- Home
- Publications
- Publication Search
- Publication Details
Title
CCR6-CCL20 axis as a therapeutic target for autoimmune diseases
Authors
Keywords
CCR6, CCL20, Mucosal tolerance, Regulatory CD4 T cells, Th17 cells
Journal
AUTOIMMUNITY REVIEWS
Volume 20, Issue 7, Pages 102846
Publisher
Elsevier BV
Online
2021-05-08
DOI
10.1016/j.autrev.2021.102846
References
Ask authors/readers for more resources
Related references
Note: Only part of the references are listed.- Guselkumab in the treatment of moderate-to-severe plaque psoriasis
- (2020) Cristina López-Sánchez et al. Immunotherapy
- Association of Pathogenic Th17 Cells with the Disease Severity and Its Potential Implication for Biological Treatment Selection in Psoriasis Patients
- (2020) Cristina Aguilar-Flores et al. MEDIATORS OF INFLAMMATION
- Structural basis for chemokine receptor CCR6 activation by the endogenous protein ligand CCL20
- (2020) David Jonathan Wasilko et al. Nature Communications
- Association study of CCR6 rs3093024 with Rheumatoid Arthritis in a Pakistani cohort
- (2020) Mehran Akhtar et al. SAUDI JOURNAL OF BIOLOGICAL SCIENCES
- The Regulatory Function of CCR9+ Dendritic Cells in Inflammation and Autoimmunity
- (2020) Manisha Pathak et al. Frontiers in Immunology
- Increased peripheral helper T cells type 17 subset correlates with the severity of psoriasis vulgaris
- (2020) Wenjing Liu et al. IMMUNOLOGY LETTERS
- Ixekizumab in the treatment of psoriatic arthritis
- (2020) Eric Lespessailles et al. Immunotherapy
- A review of secukinumab in psoriasis treatment
- (2020) Scott H Berg et al. Immunotherapy
- Efficacy of Chemokine Receptor Inhibition in Treating IL-36α–Induced Psoriasiform Inflammation
- (2019) James J. Campbell et al. JOURNAL OF IMMUNOLOGY
- The iNOS Activity During an Immune Response Controls the CNS Pathology in Experimental Autoimmune Encephalomyelitis
- (2019) Sandip Ashok Sonar et al. Frontiers in Immunology
- Serum CCL20 combined with IL-17A as early diagnostic and prognostic biomarkers for human colorectal cancer
- (2019) Dan Wang et al. Journal of Translational Medicine
- The CCL20 and CCR6 axis in psoriasis
- (2019) Kazuhisa Furue et al. SCANDINAVIAN JOURNAL OF IMMUNOLOGY
- CCR9 signaling in dendritic cells drives the differentiation of Foxp3 + Tregs and suppresses the allergic IgE response in the gut
- (2019) Manisha Pathak et al. EUROPEAN JOURNAL OF IMMUNOLOGY
- CCR6 signaling inhibits suppressor function of induced-Treg during gut inflammation
- (2018) Neeraja Kulkarni et al. JOURNAL OF AUTOIMMUNITY
- Chemokines and Chemokine Receptors as Therapeutic Targets in Inflammatory Bowel Disease; Pitfalls and Promise
- (2018) Palak J Trivedi et al. Journal of Crohns & Colitis
- Blood-brain barrier and its function during inflammation and autoimmunity
- (2018) Sandip Ashok Sonar et al. JOURNAL OF LEUKOCYTE BIOLOGY
- The Phosphorylation of CCR6 on Distinct Ser/Thr Residues in the Carboxyl Terminus Differentially Regulates Biological Function
- (2018) Mei-Yi Lu et al. Frontiers in Immunology
- Identification of a novel series of potent and selective CCR6 inhibitors as biological probes
- (2018) Taisuke Tawaraishi et al. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
- CCR6 controls autoimmune but not innate immunity-driven experimental arthritis
- (2018) Michael Bonelli et al. JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
- Is CCR6 required for the development of psoriasiform dermatitis in mice?
- (2018) Sebastian Yu et al. JOURNAL OF INVESTIGATIVE DERMATOLOGY
- Smoking, but not alcohol, is associated with risk of psoriasis in a Taiwanese population-based cohort study
- (2018) Ying-Xiu Dai et al. JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY
- Modulation of the CCR6-CCL20 Axis: A Potential Therapeutic Target in Inflammation and Cancer
- (2018) Ranmali Ranasinghe et al. Medicina-Lithuania
- IFN-γ promotes transendothelial migration of CD4+ T cells across the blood-brain barrier
- (2017) Sandip Ashok Sonar et al. IMMUNOLOGY AND CELL BIOLOGY
- Psoriasis pathogenesis and the development of novel targeted immune therapies
- (2017) Jason E. Hawkes et al. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
- Critical role of environmental factors in the pathogenesis of psoriasis
- (2017) Jinrong Zeng et al. JOURNAL OF DERMATOLOGY
- IL-17–Secreting γδ T Cells Are Completely Dependent upon CCR6 for Homing to Inflamed Skin
- (2017) James J. Campbell et al. JOURNAL OF IMMUNOLOGY
- A fully humanized IgG-like bispecific antibody for effective dual targeting of CXCR3 and CCR6
- (2017) Remy Robert et al. PLoS One
- Protein engineering of the chemokine CCL20 prevents psoriasiform dermatitis in an IL-23–dependent murine model
- (2017) A. E. Getschman et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Differentiation and Transmigration of CD4 T Cells in Neuroinflammation and Autoimmunity
- (2017) Sandip Ashok Sonar et al. Frontiers in Immunology
- The atopic dermatitis blood signature is characterized by increases in inflammatory and cardiovascular risk proteins
- (2017) Patrick M. Brunner et al. Scientific Reports
- Role of chemokine receptors and intestinal epithelial cells in the mucosal inflammation and tolerance
- (2016) Neeraja Kulkarni et al. JOURNAL OF LEUKOCYTE BIOLOGY
- Th17 Cell Pathway in Human Immunity: Lessons from Genetics and Therapeutic Interventions
- (2015) Dhavalkumar D. Patel et al. IMMUNITY
- A novel IL-17 signaling pathway controlling keratinocyte proliferation and tumorigenesis via the TRAF4–ERK5 axis
- (2015) Ling Wu et al. JOURNAL OF EXPERIMENTAL MEDICINE
- Interleukin-22 Promotes Wound Repair in Diabetes by Improving Keratinocyte Pro-Healing Functions
- (2015) Simona Avitabile et al. JOURNAL OF INVESTIGATIVE DERMATOLOGY
- Psoriasis
- (2015) Wolf-Henning Boehncke et al. LANCET
- IFN-γ ameliorates autoimmune encephalomyelitis by limiting myelin lipid peroxidation
- (2015) Rebecca A. Sosa et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- The Increased Expression of CCL20 and CCR6 in Rectal Mucosa Correlated to Severe Inflammation in Pediatric Ulcerative Colitis
- (2015) Keiichi Uchida et al. Gastroenterology Research and Practice
- CCL20andIL22Messenger RNA Expression After Adalimumab vs Methotrexate Treatment of Psoriasis
- (2015) Ari M. Goldminz et al. JAMA Dermatology
- Anti-inflammatory mechanisms of IFN-γ studied in experimental autoimmune encephalomyelitis reveal neutrophils as a potential target in multiple sclerosis
- (2015) Nichole M. Miller et al. Frontiers in Neuroscience
- Stage-Specific Role of Interferon-Gamma in Experimental Autoimmune Encephalomyelitis and Multiple Sclerosis
- (2015) Gabriel Arellano et al. Frontiers in Immunology
- MOR103, a human monoclonal antibody to granulocyte–macrophage colony-stimulating factor, in the treatment of patients with moderate rheumatoid arthritis: results of a phase Ib/IIa randomised, double-blind, placebo-controlled, dose-escalation trial
- (2014) Frank Behrens et al. ANNALS OF THE RHEUMATIC DISEASES
- MicroRNA-150 inhibits tumor invasion and metastasis by targeting the chemokine receptor CCR6, in advanced cutaneous T-cell lymphoma
- (2014) M. Ito et al. BLOOD
- Inhibiting RORγt/Th17 axis for autoimmune disorders
- (2014) Fujio Isono et al. DRUG DISCOVERY TODAY
- CCR6 and CCL20: emerging players in the pathogenesis of rheumatoid arthritis
- (2014) Adrian YS Lee et al. IMMUNOLOGY AND CELL BIOLOGY
- CCR6 Regulates the Migration of Inflammatory and Regulatory T Cells
- (2014) T. Yamazaki et al. JOURNAL OF IMMUNOLOGY
- IL-17 drives psoriatic inflammation via distinct, target cell-specific mechanisms
- (2014) H.-L. Ha et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Functional characterization of ferret CCL20 and CCR6 and identification of chemotactic inhibitors
- (2013) Shulin Qin et al. CYTOKINE
- Targeting Interleukin-6 in Rheumatoid Arthritis
- (2013) Md Yuzaiful Md Yusof et al. DRUGS
- Infliximab induces downregulation of the IL-12/IL-23 axis in 6-sulfo-LacNac (slan)+ dendritic cells and macrophages
- (2013) Patrick M. Brunner et al. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
- Dermal Clusters of Mature Dendritic Cells and T Cells Are Associated with the CCL20/CCR6 Chemokine System in Chronic Psoriasis
- (2013) Tae-Gyun Kim et al. JOURNAL OF INVESTIGATIVE DERMATOLOGY
- Secukinumab in the Treatment of Noninfectious Uveitis: Results of Three Randomized, Controlled Clinical Trials
- (2013) Andrew D. Dick et al. OPHTHALMOLOGY
- CC Chemokine Ligand 20 and Its Cognate Receptor CCR6 in Mucosal T Cell Immunology and Inflammatory Bowel Disease: Odd Couple or Axis of Evil?
- (2013) Adrian Y. S. Lee et al. Frontiers in Immunology
- Role of IL-17 in Psoriasis and Psoriatic Arthritis
- (2012) Siba P. Raychaudhuri CLINICAL REVIEWS IN ALLERGY & IMMUNOLOGY
- CCR6 Is Required for Epidermal Trafficking of γδ-T Cells in an IL-23-Induced Model of Psoriasiform Dermatitis
- (2012) Tomotaka Mabuchi et al. JOURNAL OF INVESTIGATIVE DERMATOLOGY
- A Single-nucleotide Polymorphism of CCR6 (rs3093024) Is Associated with Susceptibility to Rheumatoid Arthritis But Not Ankylosing Spondylitis, in a Taiwanese Population: Table 1.
- (2012) WEI-CHIAO CHANG et al. JOURNAL OF RHEUMATOLOGY
- Expression of chemokine CCL20 in ulcerative colitis
- (2012) HAIFENG ZHANG et al. Molecular Medicine Reports
- Caucasian and Asian Specific Rheumatoid Arthritis Risk Loci Reveal Limited Replication and Apparent Allelic Heterogeneity in North Indians
- (2012) Pushplata Prasad et al. PLoS One
- A CCR6 variant strongly associated with rheumatoid arthritis in two populations is not associated with ankylosing spondylitis
- (2012) Carla J. Cohen et al. RHEUMATOLOGY INTERNATIONAL
- Epigallocatechin-3-Gallate Ameliorates Experimental Autoimmune Encephalomyelitis by Altering Balance among CD4+ T-Cell Subsets
- (2011) Junpeng Wang et al. AMERICAN JOURNAL OF PATHOLOGY
- Expression of interleukin (IL)-1 family members upon stimulation with IL-17 differs in keratinocytes derived from patients with psoriasis and healthy donors
- (2011) P. Muhr et al. BRITISH JOURNAL OF DERMATOLOGY
- Chemokine receptors in the pathogenesis and therapy of psoriasis
- (2011) Tomotaka Mabuchi et al. JOURNAL OF DERMATOLOGICAL SCIENCE
- Epidermal CCR6 + γδ T Cells Are Major Producers of IL-22 and IL-17 in a Murine Model of Psoriasiform Dermatitis
- (2011) Tomotaka Mabuchi et al. JOURNAL OF IMMUNOLOGY
- Human Keratinocytes' Response to Injury Upregulates CCL20 and Other Genes Linking Innate and Adaptive Immunity
- (2011) Milène Kennedy-Crispin et al. JOURNAL OF INVESTIGATIVE DERMATOLOGY
- Control of TH17 cells occurs in the small intestine
- (2011) Enric Esplugues et al. NATURE
- Recruitment of CCR6-Expressing Th17 Cells by CCL 20 Secreted from IL-1β-, TNF-α-, and IL-17A-Stimulated Endometriotic Stromal Cells
- (2010) Tetsuya Hirata et al. ENDOCRINOLOGY
- CCL20 and -Defensin-2 Induce Arrest of Human Th17 Cells on Inflamed Endothelium In Vitro under Flow Conditions
- (2010) S. Ghannam et al. JOURNAL OF IMMUNOLOGY
- A phase 2, 24-week, randomized, placebo-controlled, double-blind study examining the efficacy and safety of an anti-interleukin-12 and -23 monoclonal antibody in patients with relapsing–remitting or secondary progressive multiple sclerosis
- (2010) Timothy L Vollmer et al. Multiple Sclerosis Journal
- A regulatory variant in CCR6 is associated with rheumatoid arthritis susceptibility
- (2010) Yuta Kochi et al. NATURE GENETICS
- Genome-wide association study meta-analysis identifies seven new rheumatoid arthritis risk loci
- (2010) Eli A Stahl et al. NATURE GENETICS
- Effects of AIN457, a Fully Human Antibody to Interleukin-17A, on Psoriasis, Rheumatoid Arthritis, and Uveitis
- (2010) W. Hueber et al. Science Translational Medicine
- CCR6 ligands inhibit HIV by inducing APOBEC3G
- (2009) M. K. Lafferty et al. BLOOD
- IL-21 blockade reduces graft-versus-host disease mortality by supporting inducible T regulatory cell generation
- (2009) C. Bucher et al. BLOOD
- Evidence for a cross-talk between human neutrophils and Th17 cells
- (2009) M. Pelletier et al. BLOOD
- CCR6 is required for IL-23–induced psoriasis-like inflammation in mice
- (2009) Michael N. Hedrick et al. JOURNAL OF CLINICAL INVESTIGATION
- Inhibition of CCR6 Function Reduces the Severity of Experimental Autoimmune Encephalomyelitis via Effects on the Priming Phase of the Immune Response
- (2009) A. Liston et al. JOURNAL OF IMMUNOLOGY
- Th17 Cytokines Stimulate CCL20 Expression in Keratinocytes In Vitro and In Vivo: Implications for Psoriasis Pathogenesis
- (2009) Erin G. Harper et al. JOURNAL OF INVESTIGATIVE DERMATOLOGY
- Proinflammatory Cytokines Synergistically Enhance the Production of Chemokine Ligand 20 (CCL20) from Rheumatoid Fibroblast-like Synovial Cells in vitro and Serum CCL20 Is Reduced in vivo by Biologic Disease-modifying Antirheumatic Drugs
- (2009) S.-Y. KAWASHIRI et al. JOURNAL OF RHEUMATOLOGY
- C-C chemokine receptor 6–regulated entry of TH-17 cells into the CNS through the choroid plexus is required for the initiation of EAE
- (2009) Andrea Reboldi et al. NATURE IMMUNOLOGY
- Repeated subcutaneous injections of IL12/23 p40 neutralising antibody, ustekinumab, in patients with relapsing-remitting multiple sclerosis: a phase II, double-blind, placebo-controlled, randomised, dose-ranging study
- (2008) Benjamin M Segal et al. LANCET NEUROLOGY
- Genome-wide association defines more than 30 distinct susceptibility loci for Crohn's disease
- (2008) Jeffrey C Barrett et al. NATURE GENETICS
Publish scientific posters with Peeref
Peeref publishes scientific posters from all research disciplines. Our Diamond Open Access policy means free access to content and no publication fees for authors.
Learn MoreAsk a Question. Answer a Question.
Quickly pose questions to the entire community. Debate answers and get clarity on the most important issues facing researchers.
Get Started