain phospholipid homeostasis to regulate chylomicron synthesis
- (2018) Peixiang Zhang et al. JOURNAL OF CLINICAL INVESTIGATION
- Small heterodimer partner deletion prevents hepatic steatosis and when combined with farnesoid X receptor loss protects against type 2 diabetes in mice
- (2017) Oludemilade Akinrotimi et al. HEPATOLOGY
- RNA-binding protein ZFP36L1 maintains posttranscriptional regulation of bile acid metabolism
- (2017) Elizabeth J. Tarling et al. JOURNAL OF CLINICAL INVESTIGATION
- Global burden of NAFLD and NASH: trends, predictions, risk factors and prevention
- (2017) Zobair Younossi et al. Nature Reviews Gastroenterology & Hepatology
- Intestinal Phospholipid Remodeling Is Required for Dietary-Lipid Uptake and Survival on a High-Fat Diet
- (2016) Bo Wang et al. Cell Metabolism
- Histology of Nonalcoholic Fatty Liver Disease and Nonalcoholic Steatohepatitis in Adults and Children
- (2016) David E. Kleiner et al. Clinics in Liver Disease
- An Intestinal Microbiota–Farnesoid X Receptor Axis Modulates Metabolic Disease
- (2016) Frank J. Gonzalez et al. GASTROENTEROLOGY
- Mice Abundant in Muricholic Bile Acids Show Resistance to Dietary Induced Steatosis, Weight Gain, and to Impaired Glucose Metabolism
- (2016) Ylva Bonde et al. PLoS One
- MAFG Is a Transcriptional Repressor of Bile Acid Synthesis and Metabolism
- (2015) Thomas Q. de Aguiar Vallim et al. Cell Metabolism
- Intestinal FXR agonism promotes adipose tissue browning and reduces obesity and insulin resistance
- (2015) Sungsoon Fang et al. NATURE MEDICINE
- Intestinal farnesoid X receptor signaling promotes nonalcoholic fatty liver disease
- (2014) Changtao Jiang et al. JOURNAL OF CLINICAL INVESTIGATION
- Discovery of essential fatty acids
- (2014) Arthur A. Spector et al. JOURNAL OF LIPID RESEARCH
- Intestinal transport and metabolism of bile acids
- (2014) Paul A. Dawson et al. JOURNAL OF LIPID RESEARCH
- Nutrient-sensing nuclear receptors coordinate autophagy
- (2014) Jae Man Lee et al. NATURE
- Pleiotropic Roles of Bile Acids in Metabolism
- (2013) Thomas Q. de Aguiar Vallim et al. Cell Metabolism
- Gut Microbiota Regulates Bile Acid Metabolism by Reducing the Levels of Tauro-beta-muricholic Acid, a Naturally Occurring FXR Antagonist
- (2013) Sama I. Sayin et al. Cell Metabolism
- MicroRNA-144 Regulates Hepatic ATP Binding Cassette Transporter A1 and Plasma High-Density Lipoprotein After Activation of the Nuclear Receptor Farnesoid X Receptor
- (2013) Thomas Q. de Aguiar Vallim et al. CIRCULATION RESEARCH
- Nonalcoholic fatty liver disease, hepatic insulin resistance, and type 2 Diabetes
- (2013) Andreas L. Birkenfeld et al. HEPATOLOGY
- Delineation of biochemical, molecular, and physiological changes accompanying bile acid pool size restoration in Cyp7a1−/− mice fed low levels of cholic acid
- (2012) Ryan D. Jones et al. AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY
- Loss of FXR Protects against Diet-Induced Obesity and Accelerates Liver Carcinogenesis inob/obMice
- (2012) Yanqiao Zhang et al. MOLECULAR ENDOCRINOLOGY
- Human Fatty Liver Disease: Old Questions and New Insights
- (2011) J. C. Cohen et al. SCIENCE
- Conformationally constrained farnesoid X receptor (FXR) agonists: Heteroaryl replacements of the naphthalene
- (2010) Jonathan Y. Bass et al. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
- Biochemistry, physiology, and genetics of GPAT, AGPAT, and lipin enzymes in triglyceride synthesis
- (2009) Kazuharu Takeuchi et al. AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM
- The enterohepatic circulation of bile acids in mammals: form and functions
- (2009) Alan et al. Frontiers in Bioscience-Landmark
- Genome-wide tissue-specific farnesoid X receptor binding in mouse liver and intestine
- (2009) Ann M. Thomas et al. HEPATOLOGY
- Identification of Novel Pathways That Control Farnesoid X Receptor-mediated Hypocholesterolemia
- (2009) Yanqiao Zhang et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Role of stearoyl-coenzyme A desaturase in regulating lipid metabolism
- (2008) Matthew T Flowers et al. CURRENT OPINION IN LIPIDOLOGY
- Loss of small heterodimer partner expression in the liver protects against dyslipidemia
- (2008) Helen B. Hartman et al. JOURNAL OF LIPID RESEARCH
Find Funding. Review Successful Grants.
Explore over 25,000 new funding opportunities and over 6,000,000 successful grants.
ExploreCreate your own webinar
Interested in hosting your own webinar? Check the schedule and propose your idea to the Peeref Content Team.
Create Now