Article
Environmental Sciences
Mona K. Galal, Ashraf M. Morgan, Marwa A. Ibrahim, Ahmed M. Hussien
Summary: The study revealed that atrazine induced cell-mediated immunotoxicity in rabbits, characterized by the impact on interferon-gamma and interleukin-9 genes, upregulation of caspase-3, and significant decrease in total leukocyte and lymphocyte counts. Interestingly, co-administration of glycyrrhizic acid seemed to mitigate most of the adverse effects caused by atrazine.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2021)
Review
Chemistry, Medicinal
Dominik Langer, Dariusz T. Mlynarczyk, Jolanta Dlugaszewska, Ewa Tykarska
Summary: Despite the advancement of medicine, influenza remains a significant global epidemiological problem. With the increasing resistance of influenza viruses to antiviral drugs, there is a need to search for new compounds or drug forms with high efficacy against human influenza A and B viruses. This study focuses on chemically modifying natural compounds and using modern drug carriers to enhance antiviral activity against influenza viruses. The findings provide directions for further development in this field.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2023)
Article
Biochemistry & Molecular Biology
Edward V. Evdokimovskii, Ryounghoon Jeon, Sungjo Park, Oleg Y. Pimenov, Alexey E. Alekseev
Summary: The different subtypes of alpha 2-AR exhibit varying expression profiles in the mouse ventricle, with alpha 2C playing a major role in the suppression of I-CaL, while alpha 2A is minimally involved.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Alexander Lucius, Sirjan Chhatwal, Monika Valtink, Peter S. Reinach, Aruna Li, Uwe Pleyer, Stefan Mergler
Summary: Tear film hyperosmolarity induces dry eye syndrome through TRPV1 activation. L-carnitine, a therapeutic agent, protects against hypertonicity-induced response. This study shows that L-carnitine inhibits TRPV1 activation by blocking cell volume shrinkage induced by hypertonicity.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Integrative & Complementary Medicine
Katesirin Ruamyod, Wattana B. Watanapa, Chanrit Kakhai, Pimchanok Nambundit, Sukrit Treewaree, Parin Wongsanupa
Summary: This study aimed to investigate the effect of ferulic acid, a natural compound, on pancreatic beta cell viability, Ca2+ channels, and insulin secretion. It was found that ferulic acid did not affect cell viability and rapidly increased L-type Ca2+ channel current, while having no effect on T-type Ca2+ channels. Ferulic acid also significantly increased insulin secretion, which was mediated by augmenting Ca2+ influx through L-type Ca2+ channels. This study provides the first electrophysiological demonstration of the effects of acute ferulic acid treatment on pancreatic beta cells.
JOURNAL OF INTEGRATIVE MEDICINE-JIM
(2023)
Article
Biochemistry & Molecular Biology
Alejandro Ciocci Pardo, Leandro A. Diaz Zegarra, Luisa F. Gonzalez Arbelaez, Alejandro M. Ibanez, Romina G. Diaz, Ernesto A. Aiello, Susana M. Mosca
Summary: The non-carbonic anhydrase inhibitor N-methylacetazolamide (NMA) was found to protect the myocardium against ischemia-reperfusion injury. It achieved this by attenuating mitochondrial fission through the calcineurin/Akt/PKCe-dependent pathway, as well as decreasing ICaL current. These findings suggest that NMA has potential therapeutic applications in the treatment of ischemia-reperfusion injury.
BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS
(2022)
Article
Multidisciplinary Sciences
Cigdem Cetin Aluc, Bahar Gok, Serda Kecel-Gunduz, Yasemin Budama-Kilinc
Summary: Glycyrrhizic acid (GA) is a component of licorice roots with various therapeutic properties. In this study, GA-loaded nanoparticles were prepared and evaluated for their efficacy and safety. Molecular docking analysis revealed the mechanism of GA binding to MMPs. The results suggest that GA nanoparticles could be a potential candidate for topical anti-aging skincare products.
Article
Neurosciences
Giedrius Kanaporis, Lothar A. Blatter
Summary: This study investigates the effects of SK channel activation on alternans in cardiac myocytes. The results demonstrate that SK channel activation can prevent or reduce pacing-induced alternations in CaT and APD, presenting a potential intervention for arrhythmia prevention and therapy.
JOURNAL OF PHYSIOLOGY-LONDON
(2023)
Article
Biology
Maiki K. Wakai, Mitsuru J. Nakamura, Satoshi Sawai, Kohji Hotta, Kotaro Oka
Summary: This research reveals that after sensing a mechanical cue, marine invertebrate larvae transmit internal metamorphic signals through two rounds of calcium transients in papillae, ultimately inducing tail regression. This contributes to understanding the internal mechanism of metamorphosis in response to environmental cues in marine invertebrate larvae.
PROCEEDINGS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES
(2021)
Article
Biology
Andre G. Kamkin, Olga V. Kamkina, Viktor E. Kazansky, Vadim M. Mitrokhin, Andrey Bilichenko, Elizaveta A. Nasedkina, Stanislav A. Shileiko, Anastasia S. Rodina, Alexandra D. Zolotareva, Valentin I. Zolotarev, Pavel V. Sutyagin, Mitko I. Mladenov
Summary: This study identified specific ion channels and their potential role in regulating ionic currents in rat ventricular cardiomyocytes in response to mechanical stimulation. TRPM7, TRPC1, and TRPM4 channels were found to be mechanosensitive, while Ca(V)1.2 channels showed mechanosensitive properties. These findings provide insights into the molecular mechanisms underlying stretch-induced responses in rat ventricular myocytes and have implications for understanding cardiac physiology and pathophysiology.
Review
Physiology
Galina Yu Mironova, Nadia Haghbin, Donald G. G. Welsh
Summary: This article discusses the mechanistic foundation of vascular smooth muscle contraction, including membrane potential, opening of L-type calcium channels, and intracellular rise in Ca2+. It also explores the functional coupling and cooperative behavior of neighboring channels, as well as the impact of channel trafficking on cytoskeleton dynamics.
FRONTIERS IN PHYSIOLOGY
(2022)
Article
Physiology
Marina Angelini, Arash Pezhouman, Nicoletta Savalli, Marvin G. Chang, Federica Steccanella, Kyle Scranton, Guillaume Calmettes, Michela Ottolia, Antonios Pantazis, Hrayr S. Karagueuzian, James N. Weiss, Riccardo Olcese
Summary: A new antiarrhythmic strategy based on selectively reducing late I-Ca,I-L shows promise in suppressing arrhythmias triggered by EADs while preserving myocardial function. This approach modifies the gating properties of Ca(V)1.2 channels rather than blocking their pore, thereby maintaining contractility.
JOURNAL OF GENERAL PHYSIOLOGY
(2021)
Review
Chemistry, Medicinal
Yu-Xuan Han, Qiao-Jun Jia, Dong-Feng Yang, Wei-Guo Chai, Xue-min Zhang, Qiu-Ling He, Zong-Suo Liang
Summary: Glycyrrhizic acid, the main active ingredient of licorice, has diverse biological activities, but its content fluctuates greatly among different cultivars, limiting its applications. Therefore, increasing glycyrrhizic acid content has become a research priority to improve its use.
Article
Biochemistry & Molecular Biology
Rui Cao, Yakun Li, Xiaofan Hu, Yang Qiu, Shanglin Li, Yanan Xie, Cong Xu, Chenqi Lu, Gang Chen, Jun Yang
Summary: The study investigated the protective mechanisms of glycyrrhizic acid (GA) on tacrolimus (TAC)-induced renal injury. Results showed that GA improved renal function and tubulointerstitial fibrosis, and reduced the expression of fibrosis-related proteins. Moreover, GA improved autophagic clearance and protected against cell injury. These findings suggest that GA may protect against TAC-induced renal injury by improving lysosomal function and regulating autophagy.
Article
Chemistry, Applied
Qihong Zhang, Hui Wang, Zongmiao Feng, Zhaohui Lu, Chen Su, Yunchun Zhao, Jingbo Yu, Alexandr Dushkin, Weike Su
Summary: This study successfully prepared a SD-CUR carrier with enhanced solubility and permeability, demonstrating superior pharmacological activity in hyperlipidemia rats, providing new approaches and directions for the prevention and treatment of hyperlipidemia.
FOOD HYDROCOLLOIDS
(2021)