Mesenchymal stem cells‐derived exosomes ameliorate intervertebral disc degeneration through inhibiting pyroptosis

Propionibacterium acnes induces intervertebral disc degeneration by promoting nucleus pulposus cell pyroptosis via NLRP3-dependent pathway

(2020) Danshuang He et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

ERRFI1 Inhibits Proliferation and Inflammation of Nucleus Pulposus and is Negatively Regulated by miR-2355-5p in Intervertebral Disc Degeneration

(2019) Yusong Guo et al.   SPINE

MicroRNAs as important regulators of the NLRP3 inflammasome

(2019) Parvin Zamani et al.   PROGRESS IN BIOPHYSICS & MOLECULAR BIOLOGY

Embryonic stem cell-derived exosomes inhibit doxorubicin-induced TLR4-NLRP3-mediated cell death-pyroptosis

(2019) Zahra Tavakoli Dargani et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

miR-410-3p regulates proliferation and apoptosis of fibroblast-like synoviocytes by targeting YY1 in rheumatoid arthritis

(2019) YueJiao Wang et al.   BIOMEDICINE & PHARMACOTHERAPY

Mesenchymal stem cell-derived exosomes ameliorate intervertebral disc degeneration via anti-oxidant and anti-inflammatory effects

(2019) Chen Xia et al.   FREE RADICAL BIOLOGY AND MEDICINE

Exosome Treatment Enhances Anti-Inflammatory M2 Macrophages and Reduces Inflammation-Induced Pyroptosis in Doxorubicin-Induced Cardiomyopathy

(2019) Dinender K. Singla et al.   Cells

Critical contribution of RIPK1 mediated mitochondrial dysfunction and oxidative stress to compression-induced rat nucleus pulposus cells necroptosis and apoptosis

(2018) Songfeng Chen et al.   APOPTOSIS

Therapeutic effects of gefitinib-encapsulated thermosensitive injectable hydrogel in intervertebral disc degeneration

(2018) Zongyou Pan et al.   BIOMATERIALS

Honokiol alleviates the degeneration of intervertebral disc via suppressing the activation of TXNIP-NLRP3 inflammasome signal pathway

(2018) Pan Tang et al.   FREE RADICAL BIOLOGY AND MEDICINE

Alcohol dysregulates miR-148a in hepatocytes through FoxO1, facilitating pyroptosis via TXNIP overexpression

(2018) Mi Jeong Heo et al.   GUT

miR-410-3p Suppresses Cytokine Release from Fibroblast-Like Synoviocytes by Regulating NF-κB Signaling in Rheumatoid Arthritis

(2018) YueJiao Wang et al.   INFLAMMATION

Osteogenic protein-1 inhibits nucleus pulposus cell apoptosis through regulating the NF-κB/ROS pathway in an inflammation environment

(2018) Wei Yu et al.   BIOSCIENCE REPORTS

Preclinical development of a microRNA-based therapy for intervertebral disc degeneration

(2018) Ming-liang Ji et al.   Nature Communications

Advanced glycation end products regulate anabolic and catabolic activities via NLRP3-inflammasome activation in human nucleus pulposus cells

(2017) Yu Song et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Exosomes as potential alternatives to stem cell therapy for intervertebral disc degeneration: in-vitro study on exosomes in interaction of nucleus pulposus cells and bone marrow mesenchymal stem cells

(2017) Kang Lu et al.   Stem Cell Research & Therapy

MiR-410 Down-Regulates the Expression of Interleukin-10 by Targeting STAT3 in the Pathogenesis of Systemic Lupus Erythematosus

(2016) Dongmei Liu et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

ER stress induces NLRP3 inflammasome activation and hepatocyte death

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A Systematic Review of the Safety and Efficacy of Mesenchymal Stem Cells for Disc Degeneration: Insights and Future Directions for Regenerative Therapeutics

(2014) Rita Lok-Hay Yim et al.   STEM CELLS AND DEVELOPMENT

Early MicroRNA Expression Profile as a Prognostic Biomarker for the Development of Pelvic Inflammatory Disease in a Mouse Model of Chlamydial Genital Infection

(2014) L. Yeruva et al.   mBio

Photochemically crosslinked collagen annulus plug: A potential solution solving the leakage problem of cell-based therapies for disc degeneration

(2013) T.K. Chik et al.   Acta Biomaterialia

Inflammatory Cytokines Associated with Degenerative Disc Disease Control Aggrecanase-1 (ADAMTS-4) Expression in Nucleus Pulposus Cells through MAPK and NF-κB

(2013) Ye Tian et al.   AMERICAN JOURNAL OF PATHOLOGY

Extracellular vesicles: biology and emerging therapeutic opportunities

(2013) Samir EL Andaloussi et al.   NATURE REVIEWS DRUG DISCOVERY

Role of cytokines in intervertebral disc degeneration: pain and disc content

(2013) Makarand V. Risbud et al.   Nature Reviews Rheumatology

Toll-like receptor adaptor signaling molecule MyD88 on intervertebral disk homeostasis: In vitro, ex vivo studies

(2012) Michael B. Ellman et al.   GENE

NLRP3 Inflammasome Activity Is Negatively Controlled by miR-223

(2012) F. Bauernfeind et al.   JOURNAL OF IMMUNOLOGY

Inflammasomes in health and disease

(2012) Till Strowig et al.   NATURE

Comparison of Animal Discs Used in Disc Research to Human Lumbar Disc

(2012) Brent L. Showalter et al.   SPINE

IL-18 Production Downstream of the Nlrp3 Inflammasome Confers Protection against Colorectal Tumor Formation

(2010) M. H. Zaki et al.   JOURNAL OF IMMUNOLOGY

Regulation of apoptosis in nucleus pulposus cells by optimized exogenous Bcl-2 overexpression

(2010) Hideki Sudo et al.   JOURNAL OF ORTHOPAEDIC RESEARCH

Injury-induced sequential transformation of notochordal nucleus pulposus to chondrogenic and fibrocartilaginous phenotype in the mouse

(2009) Fan Yang et al.   JOURNAL OF PATHOLOGY

Mesenchymal Stem Cells Arrest Intervertebral Disc Degeneration Through Chondrocytic Differentiation and Stimulation of Endogenous Cells

(2009) Fan Yang et al.   MOLECULAR THERAPY

Comparison of Animal Discs Used in Disc Research to Human Lumbar Disc

(2009) Jesse C. Beckstein et al.   SPINE

The cellular pathobiology of the degenerate intervertebral disc and discogenic back pain

(2008) A. J. Freemont   RHEUMATOLOGY

A Simple Disc Degeneration Model Induced by Percutaneous Needle Puncture in the Rat Tail

(2008) Bin Han et al.   SPINE