Genetics of 35 blood and urine biomarkers in the UK Biobank

Using human genetics to understand the disease impacts of testosterone in men and women

(2020) Katherine S Ruth et al.   NATURE MEDICINE

Assessing Digital Phenotyping to Enhance Genetic Studies of Human Diseases

(2020) Christopher DeBoever et al.   AMERICAN JOURNAL OF HUMAN GENETICS

A fast and scalable framework for large-scale and ultrahigh-dimensional sparse regression with application to the UK Biobank

(2020) Junyang Qian et al.   PLoS Genetics

Clinical use of current polygenic risk scores may exacerbate health disparities

(2019) Alicia R. Martin et al.   NATURE GENETICS

Complex Trait Prediction from Genome Data: Contrasting EBV in Livestock to PRS in Humans

(2019) Naomi R. Wray et al.   GENETICS

Sex-specific and pleiotropic effects underlying kidney function identified from GWAS meta-analysis

(2019) Sarah E. Graham et al.   Nature Communications

1681-P: Polyendocrinopathy in Type 1 Diabetes: A Transatlantic Comparison

(2019) JULIA HERMANN et al.   DIABETES

A catalog of genetic loci associated with kidney function from analyses of a million individuals

(2019) Matthias Wuttke et al.   NATURE GENETICS

Phenome-wide Burden of Copy-Number Variation in the UK Biobank

(2019) Matthew Aguirre et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Components of genetic associations across 2,138 phenotypes in the UK Biobank highlight adipocyte biology

(2019) Yosuke Tanigawa et al.   Nature Communications

Homogeneity in the association of body mass index with type 2 diabetes across the UK Biobank: A Mendelian randomization study

(2019) Michael Wainberg et al.   PLOS MEDICINE

Detection of widespread horizontal pleiotropy in causal relationships inferred from Mendelian randomization between complex traits and diseases

(2018) Marie Verbanck et al.   NATURE GENETICS

Genetic analysis of quantitative traits in the Japanese population links cell types to complex human diseases

(2018) Masahiro Kanai et al.   NATURE GENETICS

Medical relevance of protein-truncating variants across 337,205 individuals in the UK Biobank study

(2018) Christopher DeBoever et al.   Nature Communications

Genome-wide association study in 79,366 European-ancestry individuals informs the genetic architecture of 25-hydroxyvitamin D levels

(2018) Xia Jiang et al.   Nature Communications

Identification and functional analysis of glycemic trait loci in the China Health and Nutrition Survey

(2018) Cassandra N. Spracklen et al.   PLoS Genetics

The MR-Base platform supports systematic causal inference across the human phenome

(2018) Gibran Hemani et al.   eLife

Genome-wide polygenic scores for common diseases identify individuals with risk equivalent to monogenic mutations

(2018) Amit V. Khera et al.   NATURE GENETICS

Improving the visualization, interpretation and analysis of two-sample summary data Mendelian randomization via the Radial plot and Radial regression

(2018) Jack Bowden et al.   INTERNATIONAL JOURNAL OF EPIDEMIOLOGY

Genomic Risk Prediction of Coronary Artery Disease in 480,000 Adults

(2018) Michael Inouye et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

The UK Biobank resource with deep phenotyping and genomic data

(2018) Clare Bycroft et al.   NATURE

Fine-mapping type 2 diabetes loci to single-variant resolution using high-density imputation and islet-specific epigenome maps

(2018) Anubha Mahajan et al.   NATURE GENETICS

Genetics of blood lipids among ~300,000 multi-ethnic participants of the Million Veteran Program

(2018) Derek Klarin et al.   NATURE GENETICS

The NHGRI-EBI GWAS Catalog of published genome-wide association studies, targeted arrays and summary statistics 2019

(2018) Annalisa Buniello et al.   NUCLEIC ACIDS RESEARCH

Open Targets Platform: new developments and updates two years on

(2018) Denise Carvalho-Silva et al.   NUCLEIC ACIDS RESEARCH

Increased High-Density Lipoprotein Levels Associated with Age-Related Macular Degeneration

(2018) Johanna M. Colijn et al.   OPHTHALMOLOGY

A note on the use of Egger regression in Mendelian randomization studies

(2017) Eric AW Slob et al.   INTERNATIONAL JOURNAL OF EPIDEMIOLOGY

Apolipoprotein status in type 2 diabetes mellitus and its complications

(2017) Puhong Zhang et al.   Molecular Medicine Reports

Exome chip meta-analysis identifies novel loci and East Asian–specific coding variants that contribute to lipid levels and coronary artery disease

(2017) Xiangfeng Lu et al.   NATURE GENETICS

Exome-wide association study of plasma lipids in >300,000 individuals

(2017) Dajiang J Liu et al.   NATURE GENETICS

A framework for the investigation of pleiotropy in two-sample summary data Mendelian randomization

(2017) Jack Bowden et al.   STATISTICS IN MEDICINE

Impact of common genetic determinants of Hemoglobin A1c on type 2 diabetes risk and diagnosis in ancestrally diverse populations: A transethnic genome-wide meta-analysis

(2017) Eleanor Wheeler et al.   PLOS MEDICINE

Diabetes inHFEHemochromatosis

(2017) James C. Barton et al.   Journal of Diabetes Research

Identification of 64 Novel Genetic Loci Provides an Expanded View on the Genetic Architecture of Coronary Artery Disease

(2017) Pim van der Harst et al.   CIRCULATION RESEARCH

1000 Genomes-based meta-analysis identifies 10 novel loci for kidney function

(2017) Mathias Gorski et al.   Scientific Reports

Contrasting the Genetic Architecture of 30 Complex Traits from Summary Association Data

(2016) Huwenbo Shi et al.   AMERICAN JOURNAL OF HUMAN GENETICS

FINEMAP: efficient variable selection using summary data from genome-wide association studies

(2016) Christian Benner et al.   BIOINFORMATICS

Genomic prediction of coronary heart disease

(2016) Gad Abraham et al.   EUROPEAN HEART JOURNAL

Four Susceptibility Loci for Gallstone Disease Identified in a Meta-analysis of Genome-Wide Association Studies

(2016) Amit D. Joshi et al.   GASTROENTEROLOGY

Personalized risk prediction for type 2 diabetes: the potential of genetic risk scores

(2016) Kristi Läll et al.   GENETICS IN MEDICINE

Cystatin C and Cardiovascular Disease

(2016) Sander W. van der Laan et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

A reference panel of 64,976 haplotypes for genotype imputation

(2016)   NATURE GENETICS

Association between serum cystatin C levels and the severity or potential risk factors of acute ischemic stroke

(2016) Guo-xiang Huang et al.   NEUROLOGICAL RESEARCH

Coding Variation in ANGPTL4, LPL, and SVEP1 and the Risk of Coronary Disease

(2016)   NEW ENGLAND JOURNAL OF MEDICINE

Genome-wide study for circulating metabolites identifies 62 loci and reveals novel systemic effects of LPA

(2016) Johannes Kettunen et al.   Nature Communications

Algorithms for the Capture and Adjudication of Prevalent and Incident Diabetes in UK Biobank

(2016) Sophie V Eastwood et al.   PLoS One

Trans-Ethnic Meta-Analysis Identifies Common and Rare Variants Associated with Hepatocyte Growth Factor Levels in the Multi-Ethnic Study of Atherosclerosis (MESA)

(2015) Nicholas B. Larson et al.   ANNALS OF HUMAN GENETICS

Genome-wide Association Studies Identify Genetic Loci Associated With Albuminuria in Diabetes

(2015) Alexander Teumer et al.   DIABETES

Measures of Obesity and Risk of Crohnʼs Disease and Ulcerative Colitis

(2015) Hamed Khalili et al.   INFLAMMATORY BOWEL DISEASES

LD Score regression distinguishes confounding from polygenicity in genome-wide association studies

(2015) Brendan K Bulik-Sullivan et al.   NATURE GENETICS

Discovery and Fine-Mapping of Glycaemic and Obesity-Related Trait Loci Using High-Density Imputation

(2015) Momoko Horikoshi et al.   PLoS Genetics

Second-generation PLINK: rising to the challenge of larger and richer datasets

(2015) Christopher C Chang et al.   GigaScience

Regularization Paths for Generalized Linear Models via Coordinate Descent

(2015) Jerome Friedman et al.   Journal of Statistical Software

Association of Low-Frequency and Rare Coding-Sequence Variants with Blood Lipids and Coronary Heart Disease in 56,000 Whites and Blacks

(2014) Gina M. Peloso et al.   AMERICAN JOURNAL OF HUMAN GENETICS

A New Equation to Estimate Glomerular Filtration Rate

(2013) Andrew S. Levey et al.   ANNALS OF INTERNAL MEDICINE

Discovery and refinement of loci associated with lipid levels

(2013) Cristen J Willer et al.   NATURE GENETICS

The origin of circulating CD36 in type 2 diabetes

(2013) M J Alkhatatbeh et al.   Nutrition & Diabetes

High glucose concentrations induce TNF-α production through the down-regulation of CD33 in primary human monocytes

(2012) Yolanda Gonzalez et al.   BMC IMMUNOLOGY

Meta-analysis identifies multiple loci associated with kidney function–related traits in east Asian populations

(2012) Yukinori Okada et al.   NATURE GENETICS

Large-scale association analyses identify new loci influencing glycemic traits and provide insight into the underlying biological pathways

(2012) Robert A Scott et al.   NATURE GENETICS

Apolipoprotein A-IV improves glucose homeostasis by enhancing insulin secretion

(2012) F. Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

BEDTools: a flexible suite of utilities for comparing genomic features

(2010) Aaron R. Quinlan et al.   BIOINFORMATICS

Treatment-effect estimates adjusted for small-study effects via a limit meta-analysis

(2010) G. Rucker et al.   BIOSTATISTICS

Serum Cystatin C Level, Kidney Disease Markers, and Incidence of Age-Related Macular Degeneration

(2009) Ronald Klein   ARCHIVES OF OPHTHALMOLOGY

Evaluation of Urinary Biomarkers for Coronary Artery Disease, Diabetes, and Diabetic Kidney Disease

(2009) Janet K. Snell-Bergeon et al.   Diabetes Technology & Therapeutics

Identification of a urate transporter, ABCG2, with a common functional polymorphism causing gout

(2009) O. M. Woodward et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA