Autophagic degradation of CCN2 (cellular communication network factor 2) causes cardiotoxicity of sunitinib

Autophagosome content profiling reveals receptor-specific cargo candidates

(2021) Susanne Zellner et al.   Autophagy

PLK1 (polo like kinase 1)-dependent autophagy facilitates gefitinib-induced hepatotoxicity by degrading COX6A1 (cytochrome c oxidase subunit 6A1)

(2020) Peihua Luo et al.   Autophagy

Cytosolic HMGB1 Mediates Autophagy Activation in an Emulsified Isoflurane Anesthesia Cell Model

(2019) Rui-zhu Liu et al.   NEUROCHEMICAL RESEARCH

Mitophagy Is Essential for Maintaining Cardiac Function During High Fat Diet-Induced Diabetic Cardiomyopathy

(2019) Mingming Tong et al.   CIRCULATION RESEARCH

Doxorubicin-induced cardiomyocyte death is mediated by unchecked mitochondrial fission and mitophagy

(2019) Michael P. Catanzaro et al.   FASEB JOURNAL

Sirt3 promotes sensitivity to sunitinib-induced cardiotoxicity via inhibition of GTSP1/JNK/autophagy pathway in vivo and in vitro

(2019) Yi Yang et al.   ARCHIVES OF TOXICOLOGY

Fundamental Mechanisms of Regulated Cell Death and Implications for Heart Disease

(2019) Dominic P. Del Re et al.   PHYSIOLOGICAL REVIEWS

Cardioprotective effects of glycyrrhizic acid involve inhibition of calcium influx via L-type calcium channels and myocardial contraction in rats

(2019) Mengying Li et al.   NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY

Targeting HMGB1 ameliorates cardiac fibrosis through restoring TLR2-mediated autophagy suppression in myocardial fibroblasts

(2018) Ri-Na Wu et al.   INTERNATIONAL JOURNAL OF CARDIOLOGY

HMGB1 contributes to adriamycin-induced cardiotoxicity via up-regulating autophagy

(2018) Peihua Luo et al.   TOXICOLOGY LETTERS

HMGB1 represses the anti-cancer activity of sunitinib by governing TP53 autophagic degradation via its nucleus-to-cytoplasm transport

(2018) Peihua Luo et al.   Autophagy

The Hippo pathway in the heart: pivotal roles in development, disease, and regeneration

(2018) Jun Wang et al.   Nature Reviews Cardiology

High-mobility group box 1 protein-mediated necroptosis contributes to dasatinib-induced cardiotoxicity

(2018) Zhifei Xu et al.   TOXICOLOGY LETTERS

Oxidative stress-dependent contribution of HMGB1 to the interplay between apoptosis and autophagy in diabetic rat liver

(2017) Anja Petrović et al.   JOURNAL OF PHYSIOLOGY AND BIOCHEMISTRY

Pharmacological modulation of autophagy: therapeutic potential and persisting obstacles

(2017) Lorenzo Galluzzi et al.   NATURE REVIEWS DRUG DISCOVERY

Connective tissue growth factor and bone morphogenetic protein 2 are induced following myocardial ischemia in mice and humans

(2017) Arkady Rutkovskiy et al.   SCANDINAVIAN JOURNAL OF CLINICAL & LABORATORY INVESTIGATION

Hsp90 inhibitor geldanamycin attenuates the cytotoxicity of sunitinib in cardiomyocytes via inhibition of the autophagy pathway

(2017) Takayuki Kimura et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Erratum

(2016)   Autophagy

Autophagy promotes ferroptosis by degradation of ferritin

(2016) Wen Hou et al.   Autophagy

Drp1-Dependent Mitochondrial Autophagy Plays a Protective Role Against Pressure Overload–Induced Mitochondrial Dysfunction and Heart FailureCLINICAL PERSPECTIVE

(2016) Akihiro Shirakabe et al.   CIRCULATION

Downregulation of miR-18a induces CTGF and promotes proliferation and migration of sodium hyaluronate treated human corneal epithelial cells

(2016) Yingzhuo Guo et al.   GENE

HMGB1 induces apoptosis and EMT in association with increased autophagy following H/R injury in cardiomyocytes

(2016) FAN OUYANG et al.   INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

HMGB1 translocation is involved in the transformation of autophagy complexes and promotes chemoresistance in leukaemia

(2015) QIAN KONG et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

Autophagy in cardiovascular biology

(2015) Sergio Lavandero et al.   JOURNAL OF CLINICAL INVESTIGATION

Genetic Analysis of Connective Tissue Growth Factor as an Effector of Transforming Growth Factor β Signaling and Cardiac Remodeling

(2015) Federica Accornero et al.   MOLECULAR AND CELLULAR BIOLOGY

Critical role of RAGE and HMGB1 in inflammatory heart disease

(2015) Anna Bangert et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Glycyrrhizic acid inhibits apoptosis and fibrosis in carbon-tetrachloride-induced rat liver injury

(2015) Bo Liang   WORLD JOURNAL OF GASTROENTEROLOGY

Glycyrrhizic Acid Ameliorates HMGB1-Mediated Cell Death and Inflammation after Renal Ischemia Reperfusion Injury

(2014) Arthur Lau et al.   AMERICAN JOURNAL OF NEPHROLOGY

The selectivity of autophagy and its role in cell death and survival

(2014) Li Yu et al.   Autophagy

Dimethyl α-ketoglutarate inhibits maladaptive autophagy in pressure overload-induced cardiomyopathy

(2014) Guillermo Mariño et al.   Autophagy

HMGB1-dependent and -independent autophagy

(2014) Xiaofang Sun et al.   Autophagy

Metabolically healthy obesity and the risk of cardiovascular disease and type 2 diabetes: the Whitehall II cohort study

(2014) Guy-Marino Hinnouho et al.   EUROPEAN HEART JOURNAL

Connective tissue growth factor and cardiac diastolic dysfunction: human data from the Taiwan Diastolic Heart Failure Registry and molecular basis by cellular and animal models

(2014) Cho-Kai Wu et al.   EUROPEAN JOURNAL OF HEART FAILURE

Interactions between Autophagy Receptors and Ubiquitin-like Proteins Form the Molecular Basis for Selective Autophagy

(2014) Vladimir Rogov et al.   MOLECULAR CELL

Isolation and Culture of Adult Mouse Cardiomyocytes for Cell Signaling and in vitro Cardiac Hypertrophy

(2014) Daxiang Li et al.   Jove-Journal of Visualized Experiments

Q6, a novel hypoxia-targeted drug, regulates hypoxia-inducible factor signaling via an autophagy-dependent mechanism in hepatocellular carcinoma

(2013) Xiao-Wen Liu et al.   Autophagy

Connective tissue growth factor regulates adipocyte differentiation of mesenchymal stromal cells and facilitates leukemia bone marrow engraftment

(2013) V. L. Battula et al.   BLOOD

CCN2/CTGF attenuates myocardial hypertrophy and cardiac dysfunction upon chronic pressure-overload

(2013) Jørgen Gravning et al.   INTERNATIONAL JOURNAL OF CARDIOLOGY

Orphan nuclear receptor TR3 acts in autophagic cell death via mitochondrial signaling pathway

(2013) Wei-jia Wang et al.   Nature Chemical Biology

Multi-parameter in vitro toxicity testing of crizotinib, sunitinib, erlotinib, and nilotinib in human cardiomyocytes

(2013) Kimberly R. Doherty et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Glycyrrhizin protects rat heart against ischemia-reperfusion injury through blockade of HMGB1-dependent phospho-JNK/Bax pathway

(2012) Chang-lin Zhai et al.   ACTA PHARMACOLOGICA SINICA

Endocytosis and autophagy: Shared machinery for degradation

(2012) Christopher A. Lamb et al.   BIOESSAYS

p53/HMGB1 Complexes Regulate Autophagy and Apoptosis

(2012) K. M. Livesey et al.   CANCER RESEARCH

The Hairpin-type Tail-Anchored SNARE Syntaxin 17 Targets to Autophagosomes for Fusion with Endosomes/Lysosomes

(2012) Eisuke Itakura et al.   CELL

Metabolic regulation by HMGB1-mediated autophagy and mitophagy

(2011) Rui Kang et al.   Autophagy

HMGB1 regulates autophagy through increasing transcriptional activities of JNK and ERK in human myeloid leukemia cells

(2011) Mingyi Zhao et al.   BMB Reports

High-Mobility Group Box 1 Is Essential for Mitochondrial Quality Control

(2011) Daolin Tang et al.   Cell Metabolism

Differential Roles of GSK-3β During Myocardial Ischemia and Ischemia/Reperfusion

(2011) Peiyong Zhai et al.   CIRCULATION RESEARCH

AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1

(2011) Joungmok Kim et al.   NATURE CELL BIOLOGY

Sunitinib Malate for the Treatment of Pancreatic Neuroendocrine Tumors

(2011) Eric Raymond et al.   NEW ENGLAND JOURNAL OF MEDICINE

Mechanisms of novel cardioprotective functions of CCN2/CTGF in myocardial ischemia-reperfusion injury

(2010) M. Shakil Ahmed et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Oxidative Stress Stimulates Autophagic Flux During Ischemia/Reperfusion

(2010) Nirmala Hariharan et al.   ANTIOXIDANTS & REDOX SIGNALING

HMGB1: the missing link between diabetes mellitus and heart failure

(2010) H. Christian Volz et al.   BASIC RESEARCH IN CARDIOLOGY

Autophagic degradation of dBruce controls DNA fragmentation in nurse cells during lateDrosophila melanogasteroogenesis

(2010) Ioannis P. Nezis et al.   JOURNAL OF CELL BIOLOGY

Endogenous HMGB1 regulates autophagy

(2010) Daolin Tang et al.   JOURNAL OF CELL BIOLOGY

Myocardial Fibrosis as an Early Manifestation of Hypertrophic Cardiomyopathy

(2010) Carolyn Y. Ho et al.   NEW ENGLAND JOURNAL OF MEDICINE

Autophagy plays an important role in Sunitinib-mediated cell death in H9c2 cardiac muscle cells

(2010) Yuqin Zhao et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Autophagy in ischemic preconditioning and hibernating myocardium

(2009) Lin Yan et al.   Autophagy

Sunitinib in solid tumors

(2009) Hui K Gan et al.   EXPERT OPINION ON INVESTIGATIONAL DRUGS

Overall Survival and Updated Results for Sunitinib Compared With Interferon Alfa in Patients With Metastatic Renal Cell Carcinoma

(2009) Robert J. Motzer et al.   JOURNAL OF CLINICAL ONCOLOGY

Cardiotoxicity associated with the cancer therapeutic agent sunitinib malate

(2008) M. L. Telli et al.   ANNALS OF ONCOLOGY

Heart failure associated with sunitinib malate

(2008) Aarif Y. Khakoo et al.   CANCER

High-Mobility Group Box-1 in Ischemia-Reperfusion Injury of the Heart

(2008) Martin Andrassy et al.   CIRCULATION