Site-Specific Conjugation for Fully Controlled Glycoconjugate Vaccine Preparation

Site-Selective Functionalization of Flagellin by Steric Self-Protection: A Strategy To Facilitate Flagellin as a Self-Adjuvanting Carrier in Conjugate Vaccine

(2018) Chi-Jiun Peng et al.   CHEMBIOCHEM

Chemo- and Regioselective Lysine Modification on Native Proteins

(2018) Maria J. Matos et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Distribution of serotypes and patterns of antimicrobial resistance among commensal Streptococcus pneumoniae in nine European countries

(2018) Rachid Y. Yahiaoui et al.   BMC INFECTIOUS DISEASES

Glycoconjugate vaccines: Principles and mechanisms

(2018) Rino Rappuoli   Science Translational Medicine

Semisynthetic glycoconjugate based on dual role protein/PsaA as a pneumococcal vaccine

(2018) Maruthi Prasanna et al.   EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES

Safety and immunogenicity of a novel multiple antigen pneumococcal vaccine in adults: A Phase 1 randomised clinical trial

(2017) Claire Entwisle et al.   VACCINE

Peptide adjacent to glycosylation sites impacts immunogenicity of glycoconjugate vaccine

(2017) Zhongrui Ma et al.   Oncotarget

The immunological mechanisms that control pneumococcal carriage

(2017) Simon P. Jochems et al.   PLoS Pathogens

Neoglycoconjugate of Tetrasaccharide Representing One Repeating Unit of the Streptococcus pneumoniae Type 14 Capsular Polysaccharide Induces the Production of Opsonizing IgG1 Antibodies and Possesses the Highest Protective Activity As Compared to Hexa- and Octasaccharide Conjugates

(2017) Ekaterina A. Kurbatova et al.   Frontiers in Immunology

Immunogenicity and protective immunity against otitis media caused by pneumococcus in mice of Hib conjugate vaccine with PsaA protein carrier

(2016) Zeyu Chen et al.   Frontiers of Medicine

Effectiveness of Pneumococcal Conjugate Vaccines (PCV7 and PCV13) against Invasive Pneumococcal Disease among Children under Two Years of Age in Germany

(2016) Mark van der Linden et al.   PLoS One

Anti-Group B Streptococcus Glycan-Conjugate Vaccines Using Pilus Protein GBS80 As Carrier and Antigen: Comparing Lysine and Tyrosine-directed Conjugation

(2015) Alberto Nilo et al.   ACS Chemical Biology

Sugar-Protein Connectivity Impacts on the Immunogenicity of Site-SelectiveSalmonellaO-Antigen Glycoconjugate Vaccines

(2015) Giuseppe Stefanetti et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Correction to Exploring the Effect of Conjugation Site and Chemistry on the Immunogenicity of an anti-Group B Streptococcus Glycoconjugate Vaccine Based on GBS67 Pilus Protein and Type V Polysaccharide

(2015) Alberto Nilo et al.   BIOCONJUGATE CHEMISTRY

Cotranslational incorporation of non-standard amino acids using cell-free protein synthesis

(2015) Robert B. Quast et al.   FEBS LETTERS

Protective Immune Responses Elicited by Fusion Protein Containing PsaA and PspA Fragments

(2015) Jingcai Lu et al.   IMMUNOLOGICAL INVESTIGATIONS

Carrier priming with CRM197 or diphtheria toxoid has a different impact on the immunogenicity of the respective glycoconjugates: Biophysical and immunochemical interpretation

(2015) S. Pecetta et al.   VACCINE

Tyrosine-Directed Conjugation of Large Glycans to Proteins via Copper-Free Click Chemistry

(2014) Alberto Nilo et al.   BIOCONJUGATE CHEMISTRY

Defined Conjugation of Glycans to the Lysines of CRM197Guided by their Reactivity Mapping

(2014) Stefano Crotti et al.   CHEMBIOCHEM

Recent Mechanistic Insights on Glycoconjugate Vaccines and Future Perspectives

(2013) Francesco Berti et al.   ACS Chemical Biology

Prediction and characterization of helper T-cell epitopes from pneumococcal surface adhesin A

(2013) Rajesh Singh et al.   IMMUNOLOGY

Imperfect coordination chemistry facilitates metal ion release in the Psa permease

(2013) Rafael M Couñago et al.   Nature Chemical Biology

Synthesis of a well-defined glycoconjugate vaccine by a tyrosine-selective conjugation strategy

(2013) Qi-Ying Hu et al.   Chemical Science

A Coordinated Synthesis and Conjugation Strategy for the Preparation of Homogeneous Glycoconjugate Vaccine Candidates

(2011) Elizabeth J. Grayson et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Enhanced immunogenicity of pneumococcal surface adhesin A (PsaA) in mice via fusion to recombinant human B lymphocyte stimulator (BLyS)

(2011) Dennis O Gor et al.   Biology Direct

Novel Protein-Based Pneumococcal Vaccines Administered with the Th1-Promoting Adjuvant IC31 Induce Protective Immunity against Pneumococcal Disease in Neonatal Mice

(2011) Thorunn Asta Olafsdottir et al.   INFECTION AND IMMUNITY

A mechanism for glycoconjugate vaccine activation of the adaptive immune system and its implications for vaccine design

(2011) Fikri Y Avci et al.   NATURE MEDICINE

Cloning and optimization of induction conditions for mature PsaA (pneumococcal surface adhesin A) expression in Escherichia coli and recombinant protein stability during long-term storage

(2011) Ariane Leites Larentis et al.   PROTEIN EXPRESSION AND PURIFICATION

Th17/Th1 biased immunity to the pneumococcal proteins PcsB, StkP and PsaA in adults of different age

(2011) Petra Schmid et al.   VACCINE

Immune Responses to Recombinant Pneumococcal PsaA Antigen Delivered by a Live Attenuated Salmonella Vaccine

(2010) S. Wang et al.   INFECTION AND IMMUNITY

Concomitant administration of recombinant PsaA and PCV7 reduces Streptococcus pneumoniae serotype 19A colonization in a murine model

(2010) Melissa J. Whaley et al.   VACCINE

Preparation and immunogenicity of capsular polysaccharide–surface adhesin A (PsaA) conjugate of Streptococcus pneumoniae

(2009) Haiying Lin et al.   IMMUNOBIOLOGY

Pneumococcal Surface Adhesin A (PsaA): A Review

(2008) Gowrisankar Rajam et al.   CRITICAL REVIEWS IN MICROBIOLOGY

Identification of the Smallest Structure Capable of Evoking Opsonophagocytic Antibodies against Streptococcus pneumoniae Type 14

(2008) D. Safari et al.   INFECTION AND IMMUNITY

A functional epitope of the pneumococcal surface adhesin A activates nasopharyngeal cells and increases bacterial internalization

(2007) Gowrisankar Rajam et al.   MICROBIAL PATHOGENESIS