Molecular targets for antifungals in amino acid and protein biosynthetic pathways
Published 2021 View Full Article
- Home
- Publications
- Publication Search
- Publication Details
Title
Molecular targets for antifungals in amino acid and protein biosynthetic pathways
Authors
Keywords
-
Journal
AMINO ACIDS
Volume 53, Issue 7, Pages 961-991
Publisher
Springer Science and Business Media LLC
Online
2021-06-03
DOI
10.1007/s00726-021-03007-6
References
Ask authors/readers for more resources
Related references
Note: Only part of the references are listed.- Host-induced gene silencing of the acetolactate synthases VdILV2 and VdILV6 confers resistance to Verticillium wilt in cotton (Gossypium hirsutum L.)
- (2020) Chunyan Wei et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- Inhibition of Nonessential Bacterial Targets: Discovery of a Novel Serine O-Acetyltransferase Inhibitor
- (2020) Joana Magalhães et al. ACS Medicinal Chemistry Letters
- Fungal diseases as neglected pathogens: A wake-up call to public health officials
- (2020) Marcio L. Rodrigues et al. PLoS Neglected Tropical Diseases
- Lysine acetylation as drug target in fungi: an underexplored potential in Aspergillus spp.
- (2020) Natália Sayuri Wassano et al. BRAZILIAN JOURNAL OF MICROBIOLOGY
- Discovery of Novel Fungal Lanosterol 14α-Demethylase (CYP51)/Histone Deacetylase Dual Inhibitors to Treat Azole-Resistant Candidiasis
- (2020) Guiyan Han et al. JOURNAL OF MEDICINAL CHEMISTRY
- Aminoacyl-tRNA Synthetases
- (2020) Miguel Angel Rubio Gomez et al. RNA
- A semisynthetic borrelidin analogue BN-3b exerts potent antifungal activity against Candida albicans through ROS-mediated oxidative damage
- (2020) Hao Su et al. Scientific Reports
- Antifungal Peptides as Therapeutic Agents
- (2020) Miguel Fernández de Ullivarri et al. Frontiers in Cellular and Infection Microbiology
- Antifungal Drugs
- (2020) Jiří Houšť et al. Metabolites
- Antifungal symbiotic peptide NCR044 exhibits unique structure and multifaceted mechanisms of action that confer plant protection
- (2020) Siva L. S. Velivelli et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- New 4-methoxy-naphthalene derivatives as promisor antifungal agents for paracoccidioidomycosis treatment
- (2019) Mariane C Bagatin et al. Future Microbiology
- Insights into multifaceted activities of CysK for therapeutic interventions
- (2019) Pallavi Joshi et al. 3 Biotech
- High value-added application of sustainable natural forest product α-pinene: synthesis of myrtenal oxime esters as potential KARI inhibitors
- (2019) Gui-Shan Lin et al. ACS Sustainable Chemistry & Engineering
- Synthesis of Simplified Azasordarin Analogs as Potential Antifungal Agents
- (2019) Yibiao Wu et al. JOURNAL OF ORGANIC CHEMISTRY
- Computational identification and antifungal bioassay reveals phytosterols as potential inhibitor of Alternaria arborescens
- (2019) Prassan Choudhary et al. JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS
- FgIlv3a is crucial in branched-chain amino acid biosynthesis, vegetative differentiation, and virulence in Fusarium graminearum
- (2019) Xin Liu et al. JOURNAL OF MICROBIOLOGY
- Titrating Gene Function in the Human Fungal Pathogen Candida albicans through Poly-Adenosine Tract Insertion
- (2019) Helene Tournu et al. mSphere
- Mechanism and Inhibitor Exploration for Binuclear Mg Ketol‐acid Reductoisomerase: Targeting on the Biosynthetic Pathway of Branched‐chain Amino Acids
- (2019) Ming-Jia Yu et al. CHEMBIOCHEM
- Design, synthesis and SAR study of novel sulfonylurea derivatives containing arylpyrimidine moieties as potential anti-phytopathogenic fungal agents
- (2019) Wei Chen et al. CHINESE CHEMICAL LETTERS
- Identification of O ‐acetylhomoserine sulfhydrylase, a putative enzyme responsible for methionine biosynthesis in Clostridioides difficile : Gene cloning and biochemical characterizations
- (2019) Vitalia V. Kulikova et al. IUBMB LIFE
- Characterization of serine acetyltransferase (CysE) from methicillin-resistant Staphylococcus aureus and inhibitory effect of two natural products on CysE
- (2019) Changming Chen et al. MICROBIAL PATHOGENESIS
- A Histone Acetyltransferase Inhibitor with Antifungal Activity against CTG clade Candida Species
- (2019) Tscherner et al. Microorganisms
- New inhibitors of chorismate synthase present antifungal activity against Paracoccidioides brasiliensis
- (2019) Paulo SA Bueno et al. Future Microbiology
- Sordarin Diterpene Glycosides with an Unusual 1,3-Dioxolan-4-one Ring from the Zoanthid-Derived Fungus Curvularia hawaiiensis TA26-15
- (2019) Meng-Qi Zhang et al. JOURNAL OF NATURAL PRODUCTS
- Design, Synthesis and Antifungal Activity of Benzofuran and Its Analogues
- (2019) Hang Xu et al. CHINESE JOURNAL OF CHEMISTRY
- New inhibitors of homoserine dehydrogenase from Paracoccidioides brasiliensis presenting antifungal activity
- (2019) Paulo Sérgio Alves Bueno et al. JOURNAL OF MOLECULAR MODELING
- The regulation of the sulfur amino acid biosynthetic pathway in Cryptococcus neoformans: the relationship of Cys3, Calcineurin, and Gpp2 phosphatases
- (2019) Amanda Teixeira de Melo et al. Scientific Reports
- Structural analysis of mycobacterial homoserine transacetylases central to methionine biosynthesis reveals druggable active site
- (2019) Catherine T. Chaton et al. Scientific Reports
- Development and validation of a rapid, selective, and sensitive LC–MS/MS method for simultaneous determination of d- and l-amino acids in human serum: application to the study of hepatocellular carcinoma
- (2018) Minlu Han et al. ANALYTICAL AND BIOANALYTICAL CHEMISTRY
- Leishmania parasites are inhibited by the benzoxaborole AN2690 targeting leucyl-tRNA synthetase
- (2018) Reetika Manhas et al. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
- Crystal Structures of Cystathionine β-Synthase from Saccharomyces cerevisiae: One Enzymatic Step at a Time
- (2018) Yupeng Tu et al. BIOCHEMISTRY
- Synthesis and evaluation of antimicrobial, antitubercular and anticancer activities of 2-(1-benzoyl-1H-benzo[d]imidazol-2-ylthio)-N-substituted acetamides
- (2018) Snehlata Yadav et al. Chemistry Central Journal
- Amino Acid Metabolism and Transport Mechanisms as Potential Antifungal Targets
- (2018) Matthew McCarthy et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- Bafilomycin C1 exert antifungal effect through disturbing sterol biosynthesis in Candida albicans
- (2018) Hao Su et al. JOURNAL OF ANTIBIOTICS
- Emerging New Targets for the Treatment of Resistant Fungal Infections
- (2018) Na Liu et al. JOURNAL OF MEDICINAL CHEMISTRY
- Candida albicans Aro1 affects cell wall integrity, biofilm formation and virulence
- (2018) Ying-Chieh Yeh et al. JOURNAL OF MICROBIOLOGY IMMUNOLOGY AND INFECTION
- Antifungal dipeptides incorporating an inhibitor of homoserine dehydrogenase
- (2018) Andrzej S. Skwarecki et al. JOURNAL OF PEPTIDE SCIENCE
- Molecular and biological characterization of Sclerotinia sclerotiorum resistant to the anilinopyrimidine fungicide cyprodinil
- (2018) Yi-Ping Hou et al. PESTICIDE BIOCHEMISTRY AND PHYSIOLOGY
- How we approach combination antifungal therapy for invasive aspergillosis and mucormycosis in transplant recipients
- (2018) Ghady Haidar et al. TRANSPLANTATION
- A Fragment Library Screening Approach to Identify Selective Inhibitors against an Essential Fungal Enzyme
- (2018) Gopal P. Dahal et al. SLAS Discovery
- Low in Vitro Antifungal Activity of Tavaborole Against Yeasts and Moulds from Onychomycosis
- (2018) Mahdi Abastabar et al. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
- Structural insights into inhibitor binding to a fungal ortholog of aspartate semialdehyde dehydrogenase
- (2018) Gopal P. Dahal et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- Resistance-gene-directed discovery of a natural-product herbicide with a new mode of action
- (2018) Yan Yan et al. NATURE
- Commercial AHAS-inhibiting herbicides are promising drug leads for the treatment of human fungal pathogenic infections
- (2018) Mario D. Garcia et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Synthesis of a novel bicyclic scaffold inspired by the antifungal natural product sordarin
- (2018) Yibiao Wu et al. TETRAHEDRON LETTERS
- Rational Discovery of (+) (S) Abscisic Acid as a Potential Antifungal Agent: a Repurposing Approach
- (2018) Mohammed A. Khedr et al. Scientific Reports
- Promising New Antifungal Treatment Targeting Chorismate Synthase from Paracoccidioides brasiliensis
- (2018) Franciele Abigail Vilugron Rodrigues-Vendramini et al. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
- Isopropylmalate isomerase MoLeu1 orchestrates leucine biosynthesis, fungal development, and pathogenicity in Magnaporthe oryzae
- (2018) Wei Tang et al. APPLIED MICROBIOLOGY AND BIOTECHNOLOGY
- Design, synthesis and antifungal evaluation of borrelidin derivatives
- (2018) Caijuan Hu et al. BIOORGANIC & MEDICINAL CHEMISTRY
- Chemical preparation, biological evaluation and 3D-QSAR of ethoxysulfuron derivatives as novel antifungal agents targeting acetohydroxyacid synthase
- (2018) Ren-Jun Wu et al. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
- Structural Insights into Substrate Specificity of Cystathionine γ-Synthase from Corynebacterium glutamicum
- (2017) Hye-Young Sagong et al. JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
- Methionine synthase is localized to the nucleus inPichia pastorisandCandida albicansand to the cytoplasm inSaccharomyces cerevisiae
- (2017) Umakant Sahu et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Candida albicans Hom6 is a homoserine dehydrogenase involved in protein synthesis and cell adhesion
- (2017) Pei-Wen Tsai et al. JOURNAL OF MICROBIOLOGY IMMUNOLOGY AND INFECTION
- A Novel Antibiotic Mechanism of l-Cyclopropylalanine Blocking the Biosynthetic Pathway of Essential Amino Acid l-Leucine
- (2017) Bingji Ma et al. MOLECULES
- The MetaCyc database of metabolic pathways and enzymes
- (2017) Ron Caspi et al. NUCLEIC ACIDS RESEARCH
- Genetic variation in Dip5, an amino acid permease, and Pdr5, a multiple drug transporter, regulates glyphosate resistance in S. cerevisiae
- (2017) Xiaoqing Rong-Mullins et al. PLoS One
- Identification of Genes in Saccharomyces cerevisiae that Are Haploinsufficient for Overcoming Amino Acid Starvation
- (2017) Nancy S. Bae et al. G3-Genes Genomes Genetics
- Antifungal resistance: current trends and future strategies to combat
- (2017) Nathan Wiederhold Infection and Drug Resistance
- Stop neglecting fungi
- (2017) Nature Microbiology
- Emerging aspergillosis by azole-resistantAspergillus fumigatusat an intensive care unit in the Netherlands, 2010 to 2013
- (2016) Judith van Paassen et al. Eurosurveillance
- Mechanism and Regulation of Protein Synthesis in Saccharomyces cerevisiae
- (2016) Thomas E. Dever et al. GENETICS
- Exploration of Sulfur Assimilation of Aspergillus fumigatus Reveals Biosynthesis of Sulfur-Containing Amino Acids as a Virulence Determinant
- (2016) Jorge Amich et al. INFECTION AND IMMUNITY
- Structure-based designing of sordarin derivative as potential fungicide with pan-fungal activity
- (2016) Biprashekhar Chakraborty et al. JOURNAL OF MOLECULAR GRAPHICS & MODELLING
- Bafilomycins and Odoriferous Sesquiterpenoids from Streptomyces albolongus Isolated from Elephas maximus Feces
- (2016) Nan Ding et al. JOURNAL OF NATURAL PRODUCTS
- Design, Synthesis and Antifungal Activity of Novel Benzofuran-Triazole Hybrids
- (2016) Zhen Liang et al. MOLECULES
- Design, synthesis and SAR study of novel sulfonylureas containing an alkenyl moiety
- (2016) Wei Wei et al. ORGANIC & BIOMOLECULAR CHEMISTRY
- Fungal KATs/KDACs: A New Highway to Better Antifungal Drugs?
- (2016) Karl Kuchler et al. PLoS Pathogens
- Mechanism and Regulation of Protein Synthesis in Saccharomyces cerevisiae
- (2016) Thomas E. Dever et al. GENETICS
- Tavaborole – a treatment for onychomycosis of the toenails
- (2016) Aditya K. Gupta et al. Expert Review of Clinical Pharmacology
- “Zipped Synthesis” by Cross-Metathesis Provides a Cystathionine β-Synthase Inhibitor that Attenuates Cellular H2S Levels and Reduces Neuronal Infarction in a Rat Ischemic Stroke Model
- (2016) Christopher D. McCune et al. ACS Central Science
- DNA replication inhibitor hydroxyurea alters Fe-S centers by producing reactive oxygen species in vivo
- (2016) Meng-Er Huang et al. Scientific Reports
- N-Myristoyltransferase Is a Cell Wall Target in Aspergillus fumigatus
- (2015) Wenxia Fang et al. ACS Chemical Biology
- Azole Resistance inAspergillus fumigatus: Can We Retain the Clinical Use of Mold-Active Antifungal Azoles?
- (2015) Paul E. Verweij et al. CLINICAL INFECTIOUS DISEASES
- In vitro activity of a Hos2 deacetylase inhibitor, MGCD290, in combination with echinocandins against echinocandin-resistant Candida species
- (2015) M.A. Pfaller et al. DIAGNOSTIC MICROBIOLOGY AND INFECTIOUS DISEASE
- Diversification of Paralogous α-Isopropylmalate Synthases by Modulation of Feedback Control and Hetero-Oligomerization in Saccharomyces cerevisiae
- (2015) Geovani López et al. EUKARYOTIC CELL
- Leu1 plays a role in iron metabolism and is required for virulence in Cryptococcus neoformans
- (2015) Eunsoo Do et al. FUNGAL GENETICS AND BIOLOGY
- Genesis of Azole Antifungal Resistance from Agriculture to Clinical Settings
- (2015) Maria-Manuel Azevedo et al. JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
- Involvement of BcS tr2 in methionine biosynthesis, vegetative differentiation, multiple stress tolerance and virulence in B otrytis cinerea
- (2015) Wenyong Shao et al. MOLECULAR PLANT PATHOLOGY
- The Role of Amino Acid Permeases and Tryptophan Biosynthesis in Cryptococcus neoformans Survival
- (2015) João Daniel Santos Fernandes et al. PLoS One
- Global analysis of fungal morphology exposes mechanisms of host cell escape
- (2015) Teresa R. O’Meara et al. Nature Communications
- Acetohydroxyacid synthase FgIlv2 and FgIlv6 are involved in BCAA biosynthesis, mycelial and conidial morphogenesis and full virulence in Fusarium graminearum
- (2015) Xin Liu et al. Scientific Reports
- The importance of chorismate mutase in the biocontrol potential of Trichoderma parareesei
- (2015) Esclaudys Pérez et al. Frontiers in Microbiology
- Tavaborole: First Global Approval
- (2014) Anthony Markham DRUGS
- Structural Analysis of a Fungal Methionine Synthase with Substrates and Inhibitors
- (2014) Devinder Ubhi et al. JOURNAL OF MOLECULAR BIOLOGY
- Disrupting the methionine biosynthetic pathway inCandida guilliermondii: characterization of theMET2gene as counter-selectable marker
- (2014) Erika J. Obando Montoya et al. YEAST
- Symbiotic Plant Peptides EliminateCandida albicansBothIn Vitroand in an Epithelial Infection Model and Inhibit the Proliferation of Immortalized Human Cells
- (2014) Lilla Ördögh et al. Biomed Research International
- The shikimate pathway: Review of amino acid sequence, function and three-dimensional structures of the enzymes
- (2013) Rafia Mir et al. CRITICAL REVIEWS IN MICROBIOLOGY
- Structural insights into the mechanism of translational inhibition by the fungicide sordarin
- (2013) Biprashekhar Chakraborty et al. JOURNAL OF COMPUTER-AIDED MOLECULAR DESIGN
- Structure-Guided Design of Novel Thiazolidine Inhibitors of O-Acetyl Serine Sulfhydrylase from Mycobacterium tuberculosis
- (2013) Ömer Poyraz et al. JOURNAL OF MEDICINAL CHEMISTRY
- Discovery of a potent benzoxaborole-based anti-pneumococcal agent targeting leucyl-tRNA synthetase
- (2013) Qing-Hua Hu et al. Scientific Reports
- Plant Defensins and Defensin-Like Peptides - Biological Activities and Biotechnological Applications
- (2012) Andre de Oliveira Carvalho et al. CURRENT PHARMACEUTICAL DESIGN
- Borrelidin, a Potent Antifungal Agent: Insight into the Antifungal Mechanism against Phytophthora sojae
- (2012) Ya-Mei Gao et al. JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
- Sulfonylureas Have Antifungal Activity and Are Potent Inhibitors of Candida albicans Acetohydroxyacid Synthase
- (2012) Yu-Ting Lee et al. JOURNAL OF MEDICINAL CHEMISTRY
- Amphotericin primarily kills yeast by simply binding ergosterol
- (2012) K. C. Gray et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Hidden Killers: Human Fungal Infections
- (2012) G. D. Brown et al. Science Translational Medicine
- Plant defensins: Common fold, multiple functions
- (2012) Nicole L. van der Weerden et al. Fungal Biology Reviews
- Biodiversity in sulfur metabolism in hemiascomycetous yeasts
- (2011) Agnès Hébert et al. FEMS YEAST RESEARCH
- Fungal Homoserine Kinase (thr1Δ) Mutants Are Attenuated in Virulence and Die Rapidly upon Threonine Starvation and Serum Incubation
- (2010) Joanne M. Kingsbury et al. EUKARYOTIC CELL
- Homoserine Toxicity in Saccharomyces cerevisiae and Candida albicans Homoserine Kinase (thr1Δ) Mutants
- (2010) Joanne M. Kingsbury et al. EUKARYOTIC CELL
- Glutathione biosynthesis in the yeast pathogens Candida glabrata and Candida albicans: essential in C. glabrata, and essential for virulence in C. albicans
- (2010) A. K. Yadav et al. MICROBIOLOGY-SGM
- Candida glabratatryptophan-based pigment production via the Ehrlich pathway
- (2010) Sascha Brunke et al. MOLECULAR MICROBIOLOGY
- Pathway analysis of Candida albicans survival and virulence determinants in a murine infection model
- (2010) J. M. Becker et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Silencing of Vlaro2 for chorismate synthase revealed that the phytopathogen Verticillium longisporum induces the cross-pathway control in the xylem
- (2009) Seema Singh et al. APPLIED MICROBIOLOGY AND BIOTECHNOLOGY
- Acute intentional self-poisoning with a herbicide product containing fenoxaprop-P-ethyl, ethoxysulfuron, and isoxadifen ethyl: a prospective observational study
- (2009) Shukry Zawahir et al. CLINICAL TOXICOLOGY
- Activity of MGCD290, a Hos2 Histone Deacetylase Inhibitor, in Combination with Azole Antifungals against Opportunistic Fungal Pathogens
- (2009) M. A. Pfaller et al. JOURNAL OF CLINICAL MICROBIOLOGY
- Cytocidal amino acid starvation of Saccharomyces cerevisiae and Candida albicans acetolactate synthase (ilv2 ) mutants is influenced by the carbon source and rapamycin
- (2009) J. M. Kingsbury et al. MICROBIOLOGY-SGM
- Proteomic analysis of cytoplasmic and surface proteins from yeast cells, hyphae, and biofilms of Candida albicans
- (2009) Montserrat Martínez-Gomariz et al. PROTEOMICS
- Recent patents in antifungal agent discovery
- (2008) Roberto Di Santo EXPERT OPINION ON THERAPEUTIC PATENTS
- A Novel Histone Acetyltransferase Inhibitor Modulating Gcn5 Network: Cyclopentylidene-[4-(4′-chlorophenyl)thiazol-2-yl)hydrazone
- (2008) Franco Chimenti et al. JOURNAL OF MEDICINAL CHEMISTRY
- Threonine biosynthetic genes are essential in Cryptococcus neoformans
- (2008) J. M. Kingsbury et al. MICROBIOLOGY-SGM
- Epidemiological trends in skin mycoses worldwide
- (2008) Blanka Havlickova et al. MYCOSES
- Emergence of Azole Resistance in Aspergillus fumigatus and Spread of a Single Resistance Mechanism
- (2008) Eveline Snelders et al. PLOS MEDICINE
Discover Peeref hubs
Discuss science. Find collaborators. Network.
Join a conversationAsk a Question. Answer a Question.
Quickly pose questions to the entire community. Debate answers and get clarity on the most important issues facing researchers.
Get Started