Analogs of the Dopamine Metabolite 5,6-Dihydroxyindole Bind Directly to and Activate the Nuclear Receptor Nurr1

Fragment-like Chloroquinolineamines Activate the Orphan Nuclear Receptor Nurr1 and Elucidate Activation Mechanisms

(2021) Sabine Willems et al.   JOURNAL OF MEDICINAL CHEMISTRY

The transcription factor Nurr1 is upregulated in amyotrophic lateral sclerosis patients and SOD1-G93A mice

(2020) Valeria Valsecchi et al.   Disease Models & Mechanisms

PGE1 and PGA1 bind to Nurr1 and activate its transcriptional function

(2020) Sreekanth Rajan et al.   Nature Chemical Biology

Assessment of NR4A Ligands That Directly Bind and Modulate the Orphan Nuclear Receptor Nurr1

(2020) Paola Munoz-Tello et al.   JOURNAL OF MEDICINAL CHEMISTRY

Molecular Insights into NR4A2(Nurr1): an Emerging Target for Neuroprotective Therapy Against Neuroinflammation and Neuronal Cell Death

(2019) Md. Jakaria et al.   MOLECULAR NEUROBIOLOGY

Structure‐dependent Activation of Gene Expression by Bis‐indole and Quinoline‐derived Activators of Nuclear Receptor 4A2

(2019) Xi Li et al.   Chemical Biology & Drug Design

NURR1 Impairment in Multiple Sclerosis

(2019) Francesca Montarolo et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Chloroquine modulates inflammatory autoimmune responses through Nurr1 in autoimmune diseases

(2019) Tae-Yoon Park et al.   Scientific Reports

The Nurr1 Ligand,1,1-bis(3′-Indolyl)-1-(p-Chlorophenyl)Methane, Modulates Glial Reactivity and Is Neuroprotective in MPTP-Induced Parkinsonism

(2018) Sean L. Hammond et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Do Halogen–Hydrogen Bond Donor Interactions Dominate the Favorable Contribution of Halogens to Ligand–Protein Binding?

(2017) Fang-Yu Lin et al.   JOURNAL OF PHYSICAL CHEMISTRY B

Interactions of iron, dopamine and neuromelanin pathways in brain aging and Parkinson's disease

(2017) Fabio A. Zucca et al.   PROGRESS IN NEUROBIOLOGY

Identification of a Binding Site for Unsaturated Fatty Acids in the Orphan Nuclear Receptor Nurr1

(2016) Ian Mitchelle S. de Vera et al.   ACS Chemical Biology

Nurr1-Based Therapies for Parkinson's Disease

(2016) Jie Dong et al.   CNS Neuroscience & Therapeutics

Cation–π interactions: computational analyses of the aromatic box motif and the fluorination strategy for experimental evaluation

(2015) Matthew R. Davis et al.   PHYSICAL CHEMISTRY CHEMICAL PHYSICS

Nuclear receptor Nurr1 agonists enhance its dual functions and improve behavioral deficits in an animal model of Parkinson’s disease

(2015) Chun-Hyung Kim et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A Nurr1 Agonist Causes Neuroprotection in a Parkinson’s Disease Lesion Model Primed with the Toll-Like Receptor 3 dsRNA Inflammatory Stimulant Poly(I:C)

(2015) Gaynor A. Smith et al.   PLoS One

Measurement of histidine pKa values and tautomer populations in invisible protein states

(2014) A. L. Hansen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Novel Para-Phenyl Substituted Diindolylmethanes Protect Against MPTP Neurotoxicity and Suppress Glial Activation in a Mouse Model of Parkinson’s Disease

(2014) Briana R. De Miranda et al.   TOXICOLOGICAL SCIENCES

Low Dose Bexarotene Treatment Rescues Dopamine Neurons and Restores Behavioral Function in Models of Parkinson’s Disease

(2013) Krista McFarland et al.   ACS Chemical Neuroscience

NURR1 in Parkinson disease—from pathogenesis to therapeutic potential

(2013) Mickael Decressac et al.   Nature Reviews Neurology

Halogen bonding and other σ-hole interactions: a perspective

(2013) Peter Politzer et al.   PHYSICAL CHEMISTRY CHEMICAL PHYSICS

Anti-Parkinsonian Effects of Nurr1 Activator in Ubiquitin-Proteasome System Impairment Induced Animal Model of Parkinson’s Disease

(2012) Zhen Zhang et al.   CNS & Neurological Disorders-Drug Targets

Principles and Applications of Halogen Bonding in Medicinal Chemistry and Chemical Biology

(2012) Rainer Wilcken et al.   JOURNAL OF MEDICINAL CHEMISTRY

Molecular Interaction Studies Using Microscale Thermophoresis

(2011) Moran Jerabek-Willemsen et al.   ASSAY AND DRUG DEVELOPMENT TECHNOLOGIES

5,6-Dihydroxyindole Chemistry: Unexplored Opportunities Beyond Eumelanin

(2011) Marco d'Ischia et al.   EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

The transcription factor NURR1 exerts concentration-dependent effects on target genes mediating distinct biological processes

(2011) Magen M. Johnson   Frontiers in Neuroscience

Disentangling Eumelanin “Black Chromophore”: Visible Absorption Changes As Signatures of Oxidation State- and Aggregation-Dependent Dynamic Interactions in a Model Water-Soluble 5,6-Dihydroxyindole Polymer

(2009) Alessandro Pezzella et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY