Identification of potential therapeutic targets and mechanisms of COVID-19 through network analysis and screening of chemicals and herbal ingredients

Flow cytometry multiplexed method for the detection of neutralizing human antibodies to the native SARS‐CoV‐2 spike protein

(2021) Lydia Horndler et al.   EMBO Molecular Medicine

In silico and in vitro evaluation of kaempferol as a potential inhibitor of the SARS‐CoV ‐2 main protease ( 3CLpro )

(2021) Abbas Khan et al.   PHYTOTHERAPY RESEARCH

The miRNA: a small but powerful RNA for COVID-19

(2021) Song Zhang et al.   BRIEFINGS IN BIOINFORMATICS

The Main Receptors Involved with COVID-19: a Systematic Review and Meta-analysis

(2021) Alice Barros Câmara et al.   CURRENT MEDICINAL CHEMISTRY

Host PDZ‐containing proteins targeted by SARS‐CoV‐2

(2021) Célia Caillet‐Saguy et al.   FEBS Journal

Clinical features and prognostic factors in Covid-19: A prospective cohort study

(2021) Sanne de Bruin et al.   EBioMedicine

BioERP: biomedical heterogeneous network-based self-supervised representation learning approach for entity relationship predictions

(2021) Xiaoqi Wang et al.   BIOINFORMATICS

DeepR2cov: deep representation learning on heterogeneous drug networks to discover anti-inflammatory agents for COVID-19

(2021) Xiaoqi Wang et al.   BRIEFINGS IN BIOINFORMATICS

Comparative therapeutic efficacy of remdesivir and combination lopinavir, ritonavir, and interferon beta against MERS-CoV

(2020) Timothy P. Sheahan et al.   Nature Communications

Functional assessment of cell entry and receptor usage for SARS-CoV-2 and other lineage B betacoronaviruses

(2020) Michael Letko et al.   Nature Microbiology

Use of Hydroxychloroquine and Chloroquine During the COVID-19 Pandemic: What Every Clinician Should Know

(2020) Jinoos Yazdany et al.   ANNALS OF INTERNAL MEDICINE

A hypothesized role for dysregulated bradykinin signaling in COVID‐19 respiratory complications

(2020) Joseph A. Roche et al.   FASEB JOURNAL

Novel Coronavirus Polymerase and Nucleotidyl-Transferase Structures: Potential to Target New Outbreaks

(2020) Wen-Fa Zhang et al.   Journal of Physical Chemistry Letters

Triple combination of interferon beta-1b, lopinavir–ritonavir, and ribavirin in the treatment of patients admitted to hospital with COVID-19: an open-label, randomised, phase 2 trial

(2020) Ivan Fan-Ngai Hung et al.   LANCET

Remdesivir in adults with severe COVID-19: a randomised, double-blind, placebo-controlled, multicentre trial

(2020) Yeming Wang et al.   LANCET

Effective treatment of severe COVID-19 patients with tocilizumab

(2020) Xiaoling Xu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Treatment efficacy analysis of traditional Chinese medicine for novel coronavirus pneumonia (COVID-19): an empirical study from Wuhan, Hubei Province, China

(2020) Erdan Luo et al.   Chinese Medicine

Rosmarinic Acid Exhibits Broad Anti-Enterovirus A71 Activity by Inhibiting the Interaction between the Five-Fold Axis of Capsid VP1 and Cognate Sulfated Receptors

(2020) Chung-Fan Hsieh et al.   Emerging Microbes & Infections

Network-based drug repurposing for novel coronavirus 2019-nCoV/SARS-CoV-2

(2020) Yadi Zhou et al.   Cell Discovery

Atazanavir, alone or in combination with ritonavir, inhibits SARS-CoV-2 replication and pro-inflammatory cytokine production

(2020) Natalia Fintelman-Rodrigues et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

The important role of polysaccharides from a traditional Chinese medicine-Lung Cleansing and Detoxifying Decoction against the COVID-19 pandemic

(2020) Peng Cao et al.   CARBOHYDRATE POLYMERS

Identification of potential inhibitors of three key enzymes of SARS-CoV2 using computational approach

(2020) Hafsa Iftikhar et al.   COMPUTERS IN BIOLOGY AND MEDICINE

Network pharmacology and molecular docking analysis on molecular targets and mechanisms of Huashi Baidu formula in the treatment of COVID-19

(2020) Quyuan Tao et al.   DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY

Severe clinical outcomes of COVID-19 associated with proton pump inhibitors: a nationwide cohort study with propensity score matching

(2020) Seung Won Lee et al.   GUT

Chemical composition and pharmacological mechanism of Qingfei Paidu Decoction and Ma Xing Shi Gan Decoction against Coronavirus Disease 2019 (COVID-19): In silico and experimental study

(2020) Ruocong Yang et al.   PHARMACOLOGICAL RESEARCH

Impaired type I interferon activity and inflammatory responses in severe COVID-19 patients

(2020) Jérôme Hadjadj et al.   SCIENCE

Targeting JAK-STAT Signaling to Control Cytokine Release Syndrome in COVID-19

(2020) Wei Luo et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Exploring the SARS-CoV-2 virus-host-drug interactome for drug repurposing

(2020) Sepideh Sadegh et al.   Nature Communications

Fingolimod inhibits multiple stages of the HIV-1 life cycle

(2020) Rachel S. Resop et al.   PLoS Pathogens

Bioactive natural compounds against human coronaviruses: a review and perspective

(2020) Yanfang Xian et al.   Acta Pharmaceutica Sinica B

Repurposing existing drugs for the treatment of COVID-19/SARS-CoV-2 infection: A review describing drug mechanisms of action

(2020) Hassan Yousefi et al.   BIOCHEMICAL PHARMACOLOGY

Clinical retrospective study on the efficacy of Qingfei Paidu decoction combined with Western medicine for COVID-19 treatment

(2020) Siyi Xin et al.   BIOMEDICINE & PHARMACOTHERAPY

Databases for the targeted COVID‐19 therapeutics

(2020) Yunxia Wang et al.   BRITISH JOURNAL OF PHARMACOLOGY

An aberrant STAT pathway is central to COVID-19

(2020) Toshifumi Matsuyama et al.   CELL DEATH AND DIFFERENTIATION

Viroinformatics approach to explore the inhibitory mechanism of existing drugs repurposed to fight against COVID-19

(2020) Nousheen Bibi et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

TMPRSS2, a SARS-CoV-2 internalization protease is downregulated in head and neck cancer patients

(2020) Andrea Sacconi et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Drug Repurposing for Candidate SARS-CoV-2 Main Protease Inhibitors by a Novel In Silico Method

(2020) Milan Sencanski et al.   MOLECULES

An inflammatory cytokine signature predicts COVID-19 severity and survival

(2020) Diane Marie Del Valle et al.   NATURE MEDICINE

Drug repositioning and repurposing for Alzheimer disease

(2020) Clive Ballard et al.   Nature Reviews Neurology

Safety and Immunogenicity of Two RNA-Based Covid-19 Vaccine Candidates

(2020) Edward E. Walsh et al.   NEW ENGLAND JOURNAL OF MEDICINE

Chloroquine and hydroxychloroquine in the treatment of malaria and repurposing in treating COVID-19

(2020) Zi-Ning Lei et al.   PHARMACOLOGY & THERAPEUTICS

Systems pharmacological study illustrates the immune regulation, anti-infection, anti-inflammation, and multi-organ protection mechanism of Qing-Fei-Pai-Du decoction in the treatment of COVID-19

(2020) Jing Zhao et al.   PHYTOMEDICINE

Raltegravir, Indinavir, Tipranavir, Dolutegravir, and Etravirine against main protease and RNA-dependent RNA polymerase of SARS-CoV-2: A molecular docking and drug repurposing approach

(2020) Purushothaman Indu et al.   Journal of Infection and Public Health

Identifying potential anti-COVID-19 pharmacological components of traditional Chinese medicine Lianhuaqingwen capsule based on human exposure and ACE2 biochromatography screening

(2020) Xiaofei Chen et al.   Acta Pharmaceutica Sinica B

In Silico Structure-Based Repositioning of Approved Drugs for Spike Glycoprotein S2 Domain Fusion Peptide of SARS-CoV-2: Rationale from Molecular Dynamics and Binding Free Energy Calculations

(2020) Nishant Shekhar et al.   mSystems

Baricitinib treatment resolves lower-airway macrophage inflammation and neutrophil recruitment in SARS-CoV-2-infected rhesus macaques

(2020) Timothy N. Hoang et al.   CELL

Probing the Mechanism of Hepatotoxicity of Hexabromocyclododecanes through Toxicological Network Analysis

(2020) Weina Dai et al.   ENVIRONMENTAL SCIENCE & TECHNOLOGY

Repurposed drugs and nutraceuticals targeting envelope protein: A possible therapeutic strategy against COVID-19

(2020) Gourab Das et al.   GENOMICS

Screening and evaluation of approved drugs as inhibitors of main protease of SARS-CoV-2

(2020) Praveen Kumar Tripathi et al.   INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

Repurposed Antiviral Drugs for Covid-19 — Interim WHO Solidarity Trial Results

(2020)   NEW ENGLAND JOURNAL OF MEDICINE

STAT2 signaling restricts viral dissemination but drives severe pneumonia in SARS-CoV-2 infected hamsters

(2020) Robbert Boudewijns et al.   Nature Communications

Geranii Herba as a Potential Inhibitor of SARS-CoV-2 Main 3CLpro, Spike RBD, and Regulation of Unfolded Protein Response: An In Silico Approach

(2020) Selvaraj Arokiyaraj et al.   Antibiotics-Basel

Therapeutic strategies for hepatitis B virus infection: towards a cure

(2019) Gregory C. Fanning et al.   NATURE REVIEWS DRUG DISCOVERY

Phase Separation of Zonula Occludens Proteins Drives Formation of Tight Junctions

(2019) Oliver Beutel et al.   CELL

Drug repurposing to improve treatment of rheumatic autoimmune inflammatory diseases

(2019) Kathryn M. Kingsmore et al.   Nature Reviews Rheumatology

Revisiting Antipsychotic Drug Actions Through Gene Networks Associated With Schizophrenia

(2018) Karolina Kauppi et al.   AMERICAN JOURNAL OF PSYCHIATRY

Rosmarinic Acid Mitigates Lipopolysaccharide-Induced Neuroinflammatory Responses through the Inhibition of TLR4 and CD14 Expression and NF-κB and NLRP3 Inflammasome Activation

(2018) Yicong Wei et al.   INFLAMMATION

Hormesis as a mechanistic approach to understanding herbal treatments in traditional Chinese medicine

(2018) Dali Wang et al.   PHARMACOLOGY & THERAPEUTICS

Occam’s razor: from Ockham’s via moderna to modern data science

(2018)   SCIENCE PROGRESS

Drug repurposing: progress, challenges and recommendations

(2018) Sudeep Pushpakom et al.   NATURE REVIEWS DRUG DISCOVERY

Protein Data Bank: the single global archive for 3D macromolecular structure data

(2018) et al.   NUCLEIC ACIDS RESEARCH

Network-based in silico drug efficacy screening

(2016) Emre Guney et al.   Nature Communications

Magnesium lithospermate B and rosmarinic acid, two compounds present in Salvia miltiorrhiza, have potent antiviral activity against enterovirus 71 infections

(2015) Yi-Ching Chung et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Uncovering disease-disease relationships through the incomplete interactome

(2015) J. Menche et al.   SCIENCE

Effect of functional nuclear factor-kappaB genetic polymorphisms on hepatitis B virus persistence and their interactions with viral mutations on the risk of hepatocellular carcinoma

(2014) Q. Zhang et al.   ANNALS OF ONCOLOGY

FTY720 (fingolimod) modulates the severity of viral-induced encephalomyelitis and demyelination

(2014) Caroline A Blanc et al.   Journal of Neuroinflammation

How Thalidomide Works Against Cancer

(2014) A. K. Stewart   SCIENCE

Dipeptidyl peptidase 4 is a functional receptor for the emerging human coronavirus-EMC

(2013) V. Stalin Raj et al.   NATURE

Amantadine: The journey from fighting flu to treating Parkinson disease

(2012) G. Hubsher et al.   NEUROLOGY

Biflavonoids from Torreya nucifera displaying SARS-CoV 3CLpro inhibition

(2010) Young Bae Ryu et al.   BIOORGANIC & MEDICINAL CHEMISTRY

HIV-1 viral infectivity factor interacts with TP53 to induce G2 cell cycle arrest and positively regulate viral replication

(2010) T. Izumi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Reaction of Rosmarinic Acid with Nitrite Ions in Acidic Conditions: Discovery of Nitro- and Dinitrorosmarinic Acids as New Anti-HIV-1 Agents

(2008) Mélanie Dubois et al.   JOURNAL OF MEDICINAL CHEMISTRY

Rosmarinic acid as a downstream inhibitor of IKK-β in TNF-α-induced upregulation of CCL11 and CCR3

(2006) Jongsung Lee et al.   BRITISH JOURNAL OF PHARMACOLOGY