Physiology, signaling, and pharmacology of opioid receptors and their ligands in the gastrointestinal tract: current concepts and future perspectives
Published 2013 View Full Article
- Home
- Publications
- Publication Search
- Publication Details
Title
Physiology, signaling, and pharmacology of opioid receptors and their ligands in the gastrointestinal tract: current concepts and future perspectives
Authors
Keywords
Abdominal pain, Functional gastrointestinal disorders, Inflammatory bowel diseases, Opioid-induced bowel dysfunction, Opioid receptors and their ligands
Journal
JOURNAL OF GASTROENTEROLOGY
Volume 49, Issue 1, Pages 24-45
Publisher
Springer Nature
Online
2013-02-09
DOI
10.1007/s00535-013-0753-x
References
Ask authors/readers for more resources
Related references
Note: Only part of the references are listed.- Management of postoperative ileus: focus on alvimopan
- (2016) Conor Delaney Therapeutics and Clinical Risk Management
- Systemic Kappa Opioid Receptor Agonists in the Treatment of Chronic Pruritus: A Literature Review
- (2013) N Phan et al. ACTA DERMATO-VENEREOLOGICA
- Evaluation of Clinical Outcomes With Alvimopan in Clinical Practice
- (2012) Conor P. Delaney et al. ANNALS OF SURGERY
- Lubiprostone activates CFTR, but not ClC-2, via the prostaglandin receptor (EP4)
- (2012) Yohei Norimatsu et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- Pruritus in Chronic Cholestatic Liver Disease
- (2012) Chalermrat Bunchorntavakul et al. Clinics in Liver Disease
- Pain and genetics
- (2012) Claudia R. Fernandez Robles et al. Current Opinion in Anesthesiology
- Alternatives to prokinetics to move the pylorus and colon
- (2012) Florian Pfab et al. CURRENT OPINION IN CLINICAL NUTRITION AND METABOLIC CARE
- Non-Analgesic Effects of Opioids: Cardiovascular Effects of Opioids and their Receptor Systems
- (2012) John P. Headrick et al. CURRENT PHARMACEUTICAL DESIGN
- Non-Analgesic Effects of Opioids: Neuroprotection in the Retina
- (2012) Shahid Husain et al. CURRENT PHARMACEUTICAL DESIGN
- Lubiprostone Targets Prostanoid Signaling and Promotes Ion Transporter Trafficking, Mucus Exocytosis, and Contractility
- (2012) Robert L. Jakab et al. DIGESTIVE DISEASES AND SCIENCES
- A Meta-analysis of the Effectiveness of the Opioid Receptor Antagonist Alvimopan in Reducing Hospital Length of Stay and Time to GI Recovery in Patients Enrolled in a Standardized Accelerated Recovery Program After Abdominal Surgery
- (2012) P. G. Vaughan-Shaw et al. DISEASES OF THE COLON & RECTUM
- Opioid receptor expression in human brain and peripheral tissues using absolute quantitative real-time RT-PCR
- (2012) Jinsong Peng et al. DRUG AND ALCOHOL DEPENDENCE
- Case–control association analysis of polymorphisms in the delta-opioid receptor, OPRD1, with cocaine and opioid addicted populations
- (2012) R.C. Crist et al. DRUG AND ALCOHOL DEPENDENCE
- Opioid-Induced Bowel Dysfunction
- (2012) Christina Brock et al. DRUGS
- Antinociceptive effect of intrathecal loperamide: Role of mu-opioid receptor and calcium channels
- (2012) Rakesh Kumar et al. EUROPEAN JOURNAL OF PHARMACOLOGY
- Safety evaluation of lubiprostone in the treatment of constipation and irritable bowel syndrome
- (2012) Sherman M Chamberlain et al. Expert Opinion On Drug Safety
- The genetics of the opioid system and specific drug addictions
- (2012) Orna Levran et al. HUMAN GENETICS
- Synthesis and Biological Evaluation of an Orally Active Glycosylated Endomorphin-1
- (2012) Pegah Varamini et al. JOURNAL OF MEDICINAL CHEMISTRY
- Alvimopan Addition to a Standard Perioperative Recovery Pathway
- (2012) Edward A. Itawi et al. JSLS-Journal of the Society of Laparoendoscopic Surgeons
- Gene therapy for the treatment of chronic peripheral nervous system pain
- (2012) William F. Goins et al. NEUROBIOLOGY OF DISEASE
- Management of Postoperative Ileus
- (2012) Melissa Thompson et al. ORTHOPEDICS
- Delta and kappa opioid receptor polymorphisms influence the effects of naltrexone on subjective responses to alcohol
- (2012) James R. Ashenhurst et al. PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR
- Nigella sativa (Black Cumin) Seed Extract Alleviates Symptoms of Allergic Diarrhea in Mice, Involving Opioid Receptors
- (2012) Swantje C. Duncker et al. PLoS One
- Opiate-induced constipation related to activation of small intestine opioid μ2-receptors
- (2012) Wency Chen WORLD JOURNAL OF GASTROENTEROLOGY
- Pain management in patients with inflammatory bowel disease: insights for the clinician
- (2012) Arvind Iyengar Srinath et al. Therapeutic Advances in Gastroenterology
- Met-enkephalins in patients with inflammatory bowel diseases
- (2011) D Owczarek et al. Advances in Medical Sciences
- Mu Opioid Signaling Protects Against Acute Murine Intestinal Injury in a Manner Involving Stat3 Signaling
- (2011) Jason R. Goldsmith et al. AMERICAN JOURNAL OF PATHOLOGY
- Gene therapy for pain: Results of a phase I clinical trial
- (2011) David J. Fink et al. ANNALS OF NEUROLOGY
- Pseudomonas aeruginosa Virulence Expression Is Directly Activated by Morphine and Is Capable of Causing Lethal Gut-Derived Sepsis in Mice During Chronic Morphine Administration
- (2011) Trissa Babrowski et al. ANNALS OF SURGERY
- The central versus peripheral antinociceptive effects of μ-opioid receptor agonists in the new model of rat visceral pain
- (2011) Mahmoud Al-Khrasani et al. BRAIN RESEARCH BULLETIN
- Opioid receptor subtypes: fact or artifact?
- (2011) N. Dietis et al. BRITISH JOURNAL OF ANAESTHESIA
- The Other Side of Opioid Receptor Signalling: Regulation by Protein-Protein Interaction
- (2011) Zafiroula Georgoussi et al. CURRENT DRUG TARGETS
- Therapy with the Opioid Antagonist Naltrexone Promotes Mucosal Healing in Active Crohn’s Disease: A Randomized Placebo-Controlled Trial
- (2011) Jill P. Smith et al. DIGESTIVE DISEASES AND SCIENCES
- Safety and Efficacy of Methylnaltrexone in Shortening the Duration of Postoperative Ileus Following Segmental Colectomy: Results of Two Randomized, Placebo-Controlled Phase 3 Trials
- (2011) Chang Sik Yu et al. DISEASES OF THE COLON & RECTUM
- Morphine-induced mu opioid receptor trafficking enhances reward yet prevents compulsive drug use
- (2011) Amy Chang Berger et al. EMBO Molecular Medicine
- Localization and Regulation of Fluorescently Labeled Delta Opioid Receptor, Expressed in Enteric Neurons of Mice
- (2011) Daniel P. Poole et al. GASTROENTEROLOGY
- Salvinorin A has antiinflammatory and antinociceptive effects in experimental models of colitis in mice mediated by KOR and CB1 receptors*
- (2011) Jakub Fichna et al. INFLAMMATORY BOWEL DISEASES
- The Opioid Component of Delayed Gastrointestinal Recovery After Bowel Resection
- (2011) Timothy L. Beard et al. JOURNAL OF GASTROINTESTINAL SURGERY
- Subcutaneous methylnaltrexone for treatment of acute opioid-induced constipation: Phase 2 study in rehabilitation after orthopedic surgery
- (2011) Lucas Anissian et al. Journal of Hospital Medicine
- Tonic GABAA receptor conductance in medial subnucleus of the tractus solitarius neurons is inhibited by activation of μ-opioid receptors
- (2011) Melissa A. Herman et al. JOURNAL OF NEUROPHYSIOLOGY
- A Randomized, Placebo-Controlled Phase 3 Trial (Study SB-767905/012) of Alvimopan for Opioid-Induced Bowel Dysfunction in Patients With Non-Cancer Pain
- (2011) Jan-Peter Jansen et al. JOURNAL OF PAIN
- A Randomized, Placebo-Controlled Phase 3 Trial (Study SB-767905/013) of Alvimopan for Opioid-Induced Bowel Dysfunction in Patients With Non-Cancer Pain
- (2011) Gordon Irving et al. JOURNAL OF PAIN
- Subcutaneous Methylnaltrexone for Treatment of Opioid-Induced Constipation in Patients With Chronic, Nonmalignant Pain: A Randomized Controlled Study
- (2011) Edward Michna et al. JOURNAL OF PAIN
- Resolution of opioid-induced postoperative ileus in a newborn infant after methylnaltrexone
- (2011) Lars Garten et al. JOURNAL OF PEDIATRIC SURGERY
- Differential effects of salvinorin A on endotoxin-induced hypermotility and neurogenic ion transport in mouse ileum
- (2011) J. Fichna et al. NEUROGASTROENTEROLOGY AND MOTILITY
- Efficacy of Subcutaneous Methylnaltrexone in the Treatment of Opioid-Induced Constipation: A Responder Post Hoc Analysis
- (2011) Edward Michna et al. PAIN MEDICINE
- Management of opioid-induced nausea and vomiting in cancer patients: systematic review and evidence-based recommendations
- (2011) Eivor A Laugsand et al. PALLIATIVE MEDICINE
- Delayed Administration of D-Ala2-D-Leu5-Enkephalin, a Delta-Opioid Receptor Agonist, Improves Survival in a Rat Model of Sepsis
- (2011) Cheng Wu Tang et al. TOHOKU JOURNAL OF EXPERIMENTAL MEDICINE
- Effect of subcutaneous methylnaltrexone on patient-reported constipation symptoms
- (2011) Shrividya S. Iyer et al. VALUE IN HEALTH
- Can central antiemetic effects of opioids counter-balance opioid-induced nausea and vomiting?
- (2010) C. C. APFEL et al. ACTA ANAESTHESIOLOGICA SCANDINAVICA
- The role of opioid receptor antagonists in the treatment of opioid-induced constipation: a review
- (2010) Wojciech Leppert ADVANCES IN THERAPY
- The effects of methylnaltrexone alone and in combination with acutely administered codeine on gastrointestinal and colonic transit in health
- (2010) B. S. Wong et al. ALIMENTARY PHARMACOLOGY & THERAPEUTICS
- μ-Opioid receptor stimulation in the medial subnucleus of the tractus solitarius inhibits gastric tone and motility by reducing local GABA activity
- (2010) Melissa A. Herman et al. AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY
- Orally administered soymorphins, soy-derived opioid peptides, suppress feeding and intestinal transit via gut μ1-receptor coupled to 5-HT1A, D2, and GABAB systems
- (2010) Kentaro Kaneko et al. AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY
- Characteristics of tolerance in the guinea pig ileum produced by chronic in vivo exposure to opioid versus cannabinoid agonists
- (2010) Hercules Maguma et al. BIOCHEMICAL PHARMACOLOGY
- Extensive Changes in the Expression of the Opioid Genes between Humans and Chimpanzees
- (2010) Peter Cruz-Gordillo et al. BRAIN BEHAVIOR AND EVOLUTION
- Opioid antagonists for prevention and treatment of opioid-induced gastrointestinal effects
- (2010) Peter Holzer Current Opinion in Anesthesiology
- Development of Opioid Peptide Analogs for Pain Relief
- (2010) A. Janecka et al. CURRENT PHARMACEUTICAL DESIGN
- Lubiprostone Activates Cl− Secretion via cAMP Signaling and Increases Membrane CFTR in the Human Colon Carcinoma Cell Line, T84
- (2010) Mei Ao et al. DIGESTIVE DISEASES AND SCIENCES
- Protective Effects of Black Cumin (Nigella sativa) Oil on TNBS-Induced Experimental Colitis in Rats
- (2010) F. Isik et al. DIGESTIVE DISEASES AND SCIENCES
- Lubiprostone Reverses the Inhibitory Action of Morphine on Mucosal Secretion in Human Small Intestine
- (2010) Xiaohong Sun et al. DIGESTIVE DISEASES AND SCIENCES
- Methylnaltrexone
- (2010) Karly P. Garnock-Jones et al. DRUGS
- Functional impact of a single-nucleotide polymorphism in the OPRD1 promoter region
- (2010) Huiping Zhang et al. JOURNAL OF HUMAN GENETICS
- L-Type Calcium Channels and μ-Opioid Receptors are Involved in Mediating the Anti-Inflammatory Effects of Naloxone
- (2010) Woan-Ching Jan et al. JOURNAL OF SURGICAL RESEARCH
- Potentiating effect of morphine on oral Salmonella enterica serovar Typhimurium infection is μ-opioid receptor-dependent
- (2010) Jessica M. Breslow et al. MICROBIAL PATHOGENESIS
- Review on Molecular and Therapeutic Potential of Thymoquinone in Cancer
- (2010) Sanjeev Banerjee et al. NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL
- Antiasthmatic effect of Nigella sativa in airways of asthmatic patients
- (2010) M.H. Boskabady et al. PHYTOMEDICINE
- Endogenous Morphine Levels Are Increased in Sepsis: A Partial Implication of Neutrophils
- (2010) Elise Glattard et al. PLoS One
- Novel endomorphin analogues with antagonist activity at the mu-opioid receptor in the gastrointestinal tract
- (2010) Jakub Fichna et al. REGULATORY PEPTIDES
- Alvimopan for the Management of Postoperative Ileus After Bowel Resection: Characterization of Clinical Benefit by Pooled Responder Analysis
- (2010) Kirk Ludwig et al. WORLD JOURNAL OF SURGERY
- Effect of genetic factors on opioid action
- (2009) Branka Kosarac et al. Current Opinion in Anesthesiology
- Selective natural kappa opioid and cannabinoid receptor agonists with a potential role in the treatment of gastrointestinal dysfunction
- (2009) J. Fichna et al. DRUG NEWS & PERSPECTIVES
- Methylnaltrexone Treatment of Opioid-Induced Constipation in Patients with Advanced Illness
- (2009) Bruce H. Chamberlain et al. JOURNAL OF PAIN AND SYMPTOM MANAGEMENT
- Minireview: GPCR and G Proteins: Drug Efficacy and Activation in Live Cells
- (2009) Jean-Pierre Vilardaga et al. MOLECULAR ENDOCRINOLOGY
- Electroacupuncture attenuates visceral hyperalgesia and inhibits the enhanced excitability of colon specific sensory neurons in a rat model of irritable bowel syndrome
- (2009) g.-y. xu et al. NEUROGASTROENTEROLOGY AND MOTILITY
- Salvinorin A inhibits colonic transit and neurogenic ion transport in mice by activating κ-opioid and cannabinoid receptors
- (2009) J. Fichna et al. NEUROGASTROENTEROLOGY AND MOTILITY
- Evidence for opioid-induced release of glutamate in guinea pig longitudinal muscle–myenteric plexus strip
- (2009) Josef Donnerer et al. NEUROSCIENCE LETTERS
- Meta-analysis of the relevance of the OPRM1 118A>G genetic variant for pain treatment
- (2009) Carmen Walter et al. PAIN
- A nitro-arginine derivative of trimebutine (NO2-Arg-Trim) attenuates pain induced by colorectal distension in conscious rats
- (2009) Eleonora Distrutti et al. PHARMACOLOGICAL RESEARCH
- Opioid receptors in the gastrointestinal tract
- (2009) Peter Holzer REGULATORY PEPTIDES
- Effects of Opioid Receptor Gene Variation on Targeted Nalmefene Treatment in Heavy Drinkers
- (2008) Albert J. Arias et al. ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH
- The effect of naloxone-3-glucuronide on colonic transit time in healthy men after acute morphine administration: a placebo-controlled double-blinded crossover preclinical volunteer study
- (2008) P. NETZER et al. ALIMENTARY PHARMACOLOGY & THERAPEUTICS
- Clinical trial: alvimopan for the management of post-operative ileus after abdominal surgery: results of an international randomized, double-blind, multicentre, placebo-controlled clinical study
- (2008) M. W. BÜCHLER et al. ALIMENTARY PHARMACOLOGY & THERAPEUTICS
- The Role of Gβγ Subunits in the Organization, Assembly, and Function of GPCR Signaling Complexes
- (2008) Denis J. Dupré et al. Annual Review of Pharmacology and Toxicology
- Gastrointestinal Tract Recovery in Patients Undergoing Bowel Resection
- (2008) Kirk Ludwig ARCHIVES OF SURGERY
- Inhibitory effect of salvinorin A, from Salvia divinorum, on ileitis-induced hypermotility: cross-talk between κ-opioid and cannabinoid CB1 receptors
- (2008) R Capasso et al. BRITISH JOURNAL OF PHARMACOLOGY
- A regulatory variation in OPRK1, the gene encoding the -opioid receptor, is associated with alcohol dependence
- (2008) H. J. Edenberg et al. HUMAN MOLECULAR GENETICS
- The Opioid Antagonist Naltrexone Improves Murine Inflammatory Bowel Disease
- (2008) Gail L. Matters et al. Journal of Immunotoxicology
- Effect of chronic exposure to morphine on the rat blood-brain barrier: focus on the P-glycoprotein
- (2008) Salah Yousif et al. JOURNAL OF NEUROCHEMISTRY
- Subcutaneous Methylnaltrexone for the Treatment of Opioid-Induced Constipation in Patients with Advanced Illness: A Double-Blind, Randomized, Parallel Group, Dose-Ranging Study
- (2008) Russell K. Portenoy et al. JOURNAL OF PAIN AND SYMPTOM MANAGEMENT
- Morphine Tolerance in the Mouse Ileum and Colon
- (2008) G. R. Ross et al. JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS
- Effects of serotonin 5-HT3receptor antagonists on stress-induced colonic hyperalgesia and diarrhoea in rats: a comparative study with opioid receptor agonists, a muscarinic receptor antagonist and a synthetic polymer
- (2008) t. hirata et al. NEUROGASTROENTEROLOGY AND MOTILITY
- Alvimopan and COX-2 inhibition reverse opioid and inflammatory components of postoperative ileus
- (2008) j. schmidt et al. NEUROGASTROENTEROLOGY AND MOTILITY
- Methylnaltrexone for Opioid-Induced Constipation in Advanced Illness
- (2008) Jay Thomas et al. NEW ENGLAND JOURNAL OF MEDICINE
- Alvimopan, a peripherally acting mu-opioid receptor (PAM-OR) antagonist for the treatment of opioid-induced bowel dysfunction: Results from a randomized, double-blind, placebo-controlled, dose-finding study in subjects taking opioids for chronic non-cancer pain
- (2008) Lynn Webster et al. PAIN
- The involvement of the μ-opioid receptor in gastrointestinal pathophysiology: Therapeutic opportunities for antagonism at this receptor
- (2007) Diane L. DeHaven-Hudkins et al. PHARMACOLOGY & THERAPEUTICS
- μ opioid and CB1 cannabinoid receptor interactions: reciprocal inhibition of receptor signaling and neuritogenesis
- (2006) Carl Rios et al. BRITISH JOURNAL OF PHARMACOLOGY
Discover Peeref hubs
Discuss science. Find collaborators. Network.
Join a conversationBecome a Peeref-certified reviewer
The Peeref Institute provides free reviewer training that teaches the core competencies of the academic peer review process.
Get Started