Uncoupling of IL-6 signaling and LC3-associated phagocytosis drives immunoparalysis during sepsis
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Title
Uncoupling of IL-6 signaling and LC3-associated phagocytosis drives immunoparalysis during sepsis
Authors
Keywords
Aspergillus fumigatus, LAP, LC3-associated phagocytosis, phagosome, IL-6, JAK, NADPH oxidase, extracellular-signal-kinase regulated (ERK), microtubules, sepsis, sepsis immunoparalysis
Journal
Cell Host & Microbe
Volume 29, Issue 8, Pages 1277-1293.e6
Publisher
Elsevier BV
Online
2021-07-01
DOI
10.1016/j.chom.2021.06.002
References
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Related references
Note: Only part of the references are listed.- Cytokine release syndrome in severe COVID-19
- (2020) John B. Moore et al. SCIENCE
- Epidemiology of invasive pulmonary aspergillosis among COVID-19 intubated patients: a prospective study
- (2020) Michele Bartoletti et al. CLINICAL INFECTIOUS DISEASES
- LC3-associated phagocytosis at a glance
- (2019) Bradlee L. Heckmann et al. JOURNAL OF CELL SCIENCE
- LC3-Associated Endocytosis Facilitates β-Amyloid Clearance and Mitigates Neurodegeneration in Murine Alzheimer’s Disease
- (2019) Bradlee L. Heckmann et al. CELL
- Reply to Bazaz and Denning
- (2018) Georgios Chamilos et al. CLINICAL INFECTIOUS DISEASES
- Towards precision medicine in sepsis: a position paper from the European Society of Clinical Microbiology and Infectious Diseases
- (2018) J. Rello et al. CLINICAL MICROBIOLOGY AND INFECTION
- News Feature: The quest to solve sepsis
- (2018) Carrie Arnold PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Calcium sequestration by fungal melanin inhibits calcium–calmodulin signalling to prevent LC3-associated phagocytosis
- (2018) Irene Kyrmizi et al. Nature Microbiology
- Electrophilic properties of itaconate and derivatives regulate the IκBζ–ATF3 inflammatory axis
- (2018) Monika Bambouskova et al. NATURE
- Interleukin-22 promotes phagolysosomal fusion to induce protection against Salmonella enterica Typhimurium in human epithelial cells
- (2018) Jessica L. Forbester et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Precision Immunotherapy for Sepsis
- (2018) Annemieke M. Peters van Ton et al. Frontiers in Immunology
- The Itaconate Pathway Is a Central Regulatory Node Linking Innate Immune Tolerance and Trained Immunity
- (2018) Jorge Domínguez-Andrés et al. Cell Metabolism
- Macrophage activation by IFN-γ triggers restriction of phagosomal copper from intracellular pathogens
- (2018) Qian Shen et al. PLoS Pathogens
- Intensive care medicine research agenda on invasive fungal infection in critically ill patients
- (2017) Matteo Bassetti et al. INTENSIVE CARE MEDICINE
- Candida and invasive mould diseases in non-neutropenic critically ill patients and patients with haematological cancer
- (2017) A L Colombo et al. LANCET INFECTIOUS DISEASES
- Recognizing Sepsis as a Global Health Priority — A WHO Resolution
- (2017) Konrad Reinhart et al. NEW ENGLAND JOURNAL OF MEDICINE
- Patterns, Receptors, and Signals: Regulation of Phagosome Maturation
- (2017) Anne-Marie Pauwels et al. TRENDS IN IMMUNOLOGY
- Stat3 regulates centrosome clustering in cancer cells via Stathmin/PLK1
- (2017) Edward J. Morris et al. Nature Communications
- Infectious complications in patients on treatment with Ruxolitinib: case report and review of the literature
- (2017) Maria Veronica Dioverti et al. Infectious Diseases
- Dynein Clusters into Lipid Microdomains on Phagosomes to Drive Rapid Transport toward Lysosomes
- (2016) Ashim Rai et al. CELL
- Regulatory T Cell Specificity Directs Tolerance versus Allergy against Aeroantigens in Humans
- (2016) Petra Bacher et al. CELL
- Aspergillus Cell Wall Melanin Blocks LC3-Associated Phagocytosis to Promote Pathogenicity
- (2016) Tonia Akoumianaki et al. Cell Host & Microbe
- Noncanonical Fungal Autophagy Inhibits Inflammation in Response to IFN-γ via DAPK1
- (2016) Vasilis Oikonomou et al. Cell Host & Microbe
- The Third International Consensus Definitions for Sepsis and Septic Shock (Sepsis-3)
- (2016) Mervyn Singer et al. JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
- JAK/STAT regulation of Aspergillus fumigatus corneal infections and IL-6/23-stimulated neutrophil, IL-17, elastase, and MMP9 activity
- (2016) Patricia R. Taylor et al. JOURNAL OF LEUKOCYTE BIOLOGY
- Noncanonical autophagy inhibits the autoinflammatory, lupus-like response to dying cells
- (2016) Jennifer Martinez et al. NATURE
- Broad defects in the energy metabolism of leukocytes underlie immunoparalysis in sepsis
- (2016) Shih-Chin Cheng et al. NATURE IMMUNOLOGY
- Gene-microbiota interactions contribute to the pathogenesis of inflammatory bowel disease
- (2016) H. Chu et al. SCIENCE
- Sepsis Induces Hematopoietic Stem Cell Exhaustion and Myelosuppression through Distinct Contributions of TRIF and MYD88
- (2016) Huajia Zhang et al. Stem Cell Reports
- Acute-Phase Deaths from Murine Polymicrobial Sepsis Are Characterized by Innate Immune Suppression Rather Than Exhaustion
- (2015) Evan L. Chiswick et al. JOURNAL OF IMMUNOLOGY
- Molecular characterization of LC3-associated phagocytosis reveals distinct roles for Rubicon, NOX2 and autophagy proteins
- (2015) Jennifer Martinez et al. NATURE CELL BIOLOGY
- HTSeq--a Python framework to work with high-throughput sequencing data
- (2014) S. Anders et al. BIOINFORMATICS
- IL-12 and IL-27 regulate the phagolysosomal pathway in mycobacteria-infected human macrophages
- (2014) Joo-Yong Jung et al. Cell Communication and Signaling
- JAK2 Tyrosine Kinase Phosphorylates and Is Negatively Regulated by Centrosomal Protein Ninein
- (2014) Jennifer Jay et al. MOLECULAR AND CELLULAR BIOLOGY
- IL-1 receptor blockade restores autophagy and reduces inflammation in chronic granulomatous disease in mice and in humans
- (2014) Antonella de Luca et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Granulocyte Macrophage-Colony Stimulating Factor Induced Zn Sequestration Enhances Macrophage Superoxide and Limits Intracellular Pathogen Survival
- (2013) Kavitha Subramanian Vignesh et al. IMMUNITY
- Corticosteroids Block Autophagy Protein Recruitment in Aspergillus fumigatus Phagosomes via Targeting Dectin-1/Syk Kinase Signaling
- (2013) I. Kyrmizi et al. JOURNAL OF IMMUNOLOGY
- Activation of caspase-1 by the NLRP3 inflammasome regulates the NADPH oxidase NOX2 to control phagosome function
- (2013) Anna Sokolovska et al. NATURE IMMUNOLOGY
- Reversal of Immunoparalysis in HumansIn Vivo
- (2012) Jenneke Leentjens et al. AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
- Zymosan induces NADPH oxidase activation in human neutrophils by inducing the phosphorylation of p47phox and the activation of Rac2: Involvement of protein tyrosine kinases, PI3Kinase, PKC, ERK1/2 and p38MAPkinase
- (2012) Karama Makni-Maalej et al. BIOCHEMICAL PHARMACOLOGY
- STAR: ultrafast universal RNA-seq aligner
- (2012) Alexander Dobin et al. BIOINFORMATICS
- Immunosuppression in Patients Who Die of Sepsis and Multiple Organ Failure
- (2011) Jonathan S. Boomer et al. JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
- ROS-induced ATF3 causes susceptibility to secondary infections during sepsis-associated immunosuppression
- (2011) Wolfram Hoetzenecker et al. NATURE MEDICINE
- Microtubule-associated protein 1 light chain 3 alpha (LC3)-associated phagocytosis is required for the efficient clearance of dead cells
- (2011) J. Martinez et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- The prolyl isomerase Pin1 acts as a novel molecular switch for TNF- -induced priming of the NADPH oxidase in human neutrophils
- (2010) T. Boussetta et al. BLOOD
- Preclinical characterization of the selective JAK1/2 inhibitor INCB018424: therapeutic implications for the treatment of myeloproliferative neoplasms
- (2010) A. Quintas-Cardama et al. BLOOD
- p47phox, the phagocyte NADPH oxidase/NOX2 organizer: structure, phosphorylation and implication in diseases
- (2009) Jamel El-Benna et al. EXPERIMENTAL AND MOLECULAR MEDICINE
- CDC/NHSN surveillance definition of health care–associated infection and criteria for specific types of infections in the acute care setting
- (2008) Teresa C. Horan et al. AMERICAN JOURNAL OF INFECTION CONTROL
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