Increased glutaminyl cyclase activity in brains of Alzheimer’s disease individuals

Glutaminyl cyclase is an enzymatic modifier of the CD47- SIRPα axis and a target for cancer immunotherapy

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Glutaminyl cyclase inhibitor exhibits anti-inflammatory effects in both AD and LPS-induced inflammatory model mice

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Increased Glutaminyl Cyclase Expression in Peripheral Blood of Alzheimer's Disease Patients

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Brain Pyroglutamate Amyloid-β is Produced by Cathepsin B and is Reduced by the Cysteine Protease Inhibitor E64d, Representing a Potential Alzheimer's Disease Therapeutic

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Glutaminyl Cyclase in Human Cortex: Correlation with (pGlu)-Amyloid-β Load and Cognitive Decline in Alzheimer's Disease

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Safety, tolerability and efficacy of the glutaminyl cyclase inhibitor PQ912 in Alzheimer’s disease: results of a randomized, double-blind, placebo-controlled phase 2a study

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Synthesis and Evaluation of Diphenyl Conjugated Imidazole Derivatives as Potential Glutaminyl Cyclase Inhibitors for Treatment of Alzheimer’s Disease

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APP/Aβ structural diversity and Alzheimer's disease pathogenesis

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Glutaminyl cyclase activity correlates with levels of Aβ peptides and mediators of angiogenesis in cerebrospinal fluid of Alzheimer’s disease patients

(2017) Claire Bridel et al.   Alzheimers Research & Therapy

Alzheimer's Disease and the Amyloid-β Peptide

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When, where and how? Focus on neuronal calcium dysfunctions in Alzheimer’s Disease

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Immunotherapy targeting pyroglutamate-3 Aβ: prospects and challenges

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Isoglutaminyl cyclase contributes to CCL2-driven neuroinflammation in Alzheimer’s disease

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Identification of thyrotropin-releasing hormone as hippocampal glutaminyl cyclase substrate in neurons and reactive astrocytes

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Amyloid-β Peptide Aβ3pE-42 Induces Lipid Peroxidation, Membrane Permeabilization, and Calcium Influx in Neurons

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An anti-pyroglutamate-3 Aβ vaccine reduces plaques and improves cognition in APPswe/PS1ΔE9 mice

(2015) Jeffrey L. Frost et al.   NEUROBIOLOGY OF AGING

Synthesis and evaluation of [11C]PBD150, a radiolabeled glutaminyl cyclase inhibitor for the potential detection of Alzheimer's disease prior to amyloid β aggregation

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Do current therapeutic anti-Aβ antibodies for Alzheimer’s disease engage the target?

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Activity and Architecture of Pyroglutamate-Modified Amyloid-β (AβpE3-42) Pores

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National Institute on Aging–Alzheimer's Association guidelines for the neuropathologic assessment of Alzheimer's disease

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N-Terminal pyroglutamate formation of Aβ38 and Aβ40 enforces oligomer formation and potency to disrupt hippocampal long-term potentiation

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Disturbed Ca2+ Homeostasis Increases Glutaminyl Cyclase Expression; Connecting Two Early Pathogenic Events in Alzheimer’s Disease In Vitro

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Inhibition of glutaminyl cyclase attenuates cell migration modulated by monocyte chemoattractant proteins

(2011) Yi-Ling Chen et al.   BIOCHEMICAL JOURNAL

The isoenzyme of glutaminyl cyclase is an important regulator of monocyte infiltration under inflammatory conditions

(2011) Holger Cynis et al.   EMBO Molecular Medicine

Glutaminyl Cyclase Knock-out Mice Exhibit Slight Hypothyroidism but No Hypogonadism

(2011) Stephan Schilling et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The role of metallobiology and amyloid-β peptides in Alzheimer’s disease

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Distinct glutaminyl cyclase expression in Edinger–Westphal nucleus, locus coeruleus and nucleus basalis Meynert contributes to pGlu-Aβ pathology in Alzheimer’s disease

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Mass spectrometric characterization of brain amyloid beta isoform signatures in familial and sporadic Alzheimer’s disease

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Anti-11[E]-pyroglutamate-modified amyloid β antibodies cross-react with other pathological Aβ species: Relevance for immunotherapy

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Mammalian glutaminyl cyclases and their isoenzymes have identical enzymatic characteristics

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Developmental expression and subcellular localization of glutaminyl cyclase in mouse brain

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The Australian Imaging, Biomarkers and Lifestyle (AIBL) study of aging: methodology and baseline characteristics of 1112 individuals recruited for a longitudinal study of Alzheimer's disease

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Amyloidogenic Processing of Amyloid Precursor Protein: Evidence of a Pivotal Role of Glutaminyl Cyclase in Generation of Pyroglutamate-Modified Amyloid-β†

(2008) Holger Cynis et al.   BIOCHEMISTRY

Alternative pathways for production of β-amyloid peptides of Alzheimer's disease

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Inhibition of glutaminyl cyclase prevents pGlu-A formation after intracorticalhippocampal microinjectionin vivoin situ

(2008) Stephan Schilling et al.   JOURNAL OF NEUROCHEMISTRY

Glutaminyl cyclase inhibition attenuates pyroglutamate Aβ and Alzheimer's disease–like pathology

(2008) Stephan Schilling et al.   NATURE MEDICINE