Programmable biomaterials for dynamic and responsive drug delivery

Injectable polypeptide micelles that form radiation crosslinked hydrogels in situ for intratumoral radiotherapy

(2016) Jeffrey L. Schaal et al.   JOURNAL OF CONTROLLED RELEASE

Current applications of nanoparticles in infectious diseases

(2016) Hinojal Zazo et al.   JOURNAL OF CONTROLLED RELEASE

Dual Targeted Immunotherapy via In Vivo Delivery of Biohybrid RNAi-Peptide Nanoparticles to Tumor-Associated Macrophages and Cancer Cells

(2015) João Conde et al.   ADVANCED FUNCTIONAL MATERIALS

Aptamer–Drug Conjugates

(2015) Guizhi Zhu et al.   BIOCONJUGATE CHEMISTRY

Antibacterial and Biofilm-Disrupting Coatings from Resin Acid-Derived Materials

(2015) Mitra S. Ganewatta et al.   BIOMACROMOLECULES

Drug nano-reservoirs synthesized using layer-by-layer technologies

(2015) Rui R. Costa et al.   BIOTECHNOLOGY ADVANCES

Antibiotic loaded nanocapsules functionalized with aptamer gates for targeted destruction of pathogens

(2015) M. Kavruk et al.   CHEMICAL COMMUNICATIONS

Rationally designed molecular beacons for bioanalytical and biomedical applications

(2015) Jing Zheng et al.   CHEMICAL SOCIETY REVIEWS

In Vivo Targeting through Click Chemistry

(2015) Yevgeny Brudno et al.   ChemMedChem

Tumor-Targeted Synergistic Blockade of MAPK and PI3K from a Layer-by-Layer Nanoparticle

(2015) E. C. Dreaden et al.   CLINICAL CANCER RESEARCH

Engineered in-situ depot-forming hydrogels for intratumoral drug delivery

(2015) Amir Fakhari et al.   JOURNAL OF CONTROLLED RELEASE

Drug delivery and release systems for targeted tumor therapy

(2015) David Böhme et al.   JOURNAL OF PEPTIDE SCIENCE

Poly(l-lysine) Interfaces via Dual Click Reactions on Surface-Bound Custom-Designed Dithiol Adsorbates

(2015) Amin Shakiba et al.   LANGMUIR

Gene Knockdown by EpCAM Aptamer-siRNA Chimeras Suppresses Epithelial Breast Cancers and Their Tumor-Initiating Cells

(2015) A. Gilboa-Geffen et al.   MOLECULAR CANCER THERAPEUTICS

Programmable nanomedicine: synergistic and sequential drug delivery systems

(2015) Dennis B. Pacardo et al.   Nanoscale

Principles of nanoparticle design for overcoming biological barriers to drug delivery

(2015) Elvin Blanco et al.   NATURE BIOTECHNOLOGY

Designing DNA nanodevices for compatibility with the immune system of higher organisms

(2015) Sunaina Surana et al.   Nature Nanotechnology

Implantable hydrogel embedded dark-gold nanoswitch as a theranostic probe to sense and overcome cancer multidrug resistance

(2015) João Conde et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A synthetic hydrogel for the high-throughput study of cell–ECM interactions

(2015) Andrew D. Rape et al.   Nature Communications

Click-crosslinkable and photodegradable gelatin hydrogels for cytocompatible optical cell manipulation in natural environment

(2015) Masato Tamura et al.   Scientific Reports

Personalizing Biomaterials for Precision Nanomedicine Considering the Local Tissue Microenvironment

(2015) Nuria Oliva et al.   Advanced Healthcare Materials

Mimicking biological phenomena in hydrogel-based biomaterials to promote dynamic cellular responses

(2015) Nicholas P. Murphy et al.   Journal of Materials Chemistry B

Sustained small molecule delivery from injectable hyaluronic acid hydrogels through host–guest mediated retention

(2015) Joshua E. Mealy et al.   Journal of Materials Chemistry B

Chemical Tumor-Targeting of Nanoparticles Based on Metabolic Glycoengineering and Click Chemistry

(2014) Sangmin Lee et al.   ACS Nano

Protein–DNA Chimeras for Nano Assembly

(2014) Diana A. Pippig et al.   ACS Nano

Gel-Liposome-Mediated Co-Delivery of Anticancer Membrane-Associated Proteins and Small-Molecule Drugs for Enhanced Therapeutic Efficacy

(2014) Tianyue Jiang et al.   ADVANCED FUNCTIONAL MATERIALS

Synergistic inhibition of lung cancer cell invasion, tumor growth and angiogenesis using aptamer-siRNA chimeras

(2014) Wei-Yun Lai et al.   BIOMATERIALS

NanoKeepers: stimuli responsive nanocapsules for programmed specific targeting and drug delivery

(2014) Frank J. Hernandez et al.   CHEMICAL COMMUNICATIONS

“Click” reactions: a versatile toolbox for the synthesis of peptide-conjugates

(2014) Wen Tang et al.   CHEMICAL SOCIETY REVIEWS

Hydrogel-nanoparticle composites for optically modulated cancer therapeutic delivery

(2014) Laura E. Strong et al.   JOURNAL OF CONTROLLED RELEASE

Cocoon-Like Self-Degradable DNA Nanoclew for Anticancer Drug Delivery

(2014) Wujin Sun et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Injectable, spontaneously assembling, inorganic scaffolds modulate immune cells in vivo and increase vaccine efficacy

(2014) Jaeyun Kim et al.   NATURE BIOTECHNOLOGY

Light-triggered in vivo activation of adhesive peptides regulates cell adhesion, inflammation and vascularization of biomaterials

(2014) Ted T. Lee et al.   NATURE MATERIALS

Replenishing reservoirs in vivo

(2014) Patrick Couvreur   Nature Nanotechnology

Refilling drug delivery depots through the blood

(2014) Y. Brudno et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A Nanoparticle-Based Combination Chemotherapy Delivery System for Enhanced Tumor Killing by Dynamic Rewiring of Signaling Pathways

(2014) S. W. Morton et al.   Science Signaling

Hydrogel Doped with Nanoparticles for Local Sustained Release of siRNA in Breast Cancer

(2014) Nathaly Segovia et al.   Advanced Healthcare Materials

Cell-type-specific, Aptamer-functionalized Agents for Targeted Disease Therapy

(2014) Jiehua Zhou et al.   Molecular Therapy-Nucleic Acids

Programmable Display of DNA–Protein Chimeras for Controlling Cell–Hydrogel Interactions via Reversible Intermolecular Hybridization

(2013) Zhaoyang Zhang et al.   BIOMACROMOLECULES

Dendrimer as nanocarrier for drug delivery

(2013) Prashant Kesharwani et al.   PROGRESS IN POLYMER SCIENCE

Hydrogels for biomedical applications

(2012) Allan S. Hoffman   ADVANCED DRUG DELIVERY REVIEWS

The EPR effect for macromolecular drug delivery to solid tumors: Improvement of tumor uptake, lowering of systemic toxicity, and distinct tumor imaging in vivo

(2012) Hiroshi Maeda et al.   ADVANCED DRUG DELIVERY REVIEWS

Liposomal drug delivery systems: From concept to clinical applications

(2012) Theresa M. Allen et al.   ADVANCED DRUG DELIVERY REVIEWS

Bioorthogonal Copper-Free Click Chemistry In Vivo for Tumor-Targeted Delivery of Nanoparticles

(2012) Heebeom Koo et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Enhanced Loading and Controlled Release of Antibiotics Using Nucleic Acids As an Antibiotic-Binding Effector in Hydrogels

(2012) Xiaolong Zhang et al.   BIOMACROMOLECULES

Sequential Application of Anticancer Drugs Enhances Cell Death by Rewiring Apoptotic Signaling Networks

(2012) Michael J. Lee et al.   CELL

Functional nanoporous membranes for drug delivery

(2012) Gumhye Jeon et al.   JOURNAL OF MATERIALS CHEMISTRY

Novel HER2 Aptamer Selectively Delivers Cytotoxic Drug to HER2-positive Breast Cancer Cells in Vitro

(2012) Zhe Liu et al.   Journal of Translational Medicine

A nanoscale drug delivery carrier using nucleic acid aptamers for extended release of therapeutic

(2012) Padma Sundaram et al.   Nanomedicine-Nanotechnology Biology and Medicine

Combinatorial drug therapy for cancer in the post-genomic era

(2012) Bissan Al-Lazikani et al.   NATURE BIOTECHNOLOGY

Gold nanorods: Their potential for photothermal therapeutics and drug delivery, tempered by the complexity of their biological interactions

(2011) Alaaldin M. Alkilany et al.   ADVANCED DRUG DELIVERY REVIEWS

Hyaluronic Acid Hydrogels for Biomedical Applications

(2011) Jason A. Burdick et al.   ADVANCED MATERIALS

Nanoparticle Delivery of Cancer Drugs

(2011) Andrew Z. Wang et al.   Annual Review of Medicine

Aptamer-Mediated Inhibition ofMycobacterium tuberculosisPolyphosphate Kinase 2

(2011) Ka To Shum et al.   BIOCHEMISTRY

Hallmarks of Cancer: The Next Generation

(2011) Douglas Hanahan et al.   CELL

Photoactivatable Caged Cyclic RGD Peptide for Triggering Integrin Binding and Cell Adhesion to Surfaces

(2011) Melanie Wirkner et al.   CHEMBIOCHEM

Inhibition of HIV transmission in human cervicovaginal explants and humanized mice using CD4 aptamer-siRNA chimeras

(2011) Lee Adam Wheeler et al.   JOURNAL OF CLINICAL INVESTIGATION

Responsive layer-by-layer materials for drug delivery

(2011) Benjamin M. Wohl et al.   JOURNAL OF CONTROLLED RELEASE

Click-chemistry for nanoparticle-modification

(2011) Nanwen Li et al.   JOURNAL OF MATERIALS CHEMISTRY

In vivo modulation of dendritic cells by engineered materials: Towards new cancer vaccines

(2011) Jaeyun Kim et al.   Nano Today

Nanoparticles that communicate in vivo to amplify tumour targeting

(2011) Geoffrey von Maltzahn et al.   NATURE MATERIALS

Cell-surface sensors for real-time probing of cellular environments

(2011) Weian Zhao et al.   Nature Nanotechnology

Synthesis and functionalization of nanoengineered materials using click chemistry

(2011) Georgina K. Such et al.   PROGRESS IN POLYMER SCIENCE

An Aptamer-siRNA Chimera Suppresses HIV-1 Viral Loads and Protects from Helper CD4+ T Cell Decline in Humanized Mice

(2011) C. P. Neff et al.   Science Translational Medicine

Enhanced proteolytic degradation of molecularly engineered PEG hydrogels in response to MMP-1 and MMP-2

(2010) J. Patterson et al.   BIOMATERIALS

Cu-free click cycloaddition reactions in chemical biology

(2010) John C. Jewett et al.   CHEMICAL SOCIETY REVIEWS

Antibody–drug conjugates: targeted drug delivery for cancer

(2010) Stephen C Alley et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

Aptamers as therapeutics

(2010) Anthony D. Keefe et al.   NATURE REVIEWS DRUG DISCOVERY

Short-Term Antibiotic Treatment Has Differing Long-Term Impacts on the Human Throat and Gut Microbiome

(2010) Hedvig E. Jakobsson et al.   PLoS One

Copper-free click chemistry in living animals

(2010) P. V. Chang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Multidrug Resistance in Bacteria

(2009) Hiroshi Nikaido   Annual Review of Biochemistry

Integration column: Artificial ECM: expanding the cell biology toolbox in 3D

(2009) Matthias P. Lutolf   Integrative Biology

The changing epidemiology of resistance

(2009) P. M. Hawkey et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

Systemic administration of optimized aptamer-siRNA chimeras promotes regression of PSMA-expressing tumors

(2009) Justin P Dassie et al.   NATURE BIOTECHNOLOGY

Infection-mimicking materials to program dendritic cells in situ

(2009) Omar A. Ali et al.   NATURE MATERIALS

Functional Characterization of the Antibiotic Resistance Reservoir in the Human Microflora

(2009) M. O. A. Sommer et al.   SCIENCE

Applications of Nanoparticles in Biology

(2008) Mrinmoy De et al.   ADVANCED MATERIALS

A History of Cancer Chemotherapy

(2008) Vincent T. DeVita et al.   CANCER RESEARCH

Cu-Catalyzed Azide−Alkyne Cycloaddition

(2008) Morten Meldal et al.   CHEMICAL REVIEWS

Novel Dual Inhibitory Function Aptamer–siRNA Delivery System for HIV-1 Therapy

(2008) Jiehua Zhou et al.   MOLECULAR THERAPY

Nanoparticle therapeutics: an emerging treatment modality for cancer

(2008) Mark E. Davis et al.   NATURE REVIEWS DRUG DISCOVERY

Hydrogels in drug delivery: Progress and challenges

(2008) Todd R. Hoare et al.   POLYMER

Multifunctional nanoparticles – properties and prospects for their use in human medicine

(2008) Nuria Sanvicens et al.   TRENDS IN BIOTECHNOLOGY