SAHAquines, Novel Hybrids Based on SAHA and Primaquine Motifs, as Potential Cytostatic and Antiplasmodial Agents

Primaquine hybrids as promising antimycobacterial and antimalarial agents

(2018) Kristina Pavić et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Comprehensive review on various strategies for antimalarial drug discovery

(2017) Mitali Mishra et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Artemisinin as an anticancer drug: Recent advances in target profiling and mechanisms of action

(2017) Yin Kwan Wong et al.   MEDICINAL RESEARCH REVIEWS

Induction of autophagy and autophagy-dependent apoptosis in diffuse large B-cell lymphoma by a new antimalarial artemisinin derivative, SM1044

(2017) Chunyan Cheng et al.   Cancer Medicine

Research progress of hydroxychloroquine and autophagy inhibitors on cancer

(2016) Ting-Ting Shi et al.   CANCER CHEMOTHERAPY AND PHARMACOLOGY

A Quinacrine Analogue Selective Against Gastric Cancer Cells: Insight from Biochemical and Biophysical Studies

(2016) Ana Gomes et al.   ChemMedChem

Hybrid molecules: The privileged scaffolds for various pharmaceuticals

(2016) Shaveta et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Novel urea and bis -urea primaquine derivatives with hydroxyphenyl or halogenphenyl substituents: Synthesis and biological evaluation

(2016) I. Perković et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Design, Synthesis and Biological Evaluation of Novel Primaquine-Cinnamic Acid Conjugates of the Amide and Acylsemicarbazide Type

(2016) Kristina Pavić et al.   MOLECULES

From hybrid compounds to targeted drug delivery in antimalarial therapy

(2015) Rudi Oliveira et al.   BIOORGANIC & MEDICINAL CHEMISTRY

N-Cinnamoylation of Antimalarial Classics: Effects of Using Acyl Groups Other than Cinnamoyl toward Dual-Stage Antimalarials

(2015) Ana Gomes et al.   ChemMedChem

Anti-malarial effect of semi-synthetic drug amitozyn

(2015) Sergey O. Tcherniuk et al.   MALARIA JOURNAL

Chloroquine potentiates the anti-cancer effect of lidamycin on non-small cell lung cancer cells in vitro

(2014) Fang Liu et al.   ACTA PHARMACOLOGICA SINICA

Lysine Acetylation in Sexual Stage Malaria Parasites Is a Target for Antimalarial Small Molecules

(2014) Katharine Trenholme et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Antimalarial Activity of the Myxobacterial Macrolide Chlorotonil A

(2014) Jana Held et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Inhibition of autophagy by chloroquine potentiates synergistically anti-cancer property of artemisinin by promoting ROS dependent apoptosis

(2014) Arnab Ganguli et al.   BIOCHIMIE

“Recycling” Classical Drugs for Malaria

(2014) Cátia Teixeira et al.   CHEMICAL REVIEWS

Novel semicarbazides and ureas of primaquine with bulky aryl or hydroxyalkyl substituents: Synthesis, cytostatic and antioxidative activity

(2014) K. Pavić et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Anticancer Properties of Distinct Antimalarial Drug Classes

(2014) Rob Hooft van Huijsduijnen et al.   PLoS One

Sloth Hair as a Novel Source of Fungi with Potent Anti-Parasitic, Anti-Cancer and Anti-Bacterial Bioactivity

(2014) Sarah Higginbotham et al.   PLoS One

Relationship between Plasmodium falciparum malaria prevalence, genetic diversity and endemic Burkitt lymphoma in Malawi

(2014) W. Thomas Johnston et al.   Scientific Reports

Computational Biorheology of Human Blood Flow in Health and Disease

(2013) Dmitry A. Fedosov et al.   ANNALS OF BIOMEDICAL ENGINEERING

The discovery of colchicine-SAHA hybrids as a new class of antitumor agents

(2013) Xuan Zhang et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Recycling antimalarial leads for cancer: Antiproliferative properties of N-cinnamoyl chloroquine analogues

(2013) Bianca C. Pérez et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

The Effect of Various Zinc Binding Groups on Inhibition of Histone Deacetylases 1-11

(2013) Andreas S. Madsen et al.   ChemMedChem

Benzotriazole as a Synthetic Auxiliary

(2013) Branka Zorc et al.   CROATICA CHEMICA ACTA

Novel approaches in antimalarial drug discovery

(2013) Jana Held et al.   Expert Opinion on Drug Discovery

Histone Deacetylase (HDAC) Inhibitor Kinetic Rate Constants Correlate with Cellular Histone Acetylation but Not Transcription and Cell Viability

(2013) Benjamin E. L. Lauffer et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The metabolism of primaquine to its active metabolite is dependent on CYP 2D6

(2013) Brandon S Pybus et al.   MALARIA JOURNAL

Discovery of anticancer drugs from antimalarial natural products: a MEDLINE literature review

(2012) Robert Duffy et al.   DRUG DISCOVERY TODAY

Synthesis, evaluation of anticancer activity and COMPARE analysis of N-bis(trifluoromethyl)alkyl-N’-substituted ureas with pharmacophoric moieties

(2012) Elena L. Luzina et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Novel 1-acyl-4-substituted semicarbazide derivatives of primaquine − synthesis, cytostatic, antiviral and antioxidative studies

(2012) Ivana Perković et al.   JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY

HDAC inhibitors in parasitic diseases

(2011) Katherine T Andrews et al.   IMMUNOLOGY AND CELL BIOLOGY

Histone Deacetylases Play a Major Role in the Transcriptional Regulation of the Plasmodium falciparum Life Cycle

(2010) Balbir K. Chaal et al.   PLoS Pathogens

Urea and carbamate derivatives of primaquine: Synthesis, cytostatic and antioxidant activities

(2009) M. Šimunović et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Targeting Histone Deacetylase Inhibitors for Anti-Malarial Therapy

(2009) Katherine Andrews et al.   CURRENT TOPICS IN MEDICINAL CHEMISTRY

Transcriptional profiling of growth perturbations of the human malaria parasite Plasmodium falciparum

(2009) Guangan Hu et al.   NATURE BIOTECHNOLOGY

Identification of KD5170: A novel mercaptoketone-based histone deacetylase inhibitor

(2008) Joseph E. Payne et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Potent and selective antiplasmodial activity of the cyanobacterial alkaloid nostocarboline and its dimers

(2008) Damien Barbaras et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Primaquine revisited six decades after its discovery

(2008) Nuno Vale et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Comprehensive study of proteasome inhibitors against Plasmodium falciparum laboratory strains and field isolates from Gabon

(2008) Andrea Kreidenweiss et al.   MALARIA JOURNAL

The novel primaquine derivatives of N-alkyl, cycloalkyl or aryl urea: Synthesis, cytostatic and antiviral activity evaluations

(2007) G. Džimbeg et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Anticancer properties of artemisinin derivatives and their targeted delivery by transferrin conjugation

(2007) Ikuhiko Nakase et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS