Insights into multifaceted activities of CysK for therapeutic interventions

Is perturbation in the quaternary structure of bacterial CysE, another regulatory mechanism for cysteine synthesis?

(2018) Deepali Verma et al.   INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

In-silico screening and validation of high-affinity tetra-peptide inhibitor of Leishmania donovani O-acetyl serine sulfhydrylase (OASS)

(2018) Vishnu Kant et al.   JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS

Discovery of novel fragments inhibiting O-acetylserine sulphhydrylase by combining scaffold hopping and ligand–based drug design

(2018) Joana Magalhães et al.   JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY

Inhibition of O-acetylserine sulfhydrylase by fluoroalanine derivatives

(2018) Nina Franko et al.   JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY

Discovery of Antiamebic Compounds That Inhibit Cysteine Synthase From the Enteric Parasitic Protist Entamoeba histolytica by Screening of Microbial Secondary Metabolites

(2018) Mihoko Mori et al.   Frontiers in Cellular and Infection Microbiology

Structural characterization and functional analysis of cystathionine β-synthase: an enzyme involved in the reverse transsulfuration pathway of Bacillus anthracis

(2017) Suneeta Devi et al.   FEBS Journal

Crystallographic and mutational analyses of cystathionine β-synthase in the H2 S-synthetic gene cluster in Lactobacillus plantarum

(2017) Yasuyuki Matoba et al.   PROTEIN SCIENCE

Structural insight into the interaction ofO-acetylserine sulfhydrylase with competitive, peptidic inhibitors by saturation transfer difference-NMR

(2016) Roberto Benoni et al.   FEBS LETTERS

SalmonellaTyphimurium exhibits fluoroquinolone resistance mediated by the accumulation of the antioxidant molecule H2S in a CysK-dependent manner

(2016) J. Frávega et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

Cyclopropane-1,2-dicarboxylic acids as new tools for the biophysical investigation of O-acetylserine sulfhydrylases by fluorimetric methods and saturation transfer difference (STD) NMR

(2016) Giannamaria Annunziato et al.   JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY

Rational Design, Synthesis, and Preliminary Structure–Activity Relationships of α-Substituted-2-Phenylcyclopropane Carboxylic Acids as Inhibitors of Salmonella typhimurium O-Acetylserine Sulfhydrylase

(2016) Marco Pieroni et al.   JOURNAL OF MEDICINAL CHEMISTRY

Unraveling the essential role of CysK in CDI toxin activation

(2016) Parker M. Johnson et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

CysK Plays a Role in Biofilm Formation and Colonization by Vibrio fischeri

(2015) Priyanka Singh et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

Pyridoxal-phosphate dependent mycobacterial cysteine synthases: Structure, mechanism and potential as drug targets

(2015) Robert Schnell et al.   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

Moonlighting O-acetylserine sulfhydrylase: New functions for an old protein

(2015) Barbara Campanini et al.   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

Structure-Based Design of Inhibitors of the Crucial Cysteine Biosynthetic Pathway Enzyme O-Acetyl Serine Sulfhydrylase

(2015) Mohit Mazumder et al.   CURRENT TOPICS IN MEDICINAL CHEMISTRY

Pyrazolo[3,4-d]pyrimidines as novel inhibitors of O-acetyl-l-serine sulfhydrylase of Entamoeba histolytica: an in silico study

(2015) Umesh Yadava et al.   JOURNAL OF MOLECULAR MODELING

Increasing the structural coverage of tuberculosis drug targets

(2015) Loren Baugh et al.   TUBERCULOSIS

Identification of natural inhibitors of Entamoeba histolytica cysteine synthase from microbial secondary metabolites

(2015) Mihoko Mori et al.   Frontiers in Microbiology

Inhibitors of the Sulfur Assimilation Pathway in Bacterial Pathogens as Enhancers of Antibiotic Therapy

(2014) Barbara Campanini et al.   CURRENT MEDICINAL CHEMISTRY

CysK2 from Mycobacterium tuberculosis Is an O-Phospho-L-Serine-Dependent S-Sulfocysteine Synthase

(2014) E. M. Steiner et al.   JOURNAL OF BACTERIOLOGY

Molecular basis of ligand recognition by OASS from E. histolytica: Insights from structural and molecular dynamics simulation studies

(2013) Isha Raj et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Structural and biochemical analyses of Microcystis aeruginosa O-acetylserine sulfhydrylases reveal a negative feedback regulation of cysteine biosynthesis

(2013) Mo Lu et al.   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

Discovery of novel inhibitors targeting the Mycobacterium tuberculosis O-acetylserine sulfhydrylase (CysK1) using virtual high-throughput screening

(2013) Variam Ullas Jean kumar et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Structure-Guided Design of Novel Thiazolidine Inhibitors of O-Acetyl Serine Sulfhydrylase from Mycobacterium tuberculosis

(2013) Ömer Poyraz et al.   JOURNAL OF MEDICINAL CHEMISTRY

Computational Insights into the Mechanism of Inhibition of OASS-A by a Small Molecule Inhibitor

(2013) Agostino Bruno et al.   Molecular Informatics

Isozyme-Specific Ligands for O-acetylserine sulfhydrylase, a Novel Antibiotic Target

(2013) Francesca Spyrakis et al.   PLoS One

Identification of a target cell permissive factor required for contact-dependent growth inhibition (CDI)

(2012) E. J. Diner et al.   GENES & DEVELOPMENT

Virtual Screening, Identification and In Vitro Testing of Novel Inhibitors of O-Acetyl-L-Serine Sulfhydrylase of Entamoeba histolytica

(2012) Isha Nagpal et al.   PLoS One

Allosterically Gated Enzyme Dynamics in the Cysteine Synthase Complex Regulate Cysteine Biosynthesis in Arabidopsis thaliana

(2012) Anna Feldman-Salit et al.   STRUCTURE

Design and synthesis of trans-2-substituted-cyclopropane-1-carboxylic acids as the first non-natural small molecule inhibitors of O-acetylserine sulfhydrylase

(2012) Laura Amori et al.   MedChemComm

CysK from Lactobacillus casei encodes a protein with O-acetylserine sulfhydrylase and cysteine desulfurization activity

(2011) Biljana Bogicevic et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

Structural and Biochemical Studies of Serine Acetyltransferase Reveal Why the ParasiteEntamoeba histolyticaCannot Form a Cysteine Synthase Complex

(2011) Sudhir Kumar et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

H2S: A Universal Defense Against Antibiotics in Bacteria

(2011) K. Shatalin et al.   SCIENCE

Toxin on a stick

(2011) Stephanie K. Aoki et al.   Virulence

Cysteine biosynthesis, oxidative stress and antibiotic resistance in Salmonella typhimurium

(2010) Amy L. Turnbull et al.   RESEARCH IN MICROBIOLOGY

Comprehensive identification of essential Staphylococcus aureus genes using Transposon-Mediated Differential Hybridisation (TMDH)

(2009) Roy R Chaudhuri et al.   BMC GENOMICS

Design ofO-Acetylserine Sulfhydrylase Inhibitors by Mimicking Nature

(2009) Enea Salsi et al.   JOURNAL OF MEDICINAL CHEMISTRY

Clinical Response and Outcome of Infection with Salmonella enterica Serotype Typhi with Decreased Susceptibility to Fluoroquinolones: a United States FoodNet Multicenter Retrospective Cohort Study

(2008) J. A. Crump et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

The CymR Regulator in Complex with the Enzyme CysK Controls Cysteine Metabolism inBacillus subtilis

(2008) Catherine Tanous et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

L-Cysteine is required for induced antibiotic resistance in actively swarming Salmonella enterica serovar Typhimurium

(2008) A. L. Turnbull et al.   MICROBIOLOGY-SGM

Crystal structure of native O-acetyl-serine sulfhydrylase from Entamoeba histolytica and its complex with cysteine: Structural evidence for cysteine binding and lack of interactions with serine acetyl transferase

(2008) Krishna Chinthalapudi et al.   PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS