Stage-Specific Role of Interferon-Gamma in Experimental Autoimmune Encephalomyelitis and Multiple Sclerosis

Multiple Sclerosis and T Lymphocytes: An Entangled Story

(2015) Laurine Legroux et al.   Journal of Neuroimmune Pharmacology

Pathological mechanisms in progressive multiple sclerosis

(2015) Don H Mahad et al.   LANCET NEUROLOGY

Role of the Immunogenic and Tolerogenic Subsets of Dendritic Cells in Multiple Sclerosis

(2015) Zhong-Xiang Xie et al.   MEDIATORS OF INFLAMMATION

T cell mediated pathogenesis in EAE: Molecular mechanisms

(2015) FlorianC Kurschus   Biomedical Journal

Innate IFN-γ promotes development of experimental autoimmune encephalomyelitis: A role for NK cells and M1 macrophages

(2014) Lara S. Dungan et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

HINT1 peptide/Hsp70 complex induces NK-cell-dependent immunoregulation in a model of autoimmune demyelination

(2014) Grazyna Galazka et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Loss of IFN-  Enables the Expansion of Autoreactive CD4+ T Cells to Induce Experimental Autoimmune Encephalomyelitis by a Nonencephalitogenic Myelin Variant Antigen

(2014) J. J. Sabatino et al.   JOURNAL OF IMMUNOLOGY

In Vivo Regulation of Experimental Autoimmune Encephalomyelitis by NK Cells: Alteration of Primary Adaptive Responses

(2014) R. Winkler-Pickett et al.   JOURNAL OF IMMUNOLOGY

Absence of IFN-γ Increases Brain Pathology in Experimental Autoimmune Encephalomyelitis–Susceptible DRB1*0301.DQ8 HLA Transgenic Mice through Secretion of Proinflammatory Cytokine IL-17 and Induction of Pathogenic Monocytes/Microglia into the Central Nervous System

(2014) Ashutosh K. Mangalam et al.   JOURNAL OF IMMUNOLOGY

Site-Specific Chemokine Expression Regulates Central Nervous System Inflammation and Determines Clinical Phenotype in Autoimmune Encephalomyelitis

(2014) Joshua S. Stoolman et al.   JOURNAL OF IMMUNOLOGY

Role of gamma-delta (γδ ) T cells in autoimmunity

(2014) Sourav Paul et al.   JOURNAL OF LEUKOCYTE BIOLOGY

The Interdependent, Overlapping, and Differential Roles of Type I and II IFNs in the Pathogenesis of Experimental Autoimmune Encephalomyelitis

(2013) R. Naves et al.   JOURNAL OF IMMUNOLOGY

Activated Invariant NKT Cells Control Central Nervous System Autoimmunity in a Mechanism That Involves Myeloid-Derived Suppressor Cells

(2013) V. V. Parekh et al.   JOURNAL OF IMMUNOLOGY

The Disease-Ameliorating Function of Autoregulatory CD8 T Cells Is Mediated by Targeting of Encephalitogenic CD4 T Cells in Experimental Autoimmune Encephalomyelitis

(2013) S. B. Ortega et al.   JOURNAL OF IMMUNOLOGY

IFNγ inhibits Th17 differentiation and function via Tbet-dependent and Tbet-independent mechanisms

(2013) Wen-I Yeh et al.   JOURNAL OF NEUROIMMUNOLOGY

CD8+ T Cells Are Required For Glatiramer Acetate Therapy in Autoimmune Demyelinating Disease

(2013) Andrew F. Tyler et al.   PLoS One

The plasticity of human Treg and Th17 cells and its role in autoimmunity

(2013) Markus Kleinewietfeld et al.   SEMINARS IN IMMUNOLOGY

Functionally distinct subsets of human FOXP3+ Treg cells that phenotypically mirror effector Th cells

(2012) T. Duhen et al.   BLOOD

Natural killer cells and their receptors in multiple sclerosis

(2012) Gurman Kaur et al.   BRAIN

Identification of a human Th1-like IFNγ-secreting Treg subtype deriving from effector T cells

(2012) Ram Kumar Chowdary Venigalla et al.   JOURNAL OF AUTOIMMUNITY

Multiple sclerosis

(2012) Alyssa Nylander et al.   JOURNAL OF CLINICAL INVESTIGATION

IFN-  Limits Th9-Mediated Autoimmune Inflammation through Dendritic Cell Modulation of IL-27

(2012) G. Murugaiyan et al.   JOURNAL OF IMMUNOLOGY

The dual roles of inflammatory cytokines and chemokines in the regulation of autoimmune diseases and their clinical implications

(2012) Idit Shachar et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Antibodies Against Human BLyS and APRIL Attenuate EAE Development in Marmoset Monkeys

(2012) S. Anwar Jagessar et al.   Journal of Neuroimmune Pharmacology

IFN-gamma signaling in the central nervous system controls the course of experimental autoimmune encephalomyelitis independently of the localization and composition of inflammatory foci

(2012) Eunyoung Lee et al.   Journal of Neuroinflammation

Ectonucleotidase CD38 Demarcates Regulatory, Memory-Like CD8+ T Cells with IFN-γ-Mediated Suppressor Activities

(2012) Rajia Bahri et al.   PLoS One

CD4+CD25+Foxp3+IFN-γ+ human induced T regulatory cells are induced by interferon-γ and suppress alloresponses nonspecifically

(2011) Volker Daniel et al.   HUMAN IMMUNOLOGY

Impaired IFN-γ production and proliferation of NK cells in Multiple Sclerosis

(2011) Anna Lünemann et al.   INTERNATIONAL IMMUNOLOGY

Autoreactive Tbet-Positive CD4 T Cells Develop Independent of Classic Th1 Cytokine Signaling during Experimental Autoimmune Encephalomyelitis

(2011) Wen-I Yeh et al.   JOURNAL OF IMMUNOLOGY

Interferon-γ Orchestrates the Number and Function of Th17 Cells in Experimental Autoimmune Encephalomyelitis

(2011) Nele Berghmans et al.   JOURNAL OF INTERFERON AND CYTOKINE RESEARCH

Fate mapping of IL-17-producing T cells in inflammatory responses

(2011) Keiji Hirota et al.   NATURE IMMUNOLOGY

Identification of T helper type 1–like, Foxp3+ regulatory T cells in human autoimmune disease

(2011) Margarita Dominguez-Villar et al.   NATURE MEDICINE

Antigen-Specific CD25−Foxp3−IFN-γhighCD4+ T Cells Restrain the Development of Experimental Allergic Encephalomyelitis by Suppressing Th17

(2010) Gizi Wildbaum et al.   AMERICAN JOURNAL OF PATHOLOGY

Differentiation of Effector CD4 T Cell Populations

(2010) Jinfang Zhu et al.   Annual Review of Immunology

Suppression of experimental allergic encephalomyelitis by intraventricular administration of interferon-gamma in Lewis rats

(2010) J. A. C. VOORTHUIS et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Generation of human Th1-like regulatory CD4+ T cells by an intrinsic IFN-γ- and T-bet-dependent pathway

(2010) Jian Zheng et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Genetic proof for the transient nature of the Th17 phenotype

(2010) Florian C. Kurschus et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Immune regulatory CNS-reactive CD8+T cells in experimental autoimmune encephalomyelitis

(2010) Nathan R. York et al.   JOURNAL OF AUTOIMMUNITY

Central nervous system (CNS)–resident natural killer cells suppress Th17 responses and CNS autoimmune pathology

(2010) Junwei Hao et al.   JOURNAL OF EXPERIMENTAL MEDICINE

IL-17- and IFN- -Secreting Foxp3+ T Cells Infiltrate the Target Tissue in Experimental Autoimmunity

(2010) M. Esposito et al.   JOURNAL OF IMMUNOLOGY

Involvement of IFN-γ and perforin, but not Fas/FasL interactions in regulatory T cell-mediated suppression of experimental autoimmune encephalomyelitis

(2010) Tara Beeston et al.   JOURNAL OF NEUROIMMUNOLOGY

Abnormal B-cell cytokine responses a trigger of T-cell-mediated disease in MS?

(2009) Amit Bar-Or et al.   ANNALS OF NEUROLOGY

γδ T cells in EAE: Early trafficking events and cytokine requirements

(2009) Jillian E. Wohler et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Novel CD8+Treg suppress EAE by TGF-β- and IFN-γ-dependent mechanisms

(2009) Mei-Ling Chen et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Autoantigen Immunization at Different Sites Reveals a Role for Anti-Inflammatory Effects of IFN-  in Regulating Susceptibility to Experimental Autoimmune Encephalomyelitis

(2009) S. Pastor et al.   JOURNAL OF IMMUNOLOGY

Pathogenic MOG-reactive CD8+ T cells require MOG-reactive CD4+ T cells for sustained CNS inflammation during chronic EAE

(2009) Maria Bettini et al.   JOURNAL OF NEUROIMMUNOLOGY

Hybrid Treg cells: steel frames and plastic exteriors

(2009) Michael J Barnes et al.   NATURE IMMUNOLOGY

Invariant NKT cells inhibit development of the Th17 lineage

(2009) L. T. Mars et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Regional CNS responses to IFN-γ determine lesion localization patterns during EAE pathogenesis

(2008) Jason R. Lees et al.   JOURNAL OF EXPERIMENTAL MEDICINE

How interferon-γ keeps autoimmune diseases in check

(2008) Hilde Kelchtermans et al.   TRENDS IN IMMUNOLOGY

Revival of CD8+ Treg–mediated suppression

(2008) Trevor R.F. Smith et al.   TRENDS IN IMMUNOLOGY

IL-12/IFN-γ/NO axis plays critical role in development of Th1-mediated experimental autoimmune encephalomyelitis

(2007) Bao-Guo Xiao et al.   MOLECULAR IMMUNOLOGY

Role of natural killer cells in the pathogenesis and progression of multiple sclerosis

(2007) Barbara Morandi et al.   PHARMACOLOGICAL RESEARCH