DARK Classics in Chemical Neuroscience: Loperamide

Peripherally acting opioid analgesics and peripherally-induced analgesia

(2020) Vicente Martínez et al.   BEHAVIOURAL PHARMACOLOGY

Loperamide Abuse and Its Sequelae

(2020) Lauren Strzyzewski et al.   AMERICAN JOURNAL OF FORENSIC MEDICINE AND PATHOLOGY

Pharmacological Aspects of Over-the-Counter Opioid Drugs Misuse

(2020) Łukasz Sobczak et al.   MOLECULES

2019 Annual Report of the American Association of Poison Control Centers’ National Poison Data System (NPDS): 37th Annual Report

(2020) David D. Gummin et al.   CLINICAL TOXICOLOGY

Loperamide: A Readily Available but Dangerous Opioid Substitute

(2019) C. Michael White   JOURNAL OF CLINICAL PHARMACOLOGY

Radiographic dose‐dependency study of loperamide effects on gastrointestinal motor function in the rat. Temporal relationship with nausea‐like behavior

(2019) Gema Vera et al.   NEUROGASTROENTEROLOGY AND MOTILITY

Loperamide as a Potential Drug of Abuse and Misuse: Fatal Overdoses at the Medical University of South Carolina

(2019) John W. Powell et al.   JOURNAL OF FORENSIC SCIENCES

Electrocardiographic changes in loperamide toxicity: Case report and review of literature

(2019) Todd Teigeler et al.   JOURNAL OF CARDIOVASCULAR ELECTROPHYSIOLOGY

Non-medical use of loperamide in the UK and the USA

(2019) N E Webb et al.   QJM-AN INTERNATIONAL JOURNAL OF MEDICINE

Loperamide toxicity: recommendations for patient monitoring and management

(2019) William Eggleston et al.   CLINICAL TOXICOLOGY

Toward Directing Opioid Receptor Signaling to Refine Opioid Therapeutics

(2019) Travis W. Grim et al.   BIOLOGICAL PSYCHIATRY

Prescription opioid analgesic use in France: Trends and impact on morbidity-mortality

(2018) C. Chenaf et al.   EUROPEAN JOURNAL OF PAIN

Untangling the complexity of opioid receptor function

(2018) Rita J. Valentino et al.   NEUROPSYCHOPHARMACOLOGY

Loperamide, pimozide, and STF-62247 trigger autophagy-dependent cell death in glioblastoma cells

(2018) Svenja Zielke et al.   Cell Death & Disease

Loperamide misuse to avoid opioid withdrawal and to achieve a euphoric effect: high doses and high risk

(2018) Vincent R. Lee et al.   CLINICAL TOXICOLOGY

“Poor man’s methadone” can kill the poor man. Extra-medical uses of loperamide: a review

(2017) Maria Katselou et al.   Forensic Toxicology

Loperamide misuse and abuse

(2017) Heather Miller et al.   JOURNAL OF THE AMERICAN PHARMACISTS ASSOCIATION

Loperamide inhibits sodium channels to alleviate inflammatory hyperalgesia

(2017) Ying Wu et al.   NEUROPHARMACOLOGY

Topical Loperamide-Encapsulated Liposomal Gel Increases the Severity of Inflammation and Accelerates Disease Progression in the Adjuvant-Induced Model of Experimental Rheumatoid Arthritis

(2017) Susan Hua et al.   Frontiers in Pharmacology

Opioid Receptors

(2016) Christoph Stein   Annual Review of Medicine

Loperamide-Related Deaths in North Carolina

(2016) Sandra C. Bishop-Freeman et al.   JOURNAL OF ANALYTICAL TOXICOLOGY

Expression and physiology of opioid receptors in the gastrointestinal tract

(2016) Paula Mosińska et al.   Current Opinion in Endocrinology Diabetes and Obesity

Poor Manʼs Methadone

(2015) Jennifer Dierksen et al.   AMERICAN JOURNAL OF FORENSIC MEDICINE AND PATHOLOGY

Can Silicon Make an Excellent Drug Even Better? An in vitro and in vivo Head-to-Head Comparison between Loperamide and Its Silicon Analogue Sila-Loperamide

(2015) Marcel Geyer et al.   ChemMedChem

Ventricular Tachycardia Associated with High-Dose Chronic Loperamide Use

(2015) Hannah L. Spinner et al.   PHARMACOTHERAPY

Changes in Feeding Behavior, Locomotor Activity, and Metabolism in Rats upon Modulation of Opioid Receptors in the Gastrointestinal Tract

(2014) S. K. Sudakov et al.   BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE

Cytotoxic Effects of Loperamide Hydrochloride on Canine Cancer Cells

(2014) Rebecca Cohen REGAN et al.   JOURNAL OF VETERINARY MEDICAL SCIENCE

Loperamide overdose-induced catatonia: potential role of brain opioid system and P-glycoprotein

(2013) Enrica Di Rosa et al.   ACTA NEUROPSYCHIATRICA

Physiology, signaling, and pharmacology of opioid receptors and their ligands in the gastrointestinal tract: current concepts and future perspectives

(2013) Marta Sobczak et al.   JOURNAL OF GASTROENTEROLOGY

Antidiarrhetic loperamide hydrochloride

(2012) Jürgen Brüning et al.   ACTA CRYSTALLOGRAPHICA SECTION C-CRYSTAL STRUCTURE COMMUNICATIONS

“I just wanted to tell you that loperamide WILL WORK”: A web-based study of extra-medical use of loperamide

(2012) Raminta Daniulaityte et al.   DRUG AND ALCOHOL DEPENDENCE

Antinociceptive effect of intrathecal loperamide: Role of mu-opioid receptor and calcium channels

(2012) Rakesh Kumar et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Opioid Analgesics and P-Glycoprotein Efflux Transporters: A Potential Systems-Level Contribution to Analgesic Tolerance

(2011) Susan L. Mercer et al.   CURRENT TOPICS IN MEDICINAL CHEMISTRY

Loperamide

(2011) Claud Regnard et al.   JOURNAL OF PAIN AND SYMPTOM MANAGEMENT

Opioid receptors in the gastrointestinal tract

(2009) Peter Holzer   REGULATORY PEPTIDES

Review: Chemotherapy-induced diarrhea: pathophysiology, frequency and guideline-based management

(2009) Alexander Stein et al.   Therapeutic Advances in Medical Oncology

Binding Site of Loperamide: Automated Docking of Loperamide in Human μ- and δ-Opioid Receptors

(2008) Antonio Mazzella di Bosco et al.   Chemical Biology & Drug Design

Synthesis and Evaluation of [N-methyl-11C]N-Desmethyl-loperamide as a New and Improved PET Radiotracer for Imaging P-gp Function

(2008) Neva Lazarova et al.   JOURNAL OF MEDICINAL CHEMISTRY

Peripherally acting mu-opioid receptor agonist attenuates neuropathic pain in rats after L5 spinal nerve injury

(2008) Yun Guan et al.   PAIN