Engineering of primary metabolic pathways for titer improvement of milbemycins in Streptomyces bingchenggensis

Improved milbemycin production by engineering two Cytochromes P450 in Streptomyces bingchenggensis

(2020) Haiyan Wang et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

Developing an endogenous quorum-sensing based CRISPRi circuit for autonomous and tunable dynamic regulation of multiple targets in Streptomyces

(2020) Jinzhong Tian et al.   NUCLEIC ACIDS RESEARCH

Synthetic biology and metabolic engineering of actinomycetes for natural product discovery

(2019) Emilia Palazzotto et al.   BIOTECHNOLOGY ADVANCES

Trichophyton rubrum azole resistance mediated by a new ABC transporter, TruMDR3

(2019) Michel Monod et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Whole Genome Re-sequencing Reveals Natural Variation and Adaptive Evolution of Phytophthora sojae

(2019) Xiong Zhang et al.   Frontiers in Microbiology

Induced heterologous expression of the arginine deiminase pathway promotes growth advantages in the strict anaerobe Acetobacterium woodii

(2019) Matthias H. Beck et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

Publisher Correction: Harnessing the intracellular triacylglycerols for titer improvement of polyketides in Streptomyces

(2019) Weishan Wang et al.   NATURE BIOTECHNOLOGY

Integrated whole-genome and transcriptome sequence analysis reveals the genetic characteristics of a riboflavin-overproducing Bacillus subtilis

(2018) Guanglu Wang et al.   METABOLIC ENGINEERING

SbbR/SbbA, an Important ArpA/AfsA-Like System, Regulates Milbemycin Production in Streptomyces bingchenggensis

(2018) Hairong He et al.   Frontiers in Microbiology

CRISPR-Cpf1-Assisted Multiplex Genome Editing and Transcriptional Repression in Streptomyces

(2018) Lei Li et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

Toxicology of Avermectins and Milbemycins (Macrocyclic Lactones) and the Role of P-Glycoprotein in Dogs and Cats

(2018) Valentina M. Merola et al.   VETERINARY CLINICS OF NORTH AMERICA-SMALL ANIMAL PRACTICE

Engineered biosynthesis of milbemycins in the avermectin high-producing strain Streptomyces avermitilis

(2017) Myoun-Su Kim et al.   Microbial Cell Factories

Engineering Halomonas species TD01 for enhanced polyhydroxyalkanoates synthesis via CRISPRi

(2017) Wei Tao et al.   Microbial Cell Factories

Genome re-sequencing reveals the history of apple and supports a two-stage model for fruit enlargement

(2017) Naibin Duan et al.   Nature Communications

Combinatorial metabolic engineering using an orthogonal tri-functional CRISPR system

(2017) Jiazhang Lian et al.   Nature Communications

Role of GntR Family Regulatory Gene SCO1678 in Gluconate Metabolism in Streptomyces coelicolor M145

(2017) Olga Tsypik et al.   Biomed Research International

Transcriptomic analysis of a classical model of carbon catabolite regulation in Streptomyces coelicolor

(2016) Alba Romero-Rodríguez et al.   BMC MICROBIOLOGY

Enhanced salinomycin production by adjusting the supply of polyketide extender units in Streptomyces albus

(2016) Chenyang Lu et al.   METABOLIC ENGINEERING

Characterization of a pathway-specific activator of milbemycin biosynthesis and improved milbemycin production by its overexpression in Streptomyces bingchenggensis

(2016) Yanyan Zhang et al.   Microbial Cell Factories

Development of a Synthetic Oxytetracycline-Inducible Expression System for Streptomycetes Using de Novo Characterized Genetic Parts

(2016) Weishan Wang et al.   ACS Synthetic Biology

Advancing metabolic engineering through systems biology of industrial microorganisms

(2015) Zongjie Dai et al.   CURRENT OPINION IN BIOTECHNOLOGY

Field evaluation of the efficacy and safety of a combination of spinosad and milbemycin oxime in the treatment and prevention of naturally acquired flea infestations and treatment of intestinal nematode infections in dogs in Europe

(2015) Brad Hayes et al.   VETERINARY PARASITOLOGY

Combined application of plasma mutagenesis and gene engineering leads to 5-oxomilbemycins A3/A4 as main components from Streptomyces bingchenggensis

(2014) Hai-Yan Wang et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

Toward better understanding of artifacts in variant calling from high-coverage samples

(2014) Heng Li   BIOINFORMATICS

Comparative genomics revealed key molecular targets to rapidly convert a reference rifamycin-producing bacterial strain into an overproducer by genetic engineering

(2014) Clelia Peano et al.   METABOLIC ENGINEERING

Genetic engineering of Streptomyces bingchenggensis to produce milbemycins A3/A4 as main components and eliminate the biosynthesis of nanchangmycin

(2013) Ji Zhang et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

Complete genome sequence and comparative analysis of Acetobacter pasteurianus 386B, a strain well-adapted to the cocoa bean fermentation ecosystem

(2013) Koen Illeghems et al.   BMC GENOMICS

Comparative genomics of actinomycetes with a focus on natural product biosynthetic genes

(2013) James R Doroghazi et al.   BMC GENOMICS

Structure of NADP+-dependent glutamate dehydrogenase fromEscherichia coli - reflections on the basis of coenzyme specificity in the family of glutamate dehydrogenases

(2013) Michael A. Sharkey et al.   FEBS Journal

Characterization and analysis of an industrial strain of Streptomyces bingchenggensis by genome sequencing and gene microarray

(2013) Xiang-Jing Wang et al.   GENOME

Engineering precursor metabolite pools for increasing production of antitumor mithramycins in Streptomyces argillaceus

(2013) Daniel Zabala et al.   METABOLIC ENGINEERING

A combined approach of classical mutagenesis and rational metabolic engineering improves rapamycin biosynthesis and provides insights into methylmalonyl-CoA precursor supply pathway in Streptomyces hygroscopicus ATCC 29253

(2011) Won Seok Jung et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

Comparative genomic and transcriptomic analysis revealed genetic characteristics related to solvent formation and xylose utilization in Clostridium acetobutylicum EA 2018

(2011) Shiyuan Hu et al.   BMC GENOMICS

Metabolic Engineering for the Production of Natural Products

(2011) Lauren B. Pickens et al.   Annual Review of Chemical and Biomolecular Engineering

Cloning of Separate Meilingmycin Biosynthesis Gene Clusters by Use of Acyltransferase-Ketoreductase Didomain PCR Amplification

(2010) Y. He et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

Adaptive Evolution of Escherichia coli K-12 MG1655 during Growth on a Nonnative Carbon Source, L-1,2-Propanediol

(2010) D.-H. Lee et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

The Sequence Alignment/Map format and SAMtools

(2009) H. Li et al.   BIOINFORMATICS

Improvement of milbemycin-producing Streptomyces bingchenggensis by rational screening of ultraviolet- and chemically induced mutants

(2009) Xiang-Jing Wang et al.   WORLD JOURNAL OF MICROBIOLOGY & BIOTECHNOLOGY

Whole-genome resequencing of Escherichia coli K-12 MG1655 undergoing short-term laboratory evolution in lactate minimal media reveals flexible selection of adaptive mutations

(2009) Tom M Conrad et al.   GENOME BIOLOGY

Antibiotic Overproduction inStreptomyces coelicolorA3(2) Mediated by Phosphofructokinase Deletion

(2008) Irina Borodina et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Improving production of bioactive secondary metabolites in actinomycetes by metabolic engineering

(2008) Carlos Olano et al.   METABOLIC ENGINEERING

Production of the polyketide 6-MSA in yeast engineered for increased malonyl-CoA supply

(2008) Songsak Wattanachaisaereekul et al.   METABOLIC ENGINEERING