Apolipoprotein E isoform-dependent effects on the processing of Alzheimer's amyloid-β

Therapeutic approaches targeting Apolipoprotein E function in Alzheimer’s disease

(2020) Tosha Williams et al.   Molecular Neurodegeneration

APOE4 leads to blood–brain barrier dysfunction predicting cognitive decline

(2020) Axel Montagne et al.   NATURE

Beyond the CNS: The many peripheral roles of APOE

(2020) Ana B. Martínez-Martínez et al.   NEUROBIOLOGY OF DISEASE

Dysfunction of ABC transporters at the blood-brain barrier: Role in neurological disorders

(2020) Eva Gil-Martins et al.   PHARMACOLOGY & THERAPEUTICS

Alzheimer’s disease: unraveling APOE4 binding to amyloid-beta peptide and lipids with molecular dynamics and quantum mechanics

(2020) Jean-Numa Gillet   JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS

ApoE Lipidation as a Therapeutic Target in Alzheimer’s Disease

(2020) Maria Fe Lanfranco et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Genome-wide meta-analysis identifies new loci and functional pathways influencing Alzheimer’s disease risk

(2019) Iris E. Jansen et al.   NATURE GENETICS

Genetic meta-analysis of diagnosed Alzheimer’s disease identifies new risk loci and implicates Aβ, tau, immunity and lipid processing

(2019) Brian W. Kunkle et al.   NATURE GENETICS

APOE4-mediated amyloid-β pathology depends on its neuronal receptor LRP1

(2019) Masaya Tachibana et al.   JOURNAL OF CLINICAL INVESTIGATION

ApoE4: an emerging therapeutic target for Alzheimer’s disease

(2019) Mirna Safieh et al.   BMC Medicine

Apolipoprotein E/Aβ Complex Accumulates in AD Cortical Synapses via apoE Receptors and Is Enhanced by APOE4

(2019) Tina Bilousova et al.   AMERICAN JOURNAL OF PATHOLOGY

A Novel Apolipoprotein E Antagonist Functionally Blocks Apolipoprotein E Interaction With N-terminal Amyloid Precursor Protein, Reduces β-Amyloid-Associated Pathology, and Improves Cognition

(2019) Darrell Sawmiller et al.   BIOLOGICAL PSYCHIATRY

High‐affinity multivalent interactions between apolipoprotein E and the oligomers of amyloid‐β

(2019) Shamasree Ghosh et al.   FEBS Journal

Differential Signaling Mediated by ApoE2, ApoE3, and ApoE4 in Human Neurons Parallels Alzheimer's Disease Risk

(2019) Yu-Wen Alvin Huang et al.   JOURNAL OF NEUROSCIENCE

Apolipoprotein E and Alzheimer disease: pathobiology and targeting strategies

(2019) Yu Yamazaki et al.   Nature Reviews Neurology

Peripheral versus central nervous system APOE in Alzheimer’s disease: Interplay across the blood-brain barrier

(2019) Dustin Chernick et al.   NEUROSCIENCE LETTERS

ApoE4 Alters ABCA1 Membrane Trafficking in Astrocytes

(2019) Varun Rawat et al.   JOURNAL OF NEUROSCIENCE

P‐glycoprotein: a role in the export of amyloid‐β in Alzheimer's disease?

(2019) Amanda B. Chai et al.   FEBS Journal

ApoE isoforms and carboxyl-terminal-truncated apoE4 forms affect neuronal BACE1 levels and Aβ production independently of their cholesterol efflux capacity

(2018) Ioannis Dafnis et al.   BIOCHEMICAL JOURNAL

The Interplay Between Apolipoprotein E4 and the Autophagic–Endocytic–Lysosomal Axis

(2018) E. Schmukler et al.   MOLECULAR NEUROBIOLOGY

Gain of toxic apolipoprotein E4 effects in human iPSC-derived neurons is ameliorated by a small-molecule structure corrector

(2018) Chengzhong Wang et al.   NATURE MEDICINE

The effect of amyloid-β peptide on synaptic plasticity and memory is influenced by different isoforms, concentrations and aggregation status

(2018) Walter Gulisano et al.   NEUROBIOLOGY OF AGING

APOE4 Causes Widespread Molecular and Cellular Alterations Associated with Alzheimer’s Disease Phenotypes in Human iPSC-Derived Brain Cell Types

(2018) Yuan-Ta Lin et al.   NEURON

Clearance of Amyloid Beta and Tau in Alzheimer’s Disease: from Mechanisms to Therapy

(2018) Shu-Hui Xin et al.   NEUROTOXICITY RESEARCH

Critical aggregation concentration for the formation of early Amyloid-β (1–42) oligomers

(2018) Mercedes Novo et al.   Scientific Reports

The Physiological Roles of Amyloid-β Peptide Hint at New Ways to Treat Alzheimer's Disease

(2018) Holly M. Brothers et al.   Frontiers in Aging Neuroscience

Blocking the Apolipoprotein E/Amyloid-β Interaction Reduces Fibrillar Vascular Amyloid Deposition and Cerebral Microhemorrhages in TgSwDI Mice

(2018) Jing Yang et al.   JOURNAL OF ALZHEIMERS DISEASE

Accelerated Progression from Mild Cognitive Impairment to Dementia Among APOE ε4ε4 Carriers

(2018) Wei-Li Xu et al.   JOURNAL OF ALZHEIMERS DISEASE

Apolipoprotein E and Alzheimer’s disease: the influence of apolipoprotein E on amyloid-β and other amyloidogenic proteins

(2017) Tien-Phat V. Huynh et al.   JOURNAL OF LIPID RESEARCH

ApoE4 Accelerates Early Seeding of Amyloid Pathology

(2017) Chia-Chen Liu et al.   NEURON

A mechanism for lipid binding to apoE and the role of intrinsically disordered regions coupled to domain–domain interactions

(2017) Carl Frieden et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Neuronal hyperactivity due to loss of inhibitory tone in APOE4 mice lacking Alzheimer’s disease-like pathology

(2017) Tal Nuriel et al.   Nature Communications

APP, PSEN1, and PSEN2 mutations in early-onset Alzheimer disease: A genetic screening study of familial and sporadic cases

(2017) Hélène-Marie Lanoiselée et al.   PLOS MEDICINE

Alzheimer's Disease and the Amyloid-β Peptide

(2017) M. Paul Murphy et al.   JOURNAL OF ALZHEIMERS DISEASE

Targeting Apolipoprotein E/Amyloid β Binding by Peptoid CPO_Aβ17-21 P Ameliorates Alzheimer’s Disease Related Pathology and Cognitive Decline

(2017) Shan Liu et al.   Scientific Reports

Central Nervous System LipoproteinsHighlights

(2016) Robert W. Mahley   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

The amyloid hypothesis of Alzheimer's disease at 25 years

(2016) Dennis J Selkoe et al.   EMBO Molecular Medicine

Ten Challenges of the Amyloid Hypothesis of Alzheimer’s Disease

(2016) Kasper Planeta Kepp   JOURNAL OF ALZHEIMERS DISEASE

Attenuation of  -Amyloid Deposition and Neurotoxicity by Chemogenetic Modulation of Neural Activity

(2016) P. Yuan et al.   JOURNAL OF NEUROSCIENCE

Alzheimer's disease

(2016) Philip Scheltens et al.   LANCET

The ability of apolipoprotein E fragments to promote intraneuronal accumulation of amyloid beta peptide 42 is both isoform and size-specific

(2016) Ioannis Dafnis et al.   Scientific Reports

The Role of Amyloid-β Oligomers in Toxicity, Propagation, and Immunotherapy

(2016) Urmi Sengupta et al.   EBioMedicine

Chemical Cross-Linking/Mass Spectrometry Maps the Amyloid β Peptide Binding Region on Both Apolipoprotein E Domains

(2015) Stéphanie Deroo et al.   ACS Chemical Biology

Amyloid β oligomers in Alzheimer’s disease pathogenesis, treatment, and diagnosis

(2015) Kirsten L. Viola et al.   ACTA NEUROPATHOLOGICA

APOEε2 is associated with milder clinical and pathological Alzheimer disease

(2015) Alberto Serrano-Pozo et al.   ANNALS OF NEUROLOGY

Prevalence of Cerebral Amyloid Pathology in Persons Without Dementia

(2015) Willemijn J. Jansen et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Opposing effects of viral mediated brain expression of apolipoprotein E2 (apoE2) and apoE4 on apoE lipidation and Aβ metabolism in apoE4-targeted replacement mice

(2015) Jin Hu et al.   Molecular Neurodegeneration

Clearance systems in the brain—implications for Alzheimer disease

(2015) Jenna M. Tarasoff-Conway et al.   Nature Reviews Neurology

On the lag phase in amyloid fibril formation

(2015) Paolo Arosio et al.   PHYSICAL CHEMISTRY CHEMICAL PHYSICS

Synaptic activity and Alzheimer's disease: a critical update

(2015) Davide Tampellini   Frontiers in Neuroscience

Lipoprotein-Based Nanoparticles Rescue the Memory Loss of Mice with Alzheimer’s Disease by Accelerating the Clearance of Amyloid-Beta

(2014) Qingxiang Song et al.   ACS Nano

Amyloid-β efflux from the central nervous system into the plasma

(2014) Kaleigh Filisa Roberts et al.   ANNALS OF NEUROLOGY

The role of amyloid-beta in the regulation of memory

(2014) John E. Morley et al.   BIOCHEMICAL PHARMACOLOGY

The Binding of Apolipoprotein E to Oligomers and Fibrils of Amyloid-β Alters the Kinetics of Amyloid Aggregation

(2014) Kanchan Garai et al.   BIOCHEMISTRY

HDL and cholesterol handling in the brain

(2014) C. Vitali et al.   CARDIOVASCULAR RESEARCH

Apolipoprotein E isoforms and lipoprotein metabolism

(2014) Michael C. Phillips   IUBMB LIFE

Soluble apoE/Aβ complex: mechanism and therapeutic target for APOE4-induced AD risk

(2014) Leon M Tai et al.   Molecular Neurodegeneration

Apolipoprotein E: Structure and function in lipid metabolism, neurobiology, and Alzheimer's diseases

(2014) Yadong Huang et al.   NEUROBIOLOGY OF DISEASE

ApoE and Aβ in Alzheimer’s Disease: Accidental Encounters or Partners?

(2014) Takahisa Kanekiyo et al.   NEURON

Effects of the Absence of Apolipoprotein E on Lipoproteins, Neurocognitive Function, and Retinal Function

(2014) Angel C. Y. Mak et al.   JAMA Neurology

The global prevalence of dementia: A systematic review and metaanalysis

(2013) Martin Prince et al.   Alzheimers & Dementia

The amyloid precursor protein: A biochemical enigma in brain development, function and disease

(2013) Natalia N. Nalivaeva et al.   FEBS LETTERS

Binding of Apolipoprotein E Inhibits the Oligomer Growth of Amyloid-β Peptide in Solution as Determined by Fluorescence Cross-correlation Spectroscopy

(2013) Sonny Ly et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Levels of Soluble Apolipoprotein E/Amyloid-β (Aβ) Complex Are Reduced and Oligomeric Aβ Increased withAPOE4and Alzheimer Disease in a Transgenic Mouse Model and Human Samples

(2013) Leon M. Tai et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Apolipoprotein E and Alzheimer disease: risk, mechanisms and therapy

(2013) Chia-Chen Liu et al.   Nature Reviews Neurology

ApoE influences amyloid-  (A ) clearance despite minimal apoE/A  association in physiological conditions

(2013) P. B. Verghese et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

What are lipoproteins doing in the brain?

(2013) Hong Wang et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Apolipoprotein E as a β-amyloid-independent factor in Alzheimer’s disease

(2013) Andrew B Wolf et al.   Alzheimers Research & Therapy

Apolipoprotein E4 effects in Alzheimer’s disease are mediated by synaptotoxic oligomeric amyloid-β

(2012) Robert M. Koffie et al.   BRAIN

Differential Regulation of Amyloid-β Endocytic Trafficking and Lysosomal Degradation by Apolipoprotein E Isoforms

(2012) Jie Li et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Low-density Lipoprotein Receptor Represents an Apolipoprotein E-independent Pathway of Aβ Uptake and Degradation by Astrocytes

(2012) Jacob M. Basak et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

APOE4-specific Changes in Aβ Accumulation in a New Transgenic Mouse Model of Alzheimer Disease

(2012) Katherine L. Youmans et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Anti-apoE immunotherapy inhibits amyloid accumulation in a transgenic mouse model of Aβ amyloidosis

(2012) Jungsu Kim et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Apolipoprotein E, Especially Apolipoprotein E4, Increases the Oligomerization of Amyloid   Peptide

(2012) T. Hashimoto et al.   JOURNAL OF NEUROSCIENCE

Apolipoprotein E controls cerebrovascular integrity via cyclophilin A

(2012) Robert D. Bell et al.   NATURE

Apolipoprotein E ε4 and age effects on florbetapir positron emission tomography in healthy aging and Alzheimer disease

(2012) Adam S. Fleisher et al.   NEUROBIOLOGY OF AGING

Structural differences between apoE3 and apoE4 may be useful in developing therapeutic agents for Alzheimer's disease

(2012) C. Frieden et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

ApoE-Directed Therapeutics Rapidly Clear  -Amyloid and Reverse Deficits in AD Mouse Models

(2012) P. E. Cramer et al.   SCIENCE

Apolipoprotein E level and cholesterol are associated with reduced synaptic amyloid beta in Alzheimer’s disease and apoE TR mouse cortex

(2011) Stephen Arold et al.   ACTA NEUROPATHOLOGICA

Roles of apolipoprotein E4 (ApoE4) in the pathogenesis of Alzheimer's disease: lessons from ApoE mouse models

(2011) Yadong Huang   BIOCHEMICAL SOCIETY TRANSACTIONS

Self-Association and Stability of the ApoE Isoforms at Low pH: Implications for ApoE–Lipid Interactions

(2011) Kanchan Garai et al.   BIOCHEMISTRY

High ability of apolipoprotein E4 to stabilize amyloid-β peptide oligomers, the pathological entities responsible for Alzheimer's disease

(2011) Emilie Cerf et al.   FASEB JOURNAL

Apolipoprotein E Promotes β-Amyloid Trafficking and Degradation by Modulating Microglial Cholesterol Levels

(2011) C. Y. Daniel Lee et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Apolipoprotein E Regulates the Integrity of Tight Junctions in an Isoform-dependent Manner in anin VitroBlood-Brain Barrier Model

(2011) Kazuchika Nishitsuji et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

APOE and Alzheimer disease: a major gene with semi-dominant inheritance

(2011) E Genin et al.   MOLECULAR PSYCHIATRY

Neuronal activity regulates the regional vulnerability to amyloid-β deposition

(2011) Adam W Bero et al.   NATURE NEUROSCIENCE

The effects of APOE on brain activity do not simply reflect the risk of Alzheimer's disease

(2011) Aaron J. Trachtenberg et al.   NEUROBIOLOGY OF AGING

Topology of human apolipoprotein E3 uniquely regulates its diverse biological functions

(2011) J. Chen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

C-terminal-truncated apolipoprotein (apo) E4 inefficiently clears amyloid-  (A ) and acts in concert with A  to elicit neuronal and behavioral deficits in mice

(2011) N. Bien-Ly et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Human apoE Isoforms Differentially Regulate Brain Amyloid-  Peptide Clearance

(2011) J. M. Castellano et al.   Science Translational Medicine

Accumulation of intraneuronal Aβ correlates with ApoE4 genotype

(2010) Ditte Z. Christensen et al.   ACTA NEUROPATHOLOGICA

Influence of apolipoprotein E ɛ4 on rates of cognitive and functional decline in mild cognitive impairment

(2010) Danielle C. Whitehair et al.   Alzheimers & Dementia

Astrocytic Aβ1-42 uptake is determined by Aβ-aggregation state and the presence of amyloid-associated proteins

(2010) Henrietta M. Nielsen et al.   GLIA

ATP-binding Cassette Transporter A1 Mediates the Beneficial Effects of the Liver X Receptor Agonist GW3965 on Object Recognition Memory and Amyloid Burden in Amyloid Precursor Protein/Presenilin 1 Mice

(2010) James J. Donkin et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Alzheimer's disease: clinical trials and drug development

(2010) Francesca Mangialasche et al.   LANCET NEUROLOGY

Decreased Clearance of CNS  -Amyloid in Alzheimer's Disease

(2010) K. G. Mawuenyega et al.   SCIENCE

Apolipoprotein E-dependent accumulation of Alzheimer disease-related lesions begins in middle age

(2009) Eloise Kok et al.   ANNALS OF NEUROLOGY

Macrophage-Mediated Degradation of  -Amyloid via an Apolipoprotein E Isoform-Dependent Mechanism

(2009) L. Zhao et al.   JOURNAL OF NEUROSCIENCE

Human APOE Isoform-Dependent Effects on Brain  -Amyloid Levels in PDAPP Transgenic Mice

(2009) K. R. Bales et al.   JOURNAL OF NEUROSCIENCE

The Role of Apolipoprotein E in Alzheimer's Disease

(2009) Jungsu Kim et al.   NEURON

APOE ε4 lowers age at onset and is a high risk factor for Alzheimer's disease; A case control study from central Norway

(2008) Sigrid B Sando et al.   BMC Neurology

apoE isoform–specific disruption of amyloid β peptide clearance from mouse brain

(2008) Rashid Deane et al.   JOURNAL OF CLINICAL INVESTIGATION

Clearance mechanisms of Alzheimer's amyloid-β peptide: implications for therapeutic design and diagnostic tests

(2008) K A Bates et al.   MOLECULAR PSYCHIATRY

APOE  4 allele predicts faster cognitive decline in mild Alzheimer disease

(2008) S. Cosentino et al.   NEUROLOGY

ApoE Promotes the Proteolytic Degradation of Aβ

(2008) Qingguang Jiang et al.   NEURON