Engineering Extracellular Vesicles Restore the Impaired Cellular Uptake and Attenuate Intervertebral Disc Degeneration

A Review on the Adaption of Alginate-Gelatin Hydrogels for 3D Cultures and Bioprinting

(2021) Magdalena B. Łabowska et al.   Materials

Meet me halfway: Are in vitro 3D cancer models on the way to replace in vivo models for nanomedicine development?

(2021) Sabina Pozzi et al.   ADVANCED DRUG DELIVERY REVIEWS

Metformin facilitates mesenchymal stem cell-derived extracellular nanovesicles release and optimizes therapeutic efficacy in intervertebral disc degeneration

(2021) Zhiwei Liao et al.   BIOMATERIALS

Autophagic Degradation of Gasdermin D Protects against Nucleus Pulposus Cell Pyroptosis and Retards Intervertebral Disc Degeneration In Vivo

(2021) Zhiwei Liao et al.   Oxidative Medicine and Cellular Longevity

Extracellular Vesicles from Mesenchymal Stem Cells as Novel Treatments for Musculoskeletal Diseases

(2020) María José Alcaraz et al.   Cells

Therapeutic Potential of Extracellular Vesicles in Degenerative Diseases of the Intervertebral Disc

(2020) Nathan Piazza et al.   Frontiers in Bioengineering and Biotechnology

Propionibacterium acnes induces intervertebral disc degeneration by promoting nucleus pulposus cell pyroptosis via NLRP3-dependent pathway

(2020) Danshuang He et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Multifunctional biomimetic hydrogel systems to boost the immunomodulatory potential of mesenchymal stromal cells

(2020) Ainhoa Gonzalez-Pujana et al.   BIOMATERIALS

Mesenchymal stem cells‐derived exosomes ameliorate intervertebral disc degeneration through inhibiting pyroptosis

(2020) Jingwei Zhang et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Publisher Correction: ITGB3-mediated uptake of small extracellular vesicles facilitates intercellular communication in breast cancer cells

(2020) Pedro Fuentes et al.   Nature Communications

Angiopoietin-like protein 8 expression and association with extracellular matrix metabolism and inflammation during intervertebral disc degeneration

(2019) Zhiwei Liao et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Prdx4 limits caspase‐1 activation and restricts inflammasome‐mediated signaling by extracellular vesicles

(2019) Simone Lipinski et al.   EMBO JOURNAL

Targeting the IL-1β/IL-1Ra pathways for the aggregation of human islet amyloid polypeptide in an ex vivo organ culture system of the intervertebral disc

(2019) Xinghuo Wu et al.   EXPERIMENTAL AND MOLECULAR MEDICINE

Recent Insights on Inflammasomes, Gasdermin Pores, and Pyroptosis

(2019) Nathalia M. de Vasconcelos et al.   Cold Spring Harbor Perspectives in Biology

Mechanisms of extracellular vesicle uptake in stressed retinal pigment epithelial cell monolayers

(2019) Crystal Nicholson et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Mesenchymal stem cell-derived exosomes ameliorate intervertebral disc degeneration via anti-oxidant and anti-inflammatory effects

(2019) Chen Xia et al.   FREE RADICAL BIOLOGY AND MEDICINE

Trichomonas vaginalis extracellular vesicles are internalized by host cells using proteoglycans and caveolin-dependent endocytosis

(2019) Anand Kumar Rai et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Neurons can upregulate Cav-1 to increase intake of endothelial cells-derived extracellular vesicles that attenuate apoptosis via miR-1290

(2019) Kang-Yi Yue et al.   Cell Death & Disease

Intervertebral disc ageing and degeneration: The antiapoptotic effect of oestrogen

(2019) Sidong Yang et al.   AGEING RESEARCH REVIEWS

Intervertebral disc regeneration: From cell therapy to the development of novel bioinspired endogenous repair strategies

(2018) Johann Clouet et al.   ADVANCED DRUG DELIVERY REVIEWS

Regulation of Clathrin-Mediated Endocytosis

(2018) Marcel Mettlen et al.   Annual Review of Biochemistry

Caveolae

(2018) Robert G. Parton et al.   CURRENT BIOLOGY

Exosomes and Ectosomes in Intercellular Communication

(2018) Jacopo Meldolesi   CURRENT BIOLOGY

Honokiol alleviates the degeneration of intervertebral disc via suppressing the activation of TXNIP-NLRP3 inflammasome signal pathway

(2018) Pan Tang et al.   FREE RADICAL BIOLOGY AND MEDICINE

Peroxiredoxin2 Deficiency Aggravates Aging-Induced Insulin Resistance and Declines Muscle Strength

(2018) Hye-Na Cha et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

Mechanisms of Carrier Formation during Clathrin-Independent Endocytosis

(2018) Antonio P.A. Ferreira et al.   TRENDS IN CELL BIOLOGY

Specificities of secretion and uptake of exosomes and other extracellular vesicles for cell-to-cell communication

(2018) Mathilde Mathieu et al.   NATURE CELL BIOLOGY

Preclinical development of a microRNA-based therapy for intervertebral disc degeneration

(2018) Ming-liang Ji et al.   Nature Communications

Advanced glycation end products regulate anabolic and catabolic activities via NLRP3-inflammasome activation in human nucleus pulposus cells

(2017) Yu Song et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Cellular uptake of extracellular vesicles is mediated by clathrin-independent endocytosis and macropinocytosis

(2017) Helena Costa Verdera et al.   JOURNAL OF CONTROLLED RELEASE

Intervertebral Disk Degeneration and Repair

(2017) James Dowdell et al.   NEUROSURGERY

Rosiglitazone drives cavin-2/SDPR expression in adipocytes in a CEBPα-dependent manner

(2017) Björn Hansson et al.   PLoS One

Extracellular vesicle docking at the cellular port: Extracellular vesicle binding and uptake

(2017) Kinsley C. French et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Concise Review: MSC-Derived Exosomes for Cell-Free Therapy

(2017) Donald G. Phinney et al.   STEM CELLS

Exosomes as potential alternatives to stem cell therapy for intervertebral disc degeneration: in-vitro study on exosomes in interaction of nucleus pulposus cells and bone marrow mesenchymal stem cells

(2017) Kang Lu et al.   Stem Cell Research & Therapy

Caveolin-1 and Caveolin-2 Can Be Antagonistic Partners in Inflammation and Beyond

(2017) Cecília Jacques Gonçalves de Almeida   Frontiers in Immunology

Anti-inflammatory Chitosan/Poly-γ-glutamic acid nanoparticles control inflammation while remodeling extracellular matrix in degenerated intervertebral disc

(2016) Graciosa Q. Teixeira et al.   Acta Biomaterialia

The NLRP3/Caspase-1/Interleukin-1β Axis Is Active in Human Lumbar Cartilaginous Endplate Degeneration

(2016) Pan Tang et al.   CLINICAL ORTHOPAEDICS AND RELATED RESEARCH

Molecular mechanisms of cell death in intervertebral disc degeneration (Review)

(2016) FAN ZHANG et al.   INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

Multiple Roles of Peroxiredoxins in Inflammation

(2016)   MOLECULES AND CELLS

Herniated Lumbar Intervertebral Disk

(2016) Richard A. Deyo et al.   NEW ENGLAND JOURNAL OF MEDICINE

Advances in biological therapy for nucleus pulposus regeneration

(2016) P. Priyadarshani et al.   OSTEOARTHRITIS AND CARTILAGE

SDPR functions as a metastasis suppressor in breast cancer by promoting apoptosis

(2016) Sait Ozturk et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Initiation and perpetuation of NLRP3 inflammasome activation and assembly

(2015) Eric I. Elliott et al.   IMMUNOLOGICAL REVIEWS

Inflammation in intervertebral disc degeneration and regeneration

(2015) M. Molinos et al.   Journal of the Royal Society Interface

Mesenchymal Stem Cell-derived Extracellular Vesicles: Toward Cell-free Therapeutic Applications

(2015) Sweta Rani et al.   MOLECULAR THERAPY

Cleavage of GSDMD by inflammatory caspases determines pyroptotic cell death

(2015) Jianjin Shi et al.   NATURE

Virus Entry by Endocytosis

(2010) Jason Mercer et al.   Annual Review of Biochemistry

SDPR induces membrane curvature and functions in the formation of caveolae

(2009) Carsten G. Hansen et al.   NATURE CELL BIOLOGY