Calcium pectinate and hyaluronic acid modified lactoferrin nanoparticles loaded rhein with dual-targeting for ulcerative colitis treatment

Therapeutic Emergence of Rhein as a Potential Anticancer Drug: A Review of Its Molecular Targets and Anticancer Properties

(2020) Sahu Henamayee et al.   MOLECULES

Acute and subchronic toxicity studies of rhein in immature and d-galactose-induced aged mice and its potential hepatotoxicity mechanisms

(2020) Dong Yang et al.   DRUG AND CHEMICAL TOXICOLOGY

Formulated protein-polysaccharide-surfactant ternary complexes for co-encapsulation of curcumin and resveratrol: Characterization, stability and in vitro digestibility

(2020) Qing Guo et al.   FOOD HYDROCOLLOIDS

Rhein protects against barrier disruption and inhibits inflammation in intestinal epithelial cells

(2019) Shen Zhuang et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Enhancing the stability of oil-in-water emulsion using pectin-lactoferrin complexes

(2019) Oni Yuliarti et al.   INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

Multi-bioresponsive silk fibroin-based nanoparticles with on-demand cytoplasmic drug release capacity for CD44-targeted alleviation of ulcerative colitis

(2019) Shuangquan Gou et al.   BIOMATERIALS

Hyaluronic acid–bilirubin nanomedicine for targeted modulation of dysregulated intestinal barrier, microbiome and immune responses in colitis

(2019) Yonghyun Lee et al.   NATURE MATERIALS

Oral administration of chondroitin sulfate-functionalized nanoparticles for colonic macrophage-targeted drug delivery

(2019) Xueqing Zhang et al.   CARBOHYDRATE POLYMERS

Chitosan Ameliorates DSS-Induced Ulcerative Colitis Mice by Enhancing Intestinal Barrier Function and Improving Microflora

(2019) Jia Wang et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

A dual-action chitosan-based nanogel system of triclosan and flurbiprofen for localised treatment of periodontitis

(2019) Nafiu Aminu et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Critical role of toll-like receptor 4 (TLR4) in dextran sulfate sodium (DSS)-Induced intestinal injury and repair

(2019) Yun-Jie Shi et al.   TOXICOLOGY LETTERS

Hyaluronate/lactoferrin layer-by-layer-coated lipid nanocarriers for targeted co-delivery of rapamycin and berberine to lung carcinoma

(2018) Dalia M. Kabary et al.   COLLOIDS AND SURFACES B-BIOINTERFACES

Anti-influenza A virus activity of rhein through regulating oxidative stress, TLR4, Akt, MAPK, and NF-κB signal pathways

(2018) Qian-Wen Wang et al.   PLoS One

Low molecular weight chitosan-based conjugates for efficient Rhein oral delivery: synthesis, characterization, and pharmacokinetics

(2018) Jingwen Luo et al.   DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY

Dissolution kinetics of polyphenol bearing calcium pectate hydrogels in simulated gastric or intestinal media and their anti-carcinogenic capacities

(2017) Bilal Çakır et al.   FOOD HYDROCOLLOIDS

iRGD-modified lipid–polymer hybrid nanoparticles loaded with isoliquiritigenin to enhance anti-breast cancer effect and tumor-targeting ability

(2017) Fei Gao et al.   International Journal of Nanomedicine

Biocompatible Polyelectrolyte Complex Nanoparticles from Lactoferrin and Pectin as Potential Vehicles for Antioxidative Curcumin

(2017) Jing-Kun Yan et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Releasing characteristics of anthocyanins extract in pectin–whey protein complex microcapsules coated with zein

(2017) Arranee Chotiko et al.   JOURNAL OF FOOD SCIENCE AND TECHNOLOGY-MYSORE

Worldwide incidence and prevalence of inflammatory bowel disease in the 21st century: a systematic review of population-based studies

(2017) Siew C Ng et al.   LANCET

Ulcerative colitis

(2017) Ryan Ungaro et al.   LANCET

Orally Targeted Delivery of Tripeptide KPV via Hyaluronic Acid-Functionalized Nanoparticles Efficiently Alleviates Ulcerative Colitis

(2017) Bo Xiao et al.   MOLECULAR THERAPY

Patchouli alcohol ameliorates dextran sodium sulfate-induced experimental colitis and suppresses tryptophan catabolism

(2017) Chang Qu et al.   PHARMACOLOGICAL RESEARCH

Rhein attenuates inflammation through inhibition of NF-κB and NALP3 inflammasome in vivo and in vitro

(2017) Hui Ge et al.   Drug Design Development and Therapy

Self assembled hyaluronic acid nanoparticles as a potential carrier for targeting the inflamed intestinal mucosa

(2016) Seyed Yaser Vafaei et al.   CARBOHYDRATE POLYMERS

Calcium pectinate gel beads obtained from callus cultures pectins as promising systems for colon-targeted drug delivery

(2016) Elena A. Günter et al.   CARBOHYDRATE POLYMERS

Metabolic Activation of Rhein: Insights into the Potential Toxicity Induced by Rhein-Containing Herbs

(2016) Yuan Yuan et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

A Comprehensive and System Review for the Pharmacological Mechanism of Action of Rhein, an Active Anthraquinone Ingredient

(2016) Hao Sun et al.   Frontiers in Pharmacology

Cheese whey: A potential resource to transform into bioprotein, functional/nutritional proteins and bioactive peptides

(2015) Jay Shankar Singh Yadav et al.   BIOTECHNOLOGY ADVANCES

Self-assembled nanoparticles of acetylated cashew gum: Characterization and evaluation as potential drug carrier

(2015) Nadia A.O. Pitombeira et al.   CARBOHYDRATE POLYMERS

Rhein inhibits lipopolysaccharide-induced intestinal injury during sepsis by blocking the toll-like receptor 4 nuclear factor-κB pathway

(2015) KE ZHANG et al.   Molecular Medicine Reports

Enzyme/pH dual sensitive polymeric nanoparticles for targeted drug delivery to the inflamed colon

(2014) Muhammad Naeem et al.   COLLOIDS AND SURFACES B-BIOINTERFACES

Budesonide loaded nanoparticles with pH-sensitive coating for improved mucosal targeting in mouse models of inflammatory bowel diseases

(2014) H. Ali et al.   JOURNAL OF CONTROLLED RELEASE

Drug delivery strategies in the therapy of inflammatory bowel disease

(2013) Christian Lautenschläger et al.   ADVANCED DRUG DELIVERY REVIEWS

A lactoferrin-receptor, intelectin 1, affects uptake, sub-cellular localization and release of immunochemically detectable lactoferrin by intestinal epithelial Caco-2 cells

(2013) Y. Akiyama et al.   JOURNAL OF BIOCHEMISTRY

An Orally Administered Redox Nanoparticle That Accumulates in the Colonic Mucosa and Reduces Colitis in Mice

(2012) Long Binh Vong et al.   GASTROENTEROLOGY

Preparation of konjac glucomannan-based pulsatile capsule for colonic drug delivery system and its evaluation in vitro and in vivo

(2011) Jing Liu et al.   CARBOHYDRATE POLYMERS

Bovine Lactoferrin Can Be Taken Up By The Human Intestinal Lactoferrin Receptor And Exert Bioactivities

(2011) Bo Lönnerdal et al.   JOURNAL OF PEDIATRIC GASTROENTEROLOGY AND NUTRITION

Polymer nanoparticles: Preparation techniques and size-control parameters

(2011) J. Prasad Rao et al.   PROGRESS IN POLYMER SCIENCE

Methotrexate Bearing Calcium Pectinate Microspheres: A Platform to Achieve Colon-Specific Drug Release

(2008) M. Chaurasia et al.   Current Drug Delivery