Recent advances in the research of milbemycin biosynthesis and regulation as well as strategies for strain improvement

Engineering of primary metabolic pathways for titer improvement of milbemycins in Streptomyces bingchenggensis

(2021) Yuqing Liu et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

Improved milbemycin production by engineering two Cytochromes P450 in Streptomyces bingchenggensis

(2020) Haiyan Wang et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

Developing an endogenous quorum-sensing based CRISPRi circuit for autonomous and tunable dynamic regulation of multiple targets in Streptomyces

(2020) Jinzhong Tian et al.   NUCLEIC ACIDS RESEARCH

Synthetic Biology Tools for Novel Secondary Metabolite Discovery in Streptomyces

(2019) Namil Lee et al.   JOURNAL OF MICROBIOLOGY AND BIOTECHNOLOGY

Omics and multi-omics approaches to study the biosynthesis of secondary metabolites in microorganisms

(2018) Emilia Palazzotto et al.   CURRENT OPINION IN MICROBIOLOGY

CRISPR-Cpf1-Assisted Multiplex Genome Editing and Transcriptional Repression in Streptomyces

(2018) Lei Li et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

MilR2, a novel TetR family regulator involved in 5-oxomilbemycin A3/A4 biosynthesis in Streptomyces hygroscopicus

(2018) Keke Wei et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

Recent advances in the discovery and combinatorial biosynthesis of microbial 14-membered macrolides and macrolactones

(2018) Je Won Park et al.   JOURNAL OF INDUSTRIAL MICROBIOLOGY & BIOTECHNOLOGY

Engineered biosynthesis of milbemycins in the avermectin high-producing strain Streptomyces avermitilis

(2017) Myoun-Su Kim et al.   Microbial Cell Factories

Heterologous Biosynthesis of Spinosad: An Omics-Guided Large Polyketide Synthase Gene Cluster Reconstitution in Streptomyces

(2017) Gao-Yi Tan et al.   ACS Synthetic Biology

Toward Systems Metabolic Engineering of Streptomycetes for Secondary Metabolites Production

(2017) Helene Lunde Robertsen et al.   Biotechnology Journal

Characterization of AvaR1, a butenolide-autoregulator receptor for biosynthesis of a Streptomyces hormone in Streptomyces avermitilis

(2016) Suandi Pratama Sultan et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

Residue level and dissipation pattern of lepimectin in shallots using high-performance liquid chromatography coupled with photodiode array detection

(2016) Sung-Woo Kim et al.   BIOMEDICAL CHROMATOGRAPHY

Isolation and identification of new macrocyclic lactones from a genetically engineered strain Streptomyces bingchenggensis BCJ60

(2016) Jiansong Li et al.   JOURNAL OF ANTIBIOTICS

Enhanced production of avermectin by deletion of type III polyketide synthases biosynthetic clusterrppinStreptomyces avermitilis

(2016) L. Meng et al.   LETTERS IN APPLIED MICROBIOLOGY

Enhanced salinomycin production by adjusting the supply of polyketide extender units in Streptomyces albus

(2016) Chenyang Lu et al.   METABOLIC ENGINEERING

Characterization of a pathway-specific activator of milbemycin biosynthesis and improved milbemycin production by its overexpression in Streptomyces bingchenggensis

(2016) Yanyan Zhang et al.   Microbial Cell Factories

Development of Next Generation Synthetic Biology Tools for Use in Streptomyces venezuelae

(2016) Ryan M. Phelan et al.   ACS Synthetic Biology

Large-scale bioprocess competitiveness: the potential of dynamic metabolic control in two-stage fermentations

(2016) Jonathan M Burg et al.   Current Opinion in Chemical Engineering

One-step high-efficiency CRISPR/Cas9-mediated genome editing in Streptomyces

(2015) He Huang et al.   ACTA BIOCHIMICA ET BIOPHYSICA SINICA

Gene Replacement for the Generation of Designed Novel Avermectin Derivatives with Enhanced Acaricidal and Nematicidal Activities

(2015) Jun Huang et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

An overview on transcriptional regulators in Streptomyces

(2015) Alba Romero-Rodríguez et al.   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms

A review on the effect of macrocyclic lactones on dung-dwelling insects: Toxicity of macrocyclic lactones to dung beetles

(2015) Carmen T. Jacobs et al.   ONDERSTEPOORT JOURNAL OF VETERINARY RESEARCH

Combined application of plasma mutagenesis and gene engineering leads to 5-oxomilbemycins A3/A4 as main components from Streptomyces bingchenggensis

(2014) Hai-Yan Wang et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

Genetic engineering of Streptomyces bingchenggensis to produce milbemycins A3/A4 as main components and eliminate the biosynthesis of nanchangmycin

(2013) Ji Zhang et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

Comparative genomics of transport proteins in developmental bacteria: Myxococcus xanthus and Streptomyces coelicolor

(2013) Ilya Getsin et al.   BMC MICROBIOLOGY

Characterization and analysis of an industrial strain of Streptomyces bingchenggensis by genome sequencing and gene microarray

(2013) Xiang-Jing Wang et al.   GENOME

Genome mining of the Streptomyces avermitilis genome and development of genome-minimized hosts for heterologous expression of biosynthetic gene clusters

(2013) Haruo Ikeda et al.   JOURNAL OF INDUSTRIAL MICROBIOLOGY & BIOTECHNOLOGY

Spiroketal Formation and Modification in Avermectin Biosynthesis Involves a Dual Activity of AveC

(2013) Peng Sun et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Efficacy of a single oral administration of milbemycin oxime against natural infections of Ancylostoma braziliense in dogs

(2013) Stephen E. Bienhoff et al.   VETERINARY PARASITOLOGY

Recent Developments in the Analysis of Avermectin and Milbemycin Residues in Food Safety and the Environment

(2012) Martin Danaher et al.   CURRENT PHARMACEUTICAL BIOTECHNOLOGY

Combinatorial Biosynthesis of Cyclic Lipopeptide Antibiotics: A Model for Synthetic Biology To Accelerate the Evolution of Secondary Metabolite Biosynthetic Pathways

(2012) Richard H. Baltz   ACS Synthetic Biology

Fitness costs associated with milbemectin resistance in the two-spotted spider miteTetranychus urticae

(2011) Roberto Lomba Nicastro et al.   INTERNATIONAL JOURNAL OF PEST MANAGEMENT

Design, Synthesis, and Biological Activities of Milbemycin Analogues

(2011) Jin-Hao Zhao et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Assessing the Potential of an Induced-Mutation Strategy for Avermectin Overproducers

(2010) H. Gao et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

Cloning of Separate Meilingmycin Biosynthesis Gene Clusters by Use of Acyltransferase-Ketoreductase Didomain PCR Amplification

(2010) Y. He et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

Enhancement of avermectin and ivermectin production by overexpression of the maltose ATP-binding cassette transporter in Streptomyces avermitilis

(2010) Meng Li et al.   BIORESOURCE TECHNOLOGY

5-ketoreductase from Streptomyces bingchengensis: overexpression and preliminary characterization

(2010) Xiang-Jing Wang et al.   BIOTECHNOLOGY LETTERS

Genome Sequence of the Milbemycin-Producing Bacterium Streptomyces bingchenggensis

(2010) X.-J. Wang et al.   JOURNAL OF BACTERIOLOGY

Genome-minimized Streptomyces host for the heterologous expression of secondary metabolism

(2010) M. Komatsu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Engineering Streptomyces coelicolor for heterologous expression of secondary metabolite gene clusters

(2010) Juan Pablo Gomez-Escribano et al.   Microbial Biotechnology

Role of nsdA in negative regulation of antibiotic production and morphological differentiation in Streptomyces bingchengensis

(2009) Xiang-Jing Wang et al.   JOURNAL OF ANTIBIOTICS

Improvement of milbemycin-producing Streptomyces bingchenggensis by rational screening of ultraviolet- and chemically induced mutants

(2009) Xiang-Jing Wang et al.   WORLD JOURNAL OF MICROBIOLOGY & BIOTECHNOLOGY

Extracellular signalling, translational control, two repressors and an activator all contribute to the regulation of methylenomycin production inStreptomyces coelicolor

(2008) Sean O'Rourke et al.   MOLECULAR MICROBIOLOGY