Discovery of Semi- and Fully-Synthetic Carbohydrate Vaccines Against Bacterial Infections Using a Medicinal Chemistry Approach

Total Synthesis of Polysaccharides by Automated Glycan Assembly

(2020) A. Abragam Joseph et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Automated Glycan Assembly: A Perspective

(2019) Mónica Guberman et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Recent advances in the production of recombinant glycoconjugate vaccines

(2019) Emily Kay et al.   npj Vaccines

Synthetic Oligosaccharide-Based Vaccines Protect Mice from Clostridioides difficile Infections

(2019) Felix Broecker et al.   ACS Chemical Biology

A modular synthetic route to size-defined immunogenic Haemophilus influenzae b antigens is key to the identification of an octasaccharide lead vaccine candidate

(2018) J. Y. Baek et al.   Chemical Science

Development of an Efficacious, Semisynthetic Glycoconjugate Vaccine Candidate against Streptococcus pneumoniae Serotype 1

(2018) Benjamin Schumann et al.   ACS Central Science

Novel therapies and preventative strategies for primary and recurrent Clostridium difficile infections

(2018) Michael G. Dieterle et al.   Annals of the New York Academy of Sciences

Improving vaccines against Streptococcus pneumoniae using synthetic glycans

(2018) Paulina Kaplonek et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Emerging experience with meningococcal serogroup B protein vaccines

(2017) Daniela Toneatto et al.   Expert Review of Vaccines

A Streptococcus pneumoniae Type 2 Oligosaccharide Glycoconjugate Elicits Opsonic Antibodies and Is Protective in an Animal Model of Invasive Pneumococcal Disease

(2017) Madhu Emmadi et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Semisynthetic glycoconjugate vaccine candidate againstStreptococcus pneumoniaeserotype 5

(2017) Marilda P. Lisboa et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Automated glycan assembly using the Glyconeer 2.1 synthesizer

(2017) Heung Sik Hahm et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A semisynthetic Streptococcus pneumoniae serotype 8 glycoconjugate vaccine

(2017) Benjamin Schumann et al.   Science Translational Medicine

Deciphering Antigenic Determinants of Streptococcus pneumoniae Serotype 4 Capsular Polysaccharide using Synthetic Oligosaccharides

(2016) Andreas Geissner et al.   ACS Chemical Biology

Glycan Arrays: From Basic Biochemical Research to Bioanalytical and Biomedical Applications

(2016) Andreas Geissner et al.   Annual Review of Analytical Chemistry

Status of vaccine research and development for Shigella

(2016) Sachin Mani et al.   VACCINE

How Can Vaccines Contribute to Solving the Antimicrobial Resistance Problem?

(2016) Marc Lipsitch et al.   mBio

Multivalent display of minimal Clostridium difficile glycan epitopes mimics antigenic properties of larger glycans

(2016) Felix Broecker et al.   Nature Communications

Cross Reactive Material 197 glycoconjugate vaccines contain privileged conjugation sites

(2016) Uwe Möginger et al.   Scientific Reports

A Clostridium difficile Cell Wall Glycopolymer Locus Influences Bacterial Shape, Polysaccharide Production and Virulence

(2016) Michele Chu et al.   PLoS Pathogens

Chemical Synthesis Elucidates the Immunological Importance of a Pyruvate Modification in the Capsular Polysaccharide ofStreptococcus pneumoniaeSerotype 4

(2015) Claney L. Pereira et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Epidemiology, Clinical Presentation, Laboratory Diagnosis, Antimicrobial Resistance, and Antimicrobial Management of Invasive Salmonella Infections

(2015) John A. Crump et al.   CLINICAL MICROBIOLOGY REVIEWS

What the pediatrician should know about non-typeable Haemophilus influenzae

(2015) Janet R. Gilsdorf   JOURNAL OF INFECTION

An outbreak of carbapenem-resistant OXA-48 – producing Klebsiella pneumonia associated to duodenoscopy

(2015) Axel Kola et al.   Antimicrobial Resistance and Infection Control

Shigella Isolates From the Global Enteric Multicenter Study Inform Vaccine Development

(2014) S. Livio et al.   CLINICAL INFECTIOUS DISEASES

The Clostridium difficile PCR ribotype 027 lineage: a pathogen on the move

(2014) E. Valiente et al.   CLINICAL MICROBIOLOGY AND INFECTION

A semisynthetic carbohydrate-lipid vaccine that protects against S. pneumoniae in mice

(2014) Marco Cavallari et al.   Nature Chemical Biology

Outbreak of KPC-3 Producing Carbapenem-Resistant Klebsiella pneumoniae in a US Pediatric Hospital

(2014) Terri Stillwell et al.   Journal of the Pediatric Infectious Diseases Society

Recent Mechanistic Insights on Glycoconjugate Vaccines and Future Perspectives

(2013) Francesco Berti et al.   ACS Chemical Biology

Glycan arrays containing synthetic Clostridium difficile lipoteichoic acid oligomers as tools toward a carbohydrate vaccine

(2013) Christopher E. Martin et al.   CHEMICAL COMMUNICATIONS

Investigating the candidacy of a lipoteichoic acid-based glycoconjugate as a vaccine to combat Clostridium difficile infection

(2013) Andrew D. Cox et al.   GLYCOCONJUGATE JOURNAL

Immunological Evaluation of a Synthetic Clostridium difficile Oligosaccharide Conjugate Vaccine Candidate and Identification of a Minimal Epitope

(2013) Christopher E. Martin et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Global burden of childhood pneumonia and diarrhoea

(2013) Christa L Fischer Walker et al.   LANCET

Phosphorylation of the Synthetic Hexasaccharide Repeating Unit Is Essential for the Induction of Antibodies to Clostridium difficile PSII Cell Wall Polysaccharide

(2012) Roberto Adamo et al.   ACS Chemical Biology

Chemical Biology of Glycosylphosphatidylinositol Anchors

(2012) Yu-Hsuan Tsai et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Sequence-Defined Glycopolymer Segments Presenting Mannose: Synthesis and Lectin Binding Affinity

(2012) Daniela Ponader et al.   BIOMACROMOLECULES

The entirely carbohydrate immunogen Tn-PS A1 induces a cancer cell selective immune response and cytokine IL-17

(2012) Ravindra A. De Silva et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

Clostridium difficile carbohydrates: glucan in spores, PSII common antigen in cells, immunogenicity of PSII in swine and synthesis of a dual C. difficile–ETEC conjugate vaccine

(2012) Lisa Bertolo et al.   CARBOHYDRATE RESEARCH

Structural characterization of surface glycans from Clostridium difficile

(2012) Christopher W. Reid et al.   CARBOHYDRATE RESEARCH

Vaccination with Irradiated Tumor Cells Pulsed with an Adjuvant That Stimulates NKT Cells Is an Effective Treatment for Glioma

(2012) M. K. Hunn et al.   CLINICAL CANCER RESEARCH

Immunization strategies forClostridium difficileinfections

(2012) Fabien Rebeaud et al.   Expert Review of Vaccines

Accumulation of Activated Invariant Natural Killer T Cells in the Tumor Microenvironment after α-Galactosylceramide-Pulsed Antigen Presenting Cells

(2012) Kaoru Nagato et al.   JOURNAL OF CLINICAL IMMUNOLOGY

a Totally Synthetic, Self-Assembling, Adjuvant-Free MUC1 Glycopeptide Vaccine for Cancer Therapy

(2012) Zhi-Hua Huang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Disability-adjusted life years (DALYs) for 291 diseases and injuries in 21 regions, 1990–2010: a systematic analysis for the Global Burden of Disease Study 2010

(2012) Christopher J L Murray et al.   LANCET

Erratum

(2012)   Nanomedicine

Emergence and global spread of epidemic healthcare-associated Clostridium difficile

(2012) Miao He et al.   NATURE GENETICS

Activated iNKT Cells Promote Memory CD8+ T Cell Differentiation during Viral Infection

(2012) Emma C. Reilly et al.   PLoS One

Structural basis for lack of toxicity of the diphtheria toxin mutant CRM197

(2012) E. Malito et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A General Method for Synthesis of GPI Anchors Illustrated by the Total Synthesis of the Low-Molecular-Weight Antigen from Toxoplasma gondii

(2011) Yu-Hsuan Tsai et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Prevnar 13, the New 13-Valent Pneumococcal Conjugate Vaccine

(2011) Allana J Sucher et al.   ANNALS OF PHARMACOTHERAPY

Progress toward developing a carbohydrate-conjugate vaccine against Clostridium difficile ribotype 027: synthesis of the cell-surface polysaccharide PS-I repeating unit

(2011) Christopher E. Martin et al.   CHEMICAL COMMUNICATIONS

Recent applications of thiol–ene coupling as a click process for glycoconjugation

(2011) Alessandro Dondoni et al.   CHEMICAL SOCIETY REVIEWS

A Possible Oligosaccharide-Conjugate Vaccine Candidate for Clostridium difficile Is Antigenic and Immunogenic

(2011) Matthias A. Oberli et al.   CHEMISTRY & BIOLOGY

The economic burden of Clostridium difficile

(2011) S.M. McGlone et al.   CLINICAL MICROBIOLOGY AND INFECTION

Carbohydrates and Immunology: Synthetic Oligosaccharide Antigens for Vaccine Formulation

(2011) Laura Morelli et al.   EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

The design of semi-synthetic and synthetic glycoconjugate vaccines

(2011) Paolo Costantino et al.   Expert Opinion on Drug Discovery

A structurally diversified linker enhances the immune response to a small carbohydrate hapten

(2011) Tomasz Lipinski et al.   GLYCOCONJUGATE JOURNAL

The yin yang of bacterial polysaccharides: lessons learned from B. fragilis PSA

(2011) Neeraj K. Surana et al.   IMMUNOLOGICAL REVIEWS

Haemophilus influenzae Infections in the H. influenzae Type b Conjugate Vaccine Era

(2011) Aarti Agrawal et al.   JOURNAL OF CLINICAL MICROBIOLOGY

Vaccine discovery and translation of new vaccine technology

(2011) Rino Rappuoli et al.   LANCET

Immunological mechanisms of vaccination

(2011) Bali Pulendran et al.   NATURE IMMUNOLOGY

Pathogen-associated molecular patterns on biomaterials: a paradigm for engineering new vaccines

(2011) Stacey L. Demento et al.   TRENDS IN BIOTECHNOLOGY

Capsules ofStreptococcus pneumoniaeand Other Bacteria: Paradigms for Polysaccharide Biosynthesis and Regulation

(2010) Janet Yother   Annual Review of Microbiology

Impact of the Conjugation Method on the Immunogenicity ofStreptococcus pneumoniaeSerotype 19F Polysaccharide in Conjugate Vaccines

(2010) Jan Poolman et al.   Clinical and Vaccine Immunology

Carbohydrate-based vaccines: challenges and opportunities

(2010) Yen-Lin Huang et al.   Expert Review of Vaccines

Immunological reactions in response to apicomplexan glycosylphosphatidylinositols

(2010) F. Debierre-Grockiego et al.   GLYCOBIOLOGY

A New Pneumococcal Serotype, 11E, Has a Variably InactivatedwcjEGene

(2010) Juan J. Calix et al.   JOURNAL OF INFECTIOUS DISEASES

Toxicity and cellular uptake of gold nanoparticles: what we have learned so far?

(2010) Alaaldin M. Alkilany et al.   JOURNAL OF NANOPARTICLE RESEARCH

Molecular Analysis of Carbohydrate−Antibody Interactions: Case Study Using aBacillus anthracisTetrasaccharide

(2010) Matthias A. Oberli et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

To be or not to be a pathogen: that is the mucosally relevant question

(2010) P J Sansonetti   Mucosal Immunology

Carbohydrate vaccines: developing sweet solutions to sticky situations?

(2010) Rena D. Astronomo et al.   NATURE REVIEWS DRUG DISCOVERY

Haemophilus influenzae and the complement system

(2010) Teresia Hallström et al.   TRENDS IN MICROBIOLOGY

Evaluation of a Group A Streptococcus synthetic oligosaccharide as vaccine candidate

(2010) Anna Kabanova et al.   VACCINE

Comparative bioinformatics analysis of the mammalian and bacterial glycomes

(2010) Alexander Adibekian et al.   Chemical Science

Systematic Evaluation of Serotypes Causing Invasive Pneumococcal Disease among Children Under Five: The Pneumococcal Global Serotype Project

(2010) Hope L. Johnson et al.   PLOS MEDICINE

Production of capsular polysaccharide from Escherichia coli K4 for biotechnological applications

(2009) Donatella Cimini et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

Recent development in carbohydrate-based cancer vaccines

(2009) Zhongwu Guo et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

Beneficial effects of Bacteroides fragilis polysaccharides on the immune system

(2009) Erin et al.   Frontiers in Bioscience-Landmark

Synthetic  -(1->6)-Linked N-Acetylated and Nonacetylated Oligoglucosamines Used To Produce Conjugate Vaccines for Bacterial Pathogens

(2009) M. L. Gening et al.   INFECTION AND IMMUNITY

A Synthetic Carbohydrate-Protein Conjugate Vaccine Candidate against Shigella flexneri 2a Infection

(2009) A. Phalipon et al.   JOURNAL OF IMMUNOLOGY

Immunological Response from an Entirely Carbohydrate Antigen: Design of Synthetic Vaccines Based on Tn−PS A1 Conjugates

(2009) Ravindra A. De Silva et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

The real threat of Klebsiella pneumoniae carbapenemase-producing bacteria

(2009) Patrice Nordmann et al.   LANCET INFECTIOUS DISEASES

A self-assembling peptide acting as an immune adjuvant

(2009) J. S. Rudra et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Rational design and immunogenicity of liposome-based diepitope constructs: Application to synthetic oligosaccharides mimicking the Shigella flexneri 2a O-antigen

(2009) Fatouma Said Hassane et al.   VACCINE

Pneumococcal serotype 3 otitis media, limited effect of polysaccharide conjugate immunisation and strain characteristics

(2009) Jan Poolman et al.   VACCINE

Preparation of bacterial polysaccharide–protein conjugates: Analytical and manufacturing challenges

(2009) Carl E. Frasch   VACCINE

Pneumococcal Polysaccharide Protein D-Conjugate Vaccine (Synflorix™; PHiD-CV)

(2009) Jamie D. Croxtall et al.   PEDIATRIC DRUGS

Clostridium difficile cell-surface polysaccharides composed of pentaglycosyl and hexaglycosyl phosphate repeating units

(2008) Jeyabarathy Ganeshapillai et al.   CARBOHYDRATE RESEARCH

A Novel Linker Methodology for the Synthesis of Tailored Conjugate Vaccines Composed of Complex Carbohydrate Antigens and Specific TH‐Cell Peptide Epitopes

(2008) Sebastian Dziadek et al.   CHEMISTRY-A EUROPEAN JOURNAL

Recent Developments in Synthetic Oligosaccharide-Based Bacterial Vaccines

(2008) Vince Pozsgay   CURRENT TOPICS IN MEDICINAL CHEMISTRY

Type I Streptococcus pneumoniae carbohydrate utilizes a nitric oxide and MHC II-dependent pathway for antigen presentation

(2008) Christopher D. Velez et al.   IMMUNOLOGY

Identification of the Smallest Structure Capable of Evoking Opsonophagocytic Antibodies against Streptococcus pneumoniae Type 14

(2008) D. Safari et al.   INFECTION AND IMMUNITY

Optimization of Vi capsular polysaccharide production during growth of Salmonella enterica serotype Typhi Ty2 in a bioreactor

(2008) Hyun Jang et al.   JOURNAL OF BIOTECHNOLOGY

A microbial symbiosis factor prevents intestinal inflammatory disease

(2008) Sarkis K. Mazmanian et al.   NATURE

Synthetic GPI array to study antitoxic malaria response

(2008) Faustin Kamena et al.   Nature Chemical Biology

Qinghaosu (Artemisinin): The Price of Success

(2008) N. J. White   SCIENCE