DeepR2cov: deep representation learning on heterogeneous drug networks to discover anti-inflammatory agents for COVID-19

Network-based prediction of drug–target interactions using an arbitrary-order proximity embedded deep forest

(2020) Xiangxiang Zeng et al.   BIOINFORMATICS

Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China

(2020) Chaolin Huang et al.   LANCET

Systematic Comparison of Two Animal-to-Human Transmitted Human Coronaviruses: SARS-CoV-2 and SARS-CoV

(2020) Jiabao Xu et al.   Viruses-Basel

Detectable serum SARS-CoV-2 viral load (RNAaemia) is closely correlated with drastically elevated interleukin 6 (IL-6) level in critically ill COVID-19 patients

(2020) Xiaohua Chen et al.   CLINICAL INFECTIOUS DISEASES

Dysregulation of Immune Response in Patients With Coronavirus 2019 (COVID-19) in Wuhan, China

(2020) Chuan Qin et al.   CLINICAL INFECTIOUS DISEASES

Clinical and immunological features of severe and moderate coronavirus disease 2019

(2020) Guang Chen et al.   JOURNAL OF CLINICAL INVESTIGATION

Trials of anti-tumour necrosis factor therapy for COVID-19 are urgently needed

(2020) Marc Feldmann et al.   LANCET

COVID-19: consider cytokine storm syndromes and immunosuppression

(2020) Puja Mehta et al.   LANCET

Network-based drug repurposing for novel coronavirus 2019-nCoV/SARS-CoV-2

(2020) Yadi Zhou et al.   Cell Discovery

Minocycline attenuates testicular damages in a rat model of ischaemia/reperfusion (I/R) injury

(2020) Mahdi Azarabadi et al.   ANDROLOGIA

The pathogenesis and treatment of the `Cytokine Storm' in COVID-19

(2020) Qing Ye et al.   JOURNAL OF INFECTION

Repurpose Open Data to Discover Therapeutics for COVID-19 Using Deep Learning

(2020) Xiangxiang Zeng et al.   JOURNAL OF PROTEOME RESEARCH

Computer-aided prediction and design of IL-6 inducing peptides: IL-6 plays a crucial role in COVID-19

(2020) Anjali Dhall et al.   BRIEFINGS IN BIOINFORMATICS

Topological network measures for drug repositioning

(2020) Apurva Badkas et al.   BRIEFINGS IN BIOINFORMATICS

Sunitinib malate inhibits intestinal tumor development in male ApcMin/+ mice by down-regulating inflammation-related factors with suppressing β-cateinin/c-Myc pathway and re-balancing Bcl-6 and Caspase-3

(2020) Lai Chen et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

RHINE: Relation Structure-Aware Heterogeneous Information Network Embedding

(2020) Chuan Shi et al.   IEEE TRANSACTIONS ON KNOWLEDGE AND DATA ENGINEERING

deepDR: A network-based deep learning approach to in silico drug repositioning

(2019) Xiangxiang Zeng et al.   BIOINFORMATICS

Computational methods for identifying similar diseases

(2019) Liang Cheng et al.   Molecular Therapy-Nucleic Acids

NeoDTI: Neural integration of neighbor information from a heterogeneous network for discovering new drug-target interactions

(2018) Fangping Wan et al.   BIOINFORMATICS

MERS-CoV infection in humans is associated with a pro-inflammatory Th1 and Th17 cytokine profile

(2018) Waleed H. Mahallawi et al.   CYTOKINE

Heterogeneous Information Network Embedding for Recommendation

(2018) Chuan Shi et al.   IEEE TRANSACTIONS ON KNOWLEDGE AND DATA ENGINEERING

Network-based approach to prediction and population-based validation of in silico drug repurposing

(2018) Feixiong Cheng et al.   Nature Communications

Multilabel feature selection: A comprehensive review and guiding experiments

(2018) Shima Kashef et al.   Wiley Interdisciplinary Reviews-Data Mining and Knowledge Discovery

Deep reinforcement learning for de novo drug design

(2018) Mariya Popova et al.   Science Advances

Drug repurposing: progress, challenges and recommendations

(2018) Sudeep Pushpakom et al.   NATURE REVIEWS DRUG DISCOVERY

The BioGRID interaction database: 2019 update

(2018) Rose Oughtred et al.   NUCLEIC ACIDS RESEARCH

DrugBank 5.0: a major update to the DrugBank database for 2018

(2017) David S Wishart et al.   NUCLEIC ACIDS RESEARCH

A network integration approach for drug-target interaction prediction and computational drug repositioning from heterogeneous information

(2017) Yunan Luo et al.   Nature Communications

A standard database for drug repositioning

(2017) Adam S. Brown et al.   Scientific Data

Predicting drug target interactions using meta-path-based semantic network analysis

(2016) Gang Fu et al.   BMC BIOINFORMATICS

The Comparative Toxicogenomics Database: update 2017

(2016) Allan Peter Davis et al.   NUCLEIC ACIDS RESEARCH

Azithromycin inhibits IL-1 secretion and non-canonical inflammasome activation

(2015) Guido A. Gualdoni et al.   Scientific Reports

DOSE: an R/Bioconductor package for disease ontology semantic and enrichment analysis

(2014) Guangchuang Yu et al.   BIOINFORMATICS

Inductive matrix completion for predicting gene-disease associations

(2014) N. Natarajan et al.   BIOINFORMATICS

Cell Host Response to Infection with Novel Human Coronavirus EMC Predicts Potential Antivirals and Important Differences with SARS Coronavirus

(2013) L. Josset et al.   mBio

Proteasome Inhibitor Bortezomib Ameliorates Intestinal Injury in Mice

(2012) Koichi Yanaba et al.   PLoS One

ChEMBL: a large-scale bioactivity database for drug discovery

(2011) A. Gaulton et al.   NUCLEIC ACIDS RESEARCH

Extended-Connectivity Fingerprints

(2010) David Rogers et al.   Journal of Chemical Information and Modeling

The proteasome inhibitor bortezomib inhibits T cell-dependent inflammatory responses

(2010) Koichi Yanaba et al.   JOURNAL OF LEUKOCYTE BIOLOGY

A side effect resource to capture phenotypic effects of drugs

(2010) Michael Kuhn et al.   Molecular Systems Biology

DOCK 6: Combining techniques to model RNA-small molecule complexes

(2009) P. T. Lang et al.   RNA

Mapping the human protein interactome

(2008) Daniel Figeys   CELL RESEARCH

The antidepressant venlafaxine ameliorates murine experimental autoimmune encephalomyelitis by suppression of pro-inflammatory cytokines

(2008) Patrick Vollmar et al.   INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY

Human Protein Reference Database--2009 update

(2008) T. S. Keshava Prasad et al.   NUCLEIC ACIDS RESEARCH