Mass spectrometry imaging in zebrafish larvae for assessing drug safety and metabolism

Universal Sample Preparation Unlocking Multimodal Molecular Tissue Imaging

(2020) Andreas Dannhorn et al.   ANALYTICAL CHEMISTRY

Yolk Sac of Zebrafish Embryos as Backpack for Chemicals?

(2020) Katharina Halbach et al.   ENVIRONMENTAL SCIENCE & TECHNOLOGY

Pneumatically Sprayed Gold Nanoparticles for Mass Spectrometry Imaging of Neurotransmitters

(2020) Nolan McLaughlin et al.   JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY

Drug Administration Routes Impact the Metabolism of a Synthetic Cannabinoid in the Zebrafish Larvae Model

(2020) Yu Mi Park et al.   MOLECULES

The use of zebrafish (Danio rerio) as biomedical models

(2019) Tsegay Teame et al.   Animal Frontiers

Antitumor Activity of a Binary EGFR/DNA Targeting Strategy Overcomes Resistance of Glioblastoma Stem cells to Temozolomide

(2019) Zeinab Sharifi et al.   CLINICAL CANCER RESEARCH

Use of Zebrafish in Drug Discovery Toxicology

(2019) Steven Cassar et al.   CHEMICAL RESEARCH IN TOXICOLOGY

The Case for Modeling Human Infection in Zebrafish

(2019) Margarida C. Gomes et al.   TRENDS IN MICROBIOLOGY

Evaluation of Drug Exposure and Metabolism in Locust and Zebrafish Brains Using Mass Spectrometry Imaging

(2018) Marvin Villacrez et al.   ACS Chemical Neuroscience

Imaging and spatially resolved quantification of drug distribution in tissues by mass spectrometry

(2018) Brendan Prideaux et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

Importance of Toxicokinetics to Assess the Utility of Zebrafish Larvae as Model for Psychoactive Drug Screening Using Meta-Chlorophenylpiperazine (mCPP) as Example

(2018) Krishna Tulasi Kirla et al.   Frontiers in Pharmacology

Metabolism of primaquine in normal human volunteers: investigation of phase I and phase II metabolites from plasma and urine using ultra-high performance liquid chromatography-quadrupole time-of-flight mass spectrometry

(2018) Bharathi Avula et al.   MALARIA JOURNAL

SAHAquines, Novel Hybrids Based on SAHA and Primaquine Motifs, as Potential Cytostatic and Antiplasmodial Agents

(2018) Maja Beus et al.   ChemistryOpen

Comparison of the In Vivo Biotransformation of Two Emerging Estrogenic Contaminants, BP2 and BPS, in Zebrafish Embryos and Adults

(2017) Vincent Le Fol et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Quantification of Estradiol Uptake in Zebrafish Embryos and Larvae

(2017) Jaclyn Paige Souder et al.   TOXICOLOGICAL SCIENCES

3D MALDI Mass Spectrometry Imaging of a Single Cell: Spatial Mapping of Lipids in the Embryonic Development of Zebrafish

(2017) Maria Emilia Dueñas et al.   Scientific Reports

Rapid and cost-effective xenograft hepatocellular carcinoma model in Zebrafish for drug testing

(2016) Federica Tonon et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

From the Cover: Zebrafish Larvae Are Insensitive to Stimulation by Cocaine: Importance of Exposure Route and Toxicokinetics

(2016) Krishna Tulasi Kirla et al.   TOXICOLOGICAL SCIENCES

Pharmacokinetic Modeling of Paracetamol Uptake and Clearance in Zebrafish Larvae: Expanding the Allometric Scale in Vertebrates with Five Orders of Magnitude

(2016) Vasudev Kantae et al.   Zebrafish

MALDI Imaging mass spectrometry: current frontiers and perspectives in pathology research and practice

(2015) Michaela Aichler et al.   LABORATORY INVESTIGATION

Zebrafish as tools for drug discovery

(2015) Calum A. MacRae et al.   NATURE REVIEWS DRUG DISCOVERY

Pharmacokinetics and Pharmacodynamics of (+)-Primaquine and (−)-Primaquine Enantiomers in Rhesus Macaques (Macaca mulatta)

(2014) David Saunders et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Scalable Preparation and Differential Pharmacologic and Toxicologic Profiles of Primaquine Enantiomers

(2014) N. P. Dhammika Nanayakkara et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Tissue-, sex- and development-specific transcription profiles of eight UDP-glucuronosyltransferase genes in zebrafish (Danio rerio) and their regulation by activator of aryl hydrocarbon receptor

(2014) Verena Christen et al.   AQUATIC TOXICOLOGY

Hooking the big one: the potential of zebrafish xenotransplantation to reform cancer drug screening in the genomic era

(2014) C. J. Veinotte et al.   Disease Models & Mechanisms

Phenothiazines induce PP2A-mediated apoptosis in T cell acute lymphoblastic leukemia

(2014) Alejandro Gutierrez et al.   JOURNAL OF CLINICAL INVESTIGATION

Zebrafish xenotransplantation model for cancer stem-like cell study and high-throughput screening of inhibitors

(2014) Beibei Zhang et al.   TUMOR BIOLOGY

The zebrafish reference genome sequence and its relationship to the human genome

(2013) Kerstin Howe et al.   NATURE

Zebrafish xenografts as a tool for in vivo studies on human cancer

(2012) Martina Konantz et al.   Annals of the New York Academy of Sciences

From Omics to Drug Metabolism and High Content Screen of Natural Product in Zebrafish: A New Model for Discovery of Neuroactive Compound

(2012) Ming Wai Hung et al.   Evidence-based Complementary and Alternative Medicine

Mass spectrometry imaging for drug distribution studies

(2012) Brendan Prideaux et al.   Journal of Proteomics

The developing zebrafish (Danio rerio): A vertebrate model for high-throughput screening of chemical libraries

(2011) Charles A. Lessman   BIRTH DEFECTS RESEARCH PART C-EMBRYO TODAY-REVIEWS

Zebrafish embryos as an alternative to animal experiments—A commentary on the definition of the onset of protected life stages in animal welfare regulations

(2011) Uwe Strähle et al.   REPRODUCTIVE TOXICOLOGY

MALDI imaging mass spectrometry: bridging biology and chemistry in drug development

(2011) Stephen Castellino et al.   Bioanalysis

Analysis of primaquine and its metabolite carboxyprimaquine in biological samples: enantiomeric separation, method validation and quantification

(2010) Bharathi Avula et al.   BIOMEDICAL CHROMATOGRAPHY

How to improve R&D productivity: the pharmaceutical industry's grand challenge

(2010) Steven M. Paul et al.   NATURE REVIEWS DRUG DISCOVERY

The yolk syncytial layer in early zebrafish development

(2010) Lara Carvalho et al.   TRENDS IN CELL BIOLOGY

Characterization of UGTs Active against SAHA and Association between SAHA Glucuronidation Activity Phenotype with UGT Genotype

(2009) R. M. Balliet et al.   CANCER RESEARCH

MALDI imaging mass spectrometry for direct tissue analysis: a new frontier for molecular histology

(2008) Axel Walch et al.   HISTOCHEMISTRY AND CELL BIOLOGY

Zebrafish based assays for the assessment of cardiac, visual and gut function — potential safety screens for early drug discovery

(2008) Stéphane Berghmans et al.   JOURNAL OF PHARMACOLOGICAL AND TOXICOLOGICAL METHODS