Promising New Antifungal Treatment Targeting Chorismate Synthase from Paracoccidioides brasiliensis

Neglected endemic mycoses

(2017) Flavio Queiroz-Telles et al.   LANCET INFECTIOUS DISEASES

Itraconazole in combination with neutrophil depletion reduces the expression of genes related to pulmonary fibrosis in an experimental model of paracoccidioidomycosis

(2017) Juan David Puerta-Arias et al.   MEDICAL MYCOLOGY

Evaluation of the hepatobiliary system in patients with paracoccidioidomycosis treated with cotrimoxazole or itraconazole

(2017) Adriele Dandara Levorato et al.   MEDICAL MYCOLOGY

Healthcare workers' hands as a vehicle for the transmission of virulent strains of Candida spp.: A virulence factor approach

(2017) Karina Mayumi Sakita et al.   MICROBIAL PATHOGENESIS

Hepatic Disease with Portal Hypertension and Acute Juvenile Paracoccidioidomycosis: A Report of Two Cases and Literature Review

(2017) Priscila Marques de Macedo et al.   MYCOPATHOLOGIA

Brazilian guidelines for the clinical management of paracoccidioidomycosis

(2017) Maria Aparecida Shikanai-Yasuda et al.   Revista da Sociedade Brasileira de Medicina Tropical

Targeting pathogen metabolism without collateral damage to the host

(2017) Jurgen R. Haanstra et al.   Scientific Reports

Propolis Is an Efficient Fungicide and Inhibitor of Biofilm Production by VaginalCandida albicans

(2015) Isis Regina Grenier Capoci et al.   Evidence-based Complementary and Alternative Medicine

BindingDB in 2015: A public database for medicinal chemistry, computational chemistry and systems pharmacology

(2015) Michael K. Gilson et al.   NUCLEIC ACIDS RESEARCH

Identification of New Antifungal Compounds Targeting Thioredoxin Reductase of Paracoccidioides Genus

(2015) Ana Karina Rodrigues Abadio et al.   PLoS One

Antifungal activity of 6-quinolinyl N-oxide chalcones against Paracoccidioides

(2014) Nívea Pereira de Sá et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

Itraconazole vs. trimethoprim–sulfamethoxazole: A comparative cohort study of 200 patients with paracoccidioidomycosis

(2014) Sheila Rocha Conceição Borges et al.   MEDICAL MYCOLOGY

Synergistic and Antagonistic Drug Combinations Depend on Network Topology

(2014) Ning Yin et al.   PLoS One

Antifungal Drug Development: Challenges, Unmet Clinical Needs, and New Approaches

(2014) T. Roemer et al.   Cold Spring Harbor Perspectives in Medicine

Paracoccidioidomycosis: eco-epidemiology, taxonomy and clinical and therapeutic issues

(2013) Anamelia Lorenzetti Bocca et al.   Future Microbiology

Homology modeling of dihydrofolate reductase from T. gondii bonded to antagonists: molecular docking and molecular dynamics simulations

(2013) Débora Pacheco Homem et al.   Molecular BioSystems

In Pulmonary Paracoccidioidomycosis IL-10 Deficiency Leads to Increased Immunity and Regressive Infection without Enhancing Tissue Pathology

(2013) Tânia A. Costa et al.   PLoS Neglected Tropical Diseases

ZINC: A Free Tool to Discover Chemistry for Biology

(2012) John J. Irwin et al.   Journal of Chemical Information and Modeling

Influence of Different Media, Incubation Times, and Temperatures for Determining the MICs of Seven Antifungal Agents against Paracoccidioides brasiliensis by Microdilution

(2012) R. C. Cruz et al.   JOURNAL OF CLINICAL MICROBIOLOGY

BRENDA in 2013: integrated reactions, kinetic data, enzyme function data, improved disease classification: new options and contents in BRENDA

(2012) Ida Schomburg et al.   NUCLEIC ACIDS RESEARCH

Paracoccidioidomycosis Epidemiological Features of a 1,000-Cases Series from a Hyperendemic Area on the Southeast of Brazil

(2011) Fernando Bellissimo-Rodrigues et al.   AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE

Structural analysis of chorismate synthase from Plasmodium falciparum: A novel target for antimalaria drug discovery

(2011) Satya Tapas et al.   INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

SwissParam: A fast force field generation tool for small organic molecules

(2011) Vincent Zoete et al.   JOURNAL OF COMPUTATIONAL CHEMISTRY

The ORCA program system

(2011) Frank Neese   Wiley Interdisciplinary Reviews-Computational Molecular Science

Comparative Genomic Analysis of Human Fungal Pathogens Causing Paracoccidioidomycosis

(2011) Christopher A. Desjardins et al.   PLoS Genetics

digital briefs

(2010) LAUREN K. WOLF   CHEMICAL & ENGINEERING NEWS

A synthetic peptide selectively kills only virulent Paracoccidioides brasiliensis yeasts

(2010) Erika Seki Kioshima et al.   MICROBES AND INFECTION

Combined itraconazole-pentoxifylline treatment promptly reduces lung fibrosis induced by chronic pulmonary paracoccidioidomycosis in mice

(2010) Tonny W. Naranjo et al.   PULMONARY PHARMACOLOGY & THERAPEUTICS

Antifungal activity of schinol and a new biphenyl compound isolated from Schinus terebinthifolius against the pathogenic fungus Paracoccidioides brasiliensis

(2010) Susana Johann et al.   Annals of Clinical Microbiology and Antimicrobials

pGenTHREADER and pDomTHREADER: new methods for improved protein fold recognition and superfamily discrimination

(2009) Anna Lobley et al.   BIOINFORMATICS

AutoDock4 and AutoDockTools4: Automated docking with selective receptor flexibility

(2009) Garrett M. Morris et al.   JOURNAL OF COMPUTATIONAL CHEMISTRY

Amphotericin B: side effects and toxicity

(2009) Rafael Laniado-Laborín et al.   REVISTA IBEROAMERICANA DE MICOLOGIA

Additive effect of P10 immunization and chemotherapy in anergic mice challenged intratracheally with virulent yeasts of Paracoccidioides brasiliensis

(2008) Alexandre F. Marques et al.   MICROBES AND INFECTION

Glyphosate: a once-in-a-century herbicide

(2008) Stephen O Duke et al.   PEST MANAGEMENT SCIENCE

Synergism between natural products and antibiotics against infectious diseases

(2008) Shanmugam Hemaiswarya et al.   PHYTOMEDICINE