Host PDZ‐containing proteins targeted by SARS‐CoV‐2

Interactomic affinity profiling by holdup assay: Acetylation and distal residues impact the PDZome-binding specificity of PTEN phosphatase

(2021) Pau Jané et al.   PLoS One

Molecular basis of the interaction of the human tyrosine phosphatase PTPN3 with the hepatitis B virus core protein

(2021) Mariano Genera et al.   Scientific Reports

Role of PDZ-binding motif from West Nile virus NS5 protein on viral replication

(2021) Emilie Giraud et al.   Scientific Reports

Proteomics of SARS-CoV-2-infected host cells reveals therapy targets

(2020) Denisa Bojkova et al.   NATURE

A SARS-CoV-2 protein interaction map reveals targets for drug repurposing

(2020) David E. Gordon et al.   NATURE

Dual Specificity PDZ- and 14-3-3-Binding Motifs: A Structural and Interactomics Study

(2020) Gergo Gogl et al.   STRUCTURE

Comparing SARS-CoV-2 with SARS-CoV and influenza pandemics

(2020) Eskild Petersen et al.   LANCET INFECTIOUS DISEASES

Scaffolding proteins of vertebrate apical junctions: structure, functions and biophysics

(2020) Florian Rouaud et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Syncytia formation by SARS‐CoV‐2 infected cells

(2020) Julian Buchrieser et al.   EMBO JOURNAL

Comparing the binding properties of peptides mimicking the Envelope protein of SARS‐CoV and SARS‐CoV ‐2 to the PDZ domain of the tight junction‐associated PALS1 protein

(2020) Angelo Toto et al.   PROTEIN SCIENCE

Tight Junction Structure and Function Revisited

(2020) Tetsuhisa Otani et al.   TRENDS IN CELL BIOLOGY

Is There a Link Between the Pathogenic Human Coronavirus Envelope Protein and Immunopathology? A Review of the Literature

(2020) Dewald Schoeman et al.   Frontiers in Microbiology

Rewiring of RSK–PDZ Interactome by Linear Motif Phosphorylation

(2019) Gergő Gógl et al.   JOURNAL OF MOLECULAR BIOLOGY

Coronavirus envelope protein: current knowledge

(2019) Dewald Schoeman et al.   Virology Journal

E6 proteins from high-risk HPV, low-risk HPV, and animal papillomaviruses activate the Wnt/β-catenin pathway through E6AP-dependent degradation of NHERF1

(2019) Camille M. Drews et al.   PLoS Pathogens

Viral targeting of PDZ polarity proteins in the immune system as a potential evasion mechanism

(2019) Luis H. Gutiérrez-González et al.   FASEB JOURNAL

Molecular structure and the role of high‐temperature requirement protein 1 in skeletal disorders and cancers

(2019) Yihe Li et al.   CELL PROLIFERATION

High‐throughput competitive fluorescence polarization assay reveals functional redundancy in the S100 protein family

(2019) Márton A. Simon et al.   FEBS Journal

Role of Severe Acute Respiratory Syndrome Coronavirus Viroporins E, 3a, and 8a in Replication and Pathogenesis

(2018) Carlos Castaño-Rodriguez et al.   mBio

Sorting nexin 27 interactome in T-lymphocytes identifies zona occludens-2 dynamic redistribution at the immune synapse

(2017) María Tello-Lafoz et al.   TRAFFIC

The differential role of HTRA1 in HPV-positive and HPV-negative cervical cell line proliferation

(2016) Bruna Stuqui et al.   BMC CANCER

Molecular Basis of the Interaction of the Human Protein Tyrosine Phosphatase Non-receptor Type 4 (PTPN4) with the Mitogen-activated Protein Kinase p38γ

(2016) Pierre Maisonneuve et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Tight junctions: from simple barriers to multifunctional molecular gates

(2016) Ceniz Zihni et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Epidemiology, Genetic Recombination, and Pathogenesis of Coronaviruses

(2016) Shuo Su et al.   TRENDS IN MICROBIOLOGY

Interaction of the Human Papillomavirus E6 Oncoprotein with Sorting Nexin 27 Modulates Endocytic Cargo Transport Pathways

(2016) Ketaki Ganti et al.   PLoS Pathogens

Dual function of partitioning-defective 3 in the regulation of YAP phosphorylation and activation

(2016) Peng Zhang et al.   Cell Discovery

Deciphering the unconventional peptide binding to the PDZ domain of MAST2

(2015) Florent Delhommel et al.   BIOCHEMICAL JOURNAL

Quantifying domain-ligand affinities and specificities by high-throughput holdup assay

(2015) Renaud Vincentelli et al.   NATURE METHODS

Strategies to interfere with PDZ-mediated interactions in neurons: What we can learn from the rabies virus

(2015) Célia Caillet-Saguy et al.   PROGRESS IN BIOPHYSICS & MOLECULAR BIOLOGY

Tight Junctions Go Viral!

(2015) Jesús Torres-Flores et al.   Viruses-Basel

Structure of a Conserved Golgi Complex-targeting Signal in Coronavirus Envelope Proteins

(2014) Yan Li et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Human papillomavirus (HPV)-18 E6 oncoprotein interferes with the epithelial cell polarity Par3 protein

(2014) Florencia Facciuto et al.   Molecular Oncology

The PDZ-Binding Motif of Severe Acute Respiratory Syndrome Coronavirus Envelope Protein Is a Determinant of Viral Pathogenesis

(2014) Jose M. Jimenez-Guardeño et al.   PLoS Pathogens

Sorting nexin 27 (SNX27) associates with zonula occludens-2 (ZO-2) and modulates the epithelial tight junction

(2013) Seth P. Zimmerman et al.   BIOCHEMICAL JOURNAL

RHPN2 Drives Mesenchymal Transformation in Malignant Glioma by Triggering RhoA Activation

(2013) C. Danussi et al.   CANCER RESEARCH

The Hippo pathway: regulators and regulations

(2013) F.-X. Yu et al.   GENES & DEVELOPMENT

SHIP2 regulates epithelial cell polarity through its lipid product, which binds to Dlg1, a pathway subverted by hepatitis C virus core protein

(2013) Aline Awad et al.   MOLECULAR BIOLOGY OF THE CELL

The identification of short linear motif-mediated interfaces within the human interactome

(2012) R. J. Weatheritt et al.   BIOINFORMATICS

The emerging contribution of sequence context to the specificity of protein interactions mediated by PDZ domains

(2012) Katja Luck et al.   FEBS LETTERS

Interference with the PTEN-MAST2 Interaction by a Viral Protein Leads to Cellular Relocalization of PTEN

(2012) E. Terrien et al.   Science Signaling

Two PDZ binding motifs within NS5 have roles in Tick-borne encephalitis virus replication

(2012) Wessam Melik et al.   VIRUS RESEARCH

The Coronavirus E Protein: Assembly and Beyond

(2012) Travis R. Ruch et al.   Viruses-Basel

Emerging Theme: Cellular PDZ Proteins as Common Targets of Pathogenic Viruses

(2011) R. T. Javier et al.   JOURNAL OF VIROLOGY

The Avian Influenza Virus NS1 ESEV PDZ Binding Motif Associates with Dlg1 and Scribble To Disrupt Cellular Tight Junctions

(2011) L. Golebiewski et al.   JOURNAL OF VIROLOGY

Participation of the Cell Polarity Protein PALS1 to T-Cell Receptor-Mediated NF-κB Activation

(2011) Gabrielle Carvalho et al.   PLoS One

Mechanism underlying selective regulation of G protein-gated inwardly rectifying potassium channels by the psychostimulant-sensitive sorting nexin 27

(2011) B. Balana et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The SARS Coronavirus E Protein Interacts with PALS1 and Alters Tight Junction Formation and Epithelial Morphogenesis

(2010) Kim-Tat Teoh et al.   MOLECULAR BIOLOGY OF THE CELL

How viruses hijack cell regulation

(2010) Norman E. Davey et al.   TRENDS IN BIOCHEMICAL SCIENCES

Flavivirus NS5 associates with host-cell proteins zonula occludens-1 (ZO-1) and regulating synaptic membrane exocytosis-2 (RIMS2) via an internal PDZ binding mechanism

(2009) Karin Ellencrona et al.   BIOLOGICAL CHEMISTRY

Tick-borne encephalitis virus NS5 associates with membrane protein scribble and impairs interferon-stimulated JAK-STAT signalling

(2008) Karin Werme et al.   CELLULAR MICROBIOLOGY

Domain-swapped dimerization of ZO-1 PDZ2 generates specific and regulatory connexin43-binding sites

(2008) Jia Chen et al.   EMBO JOURNAL