Citrullination of Amyloid-β Peptides in Alzheimer’s Disease

Association of naturally occurring antibodies to β-amyloid with cognitive decline and cerebral amyloidosis in Alzheimer’s disease

(2021) Yu-Hui Liu et al.   Science Advances

Donanemab in Early Alzheimer’s Disease

(2021) Mark A. Mintun et al.   NEW ENGLAND JOURNAL OF MEDICINE

Large-scale proteomic analysis of Alzheimer’s disease brain and cerebrospinal fluid reveals early changes in energy metabolism associated with microglia and astrocyte activation

(2020) Erik C. B. Johnson et al.   NATURE MEDICINE

Increased glutaminyl cyclase activity in brains of Alzheimer’s disease individuals

(2020) Adam P. Gunn et al.   JOURNAL OF NEUROCHEMISTRY

Kinetic fingerprints differentiate the mechanisms of action of anti-Aβ antibodies

(2020) Sara Linse et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Pyroglutamation of amyloid-βx-42 (Aβx-42) followed by Aβ1-40 deposition underlies plaque polymorphism in progressing Alzheimer’s disease pathology

(2019) Wojciech Michno et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mapping Citrullinated Sites in Multiple Organs of Mice Using Hypercitrullinated Library

(2019) Justyna Fert-Bober et al.   JOURNAL OF PROTEOME RESEARCH

Establishing Signature Fragments for Identification and Sequencing of Dityrosine Cross-Linked Peptides Using Ultraviolet Photodissociation Mass Spectrometry

(2019) Soumya Mukherjee et al.   ANALYTICAL CHEMISTRY

Spontaneous Isomerization of Long-Lived Proteins Provides a Molecular Mechanism for the Lysosomal Failure Observed in Alzheimer’s Disease

(2019) Tyler R. Lambeth et al.   ACS Central Science

Direct Evidence of the Presence of Cross-Linked Aβ Dimers in the Brains of Alzheimer’s Disease Patients

(2018) Aurelio Vázquez de la Torre et al.   ANALYTICAL CHEMISTRY

Neuroinflammation is increased in the parietal cortex of atypical Alzheimer’s disease

(2018) Baayla D. C. Boon et al.   Journal of Neuroinflammation

xiSPEC: web-based visualization, analysis and sharing of proteomics data

(2018) Lars Kolbowski et al.   NUCLEIC ACIDS RESEARCH

Pyroglutamate and Isoaspartate modified Amyloid-Beta in ageing and Alzheimer’s disease

(2018) Maria Luisa Moro et al.   Acta Neuropathologica Communications

Brain ureido degenerative protein modifications are associated with neuroinflammation and proteinopathy in Alzheimer’s disease with cerebrovascular disease

(2017) Xavier Gallart-Palau et al.   Journal of Neuroinflammation

Markers of microglia in post-mortem brain samples from patients with Alzheimer’s disease: a systematic review

(2017) K E Hopperton et al.   MOLECULAR PSYCHIATRY

Cryo-EM structures of tau filaments from Alzheimer’s disease

(2017) Anthony W. P. Fitzpatrick et al.   NATURE

A phase III randomized trial of gantenerumab in prodromal Alzheimer’s disease

(2017) Susanne Ostrowitzki et al.   Alzheimers Research & Therapy

APP, PSEN1, and PSEN2 mutations in early-onset Alzheimer disease: A genetic screening study of familial and sporadic cases

(2017) Hélène-Marie Lanoiselée et al.   PLOS MEDICINE

Diversity of Amyloid-beta Proteoforms in the Alzheimer’s Disease Brain

(2017) Norelle C. Wildburger et al.   Scientific Reports

Citrullination and deamidation affect aggregation properties of amyloid β-proteins

(2016) Dai Osaki et al.   AMYLOID-JOURNAL OF PROTEIN FOLDING DISORDERS

The antibody aducanumab reduces Aβ plaques in Alzheimer’s disease

(2016) Jeff Sevigny et al.   NATURE

The MaxQuant computational platform for mass spectrometry-based shotgun proteomics

(2016) Stefka Tyanova et al.   Nature Protocols

Safety and tolerability of BAN2401 - a clinical study in Alzheimer’s disease with a protofibril selective Aβ antibody

(2016) Veronika Logovinsky et al.   Alzheimers Research & Therapy

Protein Arginine Methylation and Citrullination in Epigenetic Regulation

(2015) Jakob Fuhrmann et al.   ACS Chemical Biology

Chemical Biology of Protein Arginine Modifications in Epigenetic Regulation

(2015) Jakob Fuhrmann et al.   CHEMICAL REVIEWS

Mass spectrometric identification of citrullination sites and immunohistochemical detection of citrullinated glial fibrillary acidic protein in Alzheimer's disease brains

(2015) Akihito Ishigami et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Decreased amyloid-β and increased neuronal hyperactivity by immunotherapy in Alzheimer's models

(2015) Marc Aurel Busche et al.   NATURE NEUROSCIENCE

Citrullination and Carbamylation in the Pathophysiology of Rheumatoid Arthritis

(2015) Ger J. M. Pruijn   Frontiers in Immunology

Biochemical stages of amyloid-β peptide aggregation and accumulation in the human brain and their association with symptomatic and pathologically preclinical Alzheimer’s disease

(2014) Ajeet Rijal Upadhaya et al.   BRAIN

N-truncated amyloid β (Aβ) 4-42 forms stable aggregates and induces acute and long-lasting behavioral deficits

(2013) Yvonne Bouter et al.   ACTA NEUROPATHOLOGICA

Dual immunofluorescence study of citrullinated proteins in Alzheimer diseased frontal cortex

(2013) Anthony P. Nicholas   NEUROSCIENCE LETTERS

Immune-Mediated Pore-Forming Pathways Induce Cellular Hypercitrullination and Generate Citrullinated Autoantigens in Rheumatoid Arthritis

(2013) V. Romero et al.   Science Translational Medicine

Neuronal PAD4 expression and protein citrullination: Possible role in production of autoantibodies associated with neurodegenerative disease

(2012) Nimish K. Acharya et al.   JOURNAL OF AUTOIMMUNITY

Florbetapir PET analysis of amyloid-β deposition in the presenilin 1 E280A autosomal dominant Alzheimer's disease kindred: a cross-sectional study

(2012) Adam S Fleisher et al.   LANCET NEUROLOGY

Amyloid-related imaging abnormalities in amyloid-modifying therapeutic trials: Recommendations from the Alzheimer’s Association Research Roundtable Workgroup

(2011) Reisa A. Sperling et al.   Alzheimers & Dementia

Protein deiminases: New players in the developmentally regulated loss of neural regenerative ability

(2011) Sigrun Lange et al.   DEVELOPMENTAL BIOLOGY

Pyroglutamate Amyloid-β (Aβ): A Hatchet Man in Alzheimer Disease

(2011) Sadim Jawhar et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Autoreactive-Aβ antibodies promote APP β-secretase processing

(2011) Juan Deng et al.   JOURNAL OF NEUROCHEMISTRY

Neuroinflammation in Alzheimer's disease wanes with age

(2011) Jeroen JM Hoozemans et al.   Journal of Neuroinflammation

Nitration of Tyrosine 10 Critically Enhances Amyloid β Aggregation and Plaque Formation

(2011) Markus P. Kummer et al.   NEURON

Dual immunofluorescence study of citrullinated proteins in Parkinson diseased substantia nigra

(2011) Anthony P. Nicholas   NEUROSCIENCE LETTERS

Mass spectrometric characterization of brain amyloid beta isoform signatures in familial and sporadic Alzheimer’s disease

(2010) Erik Portelius et al.   ACTA NEUROPATHOLOGICA

On-line liquid chromatography neutral loss-triggered electron transfer dissociationmass spectrometry for the targeted analysis of citrullinated peptides

(2010) Andrew J. Creese et al.   Analytical Methods

A Quantitative Study of the Effects of Chaotropic Agents, Surfactants, and Solvents on the Digestion Efficiency of Human Plasma Proteins by Trypsin

(2010) Jennifer L. Proc et al.   JOURNAL OF PROTEOME RESEARCH

Amyloid imaging results from the Australian Imaging, Biomarkers and Lifestyle (AIBL) study of aging

(2010) Christopher C. Rowe et al.   NEUROBIOLOGY OF AGING

Proteomics Analysis Reveals Novel Components in the Detergent-Insoluble Subproteome in Alzheimer’s Disease

(2009) Yair M. Gozal et al.   JOURNAL OF PROTEOME RESEARCH

Neuroprotective natural antibodies to assemblies of amyloidogenic peptides decrease with normal aging and advancing Alzheimer's disease

(2009) M. Britschgi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Synovial fluid is a site of citrullination of autoantigens in inflammatory arthritis

(2008) Andrew Kinloch et al.   ARTHRITIS AND RHEUMATISM

Neutral loss of isocyanic acid in peptide CID spectra: A novel diagnostic marker for mass spectrometric identification of protein citrullination

(2008) Gang Hao et al.   JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY

Glutaminyl cyclase inhibition attenuates pyroglutamate Aβ and Alzheimer's disease–like pathology

(2008) Stephan Schilling et al.   NATURE MEDICINE

Straightforward ladder sequencing of peptides using a Lys-N metalloendopeptidase

(2008) Nadia Taouatas et al.   NATURE METHODS