The emerging role of peptidyl-prolyl isomerase chaperones in tau oligomerization, amyloid processing, and Alzheimer's disease

Rapamycin-binding FKBP25 associates with diverse proteins that form large intracellular entities

(2014) Andrzej Galat et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

In vitro screen of prion disease susceptibility genes using the scrapie cell assay

(2014) Craig A. Brown et al.   HUMAN MOLECULAR GENETICS

A Substrate Preference for the Rough Endoplasmic Reticulum Resident Protein FKBP22 during Collagen Biosynthesis

(2014) Yoshihiro Ishikawa et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Differential Loss of Prolyl Isomerase or Chaperone Activity of Ran-binding Protein 2 (Ranbp2) Unveils Distinct Physiological Roles of Its Cyclophilin Domain in Proteostasis

(2014) Kyoung-in Cho et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

FKBP12 regulates the localization and processing of amyloid precursor protein in human cell lines

(2014) Fan-Lun Liu et al.   JOURNAL OF BIOSCIENCES

Coupled Folding and Binding of the Disordered Protein PUMA Does Not Require Particular Residual Structure

(2014) Joseph M. Rogers et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Distinct Tau Prion Strains Propagate in Cells and Mice and Define Different Tauopathies

(2014) David W. Sanders et al.   NEURON

Immunophilin FKBP52 induces Tau-P301L filamentous assembly in vitro and modulates its activity in a model of tauopathy

(2014) J. Giustiniani et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Death-associated protein kinase 1 has a critical role in aberrant tau protein regulation and function

(2014) B M Kim et al.   Cell Death & Disease

Histone deacetylase 6 inhibition improves memory and reduces total tau levels in a mouse model of tau deposition

(2014) Maj-Linda Selenica et al.   Alzheimers Research & Therapy

Amyloid-β and Tau

(2014) George S. Bloom   JAMA Neurology

Resolving the functions of peptidylprolyl isomerases: insights from the mutagenesis of the nuclear FKBP25 enzyme

(2013) Geoff Gudavicius et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

The FKBP-Type Domain of the Human Aryl Hydrocarbon Receptor-Interacting Protein Reveals an Unusual Hsp90 Interaction

(2013) Miriam Linnert et al.   BIOCHEMISTRY

Cyclophilin D deficiency rescues Aβ-impaired PKA/CREB signaling and alleviates synaptic degeneration

(2013) Heng Du et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

FKBP14 is an essential gene that regulates Presenilin protein levels and Notch signaling in Drosophila

(2013) D. L. van de Hoef et al.   DEVELOPMENT

PP2A regulatory subunit Bα controls endothelial contractility and vessel lumen integrity via regulation of HDAC7

(2013) Maud Martin et al.   EMBO JOURNAL

Quantification of Interaction Strengths between Chaperones and Tetratricopeptide Repeat Domain-containing Membrane Proteins

(2013) Regina Schweiger et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Par14 Protein Associates with Insulin Receptor Substrate 1 (IRS-1), Thereby Enhancing Insulin-induced IRS-1 Phosphorylation and Metabolic Actions

(2013) Jun Zhang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Accelerated neurodegeneration through chaperone-mediated oligomerization of tau

(2013) Laura J. Blair et al.   JOURNAL OF CLINICAL INVESTIGATION

Targeting the mTOR Signaling Network for Alzheimer’s Disease Therapy

(2013) Chong Wang et al.   MOLECULAR NEUROBIOLOGY

Cyclophilin D Deficiency Rescues Axonal Mitochondrial Transport in Alzheimer’s Neurons

(2013) Lan Guo et al.   PLoS One

Cisphosphorylated tau as the earliest detectable pathogenic conformation in Alzheimer disease, offering novel diagnostic and therapeutic strategies

(2013) Kazuhiro Nakamura et al.   Prion

Peptidyl-prolyl isomerase activity of FK506 binding protein 12 prevents tau peptide from aggregating

(2013) T. Ikura et al.   PROTEIN ENGINEERING DESIGN & SELECTION

Cyclophilin A: a key player for human disease

(2013) P Nigro et al.   Cell Death & Disease

Biochemistry and Cell Biology of Tau Protein in Neurofibrillary Degeneration

(2013) E.-M. Mandelkow et al.   Cold Spring Harbor Perspectives in Medicine

Mutations in FKBP14 Cause a Variant of Ehlers-Danlos Syndrome with Progressive Kyphoscoliosis, Myopathy, and Hearing Loss

(2012) Matthias Baumann et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Proline Isomer-Specific Antibodies Reveal the Early Pathogenic Tau Conformation in Alzheimer's Disease

(2012) Kazuhiro Nakamura et al.   CELL

Reducing HDAC6 ameliorates cognitive deficits in a mouse model for Alzheimer's disease

(2012) Nambirajan Govindarajan et al.   EMBO Molecular Medicine

Identification of oligomers at early stages of tau aggregation in Alzheimer's disease

(2012) Cristian A. Lasagna-Reeves et al.   FASEB JOURNAL

Loss of HDAC6, a novel CHIP substrate, alleviates abnormal tau accumulation

(2012) Casey Cook et al.   HUMAN MOLECULAR GENETICS

The novel HSP90 inhibitor, PU-H71, suppresses glial cell activation but weakly affects clinical signs of EAE

(2012) Lucia Lisi et al.   JOURNAL OF NEUROIMMUNOLOGY

Prolyl Isomerase Pin1 Regulates Neuronal Differentiation via  -Catenin

(2012) K. Nakamura et al.   MOLECULAR AND CELLULAR BIOLOGY

Prion-like behaviour and tau-dependent cytotoxicity of pyroglutamylated amyloid-β

(2012) Justin M. Nussbaum et al.   NATURE

Solution Structural Analysis of the Single-Domain Parvulin TbPin1

(2012) Lifang Sun et al.   PLoS One

Glucocorticoid sensitizers Bag1 and Ppid are regulated by adolescent stress in a sex-dependent manner

(2012) Chase H. Bourke et al.   PSYCHONEUROENDOCRINOLOGY

Mouse FKBP23 mediates conformer-specific functions of BiP by catalyzing Pro117 cis/trans isomerization

(2011) Miao Feng et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Glycogen synthase kinase-3β regulates Tyr307phosphorylation of protein phosphatase-2A via protein tyrosine phosphatase 1B but not Src

(2011) Xiu-Qing Yao et al.   BIOCHEMICAL JOURNAL

Neuroprotective effects of overexpressed cyclophilin B against Aβ-induced neurotoxicity in PC12 cells

(2011) Yoojung Oh et al.   FREE RADICAL BIOLOGY AND MEDICINE

Interactions of Pathological Hallmark Proteins

(2011) Judit Oláh et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Prolyl Isomerase Pin1 Promotes Amyloid Precursor Protein (APP) Turnover by Inhibiting Glycogen Synthase Kinase-3β (GSK3β) Activity

(2011) Suk Ling Ma et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

FKBP immunophilins and Alzheimer’s disease: A chaperoned affair

(2011) Weihuan Cao et al.   JOURNAL OF BIOSCIENCES

AIP and its interacting partners

(2011) Giampaolo Trivellin et al.   JOURNAL OF ENDOCRINOLOGY

Structural Impact of Proline-Directed Pseudophosphorylation at AT8, AT100, and PHF1 Epitopes on 441-Residue Tau

(2011) Stefan Bibow et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

The involvement of FK506-binding protein 51 (FKBP5) in the behavioral and neuroendocrine effects of chronic social defeat stress

(2011) Jakob Hartmann et al.   NEUROPHARMACOLOGY

A New Anti-Depressive Strategy for the Elderly: Ablation of FKBP5/FKBP51

(2011) John C. O'Leary et al.   PLoS One

Prolyl isomerase Pin1 as a molecular switch to determine the fate of phosphoproteins

(2011) Yih-Cherng Liou et al.   TRENDS IN BIOCHEMICAL SCIENCES

Tau, prions and Aβ: the triad of neurodegeneration

(2010) Lilla Reiniger et al.   ACTA NEUROPATHOLOGICA

Preparation and Characterization of Neurotoxic Tau Oligomers

(2010) Cristian A. Lasagna-Reeves et al.   BIOCHEMISTRY

Apoptosis-Inducing Factor and Cyclophilin A Cotranslocate to the Motor Neuronal Nuclei in Amyotrophic Lateral Sclerosis Model Mice

(2010) Hirotaka Tanaka et al.   CNS Neuroscience & Therapeutics

Inhibition of FK506 Binding Proteins Reduces  -Synuclein Aggregation and Parkinson's Disease-Like Pathology

(2010) M. Gerard et al.   JOURNAL OF NEUROSCIENCE

The Hsp90 Cochaperone, FKBP51, Increases Tau Stability and Polymerizes Microtubules

(2010) U. K. Jinwal et al.   JOURNAL OF NEUROSCIENCE

Increased platelet GSK3B activity in patients with mild cognitive impairment and Alzheimer’s disease

(2010) Orestes V. Forlenza et al.   JOURNAL OF PSYCHIATRIC RESEARCH

Control of Alzheimer's Amyloid Beta Toxicity by the High Molecular Weight Immunophilin FKBP52 and Copper Homeostasis in Drosophila

(2010) Reiko Sanokawa-Akakura et al.   PLoS One

The Crystal Structure of PPIL1 Bound to Cyclosporine A Suggests a Binding Mode for a Linear Epitope of the SKIP Protein

(2010) Christian M. Stegmann et al.   PLoS One

Differential Impact of Tetratricopeptide Repeat Proteins on the Steroid Hormone Receptors

(2010) Jan-Philip Schülke et al.   PLoS One

A role for FKBP52 in Tau protein function

(2010) B. Chambraud et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Modulation of glucocorticoid receptor nuclear translocation in neurons by immunophilins FKBP51 and FKBP52: Implications for major depressive disorder

(2009) Erick T. Tatro et al.   BRAIN RESEARCH

The contribution of proline residues to protein stability is associated with isomerization equilibrium in both unfolded and folded states

(2009) Meng Ge et al.   EXTREMOPHILES

XAP2 inhibits glucocorticoid receptor activity in mammalian cells

(2009) Anna Laenger et al.   FEBS LETTERS

FKBP25, a novel regulator of the p53 pathway, induces the degradation of MDM2 and activation of p53

(2009) Anna Maria Ochocka et al.   FEBS LETTERS

Identifying genes that interact withDrosophilapresenilin and amyloid precursor protein

(2009) Diana L. van de Hoef et al.   GENESIS

HDAC6 Modulates Hsp90 Chaperone Activity and Regulates Activation of Aryl Hydrocarbon Receptor Signaling

(2009) Vikram D. Kekatpure et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Protein phosphatase 5 protects neurons against amyloid-β toxicity

(2009) Efrain Sanchez-Ortiz et al.   JOURNAL OF NEUROCHEMISTRY

Pin1 affects Tau phosphorylation in response to Aβ oligomers

(2009) Alessandra Bulbarelli et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

The Insulin/Akt Signaling Pathway Is Targeted by Intracellular β-Amyloid

(2009) Han-Kyu Lee et al.   MOLECULAR BIOLOGY OF THE CELL

A peptidyl–prolyl isomerase, FKBP12, accumulates in Alzheimer neurofibrillary tangles

(2009) Hisato Sugata et al.   NEUROSCIENCE LETTERS

The role of FKBP5, a co-chaperone of the glucocorticoid receptor in the pathogenesis and therapy of affective and anxiety disorders

(2009) Elisabeth B. Binder   PSYCHONEUROENDOCRINOLOGY

Rosiglitazone reverses memory decline and hippocampal glucocorticoid receptor down-regulation in an Alzheimer’s disease mouse model

(2008) Luis Escribano et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Inhibition of glycogen synthase kinase-3β downregulates total tau proteins in cultured neurons and its reversal by the blockade of protein phosphatase-2A

(2008) Ludovic Martin et al.   BRAIN RESEARCH

Infusion of FK506, a specific inhibitor of calcineurin, induces potent tau hyperphosphorylation in mouse brain

(2008) Jing Luo et al.   BRAIN RESEARCH BULLETIN

The crystal structure of human WD40 repeat-containing peptidylprolyl isomerase (PPWD1)

(2008) Tara L. Davis et al.   FEBS Journal

Overexpressed cyclophilin B suppresses apoptosis associated with ROS and Ca2+ homeostasis after ER stress

(2008) J. Kim et al.   JOURNAL OF CELL SCIENCE

Evasion from CypA- and APOBEC-mediated restrictions is insufficient for HIV-1 to efficiently grow in simian cells

(2008) Kazuya Kamada et al.   MICROBES AND INFECTION