Untangling the complexity of opioid receptor function

Truncated μ-Opioid Receptors With 6 Transmembrane Domains Are Essential for Opioid Analgesia

(2018) Zhigang Lu et al.   ANESTHESIA AND ANALGESIA

Structure of the Nanobody-Stabilized Active State of the Kappa Opioid Receptor

(2018) Tao Che et al.   CELL

Sleep Management Among Patients with Substance Use Disorders

(2018) Subhajit Chakravorty et al.   MEDICAL CLINICS OF NORTH AMERICA

Endogenous opioid system dysregulation in depression: implications for new therapeutic approaches

(2018) Marta Peciña et al.   MOLECULAR PSYCHIATRY

Opioid receptors: drivers to addiction?

(2018) Emmanuel Darcq et al.   NATURE REVIEWS NEUROSCIENCE

A Genetically Encoded Biosensor Reveals Location Bias of Opioid Drug Action

(2018) Miriam Stoeber et al.   NEURON

Functional Divergence of Delta and Mu Opioid Receptor Organization in CNS Pain Circuits

(2018) Dong Wang et al.   NEURON

Structure of the µ-opioid receptor–Gi protein complex

(2018) Antoine Koehl et al.   NATURE

Alternatively spliced mu opioid receptor C termini impact the diverse actions of morphine

(2017) Jin Xu et al.   JOURNAL OF CLINICAL INVESTIGATION

Structure-Based Discovery of New Antagonist and Biased Agonist Chemotypes for the Kappa Opioid Receptor

(2017) Zhong Zheng et al.   JOURNAL OF MEDICINAL CHEMISTRY

Functional μ-Opioid-Galanin Receptor Heteromers in the Ventral Tegmental Area

(2016) Estefanía Moreno et al.   JOURNAL OF NEUROSCIENCE

Structure-based discovery of opioid analgesics with reduced side effects

(2016) Aashish Manglik et al.   NATURE

Truncated mu opioid GPCR variant involvement in opioid-dependent and opioid-independent pain modulatory systems within the CNS

(2016) Gina F. Marrone et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Biased agonists of the kappa opioid receptor suppress pain and itch without causing sedation or dysphoria

(2016) Tarsis F. Brust et al.   Science Signaling

Biased agonists of the kappa opioid receptor suppress pain and itch without causing sedation or dysphoria

(2016) Tarsis F. Brust et al.   Science Signaling

Mu Opioid Receptor Actions in the Lateral Habenula

(2016) Elyssa B. Margolis et al.   PLoS One

Structural insights into µ-opioid receptor activation

(2015) Weijiao Huang et al.   NATURE

Positive allosteric modulators of the μ-opioid receptor: a novel approach for future pain medications

(2014) N T Burford et al.   BRITISH JOURNAL OF PHARMACOLOGY

Revolution in GPCR signalling: opioid receptor heteromers as novel therapeutic targets: IUPHAR Review 10

(2014) Wakako Fujita et al.   BRITISH JOURNAL OF PHARMACOLOGY

Molecular control of δ-opioid receptor signalling

(2014) Gustavo Fenalti et al.   NATURE

Separate GABA Afferents to Dopamine Neurons Mediate Acute Action of Opioids, Development of Tolerance, and Expression of Withdrawal

(2014) Aya Matsui et al.   NEURON

First Clinical Experience With TRV130: Pharmacokinetics and Pharmacodynamics in Healthy Volunteers

(2013) David G. Soergel et al.   JOURNAL OF CLINICAL PHARMACOLOGY

Opioids and their receptors: Are we there yet?

(2013) Gavril W. Pasternak   NEUROPHARMACOLOGY

Prefrontal Cortical Kappa-Opioid Receptor Modulation of Local Neurotransmission and Conditioned Place Aversion

(2013) Hugo A Tejeda et al.   NEUROPSYCHOPHARMACOLOGY

Structure of the δ-opioid receptor bound to naltrindole

(2012) Sébastien Granier et al.   NATURE

Structure of the human κ-opioid receptor in complex with JDTic

(2012) Huixian Wu et al.   NATURE

Crystal structure of the µ-opioid receptor bound to a morphinan antagonist

(2012) Aashish Manglik et al.   NATURE

Input-specific control of reward and aversion in the ventral tegmental area

(2012) Stephan Lammel et al.   NATURE

Predator stress engages corticotropin-releasing factor and opioid systems to alter the operating mode of locus coeruleus norepinephrine neurons

(2011) Andre L. Curtis et al.   NEUROPHARMACOLOGY

Truncated G protein-coupled mu opioid receptor MOR-1 splice variants are targets for highly potent opioid analgesics lacking side effects

(2011) S. Majumdar et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The habenula: from stress evasion to value-based decision-making

(2010) Okihide Hikosaka   NATURE REVIEWS NEUROSCIENCE

Cell-dependent physiological synaptic action of morphine in the rat habenular nucleus: Morphine both inhibits and facilitates excitatory synaptic transmission

(2009) Keisuke Hashimoto et al.   NEUROSCIENCE LETTERS

Presynaptic Inhibition of Diverse Afferents to the Locus Ceruleus by  -Opiate Receptors: A Novel Mechanism for Regulating the Central Norepinephrine System

(2008) A. Kreibich et al.   JOURNAL OF NEUROSCIENCE