Amino Acid Metabolism and Transport Mechanisms as Potential Antifungal Targets

The Sphingosine 1-Phosphate Analogue FTY720 Alleviates Seizure-induced Overexpression of P-Glycoprotein in Rat Hippocampus

(2018) Fei Gao et al.   BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY

Biosynthesis of galactomannans found in filamentous fungi belonging to Pezizomycotina

(2018) Takuji Oka   BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY

Xylose donor transport is critical for fungal virulence

(2018) Lucy X. Li et al.   PLoS Pathogens

Drugs currently under investigation for the treatment of invasive candidiasis

(2017) Matthew W. McCarthy et al.   EXPERT OPINION ON INVESTIGATIONAL DRUGS

Drug development challenges and strategies to address emerging and resistant fungal pathogens

(2017) Matthew W. McCarthy et al.   Expert Review of Anti-Infective Therapy

GfsA is a β1,5-galactofuranosyltransferase involved in the biosynthesis of the galactofuran side chain of fungal-type galactomannan in Aspergillus fumigatus

(2017) Yukako Katafuchi et al.   GLYCOBIOLOGY

Epidemiology of antifungal resistance in human pathogenic yeasts: current viewpoint and practical recommendations for management

(2017) Dimitrios Farmakiotis et al.   INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS

Structure and function of yeast and fungal Na+ /H+ antiporters

(2017) Debajyoti Dutta et al.   IUBMB LIFE

WciG O -Acetyltransferase Functionality Differentiates Pneumococcal Serotypes 35C and 42

(2017) K. Aaron Geno et al.   JOURNAL OF CLINICAL MICROBIOLOGY

Future Research Priorities in Fungal Resistance

(2017) Matthew W McCarthy et al.   JOURNAL OF INFECTIOUS DISEASES

Novel Agents and Drug Targets to Meet the Challenges of Resistant Fungi

(2017) Matthew W McCarthy et al.   JOURNAL OF INFECTIOUS DISEASES

Fungal infections in patients treated with ibrutinib: two unusual cases of invasive aspergillosis and cryptococcal meningoencephalitis

(2017) Marine Baron et al.   LEUKEMIA & LYMPHOMA

Administration of FTY720 during Tourniquet-Induced Limb Ischemia Reperfusion Injury Attenuates Systemic Inflammation

(2017) Anthony D. Foster et al.   MEDIATORS OF INFLAMMATION

Effects of FTY720 on Lung Injury Induced by Hindlimb Ischemia Reperfusion in Rats

(2017) Liangrong Wang et al.   MEDIATORS OF INFLAMMATION

The antifungal pipeline: a reality check

(2017) John R. Perfect   NATURE REVIEWS DRUG DISCOVERY

RNA interference mediated knockdown of Brugia malayi UDP-Galactopyranose mutase severely affects parasite viability, embryogenesis and in vivo development of infective larvae

(2017) Sweta Misra et al.   Parasites & Vectors

Deciphering the sugar biosynthetic pathway and tailoring steps of nucleoside antibiotic A201A unveils a GDP-l-galactose mutase

(2017) Qinghua Zhu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

UDP-4-Keto-6-Deoxyglucose, a Transient Antifungal Metabolite, Weakens the Fungal Cell Wall Partly by Inhibition of UDP-Galactopyranose Mutase

(2017) Liang Ma et al.   mBio

FTY720-induced endocytosis of yeast and human amino acid transporters is preceded by reduction of their inherent activity and TORC1 inhibition

(2017) Céline Barthelemy et al.   Scientific Reports

ATP phosphoribosyltransferase from symbiont Entomomyces delphacidicola invovled in histidine biosynthesis of Nilaparvata lugens (Stål)

(2016) Pin-Jun Wan et al.   AMINO ACIDS

A Plasma Membrane Association Module in Yeast Amino Acid Transporters

(2016) Dušan Popov-Čeleketić et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Vacuolar amino acid transporters upregulated by exogenous proline and involved in cellular localization of proline in Saccharomyces cerevisiae

(2016) Ikuhisa Nishida et al.   JOURNAL OF GENERAL AND APPLIED MICROBIOLOGY

The anti-Aspergillusdrug pipeline: Is the glass half full or empty?: Table 1.

(2016) Nir Osherov et al.   MEDICAL MYCOLOGY

The Mechanistic Targets of Antifungal Agents: An Overview

(2016) Tryphon K. Mazu et al.   MINI-REVIEWS IN MEDICINAL CHEMISTRY

Histidine Regulates Seed Oil Deposition through Abscisic Acid Biosynthesis and β-oxidation

(2016) Huimin Ma et al.   PLANT PHYSIOLOGY

Functional Characterization of Pneumocystis carinii Inositol Transporter 1

(2016) Melanie T. Cushion et al.   mBio

Histidine biosynthesis plays a crucial role in metal homeostasis and virulence ofAspergillus fumigatus

(2016) Anna-Maria Dietl et al.   Virulence

Isavuconazonium sulfate: a new agent for the treatment of invasive aspergillosis and invasive mucormycosis

(2016) Laura L. Kovanda et al.   Expert Review of Clinical Pharmacology

Potential Targets for Antifungal Drug Discovery Based on Growth and Virulence in Candida albicans

(2015) Xiuyun Li et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Yeast Cyc8p and Tup1p proteins function as coactivators for transcription of Stp1/2p-dependent amino acid transporter genes

(2015) Naoko Tanaka et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Identification and functional analysis of two Golgi-localized UDP-galactofuranose transporters with overlapping functions in Aspergillus niger

(2015) Joohae Park et al.   BMC MICROBIOLOGY

Stereo- and Regiocontrolled Syntheses of Exomethylenic Cyclohexane β-Amino Acid Derivatives

(2015) Loránd Kiss et al.   MOLECULES

Constitutive Tor2 Activity Promotes Retention of the Amino Acid Transporter Agp3 at Trans-Golgi/Endosomes in Fission Yeast

(2015) Qingbin Liu et al.   PLoS One

Finding the Sweet Spot: How Human Fungal Pathogens Acquire and Turn the Sugar Inositol against Their Hosts: FIG 1 

(2015) Chaoyang Xue   mBio

Essential Gene Discovery in the Basidiomycete Cryptococcus neoformans for Antifungal Drug Target Prioritization

(2015) Giuseppe Ianiri et al.   mBio

The AP-3 adaptor complex mediates sorting of yeast and mammalian PQ-loop-family basic amino acid transporters to the vacuolar/lysosomal membrane

(2015) Elisa Llinares et al.   Scientific Reports

Mold Infections of the Central Nervous System

(2014) Matthew McCarthy et al.   NEW ENGLAND JOURNAL OF MEDICINE

Aspergillus nidulans Cell Wall Composition and Function Change in Response to Hosting Several Aspergillus fumigatus UDP-Galactopyranose Mutase Activity Mutants

(2014) Md Kausar Alam et al.   PLoS One

Comparative Genomics of Pneumocystis Species Suggests the Absence of Genes for myo- Inositol Synthesis and Reliance on Inositol Transport and Metabolism

(2014) Aleksey Porollo et al.   mBio

Structural diversity and biological significance of glycosphingolipids in pathogenic and opportunistic fungi

(2014) Luciana L. Guimarães et al.   Frontiers in Cellular and Infection Microbiology

Fingolimod (FTY720) Stimulates Ca2+/Calcineurin Signaling in Fission Yeast

(2013) Kanako Hagihara et al.   PLoS One

Synthesis of Highly Functionalized Fluorinated Cispentacin Derivatives

(2012) Melinda Nonn et al.   CHEMISTRY & BIODIVERSITY

A New Access Route to Functionalized Cispentacins from Norbornene β-Amino Acids

(2012) Loránd Kiss et al.   CHEMISTRY-A EUROPEAN JOURNAL

PneumocystisS-Adenosylmethionine Transport

(2011) Oscar Perez-Leal et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Roles of the Aspergillus nidulans UDP-galactofuranose transporter, UgtA in hyphal morphogenesis, cell wall architecture, conidiation, and drug sensitivity

(2011) Sharmin Afroz et al.   FUNGAL GENETICS AND BIOLOGY

S-Adenosylmethionine Levels in the Diagnosis of Pneumocystis carinii Pneumonia in Patients with HIV Infection

(2008) M. J. Skelly et al.   CLINICAL INFECTIOUS DISEASES