Can Silicon Make an Excellent Drug Even Better? An in vitro and in vivo Head-to-Head Comparison between Loperamide and Its Silicon Analogue Sila-Loperamide

Loperamide and P-glycoprotein inhibition: assessment of the clinical relevance

(2015) Joris Vandenbossche et al.   JOURNAL OF PHARMACY AND PHARMACOLOGY

Quantitative Structure – Clearance Relationships of Acidic Drugs

(2013) Zvetanka Zhivkova et al.   MOLECULAR PHARMACEUTICS

Electron densities of bexarotene and disila-bexarotene from invariom application: a comparative study

(2013) Peter Luger et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Organosilicon Molecules with Medicinal Applications

(2012) Annaliese K. Franz et al.   JOURNAL OF MEDICINAL CHEMISTRY

Disila-analogues of the synthetic retinoids EC23 and TTNN: synthesis, structure and biological evaluation

(2012) Josef B. G. Gluyas et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Practical use of the regression offset approach for the prediction ofin vivointrinsic clearance from hepatocytes

(2012) Anna-Karin Sohlenius-Sternbeck et al.   XENOBIOTICA

High-Affinity, Selective σ Ligands of the 1,2,3,4-Tetrahydro-1,4′-silaspiro[naphthalene-1,4′-piperidine] Type: Syntheses, Structures, and Pharmacological Properties

(2011) Reinhold Tacke et al.   ChemMedChem

Silicon Analogues of the Nonpeptidic GnRH Antagonist AG-045572: Syntheses, Crystal Structure Analyses, and Pharmacological Characterization

(2011) Matthew J. Barnes et al.   ChemMedChem

Synopsis of Some Recent Tactical Application of Bioisosteres in Drug Design

(2011) Nicholas A. Meanwell   JOURNAL OF MEDICINAL CHEMISTRY

An introduction to QT interval prolongation and non-clinical approaches to assessing and reducing risk

(2010) CE Pollard et al.   BRITISH JOURNAL OF PHARMACOLOGY

The effect of plasma protein binding on in vivo efficacy: misconceptions in drug discovery

(2010) Dennis A. Smith et al.   NATURE REVIEWS DRUG DISCOVERY

Sila-Trifluperidol, a Silicon Analogue of the Dopamine (D2) Receptor Antagonist Trifluperidol: Synthesis and Pharmacological Characterization

(2010) Reinhold Tacke et al.   ORGANOMETALLICS

Relationship between Passive Permeability, Efflux, and Predictability of Clearance from In Vitro Metabolic Intrinsic Clearance

(2009) L. Huang et al.   DRUG METABOLISM AND DISPOSITION

In Vitro Metabolism of Haloperidol and Sila-Haloperidol: New Metabolic Pathways Resulting from Carbon/Silicon Exchange

(2009) T. Johansson et al.   DRUG METABOLISM AND DISPOSITION

Target site occupancy: Emerging generalizations from clinical and preclinical studies

(2009) Sarah Grimwood et al.   PHARMACOLOGY & THERAPEUTICS

Sila-Haloperidol, a Silicon Analogue of the Dopamine (D2) Receptor Antagonist Haloperidol: Synthesis, Pharmacological Properties, and Metabolic Fate

(2007) Reinhold Tacke et al.   ChemMedChem