Semi- and fully synthetic carbohydrate vaccines against pathogenic bacteria: recent developments

Discovery of Semi- and Fully-Synthetic Carbohydrate Vaccines Against Bacterial Infections Using a Medicinal Chemistry Approach

(2021) Peter H. Seeberger   CHEMICAL REVIEWS

Synthesis of the Oligosaccharides of Burkholderia pseudomallei and B. mallei Capsular Polysaccharide and Preliminary Immunological Studies of Their Protein Conjugates

(2020) Xueyun Geng et al.   JOURNAL OF ORGANIC CHEMISTRY

Structure‐Guided Design of a Group B Streptococcus Type III Synthetic Glycan–Conjugate Vaccine

(2020) Davide Oldrini et al.   CHEMISTRY-A EUROPEAN JOURNAL

Carbohydrate Conjugates in Vaccine Developments

(2020) Shuyao Lang et al.   Frontiers in Chemistry

Synthesis of Streptococcus pneumoniae serotype 9V oligosaccharide antigens

(2020) Sharavathi G Parameswarappa et al.   Beilstein Journal of Organic Chemistry

Gold nanoparticles morphology does not affect the multivalent presentation and antibody recognition of Group A Streptococcus synthetic oligorhamnans

(2020) Olimpia Pitirollo et al.   BIOORGANIC CHEMISTRY

Syntheses of Salmonella Paratyphi A associated oligosaccharide antigens and development towards anti‐paratyphoid fever vaccines

(2020) Debashis Dhara et al.   CHEMISTRY-A EUROPEAN JOURNAL

Sequential Linkage of Carbohydrate Antigens to Mimic Capsular Polysaccharides: Toward Semisynthetic Glycoconjugate Vaccine Candidates against Streptococcus pneumoniae Serotype 14

(2020) Bruna M. S. Seco et al.   ACS Chemical Biology

A stabilized glycomimetic conjugate vaccine inducing protective antibodies against Neisseria meningitidis serogroup A

(2020) Jacopo Enotarpi et al.   Nature Communications

Higher Cytokine and Opsonizing Antibody Production Induced by Bovine Serum Albumin (BSA)-Conjugated Tetrasaccharide Related to Streptococcus pneumoniae Type 3 Capsular Polysaccharide

(2020) Ekaterina A. Kurbatova et al.   Frontiers in Immunology

Safety and immunogenicity of a synthetic carbohydrate conjugate vaccine against Shigella flexneri 2a in healthy adult volunteers: a phase 1, dose-escalating, single-blind, randomised, placebo-controlled study

(2020) Dani Cohen et al.   LANCET INFECTIOUS DISEASES

One-Pot Synthesis of the Repeating Unit of Type VII Group B Streptococcus Polysaccharide and the Dimer

(2019) Han Zhang et al.   ORGANIC LETTERS

Carbohydrate Specificity and Isotypes of Monoclonal and Polyclonal Antibodies to Conjugated Tetrasaccharide, a Synthetic Analogue of Repeating Unit of Capsular Polysaccharide of Streptococcus Pneumoniae Serotype 14

(2019) Е. А. Kurbatova et al.   BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE

Semi-synthetic Glycoconjugate Vaccines to Elicit T Cell-Mediated Immune Responses and Protection against Streptococcus pneumoniae Serotype 3

(2019) Shaojie Feng et al.   ACS Infectious Diseases

Development and pre-clinical evaluation of a synthetic oligosaccharide-protein conjugate vaccine against Neisseria meningitidis serogroup C

(2019) Juned Dalal et al.   VACCINE

Regioselective strategies for the synthesis of Group Ia and Ib Streptococcus related glycans enable elucidating unique conformations of the capsular polysaccharides

(2019) Linda Del Bino et al.   CHEMISTRY-A EUROPEAN JOURNAL

Site-Specific Conjugation for Fully Controlled Glycoconjugate Vaccine Preparation

(2019) Aline Pillot et al.   Frontiers in Chemistry

Safety and immunogenicity of a novel 10-valent pneumococcal conjugate vaccine candidate in adults, toddlers, and infants in The Gambia—Results of a phase 1/2 randomized, double-blinded, controlled trial

(2019) Ed Clarke et al.   VACCINE

Group A Streptococcus Cell Wall Oligosaccharide-Streptococcal C5a Peptidase Conjugates as Effective Antibacterial Vaccines

(2019) Subo Wang et al.   ACS Infectious Diseases

Combined Chemical Synthesis and Tailored Enzymatic Elongation Provide Fully Synthetic and Conjugation-Ready Neisseria meningitidis Serogroup X Vaccine Antigens

(2018) Davide Oldrini et al.   ACS Chemical Biology

Identification of the Minimal Glycotope of Streptococcus pneumoniae 7F Capsular Polysaccharide using Synthetic Oligosaccharides

(2018) Petra Ménová et al.   CHEMISTRY-A EUROPEAN JOURNAL

Synthesis and Immunological Studies of Oligosaccharides that Consist of the Repeating Unit of Streptococcus pneumoniae Serotype 3 Capsular Polysaccharide

(2018) Chenghe Xiong et al.   CHEMISTRY-A EUROPEAN JOURNAL

O-Specific Polysaccharide of Vibrio cholerae O139: Improved Synthesis and Conjugation to BSA by Squaric Acid Chemistry

(2018) Xiaowei Lu et al.   EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

Chemical Synthesis of the Repeating Unit of Type II Group B Streptococcus Capsular Polysaccharide

(2018) Liming Shao et al.   JOURNAL OF ORGANIC CHEMISTRY

Protein Carriers for Glycoconjugate Vaccines: History, Selection Criteria, Characterization and New Trends

(2018) Francesca Micoli et al.   MOLECULES

Recent Advances in Toll Like Receptor-Targeting Glycoconjugate Vaccines

(2018) Qingjiang Li et al.   MOLECULES

Chemical synthesis and biological evaluation of penta- to octa- saccharide fragments of Vi polysaccharide from Salmonella typhi

(2018) Gao-Lan Zhang et al.   Organic Chemistry Frontiers

Development of an Efficacious, Semisynthetic Glycoconjugate Vaccine Candidate against Streptococcus pneumoniae Serotype 1

(2018) Benjamin Schumann et al.   ACS Central Science

Synthesis and biological evaluation of a trisaccharide repeating unit derivative of Streptococcus pneumoniae 19A capsular polysaccharide

(2018) Laura Morelli et al.   BIOORGANIC & MEDICINAL CHEMISTRY

On the mechanisms of conjugate vaccines

(2018) Rino Rappuoli et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Improving vaccines against Streptococcus pneumoniae using synthetic glycans

(2018) Paulina Kaplonek et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Semisynthetic glycoconjugate based on dual role protein/PsaA as a pneumococcal vaccine

(2018) Maruthi Prasanna et al.   EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES

T cells control the generation of nanomolar-affinity anti-glycan antibodies

(2017) Zinaida Polonskaya et al.   JOURNAL OF CLINICAL INVESTIGATION

Study of molecular interactions between Chitosan and Vi Antigen

(2017) Natália de Farias Silva et al.   JOURNAL OF MOLECULAR GRAPHICS & MODELLING

A Streptococcus pneumoniae Type 2 Oligosaccharide Glycoconjugate Elicits Opsonic Antibodies and Is Protective in an Animal Model of Invasive Pneumococcal Disease

(2017) Madhu Emmadi et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Structure of a protective epitope of group BStreptococcustype III capsular polysaccharide

(2017) Filippo Carboni et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Semisynthetic glycoconjugate vaccine candidate againstStreptococcus pneumoniaeserotype 5

(2017) Marilda P. Lisboa et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Synthesis of Group B Streptococcus type III polysaccharide fragments for evaluation of their interactions with monoclonal antibodies

(2017) Vittorio Cattaneo et al.   PURE AND APPLIED CHEMISTRY

A semisynthetic Streptococcus pneumoniae serotype 8 glycoconjugate vaccine

(2017) Benjamin Schumann et al.   Science Translational Medicine

Development of a synthetic Vi polysaccharide vaccine for typhoid fever

(2017) Yawei Ni et al.   VACCINE

Burkholderia pseudomallei and Burkholderia mallei vaccines: Are we close to clinical trials?

(2017) Richard W. Titball et al.   VACCINE

Deciphering minimal antigenic epitopes associated with Burkholderia pseudomallei and Burkholderia mallei lipopolysaccharide O-antigens

(2017) Marielle Tamigney Kenfack et al.   Nature Communications

Cyclopeptide scaffolds in carbohydrate-based synthetic vaccines

(2017) Carlo Pifferi et al.   Biomaterials Science

Neoglycoconjugate of Tetrasaccharide Representing One Repeating Unit of the Streptococcus pneumoniae Type 14 Capsular Polysaccharide Induces the Production of Opsonizing IgG1 Antibodies and Possesses the Highest Protective Activity As Compared to Hexa- and Octasaccharide Conjugates

(2017) Ekaterina A. Kurbatova et al.   Frontiers in Immunology

Synthesis and immunochemical evaluation of a novel Neisseria meningitidis serogroup A tetrasaccharide and its conjugate

(2017) Kishore R. Harale et al.   Organic Chemistry Frontiers

Deciphering Antigenic Determinants of Streptococcus pneumoniae Serotype 4 Capsular Polysaccharide using Synthetic Oligosaccharides

(2016) Andreas Geissner et al.   ACS Chemical Biology

Total Synthesis of the Complete Protective Antigen of Vibrio cholerae O139

(2016) Sameh E. Soliman et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Automated glycan assembly of aS. pneumoniaeserotype 3 CPS antigen

(2016) Markus W Weishaupt et al.   Beilstein Journal of Organic Chemistry

Protection against Experimental Melioidosis with a Synthetic manno-Heptopyranose Hexasaccharide Glycoconjugate

(2016) Andrew E. Scott et al.   BIOCONJUGATE CHEMISTRY

A Synthetic Carbohydrate Conjugate Vaccine Candidate against Shigellosis: Improved Bioconjugation and Impact of Alum on Immunogenicity

(2016) Robert M. F. van der Put et al.   BIOCONJUGATE CHEMISTRY

An antibacterial vaccination strategy based on a glycoconjugate containing the core lipopolysaccharide tetrasaccharide Hep2Kdo2

(2016) Lingbing Kong et al.   Nature Chemistry

Chemical Synthesis of the Repeating Unit of Type V Group B Streptococcus Capsular Polysaccharide

(2016) Jian Gao et al.   ORGANIC LETTERS

Status of vaccine research and development for Shigella

(2016) Sachin Mani et al.   VACCINE

The Effect of a BSA Conjugate of a Synthetic Hexasaccharide Related to the Fragment of Capsular Polysaccharide of Streptococcus pneumoniae Type 14 on the Activation of Innate and Adaptive Immune Responses

(2016) Nelli K. Akhmatova et al.   Frontiers in Immunology

Fully Synthetic Self-Adjuvanting α-2,9-Oligosialic Acid Based Conjugate Vaccines against Group C Meningitis

(2016) Guochao Liao et al.   ACS Central Science

Chemical Biology Approaches to Designing Defined Carbohydrate Vaccines

(2014) Chakkumkal Anish et al.   CHEMISTRY & BIOLOGY

Disease Manifestations and Pathogenic Mechanisms of Group A Streptococcus

(2014) M. J. Walker et al.   CLINICAL MICROBIOLOGY REVIEWS

Clustered carbohydrates in synthetic vaccines

(2012) Francesco Peri   CHEMICAL SOCIETY REVIEWS

The design of semi-synthetic and synthetic glycoconjugate vaccines

(2011) Paolo Costantino et al.   Expert Opinion on Drug Discovery

Vaccine discovery and translation of new vaccine technology

(2011) Rino Rappuoli et al.   LANCET

A mechanism for glycoconjugate vaccine activation of the adaptive immune system and its implications for vaccine design

(2011) Fikri Y Avci et al.   NATURE MEDICINE

Carbohydrate vaccines: developing sweet solutions to sticky situations?

(2010) Rena D. Astronomo et al.   NATURE REVIEWS DRUG DISCOVERY