DNA replication inhibitor hydroxyurea alters Fe-S centers by producing reactive oxygen species in vivo

Conserved electron donor complex Dre2-Tah18 is required for ribonucleotide reductase metallocofactor assembly and DNA synthesis

(2014) Y. Zhang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Genome-Wide Screening with Hydroxyurea Reveals a Link between Nonessential Ribosomal Proteins and Reactive Oxygen Species Production

(2013) T. Nakayashiki et al.   JOURNAL OF BACTERIOLOGY

Hydroxyurea Could Be a Good Clinically Relevant Iron Chelator

(2013) Khushnooma Italia et al.   PLoS One

Silver(I), Mercury(II), Cadmium(II), and Zinc(II) Target Exposed Enzymic Iron-Sulfur Clusters when They Toxify Escherichia coli

(2012) Fang Fang Xu et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

A S-adenosylmethionine methyltransferase-like domain within the essential, Fe-S-containing yeast protein Dre2

(2012) Nicolas Soler et al.   FEBS Journal

Redox-sensitive YFP sensors monitor dynamic nuclear and cytosolic glutathione redox changes

(2012) Michèle Dardalhon et al.   FREE RADICAL BIOLOGY AND MEDICINE

Proteolytic Degradation of the Yap1 Transcription Factor Is Regulated by Subcellular Localization and the E3 Ubiquitin Ligase Not4

(2012) Kailash Gulshan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cross talk between the nuclease and helicase activities of Dna2: role of an essential iron–sulfur cluster domain

(2012) Subhash Pokharel et al.   NUCLEIC ACIDS RESEARCH

Interactions Of Hydroxycarbamide (Hydroxyurea) With Iron And Copper: Implications On Toxicity and Therapeutic Strategies

(2011) Eleni Konstantinou et al.   HEMOGLOBIN

Interaction between the reductase Tah18 and highly conserved Fe-S containing Dre2 C-terminus is essential for yeast viability

(2011) Nicolas Soler et al.   MOLECULAR MICROBIOLOGY

Eukaryotic DNA polymerases require an iron-sulfur cluster for the formation of active complexes

(2011) Daili J A Netz et al.   Nature Chemical Biology

Fluorescent Protein-Based Redox Probes

(2010) Andreas J. Meyer et al.   ANTIOXIDANTS & REDOX SIGNALING

Thein VivoToxicity of Hydroxyurea Depends on Its Direct Target Catalase

(2010) Trine Juul et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Hydrogen peroxide inactivates the Escherichia coli Isc iron-sulphur assembly system, and OxyR induces the Suf system to compensate

(2010) Soojin Jang et al.   MOLECULAR MICROBIOLOGY

Tah18 transfers electrons to Dre2 in cytosolic iron-sulfur protein biogenesis

(2010) Daili J A Netz et al.   Nature Chemical Biology

Hydroxyurea Induces Hydroxyl Radical-Mediated Cell Death in Escherichia coli

(2009) Bryan W. Davies et al.   MOLECULAR CELL

A Newly Identified Essential Complex, Dre2-Tah18, Controls Mitochondria Integrity and Cell Death after Oxidative Stress in Yeast

(2009) Laurence Vernis et al.   PLoS One

The iron-sulfur clusters of dehydratases are primary intracellular targets of copper toxicity

(2009) L. Macomber et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Dre2, a Conserved Eukaryotic Fe/S Cluster Protein, Functions in Cytosolic Fe/S Protein Biogenesis

(2008) Y. Zhang et al.   MOLECULAR AND CELLULAR BIOLOGY

High-Quality Binary Protein Interaction Map of the Yeast Interactome Network

(2008) H. Yu et al.   SCIENCE