Drug delivery and release systems for targeted tumor therapy

Integrin-targeted delivery into cancer cells of a Pt(iv) pro-drug through conjugation to RGD-containing peptides

(2015) Anna Massaguer et al.   DALTON TRANSACTIONS

Peptide Modifications Differentially Alter G Protein-Coupled Receptor Internalization and Signaling Bias

(2014) Veronika Mäde et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Automated solid-phase peptide synthesis to obtain therapeutic peptides

(2014) Veronika Mäde et al.   Beilstein Journal of Organic Chemistry

β-Glucuronidase-responsive prodrugs for selective cancer chemotherapy: An update

(2014) Isabelle Tranoy-Opalinski et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Efficacy and Safety of AEZS-108 (LHRH Agonist Linked to Doxorubicin) in Women With Advanced or Recurrent Endometrial Cancer Expressing LHRH Receptors

(2014) Günter Emons et al.   INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER

Targeting Neuropeptide Receptors for Cancer Imaging and Therapy: Perspectives with Bombesin, Neurotensin, and Neuropeptide-Y Receptors

(2014) C. Morgat et al.   JOURNAL OF NUCLEAR MEDICINE

Novel cleavable cell-penetrating peptide-drug conjugates: synthesis and characterization

(2014) Marco Lelle et al.   JOURNAL OF PEPTIDE SCIENCE

Synthesis, characterization, and biological activity of poly(arginine)-derived cancer-targeting peptides in HepG2 liver cancer cells

(2014) Stesha C. Joseph et al.   JOURNAL OF PEPTIDE SCIENCE

An intracellularly activatable, fluorogenic probe for cancer imaging

(2014) Ruisong Tian et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Targeted Delivery System of Nanobiomaterials in Anticancer Therapy: From Cells to Clinics

(2014) Su-Eon Jin et al.   Biomed Research International

Current challenges in peptide-based drug discovery

(2014) Laszlo Otvos et al.   Frontiers in Chemistry

Molecular imaging for cancer diagnosis and surgery

(2013) Timon Hussain et al.   ADVANCED DRUG DELIVERY REVIEWS

Design of Self-Immolative Linkers for Tumour-Activated Prodrug Therapy

(2013) I. Tranoy-Opalinski et al.   Anti-Cancer Agents in Medicinal Chemistry

Cellular Uptake and Cytotoxicity of Drug–Peptide Conjugates Regulated by Conjugation Site

(2013) Pengcheng Zhang et al.   BIOCONJUGATE CHEMISTRY

Towards improved receptor targeting: anterograde transport, internalization and postendocytic trafficking of neuropeptide Y receptors

(2013) Stefanie Babilon et al.   BIOLOGICAL CHEMISTRY

Enzyme-activated nanoconjugates for tunable release of doxorubicin in hepatic cancer cells

(2013) Scott H. Medina et al.   BIOMATERIALS

Mutual prodrugs containing bio-cleavable and drug releasable disulfide linkers

(2013) Arun K. Jain et al.   BIOORGANIC CHEMISTRY

Gonadotropin-releasing hormone receptors as molecular therapeutic targets in prostate cancer: Current options and emerging strategies

(2013) Patrizia Limonta et al.   CANCER TREATMENT REVIEWS

Phase I Study of GRN1005 in Recurrent Malignant Glioma

(2013) J. Drappatz et al.   CLINICAL CANCER RESEARCH

Future directions for peptide therapeutics development

(2013) Allan A. Kaspar et al.   DRUG DISCOVERY TODAY

Antibody–drug conjugates: current status and future directions

(2013) Heidi L. Perez et al.   DRUG DISCOVERY TODAY

Novel Peptide–Doxorubucin Conjugates for Targeting Breast Cancer Cells Including the Multidrug Resistant Cells

(2013) Rania Soudy et al.   JOURNAL OF MEDICINAL CHEMISTRY

Tunable Thioesters as “Reduction” Responsive Functionality for Traceless Reversible Protein PEGylation

(2013) Jianwei Chen et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Recent trends in the design of anticancer polymer prodrug nanocarriers

(2013) Vianney Delplace et al.   Polymer Chemistry

Targeting triple-negative breast cancer through the somatostatin receptor with the new cytotoxic somatostatin analogue AN-162 [AEZS-124]

(2012) Stephan Seitz et al.   ANTI-CANCER DRUGS

The molecular basis for high affinity of a universal ligand for human bombesin receptor (BnR) family members

(2012) Hirotsugu Uehara et al.   BIOCHEMICAL PHARMACOLOGY

Antibody-Drug Conjugates for the Treatment of Cancer

(2012) John A. Flygare et al.   Chemical Biology & Drug Design

Acid-degradable polymers for drug delivery: a decade of innovation

(2012) Sandra Binauld et al.   CHEMICAL COMMUNICATIONS

Disulfide Linkage: A Potent Strategy in Tumor-Targeting Drug Discovery

(2012) J. Wang et al.   CURRENT MEDICINAL CHEMISTRY

Chemical proteomics: ligation and cleavage of protein modifications

(2012) Georg C Rudolf et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

GnRH-III based multifunctional drug delivery systems containing daunorubicin and methotrexate

(2012) Ulrike Leurs et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Enhanced cellular uptake and in vitro antitumor activity of short-chain fatty acid acylated daunorubicin–GnRH-III bioconjugates

(2012) Rózsa Hegedüs et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Synthesis and Antitumor Efficacy of a β-Glucuronidase-Responsive Albumin-Binding Prodrug of Doxorubicin

(2012) Thibaut Legigan et al.   JOURNAL OF MEDICINAL CHEMISTRY

Synthesis and in vitro cytotoxicity of cis,cis,trans-diamminedichloridodisuccinatoplatinum(iv)–peptide bioconjugates

(2012) Luca Gaviglio et al.   Metallomics

Engineering a Prostate-Specific Membrane Antigen-Activated Tumor Endothelial Cell Prodrug for Cancer Therapy

(2012) S. R. Denmeade et al.   Science Translational Medicine

Prodrug-based intracellular delivery of anticancer agents

(2011) L. Bildstein et al.   ADVANCED DRUG DELIVERY REVIEWS

In-vivo antitumour effect of daunorubicin–GnRH-III derivative conjugates on colon carcinoma-bearing mice

(2011) Marilena Manea et al.   ANTI-CANCER DRUGS

Enhanced Enzymatic Stability and Antitumor Activity of Daunorubicin-GnRH-III Bioconjugates Modified in Position 4

(2011) Marilena Manea et al.   BIOCONJUGATE CHEMISTRY

Cleavable linkers in chemical biology

(2011) Geoffray Leriche et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Design, synthesis, in vitro stability and cytostatic effect of multifunctional anticancer drug-bioconjugates containing GnRH-III as a targeting moiety

(2011) Ulrike Leurs et al.   BIOPOLYMERS

Drug release from hydrazone-containing peptide amphiphiles

(2011) John B. Matson et al.   CHEMICAL COMMUNICATIONS

Six-month preoperative octreotide treatment in unselected, de novo patients with acromegaly: effect on biochemistry, tumour volume, and postoperative cure

(2011) Sven M. Carlsen et al.   CLINICAL ENDOCRINOLOGY

The development of pyrrolobenzodiazepines as antitumour agents

(2011) John A Hartley   EXPERT OPINION ON INVESTIGATIONAL DRUGS

Anthracycline-GnRH derivative bioconjugates with different linkages: Synthesis, in vitro drug release and cytostatic effect

(2011) Pascal Schlage et al.   JOURNAL OF CONTROLLED RELEASE

Incorporation ofortho-Carbaboranyl-Nε-Modifiedl-Lysine into Neuropeptide Y Receptor Y1- and Y2-Selective Analogues

(2011) Verena M. Ahrens et al.   JOURNAL OF MEDICINAL CHEMISTRY

Radiopeptide Imaging and Therapy in Europe

(2011) V. Ambrosini et al.   JOURNAL OF NUCLEAR MEDICINE

Cell-Specific, Activatable, and Theranostic Prodrug for Dual-Targeted Cancer Imaging and Therapy

(2011) Santimukul Santra et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Safety, Pharmacokinetics, and Activity of GRN1005, a Novel Conjugate of Angiopep-2, a Peptide Facilitating Brain Penetration, and Paclitaxel, in Patients with Advanced Solid Tumors

(2011) R. Kurzrock et al.   MOLECULAR CANCER THERAPEUTICS

In vitro degradation and antitumor activity of oxime bond-linked daunorubicin–GnRH-III bioconjugates and DNA-binding properties of daunorubicin–amino acid metabolites

(2010) Erika Orbán et al.   AMINO ACIDS

Breast-Cancer Diagnosis by Neuropeptide Y Analogues: From Synthesis to Clinical Application

(2010) Irfan U. Khan et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Modular Branched Neurotensin Peptides for Tumor Target Tracing and Receptor-Mediated Therapy: A Proof-of-Concept

(2010) C. Falciani et al.   CURRENT CANCER DRUG TARGETS

Activatable cell penetrating peptides linked to nanoparticles as dual probes for in vivo fluorescence and MR imaging of proteases

(2010) E. S. Olson et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Peptide drugs to target G protein-coupled receptors

(2010) Kathrin Bellmann-Sickert et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Bombesin Receptor-Mediated Imaging and Cytotoxicity: Review and Current Status

(2010) Veronica Sancho et al.   Current Drug Delivery

Use of Analogs of Peptide Hormones Conjugated to Cytotoxic Radicals for Chemotherapy Targeted to Receptors on Tumors

(2010) Andrew V. Schally et al.   Current Drug Delivery

Somatostatin Receptor-Targeted Anti-Cancer Therapy

(2010) Li-Chun Sun et al.   Current Drug Delivery

Preclinical evaluation of properties of a new targeted cytotoxic somatostatin analog, AN-162 (AEZS-124), and its effects on tumor growth inhibition

(2009) Stephan Seitz et al.   ANTI-CANCER DRUGS

Antibody−Drug Conjugates: Linking Cytotoxic Payloads to Monoclonal Antibodies

(2009) Laurent Ducry et al.   BIOCONJUGATE CHEMISTRY

Novel tumor-targeted RGD peptide–camptothecin conjugates: Synthesis and biological evaluation

(2009) Alma Dal Pozzo et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Amino Acid-Protecting Groups

(2009) Albert Isidro-Llobet et al.   CHEMICAL REVIEWS

Synthetic therapeutic peptides: science and market

(2009) Patrick Vlieghe et al.   DRUG DISCOVERY TODAY

A novel method for monitoring the cytosolic delivery of peptide cargo

(2009) Joanne C. Cheung et al.   JOURNAL OF CONTROLLED RELEASE

Clustering and Internalization of Integrin αvβ3 With a Tetrameric RGD-synthetic Peptide

(2009) Sancey Lucie et al.   MOLECULAR THERAPY

PEGylated PAMAM Dendrimer-Doxorubicin Conjugates: In Vitro Evaluation and In Vivo Tumor Accumulation

(2009) Saijie Zhu et al.   PHARMACEUTICAL RESEARCH

Uptake of ANG1005, A Novel Paclitaxel Derivative, Through the Blood-Brain Barrier into Brain and Experimental Brain Metastases of Breast Cancer

(2009) Fancy C. Thomas et al.   PHARMACEUTICAL RESEARCH

Hydrolytic Stability of Hydrazones and Oximes

(2008) Jeet Kalia et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

In Vitroandin VivoEvaluation of Doxorubicin Conjugates with the Divalent Peptide E-[c(RGDfK)2] that Targets Integrin αvβ3

(2008) Claudia Ryppa et al.   BIOCONJUGATE CHEMISTRY

Antitumour activity of ANG1005, a conjugate between paclitaxel and the new brain delivery vector Angiopep-2

(2008) A Régina et al.   BRITISH JOURNAL OF PHARMACOLOGY

Targeting HER2-Positive Breast Cancer with Trastuzumab-DM1, an Antibody-Cytotoxic Drug Conjugate

(2008) G. D. Lewis Phillips et al.   CANCER RESEARCH

Agonist induced receptor internalization of neuropeptide Y receptor subtypes depends on third intracellular loop and C-terminus☆

(2008) Ilka Böhme et al.   CELLULAR SIGNALLING

Paclitaxel–octreotide conjugates in tumor growth inhibition of A549 human non-small cell lung cancer xenografted into nude mice

(2008) Hongchang Shen et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

International Union of Pharmacology. LXVIII. Mammalian Bombesin Receptors: Nomenclature, Distribution, Pharmacology, Signaling, and Functions in Normal and Disease States

(2008) R. T. Jensen et al.   PHARMACOLOGICAL REVIEWS

Peptide-based radiopharmaceuticals and cytotoxic conjugates: Potential tools against cancer

(2007) S.M. Okarvi   CANCER TREATMENT REVIEWS

Prodrug Strategies in Anticancer Chemotherapy

(2007) Felix Kratz et al.   ChemMedChem

Somatostatin, cortistatin and their receptors in tumours

(2007) M. Volante et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY