Lipin 2/3 phosphatidic acid phosphatases maintain phospholipid homeostasis to regulate chylomicron synthesis

Intestinal De Novo Phosphatidylcholine Synthesis is Required for Dietary Lipid Absorption and Metabolic Homeostasis

(2018) John P. Kennelly et al.   JOURNAL OF LIPID RESEARCH

Lipid sensing by mTOR complexes viade novosynthesis of phosphatidic acid

(2017) Deepak Menon et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

mTORC1 stimulates phosphatidylcholine synthesis to promote triglyceride secretion

(2017) William J. Quinn et al.   JOURNAL OF CLINICAL INVESTIGATION

Control of chylomicron export from the intestine

(2016) Charles M. Mansbach et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Recent discoveries on absorption of dietary fat: Presence, synthesis, and metabolism of cytoplasmic lipid droplets within enterocytes

(2016) Theresa D'Aquila et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Intestinal Phospholipid Remodeling Is Required for Dietary-Lipid Uptake and Survival on a High-Fat Diet

(2016) Bo Wang et al.   Cell Metabolism

Lipin-2 regulates NLRP3 inflammasome by affecting P2X 7 receptor activation

(2016) Gema Lordén et al.   JOURNAL OF EXPERIMENTAL MEDICINE

New Insights into the Regulation of Chylomicron Production

(2015) Satya Dash et al.   Annual Review of Nutrition

Increased High-Density Lipoprotein Cholesterol Levels in Mice With XX Versus XY Sex ChromosomesSignificance

(2015) Jenny C. Link et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Characterization of a Novel Intestinal Glycerol-3-phosphate Acyltransferase Pathway and Its Role in Lipid Homeostasis

(2015) Irani Khatun et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Lpcat3-dependent production of arachidonoyl phospholipids is a key determinant of triglyceride secretion

(2015) Xin Rong et al.   eLife

Fatty acid remodeling by LPCAT3 enriches arachidonate in phospholipid membranes and regulates triglyceride transport

(2015) Tomomi Hashidate-Yoshida et al.   eLife

Lipin-1 Regulates Autophagy Clearance and Intersects with Statin Drug Effects in Skeletal Muscle

(2014) Peixiang Zhang et al.   Cell Metabolism

Intestinal triacylglycerol synthesis in fat absorption and systemic energy metabolism

(2014) Chi-Liang Eric Yen et al.   JOURNAL OF LIPID RESEARCH

Diet1 Functions in the FGF15/19 Enterohepatic Signaling Axis to Modulate Bile Acid and Lipid Levels

(2013) Laurent Vergnes et al.   Cell Metabolism

Genome engineering using the CRISPR-Cas9 system

(2013) F Ann Ran et al.   Nature Protocols

Lipins, lipinopathies, and the modulation of cellular lipid storage and signaling

(2013) Lauren S. Csaki et al.   PROGRESS IN LIPID RESEARCH

Multiplex Genome Engineering Using CRISPR/Cas Systems

(2013) L. Cong et al.   SCIENCE

Lipin-1 and lipin-3 together determine adiposity in vivo

(2013) Lauren S. Csaki et al.   Molecular Metabolism

Lipid droplet formation on opposing sides of the endoplasmic reticulum

(2012) Stephen L. Sturley et al.   JOURNAL OF LIPID RESEARCH

Role of the Gut in Lipid Homeostasis

(2012) Nada A. Abumrad et al.   PHYSIOLOGICAL REVIEWS

Complex Interplay between the Lipin 1 and the Hepatocyte Nuclear Factor 4 α (HNF4α) Pathways to Regulate Liver Lipid Metabolism

(2012) Zhouji Chen et al.   PLoS One

Mouse lipin-1 and lipin-2 cooperate to maintain glycerolipid homeostasis in liver and aging cerebellum

(2012) J. R. Dwyer et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Gut triglyceride production

(2011) Xiaoyue Pan et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

mTOR Complex 1 Regulates Lipin 1 Localization to Control the SREBP Pathway

(2011) Timothy R. Peterson et al.   CELL

Phosphatidylcholine Synthesis for Lipid Droplet Expansion Is Mediated by Localized Activation of CTP:Phosphocholine Cytidylyltransferase

(2011) Natalie Krahmer et al.   Cell Metabolism

Mammalian Triacylglycerol Metabolism: Synthesis, Lipolysis, and Signaling

(2011) Rosalind A. Coleman et al.   CHEMICAL REVIEWS

Regulation of microsomal triglyceride transfer protein

(2011) M Mahmood Hussain et al.   Clinical Lipidology

Lipin-1 Phosphatidic Phosphatase Activity Modulates Phosphatidate Levels to Promote Peroxisome Proliferator-activated Receptor γ (PPARγ) Gene Expression during Adipogenesis

(2011) Peixiang Zhang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The mechanism of the formation and secretion of chylomicrons

(2010) Tammy Kindel et al.   ATHEROSCLEROSIS SUPPLEMENTS

Lipin proteins form homo- and hetero-oligomers

(2010) Guang-Hui Liu et al.   BIOCHEMICAL JOURNAL

Lipin 1 Represses NFATc4 Transcriptional Activity in Adipocytes To Inhibit Secretion of Inflammatory Factors

(2010) H. B. Kim et al.   MOLECULAR AND CELLULAR BIOLOGY

PHOSPHATIDIC ACID PHOSPHOHYDROLASE1 and 2 Regulate Phospholipid Synthesis at the Endoplasmic Reticulum in Arabidopsis

(2010) P. J. Eastmond et al.   PLANT CELL

A Conserved Serine Residue Is Required for the Phosphatidate Phosphatase Activity but Not the Transcriptional Coactivator Functions of Lipin-1 and Lipin-2

(2009) Jimmy Donkor et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Lipin 2 Is a Liver-enriched Phosphatidate Phosphohydrolase Enzyme That Is Dynamically Regulated by Fasting and Obesity in Mice

(2009) Matthew C. Gropler et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Deficiency of the intestinal enzyme acyl CoA:monoacylglycerol acyltransferase-2 protects mice from metabolic disorders induced by high-fat feeding

(2009) Chi-Liang Eric Yen et al.   NATURE MEDICINE

Mutations in LPIN1 Cause Recurrent Acute Myoglobinuria in Childhood

(2008) Avraham Zeharia et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Beyond triglyceride synthesis: the dynamic functional roles of MGAT and DGAT enzymes in energy metabolism

(2008) Yuguang Shi et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Lipin1 Is a Key Factor for the Maturation and Maintenance of Adipocytes in the Regulatory Network with CCAAT/Enhancer-binding Protein α and Peroxisome Proliferator-activated Receptor γ2

(2008) Yoo-Kyung Koh et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Chylomicron remnants are increased in the postprandial state in CD36 deficiency

(2008) Daisaku Masuda et al.   JOURNAL OF LIPID RESEARCH

Glucocorticoids and cyclic AMP selectively increase hepatic lipin-1 expression, and insulin acts antagonistically

(2008) Boripont Manmontri et al.   JOURNAL OF LIPID RESEARCH

Thematic Review Series: Glycerolipids.Multiple roles for lipins/phosphatidate phosphatase enzymes in lipid metabolism

(2008) Karen Reue et al.   JOURNAL OF LIPID RESEARCH

The many intersecting pathways underlying apolipoprotein B secretion and degradation

(2008) Jeffrey L. Brodsky et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM